PDB: 37722 件ウェブページステータス検索Chemie searchBIRD

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8AVD	Cryo-EM structure for a 3:3 complex between mouse leptin and the mouse LEP-R ectodomain (local refinement) 分子名称: Leptin, Leptin receptor, NICKEL (II) ION 著者 Verstraete, K, Savvides, S.N, Verschueren, K.G, Tsirigotaki, A. 登録日 2022-08-26 公開日 2023-04-05 最終更新日 2024-10-23 実験手法 ELECTRON MICROSCOPY (4.42 Å) 主引用文献 Mechanism of receptor assembly via the pleiotropic adipokine Leptin. Nat.Struct.Mol.Biol., 30, 2023
3F8E	Coumarins are a novel class of suicide carbonic anhydrase inhibitors 分子名称: (2Z)-3-{2-hydroxy-5-[(1S)-1-hydroxy-3-methylbutyl]-4-methoxyphenyl}prop-2-enoic acid, BENZOIC ACID, Carbonic anhydrase 2, ... 著者 Temperini, C, Maresca, A, Scozzafava, A, Supuran, C.T. 登録日 2008-11-12 公開日 2009-10-06 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Non-Zinc Mediated Inhibition of Carbonic Anhydrases: Coumarins Are a New Class of Suicide Inhibitors J.Am.Chem.Soc., 131, 2009
6XOU	CryoEM structure of human presequence protease in open state 分子名称: Presequence protease, mitochondrial 著者 Liang, W.G, Zhao, M, Tang, W. 登録日 2020-07-07 公開日 2021-07-07 最終更新日 2024-05-15 実験手法 ELECTRON MICROSCOPY (4 Å) 主引用文献 Structural basis for the mechanisms of human presequence protease conformational switch and substrate recognition. Nat Commun, 13, 2022
3WUV	Structure basis of inactivating cell abscission with chimera peptide 2 分子名称: Centrosomal protein of 55 kDa, peptide from Programmed cell death 6-interacting protein 著者 Kim, H.J, Matsuura, A, Lee, H.H. 登録日 2014-05-05 公開日 2015-07-15 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (2.79 Å) 主引用文献 Structural and biochemical insights into the role of testis-expressed gene 14 (TEX14) in forming the stable intercellular bridges of germ cells. Proc.Natl.Acad.Sci.USA, 112, 2015
6AFF	DJ-1 with compound 8 分子名称: CHLORIDE ION, Protein/nucleic acid deglycase DJ-1, methyl 2,3-bis(oxidanylidene)-1~{H}-indole-7-carboxylate 著者 Caaveiro, J.M.M, Tashiro, S, Tsumoto, K. 登録日 2018-08-08 公開日 2018-08-29 最終更新日 2024-10-30 実験手法 X-RAY DIFFRACTION (1.6 Å) 主引用文献 Discovery and Optimization of Inhibitors of the Parkinson's Disease Associated Protein DJ-1. ACS Chem. Biol., 13, 2018
6XOV	CryoEM structure of human presequence protease in partial closed state 1 分子名称: Amyloid-beta precursor protein, Presequence protease, mitochondrial 著者 Liang, W.G, Zhao, M, Tang, W. 登録日 2020-07-07 公開日 2021-07-07 最終更新日 2024-05-15 実験手法 ELECTRON MICROSCOPY (3.3 Å) 主引用文献 Structural basis for the mechanisms of human presequence protease conformational switch and substrate recognition. Nat Commun, 13, 2022
6AFJ	DJ-1 with compound 13 分子名称: CHLORIDE ION, Protein/nucleic acid deglycase DJ-1, butyl 2-[2,3-bis(oxidanylidene)indol-1-yl]ethanoate 著者 Caaveiro, J.M.M, Tashiro, S, Tsumoto, K. 登録日 2018-08-08 公開日 2018-08-29 最終更新日 2024-11-06 実験手法 X-RAY DIFFRACTION (1.48 Å) 主引用文献 Discovery and Optimization of Inhibitors of the Parkinson's Disease Associated Protein DJ-1. ACS Chem. Biol., 13, 2018
3WVV	Crystal Structure of RuCO/apo-E45C_C48AFr 分子名称: 1,2-ETHANEDIOL, CADMIUM ION, Ferritin light chain, ... 著者 Fujita, K, Tanaka, Y, Abe, S, Hikage, T, Kuchimaru, T, Kizaka-Kondoh, S, Ueno, T. 登録日 2014-06-09 公開日 2015-07-15 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (1.82 Å) 主引用文献 Intracellular CO release from composite of ferritin and ruthenium carbonyl complexes. J.Am.Chem.Soc., 136, 2014
8AK3	Drosophila melanogaster UNC89 Protein Kinase 1 in complex with ADP 分子名称: ADENOSINE-5'-DIPHOSPHATE, GLYCEROL, Obscurin 著者 Dorendorf, T, Zacharchenko, T, Mayans, O. 登録日 2022-07-29 公開日 2023-03-29 最終更新日 2024-02-07 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 PK1 from Drosophila obscurin is an inactive pseudokinase with scaffolding properties. Open Biology, 13, 2023
3F9W	Structural Insights into Lysine Multiple Methylation by SET Domain Methyltransferases, SET8-Y334F / H4-Lys20 / AdoHcy 分子名称: Histone H4, Histone-lysine N-methyltransferase SETD8, S-ADENOSYL-L-HOMOCYSTEINE 著者 Couture, J.-F, Dirk, L.M.A, Brunzelle, J.S, Houtz, R.L, Trievel, R.C. 登録日 2008-11-14 公開日 2008-11-25 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (1.6 Å) 主引用文献 Structural origins for the product specificity of SET domain protein methyltransferases. Proc.Natl.Acad.Sci.Usa, 105, 2008
8AYB	anammox-specific FabZ from Scalindua brodae 分子名称: Beta-hydroxyacyl-(Acyl-carrier-protein) dehydratase 著者 Dietl, A, Barends, T.R.M. 登録日 2022-09-02 公開日 2023-03-29 最終更新日 2024-02-07 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Structures of an unusual 3-hydroxyacyl dehydratase (FabZ) from a ladderane-producing organism with an unexpected substrate preference. J.Biol.Chem., 299, 2023
6XOT	CryoEM structure of human presequence protease in partial open state 2 分子名称: Presequence protease, mitochondrial 著者 Liang, W.G, Zhao, M, Tang, W. 登録日 2020-07-07 公開日 2021-07-07 最終更新日 2024-05-15 実験手法 ELECTRON MICROSCOPY (3.9 Å) 主引用文献 Structural basis for the mechanisms of human presequence protease conformational switch and substrate recognition. Nat Commun, 13, 2022
1ZSY	The structure of human mitochondrial 2-enoyl thioester reductase (CGI-63) 分子名称: GLYCEROL, MITOCHONDRIAL 2-ENOYL THIOESTER REDUCTASE, SULFATE ION 著者 Lukacik, P, Shafqat, N, Kavanagh, K.L, Johansson, C, Smee, C, Edwards, A, Arrowsmith, C, Sundstrom, M, von Delft, F, Oppermann, U, Structural Genomics Consortium (SGC) 登録日 2005-05-25 公開日 2005-06-07 最終更新日 2023-08-23 実験手法 X-RAY DIFFRACTION (1.75 Å) 主引用文献 The structure of human mitochondrial 2-enoyl thioester reductase (CGI-63) To be Published
8AXV	Structure of an open form of CHIKV nsP1 capping pores 分子名称: 2-amino-7-methyl-1,7-dihydro-6H-purin-6-one, ZINC ION, mRNA-capping enzyme nsP1 著者 Reguera, J, Jones, R, Hons, M. 登録日 2022-09-01 公開日 2023-03-29 実験手法 ELECTRON MICROSCOPY (2.8 Å) 主引用文献 Structural basis and dynamics of Chikungunya alphavirus RNA capping by nsP1 capping pores. Proc.Natl.Acad.Sci.USA, 120, 2023
6XOS	CryoEM structure of human presequence protease in partial open state 1 分子名称: Presequence protease, mitochondrial 著者 Liang, W.G, Zhao, M, Tang, W. 登録日 2020-07-07 公開日 2021-07-07 最終更新日 2024-05-15 実験手法 ELECTRON MICROSCOPY (3.7 Å) 主引用文献 Structural basis for the mechanisms of human presequence protease conformational switch and substrate recognition. Nat Commun, 13, 2022
7N98	Cryo-EM structure of MFSD2A 分子名称: Sodium-dependent lysophosphatidylcholine symporter 1 著者 Zhang, J, Feng, L. 登録日 2021-06-17 公開日 2021-08-04 最終更新日 2024-11-13 実験手法 ELECTRON MICROSCOPY (3.5 Å) 主引用文献 Structure and mechanism of blood-brain-barrier lipid transporter MFSD2A. Nature, 596, 2021
4LGD	Structural Basis for Autoactivation of Human Mst2 Kinase and Its Regulation by RASSF5 分子名称: MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, Ras association domain family member 5, ... 著者 Luo, X, Ni, L, Tomchick, D.R. 登録日 2013-06-27 公開日 2013-09-18 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (3.05 Å) 主引用文献 Structural Basis for Autoactivation of Human Mst2 Kinase and Its Regulation by RASSF5. Structure, 21, 2013
8AVC	Mouse leptin:LEP-R complex cryoEM structure (3:3 model) 分子名称: Leptin, Leptin receptor, NICKEL (II) ION 著者 Verstraete, K, Savvides, S.N, Verschueren, K.G, Tsirigotaki, A. 登録日 2022-08-26 公開日 2023-04-05 最終更新日 2024-10-23 実験手法 ELECTRON MICROSCOPY (4.6 Å) 主引用文献 Mechanism of receptor assembly via the pleiotropic adipokine Leptin. Nat.Struct.Mol.Biol., 30, 2023
1ZQL	DNA POLYMERASE BETA (POL B) (E.C.2.7.7.7) COMPLEXED WITH SEVEN BASE PAIRS OF DNA; SOAKED IN THE PRESENCE OF MNCL2 (15 MILLIMOLAR) AND MGCL2 (15 MILLIMOLAR) 分子名称: DNA (5'-D(*CP*AP*TP*TP*AP*GP*AP*A)-3'), DNA (5'-D(*TP*CP*TP*AP*AP*TP*G)-3'), MANGANESE (II) ION, ... 著者 Pelletier, H, Sawaya, M.R. 登録日 1996-04-12 公開日 1996-11-15 最終更新日 2023-08-02 実験手法 X-RAY DIFFRACTION (3.3 Å) 主引用文献 Characterization of the metal ion binding helix-hairpin-helix motifs in human DNA polymerase beta by X-ray structural analysis. Biochemistry, 35, 1996
4INQ	Crystal structure of Osh3 ORD in complex with PI(4)P from Saccharomyces cerevisiae 分子名称: (2R)-3-{[(S)-hydroxy{[(1R,2R,3R,4R,5S,6R)-2,3,5,6-tetrahydroxy-4-(phosphonooxy)cyclohexyl]oxy}phosphoryl]oxy}propane-1,2-diyl dioctanoate, Oxysterol-binding protein homolog 3 著者 Tong, J, Im, Y.J. 登録日 2013-01-05 公開日 2013-07-31 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Structure of osh3 reveals a conserved mode of phosphoinositide binding in oxysterol-binding proteins Structure, 21, 2013
8A5W	Crystal structure of the human phosphoserine aminotransferase (PSAT) in complex with O-phosphoserine 分子名称: (2S)-2-[(E)-[2-methyl-3-oxidanyl-5-(phosphonooxymethyl)pyridin-4-yl]methylideneamino]-3-phosphonooxy-propanoic acid, 4'-DEOXY-4'-AMINOPYRIDOXAL-5'-PHOSPHATE, PHOSPHOSERINE, ... 著者 Costanzi, E, Demitri, N, Ullah, R, Marchesan, F, Peracchi, A, Zangelmi, E, Storici, P, Campanini, B. 登録日 2022-06-16 公開日 2023-03-29 最終更新日 2024-09-11 実験手法 X-RAY DIFFRACTION (2.78 Å) 主引用文献 L-serine biosynthesis in the human central nervous system: Structure and function of phosphoserine aminotransferase. Protein Sci., 32, 2023
8A6D	10 picosecond light activated crystal structure of bovine rhodopsin in Lipidic Cubic Phase 分子名称: (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... 著者 Gruhl, T, Weinert, T, Rodrigues, M.J, Milne, C.J, Ortolani, G, Nass, K, Nango, E, Sen, S, Johnson, P.J.M, Cirelli, C, Furrer, A, Mous, S, Skopintsev, P, James, D, Dworkowski, F, Baath, P, Kekilli, D, Oserov, D, Tanaka, R, Glover, H, Bacellar, C, Bruenle, S, Casadei, C.M, Diethelm, A.D, Gashi, D, Gotthard, G, Guixa-Gonzalez, R, Joti, Y, Kabanova, V, Knopp, G, Lesca, E, Ma, P, Martiel, I, Muehle, J, Owada, S, Pamula, F, Sarabi, D, Tejero, O, Tsai, C.J, Varma, N, Wach, A, Boutet, S, Tono, K, Nogly, P, Deupi, X, Iwata, S, Neutze, R, Standfuss, J, Schertler, G.F.X, Panneels, V. 登録日 2022-06-17 公開日 2023-03-29 最終更新日 2024-02-07 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Ultrafast structural changes direct the first molecular events of vision. Nature, 615, 2023
8AFA	Cryo-EM structure of a substrate-bound glutamate transporter homologue GltTk encapsulated within a nanodisc 分子名称: ASPARTIC ACID, Proton/glutamate symporter, SDF family 著者 Whittaker, J.J, Guskov, A. 登録日 2022-07-16 公開日 2023-04-05 最終更新日 2024-07-24 実験手法 ELECTRON MICROSCOPY (3.25 Å) 主引用文献 Mutation in glutamate transporter homologue GltTk provides insights into pathologic mechanism of episodic ataxia 6. Nat Commun, 14, 2023
6ZZU	Partial structure of the substrate-free tyrosine hydroxylase (apo-TH). 分子名称: FE (III) ION, Tyrosine 3-monooxygenase 著者 Bueno-Carrasco, M.T, Cuellar, J, Santiago, C, Valpuesta, J.M, Martinez, A, Flydal, M.I. 登録日 2020-08-05 公開日 2021-11-17 最終更新日 2024-07-10 実験手法 ELECTRON MICROSCOPY (3.5 Å) 主引用文献 Structural mechanism for tyrosine hydroxylase inhibition by dopamine and reactivation by Ser40 phosphorylation. Nat Commun, 13, 2022
8A5V	Crystal structure of the human phosposerine aminotransferase (PSAT) 分子名称: 4'-DEOXY-4'-AMINOPYRIDOXAL-5'-PHOSPHATE, Phosphoserine aminotransferase, SULFATE ION 著者 Costanzi, E, Demitri, N, Ullah, R, Marchesan, F, Peracchi, A, Zangelmi, E, Storici, P, Campanini, B. 登録日 2022-06-16 公開日 2023-03-29 最終更新日 2024-02-07 実験手法 X-RAY DIFFRACTION (2.46 Å) 主引用文献 L-serine biosynthesis in the human central nervous system: Structure and function of phosphoserine aminotransferase. Protein Sci., 32, 2023

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