PDB: 456 件ウェブページステータス検索Chemie searchBIRD

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3CH3	Crystal Structure Analysis of SERA5E from plasmodium falciparum 分子名称: DIHYDROGENPHOSPHATE ION, POTASSIUM ION, Serine-repeat antigen protein 著者 Smith, B.J, Malby, R.L, Colman, P.M, Clarke, O.B. 登録日 2008-03-07 公開日 2008-03-25 最終更新日 2017-10-25 実験手法 X-RAY DIFFRACTION (1.79 Å) 主引用文献 Structural Insights into the Protease-like Antigen Plasmodium falciparum SERA5 and Its Noncanonical Active-Site Serine J.Mol.Biol., 392, 2009
4BQV	MOUSE CATHEPSIN S WITH COVALENT LIGAND 分子名称: (2S,4R)-N-(1-cyanocyclopropyl)-1-(1-methylcyclopropanecarbonyl)-4-[4-(2,2,2-trifluoroethoxy)-2-(trifluoromethyl)phenyl]sulfonylpyrrolidine-2-carboxamide, CATHEPSIN S 著者 Banner, D.W, Benz, J, Gsell, B, Stihle, M, Ruf, A, Haap, W. 登録日 2013-06-03 公開日 2014-06-18 最終更新日 2024-05-01 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 Cathepsin S Nitrile Inhibitors To be Published
2PRE	Crystal structure of plant cysteine protease Ervatamin-C complexed with irreversible inhibitor E-64 at 2.7 A resolution 分子名称: Ervatamin-C, N-[N-[1-HYDROXYCARBOXYETHYL-CARBONYL]LEUCYLAMINO-BUTYL]-GUANIDINE, SULFATE ION 著者 Ghosh, R, Chakrabarti, C, Dattagupta, J.K, Biswas, S. 登録日 2007-05-04 公開日 2008-01-22 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (2.7 Å) 主引用文献 Structural insights into the substrate specificity and activity of ervatamins, the papain-like cysteine proteases from a tropical plant, Ervatamia coronaria. Febs J., 275, 2008
1HUC	THE REFINED 2.15 ANGSTROMS X-RAY CRYSTAL STRUCTURE OF HUMAN LIVER CATHEPSIN B: THE STRUCTURAL BASIS FOR ITS SPECIFICITY 分子名称: CATHEPSIN B 著者 Musil, D, Bode, W. 登録日 1993-04-21 公開日 1995-01-26 最終更新日 2024-06-05 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 The refined 2.15 A X-ray crystal structure of human liver cathepsin B: the structural basis for its specificity. EMBO J., 10, 1991
3BC3	Exploring inhibitor binding at the S subsites of cathepsin L 分子名称: Cathepsin L heavy and light chains, S-benzyl-N-(biphenyl-4-ylacetyl)-L-cysteinyl-N~5~-(diaminomethyl)-D-ornithyl-N-(2-phenylethyl)-L-tyrosinamide 著者 Chowdhury, S.F, Joseph, L, Kumar, S, Tulsidas, S.R, Bhat, S, Ziomek, E, Nard, R.M, Sivaraman, J, Purisima, E.O. 登録日 2007-11-12 公開日 2008-03-18 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Exploring inhibitor binding at the S' subsites of cathepsin L J.Med.Chem., 51, 2008
1ME3	High Resolution Crystal Structure Analysis Of Cruzain non-covalently Bound To A Hydroxymethyl Ketone Inhibitor (II) 分子名称: Cruzipain, [1-(3-HYDROXY-2-OXO-1-PHENETHYL-PROPYLCARBAMOYL)2-PHENYL-ETHYL]-CARBAMIC ACID PYRIDIN-4-YLMETHYL ESTER 著者 Brinen, L.S, Huang, L, Ellman, J.A. 登録日 2002-08-07 公開日 2002-12-18 最終更新日 2017-10-11 実験手法 X-RAY DIFFRACTION (1.2 Å) 主引用文献 Crystal Structures of Reversible Ketone-based Inhibitors of the Cysteine Protease Cruzain Bioorg.Med.Chem., 11, 2003
3CH2	Crystal Structure Analysis of SERA5E from plasmodium falciparum 分子名称: CALCIUM ION, Serine-repeat antigen protein 著者 Smith, B.J, Malby, R.L, Colman, P.M, Clarke, O.B. 登録日 2008-03-07 公開日 2008-03-25 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Structural Insights into the Protease-like Antigen Plasmodium falciparum SERA5 and Its Noncanonical Active-Site Serine J.Mol.Biol., 392, 2009
1ME4	High Resolution Crystal Structure Analysis Of Cruzain non-covalently Bound To A Hydroxymethyl Ketone Inhibitor (I) 分子名称: CRUZIPAIN, [1-(1-BENZYL-3-HYDROXY-2-OXO-PROPYLCARBAMOYL)-2-PHENYL-ETHYL]-CARBAMIC ACID BENZYL ESTER 著者 Brinen, L.S, Huang, L, Ellman, J.A. 登録日 2002-08-07 公開日 2002-12-18 最終更新日 2017-10-11 実験手法 X-RAY DIFFRACTION (1.2 Å) 主引用文献 Crystal Structures of Reversible Ketone-based Inhibitors of the Cysteine Protease Cruzain Bioorg.Med.Chem., 11, 2003
1VSN	Crystal structure of a potent small molecule inhibitor bound to cathepsin K 分子名称: Cathepsin K, N-(2-AMINOETHYL)-N~2~-{(1S)-1-[4'-(AMINOSULFONYL)BIPHENYL-4-YL]-2,2,2-TRIFLUOROETHYL}-L-LEUCINAMIDE 著者 McGrath, M. 登録日 2007-03-19 公開日 2007-04-24 最終更新日 2023-12-27 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Identification of a potent and selective non-basic cathepsin K inhibitor. Bioorg.Med.Chem.Lett., 16, 2006
4XUI	Crystal structure analysis of cruzain bound to the no-covalent analog of WRR-483 (WRR-669) 分子名称: 1,2-ETHANEDIOL, Cruzipain, N-[(2S)-5-(carbamimidamidooxy)-1-oxo-1-{[(1E,3S)-5-phenyl-1-(pyrimidin-2-ylsulfonyl)pent-1-en-3-yl]amino}pentan-2-yl]-4-methylpiperazine-1-carboxamide 著者 Tochowicz, A, McKerrow, J.H. 登録日 2015-01-26 公開日 2015-03-11 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (2.508 Å) 主引用文献 Synthesis and Evaluation of Oxyguanidine Analogues of the Cysteine Protease Inhibitor WRR-483 against Cruzain. Acs Med.Chem.Lett., 7, 2016
4YV8	Crystal structure of cathepsin K bound to the covalent inhibitor lichostatinal 分子名称: Cathepsin K, Lichostatinal, SULFATE ION 著者 Aguda, A.H, Nguyen, N.T, Bromme, D, Brayer, G.D. 登録日 2015-03-19 公開日 2016-05-04 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Affinity Crystallography: A New Approach to Extracting High-Affinity Enzyme Inhibitors from Natural Extracts. J.Nat.Prod., 79, 2016
4YVA	Cathepsin K co-crystallized with actinomycetes extract 分子名称: Cathepsin K, SULFATE ION 著者 Aguda, A.H, Nguyen, N.T, Bromme, D, Brayer, G.D. 登録日 2015-03-19 公開日 2016-05-04 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Affinity Crystallography: A New Approach to Extracting High-Affinity Enzyme Inhibitors from Natural Extracts. J.Nat.Prod., 79, 2016
4X6J	Development of N-(Functionalized benzoyl)-homocycloleucyl-glycinonitriles as Potent Cathepsin K Inhibitors. 分子名称: 2-amino-4-chloro-N-(1-{[(2E)-2-iminoethyl]carbamoyl}cyclohexyl)benzamide, CHLORIDE ION, Cathepsin K, ... 著者 Borisek, J, Mohar, B, Vizovisek, M, Sosnowski, P, Turk, D, Turk, B, Novic, M. 登録日 2014-12-08 公開日 2015-09-09 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (1.59 Å) 主引用文献 Development of N-(Functionalized benzoyl)-homocycloleucyl-glycinonitriles as Potent Cathepsin K Inhibitors. J.Med.Chem., 58, 2015
4YYS	Ficin B crystal form II 分子名称: Ficin isoform B, PHOSPHATE ION 著者 Azarkan, M, Baeyens-Volant, D, Loris, R. 登録日 2015-03-24 公開日 2016-04-13 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (1.35 Å) 主引用文献 Crystal structure of four variants of the protease Ficin from the common fig To Be Published
4YYQ	Ficin A 分子名称: Ficin isoform A 著者 Azarkan, M, Baeyens-Volant, D, Loris, R. 登録日 2015-03-24 公開日 2016-04-13 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (1.594 Å) 主引用文献 Crystal structure of four variants of the protease Ficin from the common fig To Be Published
4YYV	Ficin isoform C crystal form II 分子名称: 3,6,9,12,15,18-HEXAOXAICOSANE, Ficin isoform C, SULFATE ION 著者 Azarkan, M, Baeyens-Volant, D, Loris, R. 登録日 2015-03-24 公開日 2016-04-13 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (1.902 Å) 主引用文献 Crystal structure of four variants of the protease Ficin from the common fig To Be Published
4YYW	Ficin D2 分子名称: Ficin isoform D, SULFATE ION 著者 Azarkan, M, Baeyens-Volant, D, Loris, R. 登録日 2015-03-24 公開日 2016-04-13 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (1.446 Å) 主引用文献 Crystal structure of four variants of the protease Ficin from the common fig To Be Published
4X6H	Development of N-(Functionalized benzoyl)-homocycloleucyl-glycinonitriles as Potent Cathepsin K Inhibitors. 分子名称: 4-amino-3-fluoro-N-(1-{[(2Z)-2-iminoethyl]carbamoyl}cyclohexyl)benzamide, 4-amino-N-{1-[(cyanomethyl)carbamoyl]cyclohexyl}-3-fluorobenzamide, Cathepsin K, ... 著者 Borisek, J, Mohar, B, Vizovisek, M, Sosnowski, P, Turk, D, Turk, B, Novic, M. 登録日 2014-12-08 公開日 2015-09-23 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (1 Å) 主引用文献 Development of N-(Functionalized benzoyl)-homocycloleucyl-glycinonitriles as Potent Cathepsin K Inhibitors. J.Med.Chem., 58, 2015
4X6I	Development of N-(Functionalized benzoyl)-homocycloleucyl-glycinonitriles as Potent Cathepsin K Inhibitors. 分子名称: 2-amino-4-bromo-N-{1-[(cyanomethyl)carbamoyl]cyclohexyl}benzamide, Cathepsin K, SULFATE ION 著者 Borisek, J, Mohar, B, Vizovisek, M, Sosnowski, P, Turk, D, Turk, B, Novic, M. 登録日 2014-12-08 公開日 2015-09-30 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (1.87 Å) 主引用文献 Development of N-(Functionalized benzoyl)-homocycloleucyl-glycinonitriles as Potent Cathepsin K Inhibitors. J.Med.Chem., 58, 2015
4YYR	Ficin B crystal form I 分子名称: Ficin B, SULFATE ION 著者 Azarkan, M, Baeyens-Volant, D, Loris, R. 登録日 2015-03-24 公開日 2016-04-13 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (1.349 Å) 主引用文献 Crystal structure of four variants of the protease Ficin from the common fig To Be Published
4YYU	Ficin C crystal form I 分子名称: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, Ficin isoform C, SULFATE ION 著者 Azarkan, M, Baeyens-Volant, D, Loris, R. 登録日 2015-03-24 公開日 2016-04-13 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (1.177 Å) 主引用文献 Crystal structure of four variants of the protease Ficin from the common fig To Be Published
6YCF	Structure the bromelain protease from Ananas comosus in complex with the E64 inhibitor 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, CITRIC ACID, FBSB, ... 著者 Azarkan, M, Charlier, P, Herman, R, Delbrassine, F, Sauvage, E, M Rabet, N, Calvo Esposito, R, Kerff, F. 登録日 2020-03-18 公開日 2020-11-25 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (1.85 Å) 主引用文献 Structures of the free and inhibitors-bound forms of bromelain and ananain from Ananas comosus stem and in vitro study of their cytotoxicity. Sci Rep, 10, 2020
6YCG	Structure the bromelain protease from Ananas comosus in complex with the TLCK inhibitor 分子名称: CITRIC ACID, FBSB, ISOPROPYL ALCOHOL, ... 著者 Azarkan, M, Charlier, P, Herman, R, Delbrassine, F, Sauvage, E, M Rabet, N, Calvo Esposito, R, Kerff, F. 登録日 2020-03-18 公開日 2020-11-25 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (1.45 Å) 主引用文献 Structures of the free and inhibitors-bound forms of bromelain and ananain from Ananas comosus stem and in vitro study of their cytotoxicity. Sci Rep, 10, 2020
6YCD	Structure the ananain protease from Ananas comosus covalently bound to the TLCK inhibitor 分子名称: Ananain, GLYCEROL, N-[(1S)-5-amino-1-(chloroacetyl)pentyl]-4-methylbenzenesulfonamide, ... 著者 Azarkan, M, Charlier, P, Herman, R, Delbrassine, F, Sauvage, E, M Rabet, N, Calvo Esposito, R, Kerff, F. 登録日 2020-03-18 公開日 2020-11-25 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (1.35 Å) 主引用文献 Structures of the free and inhibitors-bound forms of bromelain and ananain from Ananas comosus stem and in vitro study of their cytotoxicity. Sci Rep, 10, 2020
6YI7	Structure of cathepsin B1 from Schistosoma mansoni (SmCB1) in complex with an azanitrile inhibitor 分子名称: 1-[(2~{S})-1-[[iminomethyl(methyl)amino]-methyl-amino]-4-methyl-1-oxidanylidene-pentan-2-yl]-3-(phenylmethyl)urea, ACETATE ION, Cathepsin B-like peptidase (C01 family) 著者 Jilkova, A, Rezacova, P, Pachl, P, Fanfrlik, J, Rubesova, P, Guetschow, M, Mares, M. 登録日 2020-04-01 公開日 2020-12-16 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (1.29 Å) 主引用文献 Azanitrile Inhibitors of the SmCB1 Protease Target Are Lethal to Schistosoma mansoni : Structural and Mechanistic Insights into Chemotype Reactivity. Acs Infect Dis., 7, 2021

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