3RVG
Crystals structure of Jak2 with a 1-amino-5H-pyrido[4,3-b]indol-4-carboxamide inhibitor
Summary for 3RVG
Entry DOI | 10.2210/pdb3rvg/pdb |
Descriptor | Tyrosine-protein kinase JAK2, 1-(cyclohexylamino)-7-(1-methyl-1H-pyrazol-4-yl)-5H-pyrido[4,3-b]indole-4-carboxamide (3 entities in total) |
Functional Keywords | tyrosine kinase, janus kinase 2, enzyme inhibitors, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Homo sapiens (human) |
Cellular location | Endomembrane system ; Peripheral membrane protein : O60674 |
Total number of polymer chains | 1 |
Total formula weight | 36184.25 |
Authors | Lim, J.,Taoka, B.,Otte, R.D.,Spencer, K.,Dinsmore, C.J.,Altman, M.D.,Chan, G.,Rosenstein, C.,Sharma, S.,Su, H.P.,Szewczak, A.A.,Xu, L.,Yin, H.,Zugay-Murphy, J.,Marshall, C.G.,Young, J.R. (deposition date: 2011-05-06, release date: 2012-03-21, Last modification date: 2017-11-08) |
Primary citation | Lim, J.,Taoka, B.,Otte, R.D.,Spencer, K.,Dinsmore, C.J.,Altman, M.D.,Chan, G.,Rosenstein, C.,Sharma, S.,Su, H.P.,Szewczak, A.A.,Xu, L.,Yin, H.,Zugay-Murphy, J.,Marshall, C.G.,Young, J.R. Discovery of 1-amino-5H-pyrido[4,3-b]indol-4-carboxamide inhibitors of Janus kinase 2 (JAK2) for the treatment of myeloproliferative disorders. J.Med.Chem., 54:7334-7349, 2011 Cited by PubMed: 21942426DOI: 10.1021/jm200909u PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.498 Å) |
Structure validation
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