4EGI

Hsp90-alpha ATPase domain in complex with 2-Amino-4-ethylthio-6-methyl-1,3,5-triazine

Summary for 4EGI

Entry DOI	10.2210/pdb4egi/pdb
Related	4EGH 4EGK
Descriptor	Heat shock protein HSP 90-alpha, 4-(ethylsulfanyl)-6-methyl-1,3,5-triazin-2-amine (3 entities in total)
Functional Keywords	bergerat fold, hydrolase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological source	Homo sapiens (human)
Cellular location	Cytoplasm: P07900
Total number of polymer chains	1
Total formula weight	26240.48
Authors	Chen, W.J.,Wood, S.P. (deposition date: 2012-03-31, release date: 2012-05-23, Last modification date: 2024-02-28)
Primary citation	Austin, C.,Pettit, S.N.,Magnolo, S.K.,Sanvoisin, J.,Chen, W.,Wood, S.P.,Freeman, L.D.,Pengelly, R.J.,Hughes, D.E. Fragment screening using capillary electrophoresis (CEfrag) for hit identification of heat shock protein 90 ATPase inhibitors. J Biomol Screen, 17:868-876, 2012 Cited by PubMed: 22573733 DOI: 10.1177/1087057112445785 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.79 Å)

Structure validation