6RRM
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![BU of 6rrm by Molmil](/molmil-images/mine/6rrm) | Crystal structure of LdtMt2 from Mycobacterium tuberculosis bound to Ebselen | 分子名称: | 1,2-ETHANEDIOL, AMMONIUM ION, GLYCEROL, ... | 著者 | Brem, J, Lohans, C, Schofield, C. | 登録日 | 2019-05-20 | 公開日 | 2019-08-14 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (1.64 Å) | 主引用文献 | Targeting the Mycobacterium tuberculosis transpeptidase LdtMt2with cysteine-reactive inhibitors including ebselen. Chem.Commun.(Camb.), 55, 2019
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6RYJ
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3QWQ
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3QUS
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![BU of 3qus by Molmil](/molmil-images/mine/3qus) | Crystal Structure of N10-Formyltetrahydrofolate Synthetase with ATPgS | 分子名称: | 2-[2-(2-METHOXY-ETHOXY)-ETHOXY]-ETHOXYL, Formate--tetrahydrofolate ligase, MALEIC ACID, ... | 著者 | Celeste, L.R, Chai, G, Bielak, M, Lovelace, L.L, Lebioda, L. | 登録日 | 2011-02-24 | 公開日 | 2011-12-14 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (2.84 Å) | 主引用文献 | Crystal Strucutre of N10-Formyltetrahydrofolate Synthetase with ATPgS To be Published
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3QY3
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![BU of 3qy3 by Molmil](/molmil-images/mine/3qy3) | PA2801 protein, a putative Thioesterase from Pseudomonas aeruginosa | 分子名称: | CHLORIDE ION, Thioesterase | 著者 | Osipiuk, J, Xu, X, Savchenko, A, Edwards, A, Joachimiak, A, Midwest Center for Structural Genomics (MCSG) | 登録日 | 2011-03-02 | 公開日 | 2011-03-16 | 最終更新日 | 2012-10-10 | 実験手法 | X-RAY DIFFRACTION (1.75 Å) | 主引用文献 | Structure and activity of the Pseudomonas aeruginosa hotdog-fold thioesterases PA5202 and PA2801. Biochem.J., 444, 2012
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6RP0
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![BU of 6rp0 by Molmil](/molmil-images/mine/6rp0) | The crystal structure of a complex between the LlFpg protein, a THF-DNA and an inhibitor | 分子名称: | 2,8-dithioxo-1,2,3,7,8,9-hexahydro-6H-purin-6-one, DNA (5'-D(*CP*TP*CP*TP*TP*TP*(3DR)P*TP*TP*TP*CP*TP*CP*G)-3'), DNA (5'-D(*GP*CP*GP*AP*GP*AP*AP*AP*CP*AP*AP*AP*GP*A)-3'), ... | 著者 | Coste, F, Goffinont, S, Castaing, B. | 登録日 | 2019-05-13 | 公開日 | 2020-04-15 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (2.25 Å) | 主引用文献 | Thiopurine Derivative-Induced Fpg/Nei DNA Glycosylase Inhibition: Structural, Dynamic and Functional Insights. Int J Mol Sci, 21, 2020
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3QWR
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6RV1
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![BU of 6rv1 by Molmil](/molmil-images/mine/6rv1) | human Alanine:Glyoxylate Aminotransferase major allele (AGT-Ma) | 分子名称: | PYRIDOXAL-5'-PHOSPHATE, Serine--pyruvate aminotransferase | 著者 | Giardina, G, Cutruzzola, F, Cellini, B, Mirco, D. | 登録日 | 2019-05-30 | 公開日 | 2020-04-08 | 実験手法 | X-RAY DIFFRACTION (3 Å) | 主引用文献 | Cycloserine enantiomers are reversible inhibitors of human alanine:glyoxylate aminotransferase: implications for Primary Hyperoxaluria type 1. Biochem.J., 476, 2019
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3RY9
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6RWC
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3RZ1
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![BU of 3rz1 by Molmil](/molmil-images/mine/3rz1) | Fluoroalkyl and Alkyl Chains Have Similar Hydrophobicities in Binding to the Hydrophobic Wall of Carbonic Anhydrase | 分子名称: | Carbonic anhydrase 2, DIMETHYL SULFOXIDE, N-(2,2,3,3,4,4,5,5,5-nonafluoropentyl)-4-sulfamoylbenzamide, ... | 著者 | Snyder, P.W, Bai, S, Heroux, A, Whitesides, G.W. | 登録日 | 2011-05-11 | 公開日 | 2011-08-10 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (1.51 Å) | 主引用文献 | Fluoroalkyl and alkyl chains have similar hydrophobicities in binding to the "hydrophobic wall" of carbonic anhydrase. J.Am.Chem.Soc., 133, 2011
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3RU3
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![BU of 3ru3 by Molmil](/molmil-images/mine/3ru3) | Crystal structure of tm0922, a fusion of a domain of unknown function and ADP/ATP-dependent NAD(P)H-hydrate dehydratase from Thermotoga maritima soaked with NADPH and ATP. | 分子名称: | ADENOSINE-5'-TRIPHOSPHATE, BETA-6-HYDROXY-1,4,5,6-TETRAHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE, MAGNESIUM ION, ... | 著者 | Shumilin, I.A, Cymborowski, M, Lesley, S.A, Minor, W. | 登録日 | 2011-05-04 | 公開日 | 2011-06-22 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (2.605 Å) | 主引用文献 | Identification of unknown protein function using metabolite cocktail screening. Structure, 20, 2012
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3S06
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6S69
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![BU of 6s69 by Molmil](/molmil-images/mine/6s69) | Crystal structure of hTEAD2 in complex with a trisubstituted pyrazole inhibitor | 分子名称: | 3-[3-(3,4-dichlorophenyl)-4-(2-phenylethylcarbamoyl)pyrazol-1-yl]propanoic acid, MYRISTIC ACID, Transcriptional enhancer factor TEF-4 | 著者 | Sturbaut, M, Allemand, F, Guichou, J.F. | 登録日 | 2019-07-02 | 公開日 | 2020-07-22 | 最終更新日 | 2022-02-02 | 実験手法 | X-RAY DIFFRACTION (2.15 Å) | 主引用文献 | Discovery of a cryptic site at the interface 2 of TEAD - Towards a new family of YAP/TAZ-TEAD inhibitors. Eur.J.Med.Chem., 226, 2021
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3RUY
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![BU of 3ruy by Molmil](/molmil-images/mine/3ruy) | Crystal Structure of the Ornithine-oxo acid transaminase RocD from Bacillus anthracis | 分子名称: | Ornithine aminotransferase | 著者 | Anderson, S.M, Wawrzak, Z, Brunzelle, J.S, Onopriyenko, O, Peterson, S.N, Anderson, W.F, Savchenko, A, Center for Structural Genomics of Infectious Diseases (CSGID) | 登録日 | 2011-05-05 | 公開日 | 2011-05-18 | 最終更新日 | 2011-07-13 | 実験手法 | X-RAY DIFFRACTION (2.65 Å) | 主引用文献 | Crystal Structure of the Ornithine-oxo acid transaminase RocD from Bacillus anthracis To be Published
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6S07
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![BU of 6s07 by Molmil](/molmil-images/mine/6s07) | Structure of formylglycine-generating enzyme at 1.04 A in complex with copper and substrate reveals an acidic pocket for binding and acti-vation of molecular oxygen. | 分子名称: | Abz-ALA-THR-THR-PRO-LEU-CYS-GLY-PRO-SER-ARG-ALA-SER-ILE-LEU-SER-GLY-ARG, CALCIUM ION, CHLORIDE ION, ... | 著者 | Leisinger, F, Miarzlou, D.A, Seebeck, F.P. | 登録日 | 2019-06-14 | 公開日 | 2019-06-26 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (1.04 Å) | 主引用文献 | Structure of formylglycine-generating enzyme in complex with copper and a substrate reveals an acidic pocket for binding and activation of molecular oxygen. Chem Sci, 10, 2019
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3RVG
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![BU of 3rvg by Molmil](/molmil-images/mine/3rvg) | Crystals structure of Jak2 with a 1-amino-5H-pyrido[4,3-b]indol-4-carboxamide inhibitor | 分子名称: | 1-(cyclohexylamino)-7-(1-methyl-1H-pyrazol-4-yl)-5H-pyrido[4,3-b]indole-4-carboxamide, Tyrosine-protein kinase JAK2 | 著者 | Lim, J, Taoka, B, Otte, R.D, Spencer, K, Dinsmore, C.J, Altman, M.D, Chan, G, Rosenstein, C, Sharma, S, Su, H.P, Szewczak, A.A, Xu, L, Yin, H, Zugay-Murphy, J, Marshall, C.G, Young, J.R. | 登録日 | 2011-05-06 | 公開日 | 2012-03-21 | 最終更新日 | 2017-11-08 | 実験手法 | X-RAY DIFFRACTION (2.498 Å) | 主引用文献 | Discovery of 1-amino-5H-pyrido[4,3-b]indol-4-carboxamide inhibitors of Janus kinase 2 (JAK2) for the treatment of myeloproliferative disorders. J.Med.Chem., 54, 2011
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3RZ5
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![BU of 3rz5 by Molmil](/molmil-images/mine/3rz5) | Fluoroalkyl and Alkyl Chains Have Similar Hydrophobicities in Binding to the Hydrophobic Wall of Carbonic Anhydrase | 分子名称: | Carbonic anhydrase 2, DIMETHYL SULFOXIDE, N-pentyl-4-sulfamoylbenzamide, ... | 著者 | Snyder, P.W, Bai, S, Heroux, A, Whitesides, G.W. | 登録日 | 2011-05-11 | 公開日 | 2011-08-10 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (1.65 Å) | 主引用文献 | Fluoroalkyl and alkyl chains have similar hydrophobicities in binding to the "hydrophobic wall" of carbonic anhydrase. J.Am.Chem.Soc., 133, 2011
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6S5R
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![BU of 6s5r by Molmil](/molmil-images/mine/6s5r) | Cfucosylated second generation peptide dendrimer SBD6 bound to Fucose binding Lectin LecB (PA-IIL) from Pseudomonas aeruginosa at 2.08 Angstrom resolution, incomplete structure | 分子名称: | 3,7-anhydro-2,8-dideoxy-L-glycero-D-gluco-octonic acid, CALCIUM ION, Fucose-binding lectin, ... | 著者 | Baeriswyl, S, Stocker, A, Reymond, J.-L. | 登録日 | 2019-07-02 | 公開日 | 2019-08-21 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (2.076 Å) | 主引用文献 | X-Ray Crystal Structure of a Second Generation Peptide Dendrimer in Complex with Pseudomonas aeruginosa Lectin LecB Helv.Chim.Acta, 2019
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8DIC
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8DIF
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8DIH
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![BU of 8dih by Molmil](/molmil-images/mine/8dih) | Virtual screening for novel SARS-CoV-2 main protease non-covalent and covalent inhibitors | 分子名称: | (1P,1'R)-1-(isoquinolin-4-yl)-2',3'-dihydrospiro[imidazolidine-4,1'-indene]-2,5-dione, 3C-like proteinase nsp5 | 著者 | Singh, I, Shoichet, B.K. | 登録日 | 2022-06-29 | 公開日 | 2023-06-28 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (2.12 Å) | 主引用文献 | Large library docking for novel SARS-CoV-2 main protease non-covalent and covalent inhibitors. Protein Sci., 32, 2023
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8DIG
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8DII
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8DIE
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