PDB: 2624 件ウェブページステータス検索Chemie searchBIRD

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2YGN	WIF domain of human Wnt inhibitory factor 1 in complex with 1,2- dipalmitoylphosphatidylcholine 分子名称: 1,2-DIACYL-SN-GLYCERO-3-PHOSHOCHOLINE, 2-acetamido-2-deoxy-beta-D-glucopyranose, ACETATE ION, ... 著者 Malinauskas, T, Aricescu, A.R, Lu, W, Siebold, C, Jones, E.Y. 登録日 2011-04-19 公開日 2011-07-20 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (1.85 Å) 主引用文献 Modular Mechanism of Wnt Signaling Inhibition by Wnt Inhibitory Factor 1 Nat.Struct.Mol.Biol., 18, 2011
2YGQ	WIF domain-epidermal growth factor (EGF)-like domains 1-3 of human Wnt inhibitory factor 1 in complex with 1,2- dipalmitoylphosphatidylcholine 分子名称: 1,2-DIACYL-SN-GLYCERO-3-PHOSHOCHOLINE, 1,3,4,6-tetra-O-sulfo-beta-D-fructofuranose-(2-1)-2,3,4,6-tetra-O-sulfonato-alpha-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... 著者 Malinauskas, T, Aricescu, A.R, Lu, W, Siebold, C, Jones, E.Y. 登録日 2011-04-19 公開日 2011-07-13 最終更新日 2024-11-06 実験手法 X-RAY DIFFRACTION (3.951 Å) 主引用文献 Modular Mechanism of Wnt Signaling Inhibition by Wnt Inhibitory Factor 1 Nat.Struct.Mol.Biol., 18, 2011
1KV3	HUMAN TISSUE TRANSGLUTAMINASE IN GDP BOUND FORM 分子名称: GUANOSINE-5'-DIPHOSPHATE, Protein-glutamine gamma-glutamyltransferase 著者 Liu, S, Cerione, R.A, Clardy, J. 登録日 2002-01-24 公開日 2002-03-13 最終更新日 2023-08-16 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 Structural basis for the guanine nucleotide-binding activity of tissue transglutaminase and its regulation of transamidation activity. Proc.Natl.Acad.Sci.USA, 99, 2002
1BDA	CATALYTIC DOMAIN OF HUMAN SINGLE CHAIN TISSUE PLASMINOGEN ACTIVATOR IN COMPLEX WITH DANSYL-EGR-CMK (DANSYL-GLU-GLY-ARG CHLOROMETHYL KETONE) 分子名称: N-{[5-(dimethylamino)naphthalen-2-yl]sulfonyl}-L-alpha-glutamyl-N-[(1S)-4-{[amino(iminio)methyl]amino}-1-(chloroacetyl) butyl]glycinamide, SINGLE CHAIN TISSUE TYPE PLASMINOGEN ACTIVATOR 著者 Bode, W, Renatus, M, Engh, R.A. 登録日 1998-05-07 公開日 1999-05-11 最終更新日 2024-10-16 実験手法 X-RAY DIFFRACTION (3.35 Å) 主引用文献 Lysine 156 promotes the anomalous proenzyme activity of tPA: X-ray crystal structure of single-chain human tPA. EMBO J., 16, 1997
3OJM	Crystal Structure of FGF1 complexed with the ectodomain of FGFR2b harboring P253R Apert mutation 分子名称: Fibroblast growth factor receptor 2, Heparin-binding growth factor 1, SULFATE ION 著者 Beenken, A, Mohammadi, M. 登録日 2010-08-23 公開日 2011-08-31 最終更新日 2024-11-06 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Plasticity in Interactions of Fibroblast Growth Factor 1 (FGF1) N Terminus with FGF Receptors Underlies Promiscuity of FGF1. J.Biol.Chem., 287, 2012
3OJ2	Crystal structure of FGF1 complexed with the ectodomain of FGFR2b harboring the A172F Pfeiffer syndrome mutation 分子名称: Fibroblast growth factor receptor 2, Heparin-binding growth factor 1, SULFATE ION 著者 Beenken, A, Mohammadi, M. 登録日 2010-08-20 公開日 2011-08-31 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Plasticity in Interactions of Fibroblast Growth Factor 1 (FGF1) N Terminus with FGF Receptors Underlies Promiscuity of FGF1. J.Biol.Chem., 287, 2012
3OJV	Crystal Structure of FGF1 complexed with the ectodomain of FGFR1c exhibiting an ordered ligand specificity-determining betaC'-betaE loop 分子名称: 4-deoxy-2-O-sulfo-alpha-L-threo-hex-4-enopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose, Basic fibroblast growth factor receptor 1, Heparin-binding growth factor 1 著者 Beenken, A, Mohammadi, M. 登録日 2010-08-23 公開日 2011-12-28 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 Plasticity in Interactions of Fibroblast Growth Factor 1 (FGF1) N Terminus with FGF Receptors Underlies Promiscuity of FGF1. J.Biol.Chem., 287, 2012
4NG9	Factor viia in complex with the inhibitor (2R)-2-[(1-aminoisoquinolin-6-yl)amino]-2-[3-ethoxy-4-(propan-2-yloxy)phenyl]-n-(3-sulfamoylbenzyl)ethanamide 分子名称: (2R)-2-[(1-aminoisoquinolin-6-yl)amino]-2-[3-ethoxy-4-(propan-2-yloxy)phenyl]-N-(3-sulfamoylbenzyl)ethanamide, CALCIUM ION, Factor VIIa (Heavy Chain), ... 著者 Wei, A, Anumula, R. 登録日 2013-11-01 公開日 2014-01-08 最終更新日 2024-10-09 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Design and Synthesis of Phenylpyrrolidine Phenylglycinamides As Highly Potent and Selective TF-FVIIa Inhibitors. ACS Med Chem Lett, 5, 2014
4NGA	Factor viia in complex with the inhibitor (2R)-2-[(1-aminoisoquinolin-6-yl)amino]-2-[3-ethoxy-4-(propan-2-yloxy)phenyl]-N-[2-(propan-2-ylsulfonyl)benzyl]ethanamide 分子名称: (2R)-2-[(1-aminoisoquinolin-6-yl)amino]-2-[3-ethoxy-4-(propan-2-yloxy)phenyl]-N-[2-(propan-2-ylsulfonyl)benzyl]ethanamide, CALCIUM ION, Factor VIIa (Heavy Chain), ... 著者 Wei, A, Anumula, R. 登録日 2013-11-01 公開日 2014-01-08 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (2.15 Å) 主引用文献 Design and Synthesis of Phenylpyrrolidine Phenylglycinamides As Highly Potent and Selective TF-FVIIa Inhibitors. ACS Med Chem Lett, 5, 2014
4YT6	Factor VIIa in complex with the inhibitor 4-{[(R)-[5-ethoxy-2-fluoro-3-(propan-2-yloxy)phenyl](4-phenyl-1H-imidazol-2-yl)methyl]amino}benzenecarboximidamide 分子名称: 4-[[(R)-(5-ethoxy-2-fluoranyl-3-propan-2-yloxy-phenyl)-(4-phenyl-1H-imidazol-2-yl)methyl]amino]benzenecarboximidamide, CALCIUM ION, Coagulation factor VII (heavy chain), ... 著者 Wei, A. 登録日 2015-03-17 公開日 2015-04-29 最終更新日 2024-10-09 実験手法 X-RAY DIFFRACTION (2.07 Å) 主引用文献 Design and synthesis of potent, selective phenylimidazole-based FVIIa inhibitors. Bioorg.Med.Chem.Lett., 25, 2015
4YT7	Factor VIIa in complex with the inhibitor 2-(2-{(R)-[(4-carbamimidoylphenyl)amino][5-ethoxy-2-fluoro-3-(propan-2-yloxy)phenyl]methyl}-1H-imidazol-4-yl)benzamide 分子名称: 2-[2-[(R)-[(4-carbamimidoylphenyl)amino]-(5-ethoxy-2-fluoranyl-3-propan-2-yloxy-phenyl)methyl]-1H-imidazol-4-yl]benzamide, CALCIUM ION, Coagulation factor VII (heavy chain), ... 著者 Wei, A. 登録日 2015-03-17 公開日 2015-04-29 最終更新日 2024-10-16 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Design and synthesis of potent, selective phenylimidazole-based FVIIa inhibitors. Bioorg.Med.Chem.Lett., 25, 2015
2D5V	Crystal structure of HNF-6alpha DNA-binding domain in complex with the TTR promoter 分子名称: 5'-D(*AP*TP*TP*AP*TP*TP*GP*AP*CP*TP*TP*AP*GP*A)-3', 5'-D(*TP*CP*TP*AP*AP*GP*TP*CP*AP*AP*TP*AP*AP*T)-3', ACETATE ION, ... 著者 Iyaguchi, D, Yao, M, Watanabe, N, Nishihira, J, Tanaka, I. 登録日 2005-11-07 公開日 2006-12-05 最終更新日 2024-03-13 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 DNA recognition mechanism of the ONECUT homeodomain of transcription factor HNF-6 Structure, 15, 2007
7S7M	Complex of tissue inhibitor of metalloproteinases-1 (TIMP-1) mutant (L34G/M66D/T98G/P131S/Q153N) with matrix metalloproteinase-3 catalytic domain (MMP-3cd) 分子名称: CALCIUM ION, Metalloproteinase inhibitor 1, Stromelysin-1, ... 著者 Coban, M, Raeeszadeh-Sarmazdeh, M, Sankaran, B, Hockla, A, Radisky, E.S. 登録日 2021-09-16 公開日 2022-03-16 最終更新日 2024-11-06 実験手法 X-RAY DIFFRACTION (3 Å) 主引用文献 Engineering of tissue inhibitor of metalloproteinases TIMP-1 for fine discrimination between closely related stromelysins MMP-3 and MMP-10. J.Biol.Chem., 298, 2022
7S7L	Complex of tissue inhibitor of metalloproteinases-1 (TIMP-1) mutant (L34G/M66S/E67Y/L133N/S155L) with matrix metalloproteinase-3 catalytic domain (MMP-3cd) 分子名称: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, ACETATE ION, CALCIUM ION, ... 著者 Coban, M, Raeeszadeh-Sarmazdeh, M, Hockla, A, Sankaran, B, Radisky, E.S. 登録日 2021-09-16 公開日 2022-03-16 最終更新日 2024-11-06 実験手法 X-RAY DIFFRACTION (2.34 Å) 主引用文献 Engineering of tissue inhibitor of metalloproteinases TIMP-1 for fine discrimination between closely related stromelysins MMP-3 and MMP-10. J.Biol.Chem., 298, 2022
8FPT	STRUCTURE OF ALPHA-SYNUCLEIN FIBRILS DERIVED FROM HUMAN LEWY BODY DEMENTIA TISSUE 分子名称: Alpha-synuclein 著者 Barclay, A.M, Dhavale, D.D, Borcik, C.G, Rau, M.J, Basore, K, Milchberg, M.H, Warmuth, O.A, Kotzbauer, P.T, Rienstra, C.M, Schwieters, C.D. 登録日 2023-01-05 公開日 2023-02-22 最終更新日 2024-05-15 実験手法 SOLID-STATE NMR 主引用文献 Structure of alpha-synuclein fibrils derived from human Lewy body dementia tissue. Biorxiv, 2023
1TPG	F1-G MODULE PAIR RESIDUES 1-91 (C83S) OF TISSUE-TYPE PLASMINOGEN ACTIVATOR (T-PA) (NMR, 298K, PH2.95, REPRESENTATIVE STRUCTURE) 分子名称: T-PLASMINOGEN ACTIVATOR F1-G 著者 Smith, B.O, Downing, A.K, Driscoll, P.C, Dudgeon, T.J, Campbell, I.D. 登録日 1995-06-14 公開日 1995-09-15 最終更新日 2024-10-23 実験手法 SOLUTION NMR 主引用文献 The solution structure and backbone dynamics of the fibronectin type I and epidermal growth factor-like pair of modules of tissue-type plasminogen activator. Structure, 3, 1995
7AAO	Structural evolution of the tissue-specific U2AF2 paralog and alternative splicing factor LS2 分子名称: U2 snRNP auxiliary factor large subunit 著者 Kawale, A.A, Kang, H.S, Sattler, M. 登録日 2020-09-04 公開日 2021-10-06 最終更新日 2024-06-19 実験手法 SOLUTION NMR 主引用文献 Structural evolution of the tissue-specific U2AF2 paralog and alternative splicing factor LS2 To Be Published
7AAF	Structural evolution of the tissue-specific U2AF2 paralog and alternative splicing factor LS2 分子名称: U2 snRNP auxiliary factor large subunit 著者 Kawale, A.A, Kang, H.S, Sattler, M. 登録日 2020-09-04 公開日 2021-10-06 最終更新日 2024-06-19 実験手法 SOLUTION NMR 主引用文献 Structural evolution of the tissue-specific U2AF2 paralog and alternative splicing factor LS2 To Be Published
5VQP	Crystal structure of human pro-TGF-beta1 分子名称: Transforming growth factor beta-1, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose 著者 Zhao, B, Xu, S, Dong, X, Lu, C, Springer, T.A. 登録日 2017-05-09 公開日 2017-11-15 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (2.9 Å) 主引用文献 Prodomain-growth factor swapping in the structure of pro-TGF-beta 1. J. Biol. Chem., 293, 2018
1LB1	Crystal Structure of the Dbl and Pleckstrin homology domains of Dbs in complex with RhoA 分子名称: Guanine nucleotide exchange factor DBS, Transforming protein RhoA 著者 Snyder, J.T, Worthylake, D.K, Rossman, K.L, Betts, L, Pruitt, W.M, Siderovski, D.P, Der, C.J, Sondek, J. 登録日 2002-04-01 公開日 2002-05-29 最終更新日 2023-08-16 実験手法 X-RAY DIFFRACTION (2.81 Å) 主引用文献 Structural basis for the selective activation of Rho GTPases by Dbl exchange factors. Nat.Struct.Biol., 9, 2002
5ZXE	Structure of a consensus sequence derived from the FGF family 分子名称: CHLORIDE ION, Consensus sequence based basic form of fibroblast growth factor, GLYCEROL, ... 著者 Tripathi, S.K, Mandalaparthy, V, Ramaswamy, S, Gosavi, S. 登録日 2018-05-19 公開日 2019-07-24 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (1.3 Å) 主引用文献 Structure of a consensus sequence derived from the FGF family To be published
6SEO	TEAD4 bound to a FAM181B peptide 分子名称: Protein FAM181B, Transcriptional enhancer factor TEF-3 著者 Scheufler, C, Villard, F. 登録日 2019-07-30 公開日 2019-11-20 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (2.55 Å) 主引用文献 Identification of FAM181A and FAM181B as new interactors with the TEAD transcription factors. Protein Sci., 29, 2020
6SEN	TEAD4 bound to a FAM181A peptide 分子名称: Protein FAM181A, SULFATE ION, Transcriptional enhancer factor TEF-3 著者 Scheufler, C, Villard, F. 登録日 2019-07-30 公開日 2019-11-20 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (1.65 Å) 主引用文献 Identification of FAM181A and FAM181B as new interactors with the TEAD transcription factors. Protein Sci., 29, 2020
7U8D	FKBP12 mutant V55G bound to Rapa*-3Z 分子名称: (3S,5Z,6R,7E,9R,10R,12R,14S,15E,17E,19E,21S,23S,26R,27R,30R,34aS)-5-(ethoxyimino)-9,27-dihydroxy-3-{(2R)-1-[(1S,3R,4R)-4-hydroxy-3-methoxycyclohexyl]propan-2-yl}-10,21-dimethoxy-6,8,12,14,20,26-hexamethyl-5,6,9,10,12,13,14,21,22,23,24,25,26,27,32,33,34,34a-octadecahydro-3H-23,27-epoxypyrido[2,1-c][1,4]oxazacyclohentriacontine-1,11,28,29(4H,31H)-tetrone, GLYCEROL, Peptidyl-prolyl cis-trans isomerase FKBP1A 著者 Wassarman, D.R, Shokat, K.M. 登録日 2022-03-08 公開日 2022-09-21 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (1.39 Å) 主引用文献 Tissue-restricted inhibition of mTOR using chemical genetics. Proc.Natl.Acad.Sci.USA, 119, 2022
4RU2	Crystal structure of a RNA-binding protein 39 (RBM39) in complex with fragment of splicing factor (U2AF) from Mus musculus at 2.20 A resolution 分子名称: RNA-binding protein 39 (RBM39), Splicing factor U2AF 65 kDa subunit 著者 Joint Center for Structural Genomics (JCSG), Partnership for T-Cell Biology (TCELL) 登録日 2014-11-17 公開日 2015-02-04 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Crystal structure of a RNA-binding protein 39 (RBM39) in complex with fragment of splicing factor (U2AF) from Mus musculus at 2.20 A resolution To be published

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