4CE3
Hsp90 N-terminal domain bound to macrolactam analogues of radicicol.
Summary for 4CE3
| Entry DOI | 10.2210/pdb4ce3/pdb |
| Related | 4CE1 4CE2 |
| Descriptor | ATP-DEPENDENT MOLECULAR CHAPERONE HSP82, 13-Chloro-14,16-dihydroxy-2-methyl-2,3,4,5,9,10-hexahydrobenz[c][1]azacyclotetradecine-1,11(8H,12H)-dione (3 entities in total) |
| Functional Keywords | chaperone |
| Biological source | SACCHAROMYCES CEREVISIAE (BAKER'S YEAST) |
| Cellular location | Cytoplasm: P02829 |
| Total number of polymer chains | 1 |
| Total formula weight | 24560.41 |
| Authors | Roe, S.M.,Parry-Morris, S.,Prodromou, C. (deposition date: 2013-11-08, release date: 2014-01-29, Last modification date: 2023-12-20) |
| Primary citation | Dutton, B.L.,Kitson, R.R.A.,Parry-Morris, S.,Roe, S.M.,Prodromou, C.,Moody, C.J. Synthesis of Macrolactam Analogues of Radicicol and Their Binding to Heat Shock Protein Hsp90. Org.Biomol.Chem., 12:1328-, 2014 Cited by PubMed: 24435512DOI: 10.1039/C3OB42211A PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.31 Å) |
Structure validation
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