PDB: 286 件ウェブページステータス検索Chemie searchBIRD

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6C9J	AMP-activated protein kinase bound to pharmacological activator R734 分子名称: 5'-AMP-activated protein kinase catalytic subunit alpha-1, 5'-AMP-activated protein kinase subunit beta-1, 5'-AMP-activated protein kinase subunit gamma-1, ... 著者 Yan, Y, Zhou, X.E, Novick, S, Shaw, S.J, Li, Y, Brunzelle, J.S, Hitoshi, Y, Griffin, P.R, Xu, H.E, Melcher, K. 登録日 2018-01-26 公開日 2018-11-28 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (3.05 Å) 主引用文献 Structures of AMP-activated protein kinase bound to novel pharmacological activators in phosphorylated, non-phosphorylated, and nucleotide-free states. J. Biol. Chem., 294, 2019
6C9G	AMP-activated protein kinase bound to pharmacological activator R739 分子名称: 5'-AMP-activated protein kinase catalytic subunit alpha-1,5'-AMP-activated protein kinase catalytic subunit alpha-1, 5'-AMP-activated protein kinase subunit beta-1, 5'-AMP-activated protein kinase subunit gamma-1, ... 著者 Yan, Y, Zhou, X.E, Novick, S, Shaw, S.J, Li, Y, Hitoshi, Y, Brunzelle, J.S, Griffin, P.R, Xu, H.E, Melcher, K. 登録日 2018-01-26 公開日 2018-11-28 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (2.7 Å) 主引用文献 Structures of AMP-activated protein kinase bound to novel pharmacological activators in phosphorylated, non-phosphorylated, and nucleotide-free states. J. Biol. Chem., 294, 2019
7MYJ	Structure of full length human AMPK (a2b1g1) in complex with a small molecule activator MSG011 分子名称: (5S,6R,7R,9R,13cR,14R,16aS)-6-methoxy-5-methyl-7-(methylamino)-6,7,8,9,14,15,16,16a-octahydro-5H,13cH-5,9-epoxy-4b,9a,1 5-triazadibenzo[b,h]cyclonona[1,2,3,4-jkl]cyclopenta[e]-as-indacen-14-ol, 5'-AMP-activated protein kinase catalytic subunit alpha-2, 5'-AMP-activated protein kinase subunit beta-1, ... 著者 Ovens, A.J, Gee, Y.S, Ling, N.X.Y, Waters, N.J, Yu, D, Scott, J.W, Parker, M.W, Hoffman, N.J, Kemp, B.E, Baell, J.B, Oakhill, J.S, Langendorf, C.G. 登録日 2021-05-21 公開日 2022-06-29 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (2.95 Å) 主引用文献 Structure-function analysis of the AMPK activator SC4 and identification of a potent pan AMPK activator. Biochem.J., 479, 2022
4L3V	Crystal structure of delta516-525 human cystathionine beta-synthase 分子名称: Cystathionine beta-synthase, PROTOPORPHYRIN IX CONTAINING FE, PYRIDOXAL-5'-PHOSPHATE 著者 Ereno, J, Majtan, T, Oyenarte, I, Kraus, J.P, Martinez, L.A. 登録日 2013-06-07 公開日 2013-09-18 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (3.628 Å) 主引用文献 Structural basis of regulation and oligomerization of human cystathionine beta-synthase, the central enzyme of transsulfuration. Proc.Natl.Acad.Sci.USA, 110, 2013
6C9F	AMP-activated protein kinase bound to pharmacological activator R734 分子名称: 5'-AMP-activated protein kinase catalytic subunit alpha-1,5'-AMP-activated protein kinase catalytic subunit alpha-1, 5'-AMP-activated protein kinase subunit beta-1, 5'-AMP-activated protein kinase subunit gamma-1, ... 著者 Yan, Y, Zhou, X.E, Novick, S, Shaw, S.J, Li, Y, Hitoshi, Y, Brunzelle, J.S, Griffin, P.R, Xu, H.E, Melcher, K. 登録日 2018-01-26 公開日 2018-11-28 最終更新日 2019-12-25 実験手法 X-RAY DIFFRACTION (2.924 Å) 主引用文献 Structures of AMP-activated protein kinase bound to novel pharmacological activators in phosphorylated, non-phosphorylated, and nucleotide-free states. J. Biol. Chem., 294, 2019
4L27	Crystal structure of delta1-39 and delta516-525 human cystathionine beta-synthase D444N mutant containing C-terminal 6xHis tag 分子名称: Cystathionine beta-synthase, PROTOPORPHYRIN IX CONTAINING FE, PYRIDOXAL-5'-PHOSPHATE 著者 Ereno, J, Majtan, T, Oyenarte, I, Kraus, J.P, Martinez, L.A. 登録日 2013-06-04 公開日 2013-09-18 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (3.391 Å) 主引用文献 Structural basis of regulation and oligomerization of human cystathionine beta-synthase, the central enzyme of transsulfuration. Proc.Natl.Acad.Sci.USA, 110, 2013
1MEH	Inosine Monophosphate Dehydrogenase (IMPDH) From Tritrichomonas Foetus with IMP and MOA bound 分子名称: INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE, INOSINIC ACID, MYCOPHENOLIC ACID, ... 著者 Prosise, G.L, Luecke, H. 登録日 2002-08-08 公開日 2003-08-12 最終更新日 2011-07-13 実験手法 X-RAY DIFFRACTION (1.95 Å) 主引用文献 Crystal Structures of Tritrichomonas foetus Inosine Monophosphate Dehydrogenase in Complex with Substrate, Cofactor and Analogs: A Structural Basis for the Random-in Ordered-out Kinetic Mechanism J.Mol.Biol., 326, 2003
1MEI	Inosine Monophosphate Dehydrogenase (IMPDH) From Tritrichomonas Foetus with XMP and mycophenolic acid bound 分子名称: INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE, MYCOPHENOLIC ACID, POTASSIUM ION, ... 著者 Prosise, G.L, Luecke, H. 登録日 2002-08-08 公開日 2003-08-12 最終更新日 2011-07-13 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Crystal Structures of Tritrichomonas foetus Inosine Monophosphate Dehydrogenase in Complex with Substrate, Cofactor and Analogs: A Structural Basis for the Random-in Ordered-out Kinetic Mechanism J.Mol.Biol., 326, 2003
1ME8	Inosine Monophosphate Dehydrogenase (IMPDH) From Tritrichomonas Foetus with RVP bound 分子名称: INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE, POTASSIUM ION, RIBAVIRIN MONOPHOSPHATE, ... 著者 Prosise, G.L, Wu, J, Luecke, H. 登録日 2002-08-08 公開日 2003-01-14 最終更新日 2011-07-13 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Crystal Structure of Tritrichomonas foetus Inosine Monophosphate Dehydrogenase in Complex with the Inhibitor Ribavirin Monophosphate Reveals a Catalysis-dependent Ion-binding Site J.Biol.Chem., 277, 2002
1ME7	Inosine Monophosphate Dehydrogenase (IMPDH) From Tritrichomonas Foetus with RVP and MOA bound 分子名称: INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE, MYCOPHENOLIC ACID, POTASSIUM ION, ... 著者 Prosise, G.L, Wu, J, Luecke, H. 登録日 2002-08-08 公開日 2003-01-14 最終更新日 2011-07-13 実験手法 X-RAY DIFFRACTION (2.15 Å) 主引用文献 Crystal Structure of Tritrichomonas foetus Inosine Monophosphate Dehydrogenase in Complex with the Inhibitor Ribavirin Monophosphate Reveals a Catalysis-dependent Ion-binding Site J.Biol.Chem., 277, 2002
5K24	Crystal structure of the complex between phosphatase PRL-2 in the oxidized state with the Bateman domain of murine magnesium transporter CNNM3 分子名称: CITRATE ANION, Metal transporter CNNM3, Protein tyrosine phosphatase type IVA 2 著者 Kozlov, G, Gulerez, I, Gehring, K. 登録日 2016-05-18 公開日 2016-10-12 最終更新日 2018-10-03 実験手法 X-RAY DIFFRACTION (3.1 Å) 主引用文献 PRL3 phosphatase active site is required for binding the putative magnesium transporter CNNM3. Sci Rep, 7, 2017
5K25	Crystal structure of human phosphatase PRL-2 in complex with the ADP-bound Bateman domain of human magnesium transporter CNNM3 分子名称: ADENOSINE-5'-DIPHOSPHATE, Metal transporter CNNM3, Protein tyrosine phosphatase type IVA 2 著者 Gulerez, I, Kozlov, G, Gehring, K. 登録日 2016-05-18 公開日 2016-10-12 最終更新日 2018-10-03 実験手法 X-RAY DIFFRACTION (3.05 Å) 主引用文献 PRL3 phosphatase active site is required for binding the putative magnesium transporter CNNM3. Sci Rep, 7, 2017
5K22	Crystal structure of the complex between human PRL-2 phosphatase in reduced state and Bateman domain of human CNNM3 分子名称: Metal transporter CNNM3, Protein tyrosine phosphatase type IVA 2 著者 Kozlov, G, Wu, H, Gehring, K. 登録日 2016-05-18 公開日 2016-10-12 最終更新日 2024-03-06 実験手法 X-RAY DIFFRACTION (3 Å) 主引用文献 Phosphocysteine in the PRL-CNNM pathway mediates magnesium homeostasis. EMBO Rep., 17, 2016
5K23	Crystal structure of the complex between human phosphatase PRL-2 in the oxidized state with the Bateman domain of human magnesium transporter CNNM3 分子名称: Metal transporter CNNM3, Protein tyrosine phosphatase type IVA 2 著者 Gulerez, I, Kozlov, G, Gehring, K. 登録日 2016-05-18 公開日 2016-10-12 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (2.96 Å) 主引用文献 PRL3 phosphatase active site is required for binding the putative magnesium transporter CNNM3. Sci Rep, 7, 2017
5KQ5	AMPK bound to allosteric activator 分子名称: 5'-AMP-activated protein kinase catalytic subunit alpha-1, 5'-AMP-activated protein kinase subunit beta-1, 5'-AMP-activated protein kinase subunit gamma-1, ... 著者 Calabrese, M.F, Kurumbail, R.G. 登録日 2016-07-05 公開日 2016-08-17 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (3.41 Å) 主引用文献 Discovery and Preclinical Characterization of 6-Chloro-5-[4-(1-hydroxycyclobutyl)phenyl]-1H-indole-3-carboxylic Acid (PF-06409577), a Direct Activator of Adenosine Monophosphate-activated Protein Kinase (AMPK), for the Potential Treatment of Diabetic Nephropathy. J.Med.Chem., 59, 2016
3PC4	Full length structure of cystathionine beta-synthase from Drosophila in complex with serine 分子名称: (E)-N-({3-hydroxy-2-methyl-5-[(phosphonooxy)methyl]pyridin-4-yl}methylidene)-L-serine, CG1753, isoform A, ... 著者 Koutmos, M, Smith, J.L. 登録日 2010-10-21 公開日 2010-12-01 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 Structural basis for substrate activation and regulation by cystathionine beta-synthase (CBS) domains in cystathionine {beta}-synthase. Proc.Natl.Acad.Sci.USA, 107, 2010
6U9O	Human IMPDH2 treated with ATP, IMP, NAD+, and 2 mM GTP. Fully compressed filament segment reconstruction. 分子名称: ADENOSINE-5'-TRIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, INOSINIC ACID, ... 著者 Johnson, M.C, Kollman, J.M. 登録日 2019-09-09 公開日 2020-03-25 最終更新日 2024-03-20 実験手法 ELECTRON MICROSCOPY (3.36 Å) 主引用文献 Cryo-EM structures demonstrate human IMPDH2 filament assembly tunes allosteric regulation. Elife, 9, 2020
3PC2	Full length structure of cystathionine beta-synthase from Drosophila 分子名称: CG1753, isoform A, PROTOPORPHYRIN IX CONTAINING FE, ... 著者 Koutmos, M, Smith, J.L. 登録日 2010-10-21 公開日 2010-12-01 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Structural basis for substrate activation and regulation by cystathionine beta-synthase (CBS) domains in cystathionine {beta}-synthase. Proc.Natl.Acad.Sci.USA, 107, 2010
3PC3	Full length structure of cystathionine beta-synthase from Drosophila in complex with aminoacrylate 分子名称: 2-[({3-HYDROXY-2-METHYL-5-[(PHOSPHONOOXY)METHYL]PYRIDIN-4-YL}METHYL)AMINO]ACRYLIC ACID, CG1753, isoform A, ... 著者 Koutmos, M, Smith, J.L. 登録日 2010-10-21 公開日 2010-12-01 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (1.55 Å) 主引用文献 Structural basis for substrate activation and regulation by cystathionine beta-synthase (CBS) domains in cystathionine {beta}-synthase. Proc.Natl.Acad.Sci.USA, 107, 2010
6UA5	Human IMPDH2 treated with ATP, IMP, NAD+, and 2 mM GTP. Free interfacial octamer reconstruction. 分子名称: INOSINIC ACID, Inosine-5'-monophosphate dehydrogenase 2, NICOTINAMIDE-ADENINE-DINUCLEOTIDE 著者 Johnson, M.C, Kollman, J.M. 登録日 2019-09-10 公開日 2020-03-25 最終更新日 2024-03-20 実験手法 ELECTRON MICROSCOPY (3.79 Å) 主引用文献 Cryo-EM structures demonstrate human IMPDH2 filament assembly tunes allosteric regulation. Elife, 9, 2020
6U8S	Human IMPDH2 treated with ATP, IMP, NAD+, and 2 mM GTP. Filament assembly interface reconstruction. 分子名称: INOSINIC ACID, Inosine-5'-monophosphate dehydrogenase 2, NICOTINAMIDE-ADENINE-DINUCLEOTIDE 著者 Johnson, M.C, Kollman, J.M. 登録日 2019-09-05 公開日 2020-03-25 最終更新日 2024-03-20 実験手法 ELECTRON MICROSCOPY (3.14 Å) 主引用文献 Cryo-EM structures demonstrate human IMPDH2 filament assembly tunes allosteric regulation. Elife, 9, 2020
6Z3S	Crystal structure of delta466-491 cystathionine beta-synthase from Toxoplasma gondii with O-Acetylserine 分子名称: 2-[({3-HYDROXY-2-METHYL-5-[(PHOSPHONOOXY)METHYL]PYRIDIN-4-YL}METHYL)AMINO]ACRYLIC ACID, Cystathionine beta-synthase 著者 Fernandez-Rodriguez, C, Oyenarte, I, Conter, C, Gonzalez-Recio, I, Quintana, I, Martinez-Chantar, M, Astegno, A, Martinez-Cruz, L.A. 登録日 2020-05-21 公開日 2021-06-02 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (3.048 Å) 主引用文献 Structural insight into the unique conformation of cystathionine beta-synthase from Toxoplasma gondii . Comput Struct Biotechnol J, 19, 2021
6UA2	Human IMPDH2 treated with ATP, IMP, NAD+, and 2 mM GTP. Bent (2/4 compressed, 2/4 extended) segment reconstruction. 分子名称: ADENOSINE-5'-TRIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, INOSINIC ACID, ... 著者 Johnson, M.C, Kollman, J.M. 登録日 2019-09-10 公開日 2020-03-25 最終更新日 2024-03-20 実験手法 ELECTRON MICROSCOPY (4.2 Å) 主引用文献 Cryo-EM structures demonstrate human IMPDH2 filament assembly tunes allosteric regulation. Elife, 9, 2020
6UAJ	Human IMPDH2 treated with ATP, IMP, NAD+, and 2 mM GTP. Free canonical octamer reconstruction. 分子名称: ADENOSINE-5'-TRIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, INOSINIC ACID, ... 著者 Johnson, M.C, Kollman, J.M. 登録日 2019-09-10 公開日 2020-03-25 最終更新日 2024-03-20 実験手法 ELECTRON MICROSCOPY (3.84 Å) 主引用文献 Cryo-EM structures demonstrate human IMPDH2 filament assembly tunes allosteric regulation. Elife, 9, 2020
6UC2	Human IMPDH2 treated with ATP and 2 mM GTP. Free canonical octamer reconstruction. 分子名称: ADENOSINE-5'-TRIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, Inosine-5'-monophosphate dehydrogenase 2 著者 Johnson, M.C, Kollman, J.M. 登録日 2019-09-13 公開日 2020-03-25 最終更新日 2024-03-20 実験手法 ELECTRON MICROSCOPY (4.48 Å) 主引用文献 Cryo-EM structures demonstrate human IMPDH2 filament assembly tunes allosteric regulation. Elife, 9, 2020

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