PDB: 496 件ウェブページステータス検索Chemie searchBIRD

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3U7X	Crystal structure of the human eIF4E-4EBP1 peptide complex without cap 分子名称: Eukaryotic translation initiation factor 4E, Eukaryotic translation initiation factor 4E-binding protein 1, SULFATE ION, ... 著者 Siddiqui, N, Tempel, W, Nedyalkova, L, Wernimont, A.K, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Weigelt, J, Borden, K.L.B, Park, H, Structural Genomics Consortium (SGC) 登録日 2011-10-14 公開日 2011-11-02 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Structural Insights into the Allosteric Effects of 4EBP1 on the Eukaryotic Translation Initiation Factor eIF4E. J.Mol.Biol., 415, 2012
8CL1	HIV-1 mature capsid hexamer from CA-IP6 CLPs, bound to CPSF6 peptide. 分子名称: Cleavage and polyadenylation specificity factor subunit 6, Gag polyprotein 著者 Stacey, J.C.V, Briggs, J.A.G. 登録日 2023-02-16 公開日 2023-04-26 実験手法 ELECTRON MICROSCOPY (3.35 Å) 主引用文献 Two structural switches in HIV-1 capsid regulate capsid curvature and host factor binding. Proc.Natl.Acad.Sci.USA, 120, 2023
8CL2	HIV-1 mature capsid pentamer from CA-IP6 CLPs bound to CPSF6 peptide 分子名称: Gag polyprotein 著者 Stacey, J.C.V, Briggs, J.A.G. 登録日 2023-02-16 公開日 2023-04-26 実験手法 ELECTRON MICROSCOPY (3.45 Å) 主引用文献 Two structural switches in HIV-1 capsid regulate capsid curvature and host factor binding. Proc.Natl.Acad.Sci.USA, 120, 2023
8CKZ	HIV-1 mature capsid pentamer from CA-IP6 CLPs bound to Nup153 peptide 分子名称: Gag polyprotein 著者 Stacey, J.C.V, Briggs, J.A.G. 登録日 2023-02-16 公開日 2023-04-26 実験手法 ELECTRON MICROSCOPY (3.07 Å) 主引用文献 Two structural switches in HIV-1 capsid regulate capsid curvature and host factor binding. Proc.Natl.Acad.Sci.USA, 120, 2023
8CL3	HIV-1 mature capsid hexamer from CA-IP6 CLPs, bound to Sec24C peptide. 分子名称: Gag polyprotein, Protein transport protein Sec24C 著者 Stacey, J.C.V, Briggs, J.A.G. 登録日 2023-02-16 公開日 2023-04-26 実験手法 ELECTRON MICROSCOPY (3.14 Å) 主引用文献 Two structural switches in HIV-1 capsid regulate capsid curvature and host factor binding. Proc.Natl.Acad.Sci.USA, 120, 2023
8CKW	HIV-1 mature capsid pentamer from CA-IP6 CLPs 分子名称: Gag polyprotein 著者 Stacey, J.C.V, Briggs, J.A.G. 登録日 2023-02-16 公開日 2023-04-26 実験手法 ELECTRON MICROSCOPY (3.12 Å) 主引用文献 Two structural switches in HIV-1 capsid regulate capsid curvature and host factor binding. Proc.Natl.Acad.Sci.USA, 120, 2023
8CKX	HIV-1 mature capsid hexamer next to pentamer (type I) from CA-IP6 CLPs 分子名称: Gag polyprotein 著者 Stacey, J.C.V, Briggs, J.A.G. 登録日 2023-02-16 公開日 2023-04-26 実験手法 ELECTRON MICROSCOPY (2.97 Å) 主引用文献 Two structural switches in HIV-1 capsid regulate capsid curvature and host factor binding. Proc.Natl.Acad.Sci.USA, 120, 2023
8CL0	HIV-1 mature capsid hexamer next to pentamer (type I) from CA-IP6 CLPs bound to Nup153 peptide. 分子名称: Gag polyprotein, Nuclear pore complex protein Nup153 著者 Stacey, J.C.V, Briggs, J.A.G. 登録日 2023-02-16 公開日 2023-04-26 実験手法 ELECTRON MICROSCOPY (3.12 Å) 主引用文献 Two structural switches in HIV-1 capsid regulate capsid curvature and host factor binding. Proc.Natl.Acad.Sci.USA, 120, 2023
8CL4	HIV-1 mature capsid pentamer from CA-IP6 CLPs bound to Sec24C peptide 分子名称: Gag polyprotein 著者 Stacey, J.C.V, Briggs, J.A.G. 登録日 2023-02-16 公開日 2023-04-26 実験手法 ELECTRON MICROSCOPY (3.14 Å) 主引用文献 Two structural switches in HIV-1 capsid regulate capsid curvature and host factor binding. Proc.Natl.Acad.Sci.USA, 120, 2023
8CKV	HIV-1 mature capsid hexamer from CA-IP6 CLPs 分子名称: Gag polyprotein 著者 Stacey, J.C.V, Briggs, J.A.G. 登録日 2023-02-16 公開日 2023-04-26 実験手法 ELECTRON MICROSCOPY (2.89 Å) 主引用文献 Two structural switches in HIV-1 capsid regulate capsid curvature and host factor binding. Proc.Natl.Acad.Sci.USA, 120, 2023
8CKY	HIV-1 mature capsid hexamer from CA-IP6 CLPs, bound to Nup153 peptide 分子名称: Gag polyprotein, Nuclear pore complex protein Nup153 著者 Stacey, J.C.V, Briggs, J.A.G. 登録日 2023-02-16 公開日 2023-04-26 実験手法 ELECTRON MICROSCOPY (2.6 Å) 主引用文献 Two structural switches in HIV-1 capsid regulate capsid curvature and host factor binding. Proc.Natl.Acad.Sci.USA, 120, 2023
2M8L	HIV capsid dimer structure 分子名称: Capsid protein p24 著者 Deshmukh, L, Schwieters, C.D, Grishaev, A, Clore, G, Ghirlando, R. 登録日 2013-05-23 公開日 2013-11-20 最終更新日 2023-06-14 実験手法 SOLUTION NMR, SOLUTION SCATTERING 主引用文献 Structure and Dynamics of Full-Length HIV-1 Capsid Protein in Solution. J.Am.Chem.Soc., 135, 2013
2OJG	Crystal structure of ERK2 in complex with N,N-dimethyl-4-(4-phenyl-1H-pyrazol-3-yl)-1H-pyrrole-2-carboxamide 分子名称: Mitogen-activated protein kinase 1, N,N-DIMETHYL-4-(4-PHENYL-1H-PYRAZOL-3-YL)-1H-PYRROLE-2-CARBOXAMIDE, SULFATE ION 著者 Xie, X, Jacobs, M.D. 登録日 2007-01-12 公開日 2007-02-06 最終更新日 2023-12-27 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Flipped Out: Structure-Guided Design of Selective Pyrazolylpyrrole ERK Inhibitors. J.Med.Chem., 50, 2007
2OJI	Crystal structure of ERK2 in complex with N-benzyl-4-(4-(3-chlorophenyl)-1H-pyrazol-3-yl)-1H-pyrrole-2-carboxamide 分子名称: Mitogen-activated protein kinase 1, N-BENZYL-4-[4-(3-CHLOROPHENYL)-1H-PYRAZOL-3-YL]-1H-PYRROLE-2-CARBOXAMIDE, SULFATE ION 著者 Xie, X, Jacobs, M.D. 登録日 2007-01-12 公開日 2007-02-06 最終更新日 2023-12-27 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 Flipped Out: Structure-Guided Design of Selective Pyrazolylpyrrole ERK Inhibitors. J.Med.Chem., 50, 2007
2OJJ	Crystal structure of ERK2 in complex with (S)-N-(1-(3-chloro-4-fluorophenyl)-2-hydroxyethyl)-4-(4-(3-chlorophenyl)-1H-pyrazol-3-yl)-1H-pyrrole-2-carboxamide 分子名称: (S)-N-(1-(3-CHLORO-4-FLUOROPHENYL)-2-HYDROXYETHYL)-4-(4-(3-CHLOROPHENYL)-1H-PYRAZOL-3-YL)-1H-PYRROLE-2-CARBOXAMIDE, Mitogen-activated protein kinase 1, SULFATE ION 著者 Xie, X, Jacobs, M.D. 登録日 2007-01-12 公開日 2007-02-06 最終更新日 2023-12-27 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Flipped Out: Structure-Guided Design of Selective Pyrazolylpyrrole ERK Inhibitors. J.Med.Chem., 50, 2007
2P55	X-ray structure of the human mitogen-activated protein kinase kinase 1 (MEK1) in a complex with ligand and MgATP 分子名称: 2-[(4-ETHYNYL-2-FLUOROPHENYL)AMINO]-3,4-DIFLUORO-N-(2-HYDROXYETHOXY)BENZAMIDE, ADENOSINE-5'-TRIPHOSPHATE, Dual specificity mitogen-activated protein kinase kinase 1, ... 著者 Ohren, J.F, Pavlovsky, A.G. 登録日 2007-03-14 公開日 2007-10-02 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 4-anilino-5-carboxamido-2-pyridone derivatives as noncompetitive inhibitors of mitogen-activated protein kinase kinase. J.Med.Chem., 50, 2007
2PWO	Crystal Structure of HIV-1 CA146 A92E Psuedo Cell 分子名称: CHLORIDE ION, Gag-Pol polyprotein (Pr160Gag-Pol) 著者 Kelly, B.N. 登録日 2007-05-11 公開日 2007-09-25 最終更新日 2024-04-03 実験手法 X-RAY DIFFRACTION (1.45 Å) 主引用文献 Structure of the Antiviral Assembly Inhibitor CAP-1 Complex with the HIV-1 CA Protein. J.Mol.Biol., 373, 2007
2PWM	Crystal Structure of HIV-1 CA146 A92E real cell 分子名称: CHLORIDE ION, Gag-Pol polyprotein 著者 Kelly, B.N. 登録日 2007-05-11 公開日 2007-09-25 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Structure of the Antiviral Assembly Inhibitor CAP-1 Complex with the HIV-1 CA Protein. J.Mol.Biol., 373, 2007
2PXR	Crystal Structure of HIV-1 CA146 in the Presence of CAP-1 分子名称: CHLORIDE ION, Gag-Pol polyprotein (Pr160Gag-Pol), ZINC ION 著者 Kelly, B.N. 登録日 2007-05-14 公開日 2007-09-25 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (1.5 Å) 主引用文献 Structure of the Antiviral Assembly Inhibitor CAP-1 Complex with the HIV-1 CA Protein. J.Mol.Biol., 373, 2007
2M8N	HIV-1 capsid monomer structure 分子名称: Capsid protein p24 著者 Deshmukh, L, Schwieters, C.D, Grishaev, A, Clore, G, Ghirlando, R. 登録日 2013-05-24 公開日 2013-11-20 最終更新日 2023-06-14 実験手法 SOLUTION NMR, SOLUTION SCATTERING 主引用文献 Structure and Dynamics of Full-Length HIV-1 Capsid Protein in Solution. J.Am.Chem.Soc., 135, 2013
2M8P	The structure of the W184AM185A mutant of the HIV-1 capsid protein 分子名称: Capsid protein p24 著者 Deshmukh, L, Schwieters, C.D, Grishaev, A, Clore, G, Ghirlando, R. 登録日 2013-05-24 公開日 2013-11-20 最終更新日 2023-06-14 実験手法 SOLUTION NMR, SOLUTION SCATTERING 主引用文献 Structure and Dynamics of Full-Length HIV-1 Capsid Protein in Solution. J.Am.Chem.Soc., 135, 2013
7UMB	NanoBRET tracer Tram-bo bound to a KSR2-MEK1 complex 分子名称: Dual specificity mitogen-activated protein kinase kinase 1, Kinase suppressor of Ras 2, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ... 著者 Marsiglia, W.M, Khan, K.M, Dar, A.C. 登録日 2022-04-06 公開日 2023-09-27 最終更新日 2024-03-20 実験手法 X-RAY DIFFRACTION (3.231 Å) 主引用文献 Live-cell target engagement of allosteric MEKi on MEK-RAF/KSR-14-3-3 complexes. Nat.Chem.Biol., 20, 2024
3EQD	X-ray structure of the human mitogen-activated protein kinase kinase 1 (MEK1) in a binary complex with ATP-GS and MG2P 分子名称: CALCIUM ION, Dual specificity mitogen-activated protein kinase kinase 1, MAGNESIUM ION, ... 著者 Fischmann, T.O. 登録日 2008-09-30 公開日 2009-02-24 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Crystal Structures of MEK1 Binary and Ternary Complexes with Nucleotides and Inhibitors. Biochemistry, 48, 2009
3E8N	X-ray structure of the human mitogen-activated protein kinase kinase 1 (MEK1) complexed with a potent inhibitor RDEA119 and MgATP 分子名称: ADENOSINE-5'-TRIPHOSPHATE, Dual specificity mitogen-activated protein kinase kinase 1, MAGNESIUM ION, ... 著者 Yan, S, Wang, Z.M. 登録日 2008-08-20 公開日 2009-09-01 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 RDEA119/BAY 869766: a potent, selective, allosteric inhibitor of MEK1/2 for the treatment of cancer. Cancer Res., 69, 2009
7W5O	Crystal structure of ERK2 with an allosteric inhibitor 分子名称: (2R,3R,4S,5R)-2-(4-AMINO-5-IODO-7H-PYRROLO[2,3-D]PYRIMIDIN-7-YL)-5-(HYDROXYMETHYL)TETRAHYDROFURAN-3,4-DIOL, 13-[4-({Imidazo[1,2-a]pyridin-2-yl}methoxy)phenyl]-4,8-dioxa-12,14,16,18-tetraazatetracyclo[9.7.0.0^{3,9}.0^{12,17}]octadeca-1(11),2,9,15,17-pentaen-15-amine, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, ... 著者 Yoshida, M, Kinoshita, T. 登録日 2021-11-30 公開日 2022-02-23 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (2.35 Å) 主引用文献 Identification of a novel target site for ATP-independent ERK2 inhibitors. Biochem.Biophys.Res.Commun., 593, 2022

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