PDB: 4939 件ウェブページステータス検索Chemie searchBIRD

---

6QF4	X-Ray structure of human Serine/Threonine Kinase 17B (STK17B) aka DRAK2 in complex with ADP obtained by on-chip soaking 分子名称: 1,2-ETHANEDIOL, ACETATE ION, ADENOSINE-5'-DIPHOSPHATE, ... 著者 Lieske, J, Cerv, M, Kreida, S, Barthelmess, M, Fischer, P, Pakendorf, T, Yefanov, O, Mariani, V, Seine, T, Ross, B.H, Crosas, E, Lorbeer, O, Burkhardt, A, Lane, T.J, Guenther, S, Bergtholdt, J, Schoen, S, Tornroth-Horsefield, S, Chapman, H.N, Meents, A. 登録日 2019-01-09 公開日 2019-07-10 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (2.495 Å) 主引用文献 On-chip crystallization for serial crystallography experiments and on-chip ligand-binding studies. Iucrj, 6, 2019
6QFR	Structure of the mitogen activated kinase kinase 7 dfg-out conformation 分子名称: Dual specificity mitogen-activated protein kinase kinase 7 著者 Wolle, P, Mueller, M.P, Rauh, D. 登録日 2019-01-10 公開日 2019-05-22 最終更新日 2024-05-15 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Characterization of Covalent Pyrazolopyrimidine-MKK7 Complexes and a Report on a Unique DFG-in/Leu-in Conformation of Mitogen-Activated Protein Kinase Kinase 7 (MKK7). J.Med.Chem., 62, 2019
4FKI	Crystal Structure of the Cdk2 in Complex with Aminopyrazole Inhibitor 分子名称: Cyclin-dependent kinase 2, N-(5-cyclopropyl-1H-pyrazol-3-yl)-2-[4-(trifluoromethoxy)phenyl]acetamide 著者 Kang, Y.N, Stuckey, J.A. 登録日 2012-06-13 公開日 2013-05-08 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (1.6 Å) 主引用文献 Crystal Structure of the Cdk2 in Complex with Aminopyrazole Inhibitor To be Published
4FKT	Crystal structure of the cdk2 in complex with oxindole inhibitor 分子名称: Cyclin-dependent kinase 2, N-[2-(dimethylamino)ethyl]-4-{[(Z)-(2-oxo-1,2-dihydro-3H-indol-3-ylidene)methyl]amino}benzenesulfonamide 著者 Kang, Y.N, Stuckey, J.A. 登録日 2012-06-13 公開日 2013-05-08 最終更新日 2013-05-22 実験手法 X-RAY DIFFRACTION (1.6 Å) 主引用文献 Crystal structure of the cdk2 in complex with oxindole inhibitor To be Published
6Q4D	CDK2 in complex with FragLite31 分子名称: 2-(4-bromanyl-2-methoxy-phenyl)ethanoic acid, Cyclin-dependent kinase 2 著者 Wood, D.J, Martin, M.P, Noble, M.E.M. 登録日 2018-12-05 公開日 2019-03-20 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (1.07 Å) 主引用文献 FragLites-Minimal, Halogenated Fragments Displaying Pharmacophore Doublets. An Efficient Approach to Druggability Assessment and Hit Generation. J.Med.Chem., 62, 2019
4FIH	Catalytic domain of human PAK4 with QKFTGLPRQW peptide 分子名称: Serine/threonine-protein kinase PAK 4 著者 Ha, B.H, Boggon, T.J. 登録日 2012-06-08 公開日 2012-09-12 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (1.97 Å) 主引用文献 Type II p21-activated kinases (PAKs) are regulated by an autoinhibitory pseudosubstrate. Proc.Natl.Acad.Sci.USA, 109, 2012
6QE1	P38 alpha complex with AR117046 分子名称: 1-[5-~{tert}-butyl-2-(4-methylphenyl)pyrazol-3-yl]-3-[(1~{S},4~{R})-4-[(3-propan-2-yl-[1,2,4]triazolo[4,3-a]pyridin-6-yl)oxy]-1,2,3,4-tetrahydronaphthalen-1-yl]urea, 2-fluoro-4-[4-(4-fluorophenyl)-1H-pyrazol-3-yl]pyridine, Mitogen-activated protein kinase 14 著者 Brown, D.G, Hurley, C, Irving, S.L. 登録日 2019-01-03 公開日 2020-01-29 最終更新日 2024-05-15 実験手法 X-RAY DIFFRACTION (1.85 Å) 主引用文献 P38 alpha complex with AR117045 and AR117046 To Be Published
4FKQ	Crystal structure of the cdk2 in complex with oxindole inhibitor 分子名称: 4-[(2Z)-2-(7-oxidanylidene-3,6-dihydropyrrolo[3,2-e]benzotriazol-8-ylidene)hydrazinyl]benzenesulfonamide, Cyclin-dependent kinase 2, GLYCEROL 著者 Kang, Y.N, Stuckey, J.A. 登録日 2012-06-13 公開日 2013-05-08 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (1.75 Å) 主引用文献 Crystal structure of the cdk2 in complex with oxindole inhibitor To be Published
4FGB	Crystal structure of human calcium/calmodulin-dependent protein kinase I apo form 分子名称: Calcium/calmodulin-dependent protein kinase type 1 著者 Zha, M, Zhong, C, Ou, Y, Wang, J, Han, L, Ding, J. 登録日 2012-06-04 公開日 2013-01-23 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 Crystal structures of human CaMKIalpha reveal insights into the regulation mechanism of CaMKI. Plos One, 7, 2012
4FMQ	Crystal structure of human ERK2 complexed with a MAPK docking peptide 分子名称: MAPK DOCKING PEPTIDE, Mitogen-activated protein kinase 1, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER 著者 Gogl, G, Toeroe, I, Remenyi, A. 登録日 2012-06-18 公開日 2012-10-31 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (2.098 Å) 主引用文献 Specificity of linear motifs that bind to a common mitogen-activated protein kinase docking groove. Sci.Signal., 5, 2012
4FIJ	Catalytic domain of human PAK4 分子名称: Serine/threonine-protein kinase PAK 4 著者 Ha, B.H, Boggon, T.J. 登録日 2012-06-08 公開日 2012-09-12 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Type II p21-activated kinases (PAKs) are regulated by an autoinhibitory pseudosubstrate. Proc.Natl.Acad.Sci.USA, 109, 2012
4FKU	Crystal structure of the cdk2 in complex with oxindole inhibitor 分子名称: (3Z)-2-oxo-3-[2-(4-sulfamoylphenyl)hydrazinylidene]-2,3-dihydro-1H-indole-5-carboxylic acid, Cyclin-dependent kinase 2, GLYCEROL 著者 Kang, Y.N, Stuckey, J.A. 登録日 2012-06-13 公開日 2013-05-08 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (1.47 Å) 主引用文献 Crystal structure of the cdk2 in complex with oxindole inhibitor To be Published
6QFT	Structure of the mitogen activated kinase kinase 7 in complex with pyrazolopyrimidin 1b 分子名称: 1-[(3~{R})-3-(4-azanyl-3-iodanyl-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl]propan-1-one, Dual specificity mitogen-activated protein kinase kinase 7 著者 Wolle, P, Mueller, M.P, Rauh, D. 登録日 2019-01-10 公開日 2019-05-22 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (2.7 Å) 主引用文献 Characterization of Covalent Pyrazolopyrimidine-MKK7 Complexes and a Report on a Unique DFG-in/Leu-in Conformation of Mitogen-Activated Protein Kinase Kinase 7 (MKK7). J.Med.Chem., 62, 2019
4FR4	Crystal structure of human serine/threonine-protein kinase 32A (YANK1) 分子名称: 1,2-ETHANEDIOL, STAUROSPORINE, Serine/threonine-protein kinase 32A 著者 Chaikuad, A, Elkins, J.M, Krojer, T, Mahajan, P, Goubin, S, Szklarz, M, Tumber, A, Wang, J, Savitsky, P, Shrestha, B, Daga, N, Picaud, S, Fedorov, O, Allerston, C.K, Latwiel, S.V.A, Vollmar, M, Canning, P, von Delft, F, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Knapp, S, Structural Genomics Consortium (SGC) 登録日 2012-06-26 公開日 2012-07-18 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (2.29 Å) 主引用文献 Crystal structure of human serine/threonine-protein kinase 32A (YANK1) To be Published
6QJ7	Difluorophenyl diacylhydrazides: Potent inhibitors of Serum- and Glucocorticoid-inducible Kinase 1 (SGK1) 分子名称: cAMP-dependent protein kinase catalytic subunit alpha, cAMP-dependent protein kinase inhibitor alpha, ~{N}'-[(2~{S})-2-[3,5-bis(fluoranyl)phenyl]-2-oxidanyl-ethanoyl]-2-ethyl-3-methyl-4-oxidanyl-benzohydrazide 著者 Graedler, U. 登録日 2019-01-23 公開日 2020-02-12 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (1.69 Å) 主引用文献 Difluorophenyl diacylhydrazides: Potent inhibitors of Serum- and Glucocorticoid-inducible Kinase 1 (SGK1) To Be Published
4FKG	Crystal structure of the cdk2 in complex with aminopyrazole inhibitor 分子名称: 4-[(5-cyclopropyl-1H-pyrazol-3-yl)carbamoyl]benzoic acid, Cyclin-dependent kinase 2 著者 Kang, Y.N, Stuckey, J.A. 登録日 2012-06-13 公開日 2013-05-08 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (1.51 Å) 主引用文献 Crystal structure of the cdk2 in complex with aminopyrazole inhibitor To be Published
4FKS	Crystal structure of the cdk2 in complex with oxindole inhibitor 分子名称: Cyclin-dependent kinase 2, N-[(4-{[(Z)-(7-oxo-6,7-dihydro-8H-[1,3]thiazolo[5,4-e]indol-8-ylidene)methyl]amino}phenyl)sulfonyl]acetamide 著者 Kang, Y.N, Stuckey, J.A. 登録日 2012-06-13 公開日 2013-05-08 最終更新日 2013-05-22 実験手法 X-RAY DIFFRACTION (1.55 Å) 主引用文献 Crystal structure of the cdk2 in complex with oxindole inhibitor To be Published
4FI1	Crystal structure of scCK2 alpha in complex with ATP 分子名称: ADENOSINE-5'-TRIPHOSPHATE, Casein kinase II subunit alpha, MAGNESIUM ION, ... 著者 Liu, H, Wang, H, Teng, M, Li, X. 登録日 2012-06-07 公開日 2013-06-19 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (2.09 Å) 主引用文献 Crystal structure of scCK2 alpha in complex with ATP To be Published
6QFL	Structure of the mitogen activated kinase kinase 7 active conformation 分子名称: Dual specificity mitogen-activated protein kinase kinase 7 著者 Wolle, P, Mueller, M.P, Rauh, D. 登録日 2019-01-10 公開日 2019-05-22 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Characterization of Covalent Pyrazolopyrimidine-MKK7 Complexes and a Report on a Unique DFG-in/Leu-in Conformation of Mitogen-Activated Protein Kinase Kinase 7 (MKK7). J.Med.Chem., 62, 2019
6QG7	Structure of the mitogen activated kinase kinase 7 in complex with pyrazolopyrimidine 1k 分子名称: (R)-1-(3-(4-amino-3-(naphthalen-1-yl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)prop-2-en-1-one, Dual specificity mitogen-activated protein kinase kinase 7 著者 Wolle, P, Mueller, M.P, Rauh, D. 登録日 2019-01-10 公開日 2019-05-22 最終更新日 2019-06-26 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Characterization of Covalent Pyrazolopyrimidine-MKK7 Complexes and a Report on a Unique DFG-in/Leu-in Conformation of Mitogen-Activated Protein Kinase Kinase 7 (MKK7). J.Med.Chem., 62, 2019
6QHR	Structure of the mitogen activated kinase kinase 7 in complex with pyrazolopyrimidine 1m 分子名称: 1-[(3~{R})-3-[4-azanyl-3-(1~{H}-pyrrolo[2,3-b]pyridin-5-yl)pyrazolo[3,4-d]pyrimidin-1-yl]piperidin-1-yl]propan-1-one, Dual specificity mitogen-activated protein kinase kinase 7 著者 Wolle, P, Mueller, M.P, Rauh, D. 登録日 2019-01-17 公開日 2019-05-22 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (2.52 Å) 主引用文献 Characterization of Covalent Pyrazolopyrimidine-MKK7 Complexes and a Report on a Unique DFG-in/Leu-in Conformation of Mitogen-Activated Protein Kinase Kinase 7 (MKK7). J.Med.Chem., 62, 2019
6Q38	The Crystal structure of CK2a bound to P1-C4 分子名称: 3,5-bis(1-methyl-1,2,3-triazol-4-yl)benzoic acid, BENZOIC ACID, Casein kinase II subunit alpha, ... 著者 Brear, P, Iegre, J, Baker, D, Tan, Y, Sore, H, Donovan, D, Spring, D, Chandra, V, Hyvonen, M. 登録日 2018-12-03 公開日 2019-04-24 最終更新日 2024-03-06 実験手法 X-RAY DIFFRACTION (1.74 Å) 主引用文献 Efficient development of stable and highly functionalised peptides targeting the CK2 alpha /CK2 beta protein-protein interaction. Chem Sci, 10, 2019
6Q4Q	The Crystal structure of CK2a bound to P2-C4 分子名称: 3,5-bis(1-methyl-1,2,3-triazol-4-yl)benzoic acid, ACETATE ION, BENZOIC ACID, ... 著者 Brear, P, Iegre, J, Baker, D, Tan, Y, Sore, H, Donovan, D, Spring, D, Chandra, V, Hyvonen, M. 登録日 2018-12-06 公開日 2019-04-24 最終更新日 2024-03-06 実験手法 X-RAY DIFFRACTION (1.45 Å) 主引用文献 Efficient development of stable and highly functionalised peptides targeting the CK2 alpha /CK2 beta protein-protein interaction. Chem Sci, 10, 2019
6QS5	Crystal Structure of maize CK2 in complex with tyrphostin AG99 分子名称: (~{E})-3-[3,4-bis(oxidanyl)phenyl]-2-cyano-prop-2-enamide, Casein kinase II subunit alpha 著者 Lolli, G, Mazzorana, M, Battistutta, R. 登録日 2019-02-20 公開日 2019-02-27 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (1.961 Å) 主引用文献 Inhibition of protein kinase CK2 by flavonoids and tyrphostins. A structural insight. Biochemistry, 51, 2012
4FG9	Crystal structure of human calcium/calmodulin-dependent protein kinase I 1-320 in complex with ATP 分子名称: ADENOSINE-5'-TRIPHOSPHATE, Calcium/calmodulin-dependent protein kinase type 1 著者 Zha, M, Zhong, C, Ou, Y, Wang, J, Han, L, Ding, J. 登録日 2012-06-04 公開日 2013-01-23 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Crystal structures of human CaMKIalpha reveal insights into the regulation mechanism of CaMKI. Plos One, 7, 2012

<234567891011121314151617>