PDB: 957 件ウェブページステータス検索Chemie searchBIRD

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5O2U	Llama VHH in complex with p24 分子名称: Capsid protein p24, VHH 59H10 著者 Caillat, C, Verrips, T, Weissenhorn, W. 登録日 2017-05-22 公開日 2017-06-21 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (2.76 Å) 主引用文献 Unravelling the Molecular Basis of High Affinity Nanobodies against HIV p24: In Vitro Functional, Structural, and in Silico Insights. ACS Infect Dis, 3, 2017
2P55	X-ray structure of the human mitogen-activated protein kinase kinase 1 (MEK1) in a complex with ligand and MgATP 分子名称: 2-[(4-ETHYNYL-2-FLUOROPHENYL)AMINO]-3,4-DIFLUORO-N-(2-HYDROXYETHOXY)BENZAMIDE, ADENOSINE-5'-TRIPHOSPHATE, Dual specificity mitogen-activated protein kinase kinase 1, ... 著者 Ohren, J.F, Pavlovsky, A.G. 登録日 2007-03-14 公開日 2007-10-02 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 4-anilino-5-carboxamido-2-pyridone derivatives as noncompetitive inhibitors of mitogen-activated protein kinase kinase. J.Med.Chem., 50, 2007
2OJG	Crystal structure of ERK2 in complex with N,N-dimethyl-4-(4-phenyl-1H-pyrazol-3-yl)-1H-pyrrole-2-carboxamide 分子名称: Mitogen-activated protein kinase 1, N,N-DIMETHYL-4-(4-PHENYL-1H-PYRAZOL-3-YL)-1H-PYRROLE-2-CARBOXAMIDE, SULFATE ION 著者 Xie, X, Jacobs, M.D. 登録日 2007-01-12 公開日 2007-02-06 最終更新日 2023-12-27 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Flipped Out: Structure-Guided Design of Selective Pyrazolylpyrrole ERK Inhibitors. J.Med.Chem., 50, 2007
5NVN	Crystal structure of the human 4EHP-4E-BP1 complex 分子名称: Eukaryotic translation initiation factor 4E type 2, Eukaryotic translation initiation factor 4E-binding protein 1, FORMIC ACID 著者 Peter, D, Sandmeir, F, Valkov, E. 登録日 2017-05-04 公開日 2017-07-26 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 GIGYF1/2 proteins use auxiliary sequences to selectively bind to 4EHP and repress target mRNA expression. Genes Dev., 31, 2017
2OJJ	Crystal structure of ERK2 in complex with (S)-N-(1-(3-chloro-4-fluorophenyl)-2-hydroxyethyl)-4-(4-(3-chlorophenyl)-1H-pyrazol-3-yl)-1H-pyrrole-2-carboxamide 分子名称: (S)-N-(1-(3-CHLORO-4-FLUOROPHENYL)-2-HYDROXYETHYL)-4-(4-(3-CHLOROPHENYL)-1H-PYRAZOL-3-YL)-1H-PYRROLE-2-CARBOXAMIDE, Mitogen-activated protein kinase 1, SULFATE ION 著者 Xie, X, Jacobs, M.D. 登録日 2007-01-12 公開日 2007-02-06 最終更新日 2023-12-27 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Flipped Out: Structure-Guided Design of Selective Pyrazolylpyrrole ERK Inhibitors. J.Med.Chem., 50, 2007
2OJI	Crystal structure of ERK2 in complex with N-benzyl-4-(4-(3-chlorophenyl)-1H-pyrazol-3-yl)-1H-pyrrole-2-carboxamide 分子名称: Mitogen-activated protein kinase 1, N-BENZYL-4-[4-(3-CHLOROPHENYL)-1H-PYRAZOL-3-YL]-1H-PYRROLE-2-CARBOXAMIDE, SULFATE ION 著者 Xie, X, Jacobs, M.D. 登録日 2007-01-12 公開日 2007-02-06 最終更新日 2023-12-27 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 Flipped Out: Structure-Guided Design of Selective Pyrazolylpyrrole ERK Inhibitors. J.Med.Chem., 50, 2007
5NHH	Human Erk2 with an Erk1/2 inhibitor 分子名称: 5-(2-methoxyethyl)-2-[2-(oxan-4-ylamino)pyrimidin-4-yl]-6,7-dihydro-1~{H}-pyrrolo[3,2-c]pyridin-4-one, Mitogen-activated protein kinase 1, SULFATE ION 著者 Debreczeni, J.E, Ward, R.A, Bethel, P, Cook, C, Davies, E, Eckersley, K, Fairley, G, Feron, L, Flemington, V, Graham, M.A, Greenwood, R, Hopcroft, P, Howard, T.D, Hudson, J, James, M, Jones, C.D, Jones, C.R, Lamont, S, Lewis, R, Lindsay, N, Roberts, K, Simpson, I, StGallay, S, Swallow, S, Tonge, M. 登録日 2017-03-21 公開日 2017-04-19 最終更新日 2024-05-08 実験手法 X-RAY DIFFRACTION (1.94 Å) 主引用文献 Structure-Guided Discovery of Potent and Selective Inhibitors of ERK1/2 from a Modestly Active and Promiscuous Chemical Start Point. J. Med. Chem., 60, 2017
5NGU	Human Erk2 with an Erk1/2 inhibitor 分子名称: 2-[2-[[4-(4-methylpiperazin-1-yl)phenyl]amino]pyrimidin-4-yl]-1,5,6,7-tetrahydropyrrolo[3,2-c]pyridin-4-one, Mitogen-activated protein kinase 1, SULFATE ION 著者 Debreczeni, J.E, Ward, R.A, Bethel, P, Cook, C, Davies, E, Eckersley, K, Fairley, G, Feron, L, Flemington, V, Graham, M.A, Greenwood, R, Hopcroft, P, Howard, T.D, Hudson, J, James, M, Jones, C.D, Jones, C.R, Lamont, S, Lewis, R, Lindsay, N, Roberts, K, Simpson, I, StGallay, S, Swallow, S, Tonge, M. 登録日 2017-03-20 公開日 2017-04-19 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (2.74 Å) 主引用文献 Structure-Guided Discovery of Potent and Selective Inhibitors of ERK1/2 from a Modestly Active and Promiscuous Chemical Start Point. J. Med. Chem., 60, 2017
5NHO	Human Erk2 with an Erk1/2 inhibitor 分子名称: (6~{S})-5-(2-methoxyethyl)-6-methyl-2-[5-methyl-2-[(2-methylpyrazol-3-yl)amino]pyrimidin-4-yl]-6,7-dihydro-1~{H}-pyrrolo[3,2-c]pyridin-4-one, Mitogen-activated protein kinase 1, SULFATE ION 著者 Debreczeni, J.E, Ward, R.A, Bethel, P, Cook, C, Davies, E, Eckersley, K, Fairley, G, Feron, L, Flemington, V, Graham, M.A, Greenwood, R, Hopcroft, P, Howard, T.D, Hudson, J, James, M, Jones, C.D, Jones, C.R, Lamont, S, Lewis, R, Lindsay, N, Roberts, K, Simpson, I, StGallay, S, Swallow, S, Tonge, M. 登録日 2017-03-22 公開日 2017-04-19 最終更新日 2024-05-08 実験手法 X-RAY DIFFRACTION (2.24 Å) 主引用文献 Structure-Guided Discovery of Potent and Selective Inhibitors of ERK1/2 from a Modestly Active and Promiscuous Chemical Start Point. J. Med. Chem., 60, 2017
5NHV	Human Erk2 with an Erk1/2 inhibitor 分子名称: 7-[2-(oxan-4-ylamino)pyrimidin-4-yl]-3,4-dihydro-2~{H}-pyrrolo[1,2-a]pyrazin-1-one, Mitogen-activated protein kinase 1, SULFATE ION 著者 Debreczeni, J.E, Ward, R.A, Bethel, P, Cook, C, Davies, E, Eckersley, K, Fairley, G, Feron, L, Flemington, V, Graham, M.A, Greenwood, R, Hopcroft, P, Howard, T.D, Hudson, J, James, M, Jones, C.D, Jones, C.R, Lamont, S, Lewis, R, Lindsay, N, Roberts, K, Simpson, I, StGallay, S, Swallow, S, Tonge, M. 登録日 2017-03-22 公開日 2017-04-19 最終更新日 2024-05-08 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Structure-Guided Discovery of Potent and Selective Inhibitors of ERK1/2 from a Modestly Active and Promiscuous Chemical Start Point. J. Med. Chem., 60, 2017
5ONS	Crystal structure of the minimal DENR-MCTS1 complex 分子名称: Density-regulated protein, GLYCEROL, Malignant T-cell-amplified sequence 1, ... 著者 Ahmed, Y.L, Sinning, I. 登録日 2017-08-04 公開日 2018-05-23 最終更新日 2024-05-08 実験手法 X-RAY DIFFRACTION (2.14 Å) 主引用文献 DENR-MCTS1 heterodimerization and tRNA recruitment are required for translation reinitiation. PLoS Biol., 16, 2018
2PWO	Crystal Structure of HIV-1 CA146 A92E Psuedo Cell 分子名称: CHLORIDE ION, Gag-Pol polyprotein (Pr160Gag-Pol) 著者 Kelly, B.N. 登録日 2007-05-11 公開日 2007-09-25 最終更新日 2024-04-03 実験手法 X-RAY DIFFRACTION (1.45 Å) 主引用文献 Structure of the Antiviral Assembly Inhibitor CAP-1 Complex with the HIV-1 CA Protein. J.Mol.Biol., 373, 2007
2PWM	Crystal Structure of HIV-1 CA146 A92E real cell 分子名称: CHLORIDE ION, Gag-Pol polyprotein 著者 Kelly, B.N. 登録日 2007-05-11 公開日 2007-09-25 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Structure of the Antiviral Assembly Inhibitor CAP-1 Complex with the HIV-1 CA Protein. J.Mol.Biol., 373, 2007
2PXR	Crystal Structure of HIV-1 CA146 in the Presence of CAP-1 分子名称: CHLORIDE ION, Gag-Pol polyprotein (Pr160Gag-Pol), ZINC ION 著者 Kelly, B.N. 登録日 2007-05-14 公開日 2007-09-25 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (1.5 Å) 主引用文献 Structure of the Antiviral Assembly Inhibitor CAP-1 Complex with the HIV-1 CA Protein. J.Mol.Biol., 373, 2007
3PP1	Crystal Structure of the Human Mitogen-activated protein kinase kinase 1 (MEK 1) in complex with ligand and MgATP 分子名称: 3-[(2R)-2,3-dihydroxypropyl]-6-fluoro-5-[(2-fluoro-4-iodophenyl)amino]-8-methylpyrido[2,3-d]pyrimidine-4,7(3H,8H)-dione, ACETATE ION, ADENOSINE-5'-TRIPHOSPHATE, ... 著者 Dougan, D.R. 登録日 2010-11-23 公開日 2011-02-23 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (2.7 Å) 主引用文献 Discovery of TAK-733, a potent and selective MEK allosteric site inhibitor for the treatment of cancer. Bioorg.Med.Chem.Lett., 21, 2011
3QYW	Crystal structure of ERK2 in complex with an inhibitor 分子名称: 6-(3-bromophenyl)-7H-purin-2-amine, DIMETHYL SULFOXIDE, Mitogen-activated protein kinase 1, ... 著者 Gelin, M, Pochet, S, Hoh, F, Pirochi, M, Guichou, J.-F, Ferrer, J.-L, Labesse, G. 登録日 2011-03-04 公開日 2011-08-24 最終更新日 2017-11-08 実験手法 X-RAY DIFFRACTION (1.5 Å) 主引用文献 In-plate protein crystallization, in situ ligand soaking and X-ray diffraction. Acta Crystallogr.,Sect.D, 67, 2011
3QYZ	Crystal structure of ERK2 in complex with an inhibitor 分子名称: 5'-azido-8-bromo-5'-deoxyadenosine, BETA-MERCAPTOETHANOL, DIMETHYL SULFOXIDE, ... 著者 Gelin, M, Pochet, S, Hoh, F, Pirochi, M, Guichou, J.-F, Ferrer, J.-L, Labesse, G. 登録日 2011-03-04 公開日 2011-08-24 最終更新日 2017-11-08 実験手法 X-RAY DIFFRACTION (1.46 Å) 主引用文献 In-plate protein crystallization, in situ ligand soaking and X-ray diffraction. Acta Crystallogr.,Sect.D, 67, 2011
3SA0	Complex of ERK2 with norathyriol 分子名称: Mitogen-activated protein kinase 1, SULFATE ION, norathyriol 著者 Kurinov, I, Malakhova, M. 登録日 2011-06-02 公開日 2011-12-14 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (1.5947 Å) 主引用文献 Norathyriol Suppresses Skin Cancers Induced by Solar Ultraviolet Radiation by Targeting ERK Kinases. Cancer Res., 72, 2012
3SLS	Crystal Structure of human MEK-1 kinase in complex with UCB1353770 and AMPPNP 分子名称: 2-[(2-fluoro-4-iodophenyl)amino]-5,5-dimethyl-8-oxo-N-[(3R)-piperidin-3-yl]-5,6,7,8-tetrahydro-4H-thieno[2,3-c]azepine-3-carboxamide, Dual specificity mitogen-activated protein kinase kinase 1, MAGNESIUM ION, ... 著者 Meier, C, Ceska, T.A. 登録日 2011-06-25 公開日 2012-02-29 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Engineering human MEK-1 for structural studies: A case study of combinatorial domain hunting. J.Struct.Biol., 177, 2012
3TEI	Crystal structure of human ERK2 complexed with a MAPK docking peptide 分子名称: Mitogen-activated protein kinase 1, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, Ribosomal protein S6 kinase alpha-1 著者 Gogl, G, Remenyi, A. 登録日 2011-08-15 公開日 2012-08-15 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (2.404 Å) 主引用文献 Specificity of linear motifs that bind to a common mitogen-activated protein kinase docking groove. Sci.Signal., 5, 2012
3R63	Structure of ERK2 (SPE) mutant (S246E) 分子名称: Mitogen-activated protein kinase 1 著者 Livnah, O, Karamansha, Y. 登録日 2011-03-21 公開日 2011-08-17 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 Nuclear ERK translocation is mediated by protein kinase CK2 and accelerated by autophosphorylation. Mol.Cell.Biol., 31, 2011
3R90	Crystal structure of Malignant T cell-amplified sequence 1 protein 分子名称: GLYCEROL, Malignant T cell-amplified sequence 1, SULFATE ION, ... 著者 Hong, B, Dimov, S, Tempel, W, Tong, Y, Wernimont, A.K, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Weigelt, J, Park, H, Structural Genomics Consortium (SGC) 登録日 2011-03-24 公開日 2011-04-13 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 Crystal structure of Malignant T cell-amplified sequence 1 protein to be published
3U7X	Crystal structure of the human eIF4E-4EBP1 peptide complex without cap 分子名称: Eukaryotic translation initiation factor 4E, Eukaryotic translation initiation factor 4E-binding protein 1, SULFATE ION, ... 著者 Siddiqui, N, Tempel, W, Nedyalkova, L, Wernimont, A.K, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Weigelt, J, Borden, K.L.B, Park, H, Structural Genomics Consortium (SGC) 登録日 2011-10-14 公開日 2011-11-02 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Structural Insights into the Allosteric Effects of 4EBP1 on the Eukaryotic Translation Initiation Factor eIF4E. J.Mol.Biol., 415, 2012
7RAR	Structure of Q67H mutant of disulfide stabilized HIV-1 CA hexamer 分子名称: CHLORIDE ION, Capsid protein p24, IODIDE ION 著者 Bester, S.M, Kvaratskhelia, M. 登録日 2021-07-02 公開日 2022-09-28 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (2.15 Å) 主引用文献 Structural and Mechanistic Bases of Viral Resistance to HIV-1 Capsid Inhibitor Lenacapavir. Mbio, 13, 2022
7RJ4	Co-crystal structure of lenacapavir bound to N74D mutant of disulfide stabilized HIV-1 CA hexamer 分子名称: CAPSID PROTEIN P24, CHLORIDE ION, IODIDE ION, ... 著者 Bester, S.M, Kvaratskhelia, M. 登録日 2021-07-20 公開日 2022-07-27 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (3.32 Å) 主引用文献 Structural and Mechanistic Bases of Viral Resistance to HIV-1 Capsid Inhibitor Lenacapavir. Mbio, 13, 2022

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