PDB: 2759 件ウェブページステータス検索Chemie searchBIRD

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4CE3	Hsp90 N-terminal domain bound to macrolactam analogues of radicicol. 分子名称: 13-Chloro-14,16-dihydroxy-2-methyl-2,3,4,5,9,10-hexahydrobenz[c][1]azacyclotetradecine-1,11(8H,12H)-dione, ATP-DEPENDENT MOLECULAR CHAPERONE HSP82 著者 Roe, S.M, Parry-Morris, S, Prodromou, C. 登録日 2013-11-08 公開日 2014-01-29 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (2.31 Å) 主引用文献 Synthesis of Macrolactam Analogues of Radicicol and Their Binding to Heat Shock Protein Hsp90. Org.Biomol.Chem., 12, 2014
7QQJ	Sucrose phosphorylase from Jeotgalibaca ciconiae 分子名称: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, Sucrose phosphorylase 著者 Ubiparip, Z, Capra, N, Rozeboom, H.J, Desmet, T, Thunnissen, A.M.W.H. 登録日 2022-01-08 公開日 2023-01-18 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (2.05 Å) 主引用文献 Sucrose phosphorylase from Jeotgalibaca ciconiae To Be Published
4CE1	Hsp90 N-terminal domain bound to macrolactam analogues of radicicol. 分子名称: 15-Chloro-16,18-dihydroxy-2-methyl-3,4,7,8,9,10,11,12-octahydrobenz[c][1]azacyclohexadecine-1,13(2H,14H)-dione, ATP-DEPENDENT MOLECULAR CHAPERONE HSP82 著者 Roe, S.M, Parry-Morris, S, Prodromou, C. 登録日 2013-11-08 公開日 2014-01-29 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (2.01 Å) 主引用文献 Synthesis of Macrolactam Analogues of Radicicol and Their Binding to Heat Shock Protein Hsp90. Org.Biomol.Chem., 12, 2014
4CE2	Hsp90 N-terminal domain bound to macrolactam analogues of radicicol. 分子名称: (9E)-19-CHLORANYL-13-METHYL-16,18-BIS(OXIDANYL)-13-AZABICYCLO[13.4.0]NONADECA-1(15),9,16,18-TETRAENE-3,14-DIONE, ATP-DEPENDENT MOLECULAR CHAPERONE HSP82 著者 Roe, S.M, Parry-Morris, S, Prodromou, C. 登録日 2013-11-08 公開日 2014-01-29 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (2.38 Å) 主引用文献 Synthesis of macrolactam analogues of radicicol and their binding to heat shock protein Hsp90. Org. Biomol. Chem., 12, 2014
5URA	Enantiomer-Specific Binding of the Potent Antinociceptive Agent SBFI-26 to Anandamide transporters FABP7 分子名称: (1S,2S,3S,4S)-3-{[(naphthalen-1-yl)oxy]carbonyl}-2,4-diphenylcyclobutane-1-carboxylic acid, Fatty acid-binding protein, brain, ... 著者 Hsu, H.-C, Li, H. 登録日 2017-02-09 公開日 2017-08-23 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (1.85002172 Å) 主引用文献 The Antinociceptive Agent SBFI-26 Binds to Anandamide Transporters FABP5 and FABP7 at Two Different Sites. Biochemistry, 56, 2017
5UR9	Enantiomer-Specific Binding of the Potent Antinociceptive Agent SBFI-26 to Anandamide transporters FABP5 分子名称: (1S,2S,3S,4S)-3-{[(naphthalen-1-yl)oxy]carbonyl}-2,4-diphenylcyclobutane-1-carboxylic acid, Fatty acid-binding protein, epidermal, ... 著者 Hsu, H.-C, Li, H. 登録日 2017-02-09 公開日 2017-08-23 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (2.19800353 Å) 主引用文献 The Antinociceptive Agent SBFI-26 Binds to Anandamide Transporters FABP5 and FABP7 at Two Different Sites. Biochemistry, 56, 2017
4EGK	Human Hsp90-alpha ATPase domain bound to Radicicol 分子名称: Heat shock protein HSP 90-alpha, RADICICOL 著者 Chen, W.J, Wood, S.P. 登録日 2012-03-31 公開日 2012-05-23 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (1.69 Å) 主引用文献 Fragment screening using capillary electrophoresis (CEfrag) for hit identification of heat shock protein 90 ATPase inhibitors. J Biomol Screen, 17, 2012
1QY8	Crystal Structure of the N-domain of the ER Hsp90 chaperone GRP94 in complex with Radicicol 分子名称: Endoplasmin, RADICICOL 著者 Soldano, K.L, Jivan, A, Nicchitta, C.V, Gewirth, D.T. 登録日 2003-09-09 公開日 2003-11-11 最終更新日 2023-08-23 実験手法 X-RAY DIFFRACTION (1.85 Å) 主引用文献 Structure of the N-terminal domain of GRP94. Basis for ligand specificity and regulation J.Biol.Chem., 278, 2003
2F1E	Solution structure of ApaG protein 分子名称: Protein apaG 著者 Contessa, G, Pertinhez, T.A, Spisni, A, Paci, M, Farah, C.S, Cicero, D.O. 登録日 2005-11-14 公開日 2006-10-24 最終更新日 2024-05-29 実験手法 SOLUTION NMR 主引用文献 Solution structure of ApaG from Xanthomonas axonopodis pv. citri reveals a fibronectin-3 fold. Proteins, 67, 2007
5K1N	Human TTR altered by a rhenium tris-carbonyl Pyta-C12 derivative 分子名称: 1,2-ETHANEDIOL, ACETATE ION, DI(HYDROXYETHYL)ETHER, ... 著者 Stura, E.A, Ciccone, L, Shepard, W. 登録日 2016-05-18 公開日 2016-07-20 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (1.81 Å) 主引用文献 Human TTR conformation altered by rhenium tris-carbonyl derivatives. J.Struct.Biol., 195, 2016
5K1J	Human TTR altered by a rhenium tris-carbonyl Pyta-C8 derivative 分子名称: 1,2-ETHANEDIOL, ACETATE ION, DIMETHYL SULFOXIDE, ... 著者 Stura, E.A, Ciccone, L, Shepard, W. 登録日 2016-05-18 公開日 2016-07-20 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (1.69 Å) 主引用文献 Human TTR conformation altered by rhenium tris-carbonyl derivatives. J.Struct.Biol., 195, 2016
5NNW	NLPPya in complex with glucosamine 分子名称: 2-amino-2-deoxy-beta-D-glucopyranose, 25 kDa protein elicitor, MAGNESIUM ION 著者 Podobnik, M, Anderluh, G, Lenarcic, T. 登録日 2017-04-10 公開日 2017-12-27 最終更新日 2024-10-16 実験手法 X-RAY DIFFRACTION (1.54 Å) 主引用文献 Eudicot plant-specific sphingolipids determine host selectivity of microbial NLP cytolysins. Science, 358, 2017
5NO9	NLPPya in complex with mannosamine 分子名称: 2-amino-2-deoxy-alpha-D-mannopyranose, 25 kDa protein elicitor, MAGNESIUM ION 著者 Podobnik, M, Anderluh, G, Lenarcic, T. 登録日 2017-04-11 公開日 2017-12-27 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (1.75 Å) 主引用文献 Eudicot plant-specific sphingolipids determine host selectivity of microbial NLP cytolysins. Science, 358, 2017
8AF2	Human Sterol Carrier Protein with unnatural amino acid 2,2'-bipyridine alanine incorporated at position 111 分子名称: COPPER (II) ION, Enoyl-CoA hydratase 2, FRAGMENT OF TRITON X-100, ... 著者 Richardson, J.M, Klemencic, E, Jarvis, A.G. 登録日 2022-07-15 公開日 2023-08-16 最終更新日 2024-04-03 実験手法 X-RAY DIFFRACTION (2.51 Å) 主引用文献 Using BpyAla to generate copper artificial metalloenzymes: a catalytic and structural study. Catalysis Science And Technology, 14, 2024
8AF3	Sterol carrier protein Artifical metalloenzyme incorporating Q111C mutation coupled to 2,2'-bipyridine 分子名称: COPPER (II) ION, Enoyl-CoA hydratase 2, FRAGMENT OF TRITON X-100, ... 著者 Richardson, J.M, Klemencic, E, Jarvis, A.G. 登録日 2022-07-15 公開日 2023-08-16 最終更新日 2024-07-10 実験手法 X-RAY DIFFRACTION (1.52 Å) 主引用文献 Using BpyAla to generate copper artificial metalloenzymes: a catalytic and structural study. Catalysis Science And Technology, 14, 2024
7NFW	Human 14-3-3 sigma in complex with human Estrogen Receptor alpha peptide 分子名称: 14-3-3 protein sigma, Estrogen receptor 著者 Roversi, P, Falcicchio, M, Doveston, R. 登録日 2021-02-08 公開日 2021-02-17 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (1.19 Å) 主引用文献 Cooperative stabilisation of 14-3-3 sigma protein-protein interactions via covalent protein modification. Chem Sci, 12, 2021
7NIZ	Human 14-3-3 sigma in complex with human Estrogen Receptor alpha peptide and ligands Fusicoccin-A and WR-1065 分子名称: 14-3-3 protein sigma, Estrogen receptor, FUSICOCCIN, ... 著者 Roversi, P, Falcicchio, M, Doveston, R. 登録日 2021-02-14 公開日 2021-12-01 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (1.48 Å) 主引用文献 Cooperative stabilisation of 14-3-3 sigma protein-protein interactions via covalent protein modification. Chem Sci, 12, 2021
4PME	Human transthyretin (TTR) complexed with ferulic acid and curcumin. 分子名称: (1Z,4Z,6E)-5-hydroxy-1,7-bis(4-hydroxy-3-methoxyphenyl)hepta-1,4,6-trien-3-one, 1,2-ETHANEDIOL, 3-(4-HYDROXY-3-METHOXYPHENYL)-2-PROPENOIC ACID, ... 著者 Stura, E.A, Ciccone, L. 登録日 2014-05-21 公開日 2014-10-08 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (1.264 Å) 主引用文献 Transthyretin complexes with curcumin and bromo-estradiol: evaluation of solubilizing multicomponent mixtures. N Biotechnol, 32, 2014
3MBK	The 1.35 A Structure of the Phosphatase Domain of the Suppressor of T Cell Receptor Signalling Protein in Complex with Sulphate 分子名称: SULFATE ION, Ubiquitin-associated and SH3 domain-containing protein B 著者 Nassar, N, Jakoncic, J. 登録日 2010-03-25 公開日 2010-06-23 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (1.35 Å) 主引用文献 The 1.35 A resolution structure of the phosphatase domain of the suppressor of T-cell receptor signaling protein in complex with sulfate. Acta Crystallogr.,Sect.F, 66, 2010
4PM1	Human transthyretin (TTR) complexed with 16-alpha-bromo-estradiol 分子名称: (14beta,16alpha,17alpha)-16-bromoestra-1,3,5(10)-triene-3,17-diol, 1,2-ETHANEDIOL, Transthyretin 著者 Stura, E.A, Ciccone, L. 登録日 2014-05-20 公開日 2014-10-08 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (1.23 Å) 主引用文献 Transthyretin complexes with curcumin and bromo-estradiol: evaluation of solubilizing multicomponent mixtures. N Biotechnol, 32, 2014
4PMF	Human transthyretin (TTR) complexed with curcumin 分子名称: (1Z,4Z,6E)-5-hydroxy-1,7-bis(4-hydroxy-3-methoxyphenyl)hepta-1,4,6-trien-3-one, 1,2-ETHANEDIOL, SODIUM ION, ... 著者 Stura, E.A, Ciccone, L. 登録日 2014-05-21 公開日 2014-10-08 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (1.35 Å) 主引用文献 Transthyretin complexes with curcumin and bromo-estradiol: evaluation of solubilizing multicomponent mixtures. N Biotechnol, 32, 2014
4TQI	Human transthyretin (TTR) complexed with 3-(9H-fluoren-9-ylideneaminooxy)propanoic acid in a dual binding mode 分子名称: (2S)-3-[(9H-fluoren-9-ylideneamino)oxy]-2-methylpropanoic acid, GLYCEROL, Transthyretin 著者 Stura, E.A, Ciccone, L, Nencetti, S, Rossello, A, Orlandini, E. 登録日 2014-06-11 公開日 2015-06-24 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (1.25 Å) 主引用文献 X-ray crystal structure and activity of fluorenyl-based compounds as transthyretin fibrillogenesis inhibitors. J Enzyme Inhib Med Chem, 2015
1TW6	Structure of an ML-IAP/XIAP chimera bound to a 9mer peptide derived from Smac 分子名称: 1,2-ETHANEDIOL, 2-[BIS-(2-HYDROXY-ETHYL)-AMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, Baculoviral IAP repeat-containing protein 7, ... 著者 Franklin, M.C, Vucic, D, Wallweber, H.J.A, Das, K, Shin, H, Elliott, L.O, Kadkhodayan, S, Deshayes, K, Salvesen, G.S, Fairbrother, W.J. 登録日 2004-06-30 公開日 2004-11-02 最終更新日 2023-08-23 実験手法 X-RAY DIFFRACTION (1.713 Å) 主引用文献 Engineering ML-IAP to produce an extraordinarily potent caspase 9 inhibitor: implications for Smac-dependent anti-apoptotic activity of ML-IAP Biochem.J., 385, 2005
3KGA	Crystal structure of MAPKAP kinase 2 (MK2) complexed with a potent 3-aminopyrazole ATP site inhibitor 分子名称: 6-{3-amino-1-[3-(1H-indol-6-yl)phenyl]-1H-pyrazol-4-yl}-3,4-dihydroisoquinolin-1(2H)-one, MAGNESIUM ION, MAP kinase-activated protein kinase 2 著者 Kroemer, M, Velcicky, J, Izaac, A, Be, C, Huppertz, C, Pflieger, D, Schlapbach, A, Scheufler, C. 登録日 2009-10-28 公開日 2010-01-26 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (2.55 Å) 主引用文献 Novel 3-aminopyrazole inhibitors of MK-2 discovered by scaffold hopping strategy. Bioorg.Med.Chem.Lett., 20, 2010
2IWU	Analogues of radicicol bound to the ATP-binding site of Hsp90 分子名称: (5E)-12-CHLORO-13,15-DIHYDROXY-4,7,8,9-TETRAHYDRO-2-BENZOXACYCLOTRIDECINE-1,10(3H,11H)-DIONE, ATP-DEPENDENT MOLECULAR CHAPERONE HSP82 著者 Roe, S.M, Prodromou, C, Pearl, L.H. 登録日 2006-07-04 公開日 2006-11-30 最終更新日 2023-12-13 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 Inhibition of Hsp90 with Synthetic Macrolactones: Synthesis and Structural and Biological Evaluation of Ring and Conformational Analogs of Radicicol. Chem.Biol., 13, 2006

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