4EGK

Human Hsp90-alpha ATPase domain bound to Radicicol

Summary for 4EGK

Entry DOI	10.2210/pdb4egk/pdb
Related	4EGH 4EGI
Descriptor	Heat shock protein HSP 90-alpha, RADICICOL (3 entities in total)
Functional Keywords	bergerat fold, hydrolase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological source	Homo sapiens (human)
Cellular location	Cytoplasm: P07900
Total number of polymer chains	1
Total formula weight	26435.02
Authors	Chen, W.J.,Wood, S.P. (deposition date: 2012-03-31, release date: 2012-05-23, Last modification date: 2024-02-28)
Primary citation	Austin, C.,Pettit, S.N.,Magnolo, S.K.,Sanvoisin, J.,Chen, W.,Wood, S.P.,Freeman, L.D.,Pengelly, R.J.,Hughes, D.E. Fragment screening using capillary electrophoresis (CEfrag) for hit identification of heat shock protein 90 ATPase inhibitors. J Biomol Screen, 17:868-876, 2012 Cited by PubMed: 22573733 DOI: 10.1177/1087057112445785 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.69 Å)

Structure validation