4YBB
| High-resolution structure of the Escherichia coli ribosome | 分子名称: | (4S)-2-METHYL-2,4-PENTANEDIOL, 1,2-ETHANEDIOL, 1,4-DIAMINOBUTANE, ... | 著者 | Noeske, J, Wasserman, M.R, Terry, D.S, Altman, R.B, Blanchard, S.C, Cate, J.H.D. | 登録日 | 2015-02-18 | 公開日 | 2015-03-18 | 最終更新日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | High-resolution structure of the Escherichia coli ribosome. Nat.Struct.Mol.Biol., 22, 2015
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3ZME
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9B00
| Crystal structure of the wild-type Thermus thermophilus 70S ribosome in complex with berberine analog of chloramphenicol CAM-BER, mRNA, deacylated A- and E-site tRNAphe, and deacylated P-site tRNAmet at 2.80A resolution | 分子名称: | 13-(2-{[(1R,2R)-1,3-dihydroxy-1-(4-nitrophenyl)propan-2-yl]amino}-2-oxoethyl)-9,10-dimethoxy-5,6-dihydro-2H-[1,3]dioxolo[4,5-g]isoquinolino[3,2-a]isoquinolin-7-ium, 16S Ribosomal RNA, 23S Ribosomal RNA, ... | 著者 | Batool, Z, Pavlova, J.A, Paranjpe, M.N, Tereshchenkov, A.G, Lukianov, D.A, Osterman, I.A, Bogdanov, A.A, Sumbatyan, N.V, Polikanov, Y.S. | 登録日 | 2024-03-11 | 公開日 | 2024-08-07 | 最終更新日 | 2024-09-25 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | Berberine analog of chloramphenicol exhibits a distinct mode of action and unveils ribosome plasticity. Structure, 32, 2024
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7ACR
| Structure of post-translocated trans-translation complex on E. coli stalled ribosome. | 分子名称: | 16S ribosomal RNA, 23S ribosomal RNA, 30S ribosomal protein S10, ... | 著者 | Guyomar, C, D'Urso, G, Chat, S, Giudice, E, Gillet, R. | 登録日 | 2020-09-11 | 公開日 | 2021-08-18 | 最終更新日 | 2024-04-24 | 実験手法 | ELECTRON MICROSCOPY (3.44 Å) | 主引用文献 | Structures of tmRNA and SmpB as they transit through the ribosome. Nat Commun, 12, 2021
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7AC7
| Structure of accomodated trans-translation complex on E. Coli stalled ribosome. | 分子名称: | 16S ribosomal RNA, 23S ribosomal RNA, 30S ribosomal protein S10, ... | 著者 | Guyomar, C, D'Urso, G, Chat, S, Giudice, E, Gillet, R. | 登録日 | 2020-09-10 | 公開日 | 2021-08-18 | 最終更新日 | 2024-04-24 | 実験手法 | ELECTRON MICROSCOPY (3.08 Å) | 主引用文献 | Structures of tmRNA and SmpB as they transit through the ribosome. Nat Commun, 12, 2021
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7ACJ
| Structure of translocated trans-translation complex on E. coli stalled ribosome. | 分子名称: | 16S ribosomal RNA, 23S ribosomal RNA, 30S ribosomal protein S10, ... | 著者 | Guyomar, C, D'Urso, G, Chat, S, Giudice, E, Gillet, R. | 登録日 | 2020-09-11 | 公開日 | 2021-08-18 | 最終更新日 | 2024-04-24 | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | 主引用文献 | Structures of tmRNA and SmpB as they transit through the ribosome. Nat Commun, 12, 2021
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4WNN
| SPT16-H2A-H2B FACT HISTONE Complex | 分子名称: | Histone H2A.1, Histone H2B.1, PHOSPHATE ION, ... | 著者 | Kemble, D.J, Hill, C.P, Whitby, F.G, Formosa, T, McCullough, L.L. | 登録日 | 2014-10-13 | 公開日 | 2015-10-21 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | FACT Disrupts Nucleosome Structure by Binding H2A-H2B with Conserved Peptide Motifs. Mol.Cell, 60, 2015
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7B5L
| Ubiquitin ligation to F-box protein substrates by SCF-RBR E3-E3 super-assembly: NEDD8-CUL1-RBX1-SKP1-SKP2-CKSHS1-Cyclin A-CDK2-p27-UBE2L3~Ub~ARIH1. Transition State 1 | 分子名称: | 5-azanylpentan-2-one, Cullin-1, Cyclin-A2, ... | 著者 | Horn-Ghetko, D, Prabu, J.R, Schulman, B.A. | 登録日 | 2020-12-04 | 公開日 | 2021-02-10 | 最終更新日 | 2021-03-10 | 実験手法 | ELECTRON MICROSCOPY (3.8 Å) | 主引用文献 | Ubiquitin ligation to F-box protein targets by SCF-RBR E3-E3 super-assembly. Nature, 590, 2021
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7B5K
| E. coli 70S containing suppressor tRNA in the A-site stabilized by a Negamycin analogue and P-site tRNA-nascent chain. | 分子名称: | 16S rRNA, 2-[[[(3~{R},5~{R})-3-azanyl-6-(3-azanylpropylamino)-5-oxidanyl-hexanoyl]amino]-methyl-amino]ethanoic acid, 23S rRNA, ... | 著者 | Albers, S, Beckert, B, Matthies, M, Schuster, R, Riedner, M, Seuring, C, Sanyal, S, Torda, A, Wilson, N.D, Ignatova, Z. | 登録日 | 2020-12-03 | 公開日 | 2021-05-26 | 最終更新日 | 2024-04-24 | 実験手法 | ELECTRON MICROSCOPY (2.9 Å) | 主引用文献 | Harnessing evolutionarily flexibility in tRNAs to maximize nonsense suppression activities Nat Commun, 2021
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5NEV
| CDK2/Cyclin A in complex with compound 73 | 分子名称: | 4-[[6-(3-phenylphenyl)-7~{H}-purin-2-yl]amino]benzenesulfonamide, Cyclin-A2, Cyclin-dependent kinase 2 | 著者 | Coxon, C.R, Anscombe, E, Harnor, S.J, Martin, M.P, Carbain, B, Hardcastle, I.R, Harlow, L.K, Korolchuk, S, Matheson, C.J, Noble, M.E.M, Newell, D.R, Turner, D, Sivaprakasam, M, Wang, L.Z, Wong, C, Golding, B.T, Griffin, R.J, Cano, G. | 登録日 | 2017-03-12 | 公開日 | 2017-03-29 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (2.97 Å) | 主引用文献 | Cyclin-Dependent Kinase (CDK) Inhibitors: Structure-Activity Relationships and Insights into the CDK-2 Selectivity of 6-Substituted 2-Arylaminopurines. J. Med. Chem., 60, 2017
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8Y0W
| dormant ribosome with eIF5A, eEF2 and SERBP1 | 分子名称: | 18S rRNA, 28S rRNA, 40S ribosomal protein S10, ... | 著者 | Du, M, Zeng, F. | 登録日 | 2024-01-23 | 公開日 | 2024-02-07 | 最終更新日 | 2024-08-21 | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | 主引用文献 | Implication of Stm1 in the protection of eIF5A, eEF2 and tRNA through dormant ribosomes. Front Mol Biosci, 11, 2024
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8Y0X
| Dormant ribosome with SERBP1 | 分子名称: | 18S rRNA, 28S rRNA, 40S ribosomal protein S10, ... | 著者 | Du, M, Zeng, F. | 登録日 | 2024-01-23 | 公開日 | 2024-02-07 | 最終更新日 | 2024-08-21 | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | 主引用文献 | Implication of Stm1 in the protection of eIF5A, eEF2 and tRNA through dormant ribosomes. Front Mol Biosci, 11, 2024
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8YOO
| Cryo-EM structure of the human 80S ribosome with 100 um Tigecycline | 分子名称: | 18S rRNA, 28S rRNA, 40S ribosomal protein S10, ... | 著者 | Li, X, Wang, M, Denk, T, Cheng, J. | 登録日 | 2024-03-13 | 公開日 | 2024-07-10 | 実験手法 | ELECTRON MICROSCOPY (2 Å) | 主引用文献 | Structural basis for differential inhibition of eukaryotic ribosomes by tigecycline. Nat Commun, 15, 2024
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8YOP
| Cryo-EM structure of the human 80S ribosome with 4 um Tigecycline | 分子名称: | 18S rRNA, 28S rRNA, 40S ribosomal protein S10, ... | 著者 | Li, X, Wang, M, Denk, T, Cheng, J. | 登録日 | 2024-03-13 | 公開日 | 2024-07-10 | 実験手法 | ELECTRON MICROSCOPY (2.2 Å) | 主引用文献 | Structural basis for differential inhibition of eukaryotic ribosomes by tigecycline. Nat Commun, 15, 2024
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5MHQ
| CCT068127 in complex with CDK2 | 分子名称: | (2~{R},3~{S})-3-[[9-propan-2-yl-6-(pyridin-3-ylmethylamino)purin-2-yl]amino]pentan-2-ol, Cyclin-dependent kinase 2 | 著者 | Whittaker, S.R, Barlow, C, Martin, M.P, Mancusi, C, Wagner, S, Barrie, E, te Poele, R, Sharp, S, Brown, N, Wilson, S, Clarke, P, Walton, M.I, MacDonald, E, Blagg, J, Noble, M.E.M, Garrett, M.D, Workman, P. | 登録日 | 2016-11-25 | 公開日 | 2017-12-20 | 最終更新日 | 2018-03-14 | 実験手法 | X-RAY DIFFRACTION (1.3 Å) | 主引用文献 | Molecular profiling and combinatorial activity of CCT068127: a potent CDK2 and CDK9 inhibitor. Mol Oncol, 12, 2018
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6XZA
| E. coli 70S ribosome in complex with dirithromycin, and deacylated tRNA(iMet) (focused classification). | 分子名称: | 16S rRNA, 23S rRNA, 30S ribosomal protein S10, ... | 著者 | Pichkur, E.B, Polikanov, Y.S, Myasnikov, A.G, Konevega, A.L. | 登録日 | 2020-02-03 | 公開日 | 2020-11-04 | 最終更新日 | 2024-04-24 | 実験手法 | ELECTRON MICROSCOPY (2.66 Å) | 主引用文献 | Insights into the improved macrolide inhibitory activity from the high-resolution cryo-EM structure of dirithromycin bound to the E. coli 70S ribosome. Rna, 26, 2020
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5LJ3
| Structure of the core of the yeast spliceosome immediately after branching | 分子名称: | CEF1, CLF1, CWC15, ... | 著者 | Galej, W.P, Wilkinson, M.F, Fica, S.M, Oubridge, C, Newman, A.J, Nagai, K. | 登録日 | 2016-07-17 | 公開日 | 2016-08-03 | 最終更新日 | 2019-10-23 | 実験手法 | ELECTRON MICROSCOPY (3.8 Å) | 主引用文献 | Cryo-EM structure of the spliceosome immediately after branching. Nature, 537, 2016
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3LSG
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6V7W
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6M5F
| Crystal structure of HinK, a LysR family transcriptional regulator from Pseudomonas aeruginosa | 分子名称: | Probable transcriptional regulator | 著者 | Wang, Y, Lan, L, Cao, Q, Gan, J, Wang, F. | 登録日 | 2020-03-10 | 公開日 | 2021-03-17 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.75 Å) | 主引用文献 | Crystal structure of HinK, a LysR family transcriptional regulator from Pseudomonas aeruginosa To Be Published
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6XZB
| E. coli 70S ribosome in complex with dirithromycin, fMet-Phe-tRNA(Phe) and deacylated tRNA(iMet) (focused classification). | 分子名称: | 16S rRNA, 23S rRNA, 30S ribosomal protein S10, ... | 著者 | Pichkur, E.B, Polikanov, Y.S, Myasnikov, A.G, Konevega, A.L. | 登録日 | 2020-02-03 | 公開日 | 2020-11-04 | 最終更新日 | 2024-04-24 | 実験手法 | ELECTRON MICROSCOPY (2.54 Å) | 主引用文献 | Insights into the improved macrolide inhibitory activity from the high-resolution cryo-EM structure of dirithromycin bound to the E. coli 70S ribosome. Rna, 26, 2020
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8EJV
| The crystal structure of Pseudomonas putida PcaR in complex with succinate | 分子名称: | 1,2-ETHANEDIOL, CHLORIDE ION, PHOSPHATE ION, ... | 著者 | Pham, C, Skarina, T, Di Leo, R, Stogios, P.J, Mahadevan, R, Savchenko, A. | 登録日 | 2022-09-19 | 公開日 | 2024-03-20 | 実験手法 | X-RAY DIFFRACTION (2.43 Å) | 主引用文献 | The crystal structure of Pseudomonas putida PcaR in complex with succinate To Be Published
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8EJU
| The crystal structure of Pseudomonas putida PcaR | 分子名称: | CHLORIDE ION, PHOSPHATE ION, Transcription regulatory protein (Pca regulon), ... | 著者 | Pham, C, Skarina, T, Di Leo, R, Stogios, P.J, Mahadevan, R, Savchenko, A. | 登録日 | 2022-09-19 | 公開日 | 2024-03-20 | 実験手法 | X-RAY DIFFRACTION (1.74 Å) | 主引用文献 | The crystal structure of Pseudomonas putida PcaR To Be Published
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8G6W
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8FIZ
| Cryo-EM structure of E. coli 70S Ribosome containing mRNA and tRNA (in the transcription-translation complex) | 分子名称: | 16S rRNA, 23S rRNA, 30S ribosomal protein S10, ... | 著者 | Florez Ariza, A, Wee, L, Tong, A, Canari, C, Grob, P, Nogales, E, Bustamante, C. | 登録日 | 2022-12-18 | 公開日 | 2023-03-29 | 最終更新日 | 2024-06-19 | 実験手法 | ELECTRON MICROSCOPY (3.8 Å) | 主引用文献 | A trailing ribosome speeds up RNA polymerase at the expense of transcript fidelity via force and allostery. Cell, 186, 2023
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