PDB: 1955 件ウェブページステータス検索Chemie searchBIRD

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7XD9	Crystal Structure of Dengue Virus serotype 2 (DENV2) Polymerase Elongation Complex (CTP Form) 分子名称: CYTIDINE-5'-TRIPHOSPHATE, GLYCEROL, MAGNESIUM ION, ... 著者 Wu, J, Wang, X, Gong, P. 登録日 2022-03-26 公開日 2022-12-21 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (2.58 Å) 主引用文献 Structural basis of transition from initiation to elongation in de novo viral RNA-dependent RNA polymerases. Proc.Natl.Acad.Sci.USA, 120, 2023
7XD8	Crystal Structure of Dengue Virus Serotype 2 (DENV2) Polymerase Elongation Complex (Native Form) 分子名称: GLYCEROL, NS5, RNA (30-mer), ... 著者 Wu, J, Wang, X, Gong, P. 登録日 2022-03-26 公開日 2022-12-21 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (2.85 Å) 主引用文献 Structural basis of transition from initiation to elongation in de novo viral RNA-dependent RNA polymerases. Proc.Natl.Acad.Sci.USA, 120, 2023
4IKA	Crystal structure of EV71 3Dpol-VPg 分子名称: 3Dpol, NICKEL (II) ION, VPg 著者 Chen, C, Wang, Y.X, Lou, Z.Y. 登録日 2012-12-25 公開日 2013-09-04 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (2.7 Å) 主引用文献 Crystal structure of enterovirus 71 RNA-dependent RNA polymerase complexed with its protein primer VPg: implication for a trans mechanism of VPg uridylylation J.Virol., 87, 2013
5TSN	Crystal structures of Norwalk virus polymerase bound to an RNA primer-template duplex 分子名称: MANGANESE (II) ION, Norwalk virus polymerase, RNA (5'-R(*UP*GP*CP*CP*CP*GP*GP*G)-3') 著者 Shaik, M.M, Ng, K.K. 登録日 2016-10-30 公開日 2017-04-12 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Norovirus RNA-dependent RNA polymerase: A computational study of metal-binding preferences. Proteins, 85, 2017
7W9S	Crystal structure of the enterovirus 71 polymerase elongation complex (C1S3 form) 分子名称: CYTIDINE-5'-TRIPHOSPHATE, Genome polyprotein, MAGNESIUM ION, ... 著者 Wang, M, Gong, P. 登録日 2021-12-10 公開日 2022-11-16 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (2.53 Å) 主引用文献 Crystal structure of a pre-chemistry viral RNA-dependent RNA polymerase suggests participation of two basic residues in catalysis. Nucleic Acids Res., 50, 2022
2JC1	CRYSTAL STRUCTURE OF HEPATITIS C VIRUS POLYMERASE IN COMPLEX WITH INHIBITOR SB698223 分子名称: (2S,4S,5R)-1-(4-TERT-BUTYLBENZOYL)-2-ISOBUTYL-5-(1,3-THIAZOL-2-YL)PYRROLIDINE-2,4-DICARBOXYLIC ACID, RNA-DEPENDENT RNA-POLYMERASE 著者 Wonacott, A, Skarzynski, T, Singh, O.M. 登録日 2006-12-18 公開日 2007-02-13 最終更新日 2024-05-08 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Optimization of Novel Acyl Pyrrolidine Inhibitors of Hepatitis C Virus RNA-Dependent RNA Polymerase Leading to a Development Candidate. J.Med.Chem., 50, 2007
2JC0	CRYSTAL STRUCTURE OF HEPATITIS C VIRUS POLYMERASE IN COMPLEX WITH INHIBITOR SB655264 分子名称: (2S,4S,5R)-2-ISOBUTYL-5-(2-THIENYL)-1-[4-(TRIFLUOROMETHYL)BENZOYL]PYRROLIDINE-2,4-DICARBOXYLIC ACID, RNA-DEPENDENT RNA-POLYMERASE 著者 Wonacott, A, Skarzynski, T, Singh, O.M. 登録日 2006-12-18 公開日 2007-02-13 最終更新日 2024-05-08 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Optimization of Novel Acyl Pyrrolidine Inhibitors of Hepatitis C Virus RNA-Dependent RNA Polymerase Leading to a Development Candidate. J.Med.Chem., 50, 2007
6H9R	Dengue-RdRp3-inhibitor complex soaking 分子名称: 2-(4-methoxy-3-thiophen-2-yl-phenyl)ethanoic acid, DI(HYDROXYETHYL)ETHER, Genome polyprotein, ... 著者 Talapatra, S.K, Kozielski, F. 登録日 2018-08-05 公開日 2019-03-13 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Development and validation of RdRp Screen, a crystallization screen for viral RNA-dependent RNA polymerases. Biol Open, 8, 2019
6H80	Dengue-RdRp3-inhibitor complex co-crystallisation 分子名称: 2-(4-methoxy-3-thiophen-2-yl-phenyl)ethanoic acid, DI(HYDROXYETHYL)ETHER, Genome polyprotein, ... 著者 Talapatra, S.K, Kozielski, F. 登録日 2018-07-31 公開日 2019-03-13 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Development and validation of RdRp Screen, a crystallization screen for viral RNA-dependent RNA polymerases. Biol Open, 8, 2019
6KR2	Crystal structure of Dengue virus nonstructural protein NS5 (form 1) 分子名称: Genome polyprotein, S-ADENOSYL-L-HOMOCYSTEINE, ZINC ION 著者 Wu, J, Lu, G, Ye, H.Q, Gong, P. 登録日 2019-08-20 公開日 2020-04-01 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (3.06 Å) 主引用文献 A conformation-based intra-molecular initiation factor identified in the flavivirus RNA-dependent RNA polymerase. Plos Pathog., 16, 2020
7EKJ	Crystals structure of classical swine fever virus NS5B (residues 91-694) 分子名称: Classical swine fever virus NS5B 著者 Liu, W, Gong, P. 登録日 2021-04-05 公開日 2021-07-28 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (3.06 Å) 主引用文献 An induced-fit de novo initiation mechanism suggested by a pestivirus RNA-dependent RNA polymerase. Nucleic Acids Res., 49, 2021
2R7Q	Crystal Structure of VP1 apoenzyme of Rotavirus SA11 (C-terminal hexahistidine-tagged) 分子名称: RNA-dependent RNA polymerase 著者 Lu, X, Harrison, S.C, Tao, Y.J, Patton, J.T, Nibert, M.L. 登録日 2007-09-09 公開日 2008-07-29 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (2.9 Å) 主引用文献 Mechanism for coordinated RNA packaging and genome replication by rotavirus polymerase VP1. Structure, 16, 2008
2R7O	Crystal Structure of VP1 apoenzyme of Rotavirus SA11 (N-terminal hexahistidine-tagged) 分子名称: RNA-dependent RNA polymerase 著者 Lu, X, Harrison, S.C, Tao, Y.J, Patton, J.T, Nibert, M.L. 登録日 2007-09-09 公開日 2008-07-29 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (3.35 Å) 主引用文献 Mechanism for coordinated RNA packaging and genome replication by rotavirus polymerase VP1. Structure, 16, 2008
8C4S	Apo Hantaan virus polymerase core 分子名称: RNA-directed RNA polymerase L 著者 Durieux trouilleton, Q, Arragain, B, Malet, H. 登録日 2023-01-04 公開日 2023-06-07 実験手法 ELECTRON MICROSCOPY (3.27 Å) 主引用文献 Structures of active Hantaan virus polymerase uncover the mechanisms of Hantaviridae genome replication. Nat Commun, 14, 2023
4ZPB	Coxsackievirus B3 Polymerase - F364W mutant 分子名称: RNA-directed RNA polymerase 著者 Peersen, O.B, McDonald, S.M. 登録日 2015-05-07 公開日 2016-05-11 最終更新日 2024-03-06 実験手法 X-RAY DIFFRACTION (1.797 Å) 主引用文献 Design of a Genetically Stable High Fidelity Coxsackievirus B3 Polymerase That Attenuates Virus Growth in Vivo. J.Biol.Chem., 291, 2016
4ZPD	Coxsackievirus B3 Polymerase - A345V mutant 分子名称: RNA-directed RNA polymerase 著者 Peersen, O.B, McDonald, S.M. 登録日 2015-05-07 公開日 2016-05-11 最終更新日 2024-03-06 実験手法 X-RAY DIFFRACTION (1.797 Å) 主引用文献 Design of a Genetically Stable High Fidelity Coxsackievirus B3 Polymerase That Attenuates Virus Growth in Vivo. J.Biol.Chem., 291, 2016
4ZPA	Coxsackievirus B3 Polymerase - F364Y mutant 分子名称: RNA-directed RNA polymerase, SULFATE ION 著者 Peersen, O.B, McDonald, S.M. 登録日 2015-05-07 公開日 2016-05-11 最終更新日 2024-03-06 実験手法 X-RAY DIFFRACTION (2.665 Å) 主引用文献 Design of a Genetically Stable High Fidelity Coxsackievirus B3 Polymerase That Attenuates Virus Growth in Vivo. J.Biol.Chem., 291, 2016
2XI2	HCV-H77 NS5B Apo Polymerase 分子名称: RNA-directed RNA polymerase, SULFATE ION 著者 Harrus, D, Ahmed-El-Sayed, N, Simister, P.C, Miller, S, Triconnet, M, Hagedorn, C.H, Mahias, K, Rey, F.A, Astier-Gin, T, Bressanelli, S. 登録日 2010-06-25 公開日 2010-08-04 最終更新日 2024-03-27 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Further Insights Into the Roles of GTP and the C- Terminus of the Hepatitis C Virus Polymerase in the Initiation of RNA Synthesis J.Biol.Chem., 285, 2010
1L9K	dengue methyltransferase 分子名称: RNA-DIRECTED RNA POLYMERASE, S-ADENOSYL-L-HOMOCYSTEINE, SULFATE ION 著者 Egloff, M.P, Benarroch, D, Selisko, B, Romette, J.L, Canard, B. 登録日 2002-03-25 公開日 2003-03-25 最終更新日 2024-02-14 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 An RNA cap (nucleoside-2'-O-) methyltransferase in the flavivirus RNA polymerase NS5: crystal structure and functional characterization Embo J., 21, 2002
5CCV	Crystal structure of full-length NS5 from dengue virus type 3 分子名称: RNA-directed RNA polymerase NS5, S-ADENOSYL-L-HOMOCYSTEINE, ZINC ION 著者 Klema, V.J, Choi, K.H. 登録日 2015-07-02 公開日 2016-02-03 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (3.6 Å) 主引用文献 Dengue Virus Nonstructural Protein 5 (NS5) Assembles into a Dimer with a Unique Methyltransferase and Polymerase Interface. Plos Pathog., 12, 2016
4K4T	Poliovirus polymerase elongation complex (r4_form) 分子名称: GLYCEROL, RNA (5'-R(*AP*AP*GP*UP*CP*UP*CP*CP*AP*GP*GP*UP*CP*UP*CP*UP*CP*GP*GP*AP*AP*A)-3'), RNA (5'-R(*GP*GP*GP*AP*GP*AP*UP*GP*A)-3'), ... 著者 Gong, P, Peersen, O.B. 登録日 2013-04-12 公開日 2013-05-22 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (2.75 Å) 主引用文献 Structures of coxsackievirus, rhinovirus, and poliovirus polymerase elongation complexes solved by engineering RNA mediated crystal contacts. Plos One, 8, 2013
4K4S	Poliovirus polymerase elongation complex (r3_form) 分子名称: GLYCEROL, RNA (5'-R(*AP*AP*GP*UP*CP*UP*CP*CP*AP*GP*GP*UP*CP*UP*CP*UP*CP*GP*CP*GP*AP*AP*A)-3'), RNA (5'-R(*GP*GP*GP*AP*GP*AP*UP*GP*A)-3'), ... 著者 Gong, P, Peersen, O.B. 登録日 2013-04-12 公開日 2013-05-22 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Structures of coxsackievirus, rhinovirus, and poliovirus polymerase elongation complexes solved by engineering RNA mediated crystal contacts. Plos One, 8, 2013
4K4U	Poliovirus polymerase elongation complex (r5_form) 分子名称: RNA (5'-R(*AP*AP*GP*UP*CP*UP*CP*CP*AP*GP*GP*UP*CP*UP*CP*UP*CP*UP*CP*GP*UP*CP*GP*AP*AP*A)-3'), RNA (5'-R(*UP*GP*UP*UP*CP*GP*AP*CP*GP*AP*GP*AP*GP*AP*GP*A)-3'), RNA (5'-R(P*GP*GP*GP*GP*GP*AP*GP*AP*UP*GP*A)-3'), ... 著者 Gong, P, Peersen, O.B. 登録日 2013-04-12 公開日 2013-05-22 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (2.85 Å) 主引用文献 Structures of coxsackievirus, rhinovirus, and poliovirus polymerase elongation complexes solved by engineering RNA mediated crystal contacts. Plos One, 8, 2013
4K4V	Poliovirus polymerase elongation complex (r5+1_form) 分子名称: DNA/RNA (5'-R(*UP*GP*UP*UP*CP*GP*AP*CP*GP*AP*GP*AP*GP*AP*GP*A)-D(P*C)-3'), RNA (5'-R(*AP*AP*GP*UP*CP*UP*CP*CP*AP*GP*GP*UP*CP*UP*CP*UP*CP*UP*CP*GP*UP*CP*GP*AP*AP*A)-3'), RNA-directed RNA polymerase 3D-POL, ... 著者 Gong, P, Peersen, O.B. 登録日 2013-04-12 公開日 2013-05-22 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (2.63 Å) 主引用文献 Structures of coxsackievirus, rhinovirus, and poliovirus polymerase elongation complexes solved by engineering RNA mediated crystal contacts. Plos One, 8, 2013
4K4W	Poliovirus polymerase elongation complex (r5+2_form) 分子名称: RNA (5'-R(*UP*GP*UP*UP*CP*GP*AP*CP*GP*AP*GP*AP*GP*AP*GP*AP*CP*C)-3'), RNA (5'-R(P*GP*GP*GP*AP*GP*AP*UP*GP*AP*AP*AP*GP*UP*CP*UP*CP*CP*AP*GP*GP*UP*CP*UP*CP*UP*CP*UP*CP*GP*UP*CP*GP*AP*AP*A)-3'), RNA-directed RNA polymerase 3D-POL 著者 Gong, P, Peersen, O.B. 登録日 2013-04-12 公開日 2013-05-22 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (2.69 Å) 主引用文献 Structures of coxsackievirus, rhinovirus, and poliovirus polymerase elongation complexes solved by engineering RNA mediated crystal contacts. Plos One, 8, 2013

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