PDB: 4050 件ウェブページステータス検索Chemie searchBIRD

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4EST	CRYSTAL STRUCTURE OF THE COVALENT COMPLEX FORMED BY A PEPTIDYL ALPHA,ALPHA-DIFLUORO-BETA-KETO AMIDE WITH PORCINE PANCREATIC ELASTASE AT 1.78-ANGSTROMS RESOLUTION 分子名称: CALCIUM ION, ELASTASE, INHIBITOR ACE-ALA-PRO-VAI-DIFLUORO-N-PHENYLETHYLACETAMIDE, ... 著者 Takahashi, L.H, Radhakrishnan, R, Rosenfieldjunior, R.E, Meyerjunior, E.F, Trainor, D.A. 登録日 1989-05-15 公開日 1992-04-15 最終更新日 2024-07-10 実験手法 X-RAY DIFFRACTION (1.78 Å) 主引用文献 Crystal Structure of the Covalent Complex Formed by a Peptidyl Alpha,Alpha-Difluoro-Beta-Keto Amide with Porcine Pancreatic Elastase at 1.78-Angstroms Resolution J.Am.Chem.Soc., 111, 1989
5MJT	Thrombin Mutant A190S in complex with (S) -1 - ((R) -2-amino-3,3-diphenylpropanoyl) -N- (3-chlorobenzyl) pyrrolidine-2-carboxamide 分子名称: DIMETHYL SULFOXIDE, GLYCEROL, Hirudin variant-2, ... 著者 Marca, A, Sandner, A, Heine, A, Klebe, G. 登録日 2016-12-01 公開日 2017-12-20 実験手法 X-RAY DIFFRACTION (1.4 Å) 主引用文献 Thrombin Mutant A190S in complex with (S) -1 - ((R) -2-amino-3,3-diphenylpropanoyl) -N- (3-chlorobenzyl) pyrrolidine-2-carboxamide to be published
5MRS	Crystal structure of L1 protease Lysobacter sp. XL1 in complex with AEBSF 分子名称: 4-(2-AMINOETHYL)BENZENESULFONYL FLUORIDE, CHLORIDE ION, DI(HYDROXYETHYL)ETHER, ... 著者 Gabdulkhakov, A, Tishchenko, S, Lisov, A, Leontievsky, A. 登録日 2016-12-26 公開日 2018-01-17 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Crystal structure of L1 protease Lysobacter sp. XL1 in complex with AEBSF To Be Published
4FU9	Crystal Structure of the Urokinase 分子名称: 6-[(Z)-AMINO(IMINO)METHYL]-N-PHENYL-2-NAPHTHAMIDE, ACETATE ION, GLYCEROL, ... 著者 Kang, Y.N, Stuckey, J.A, Nienaber, V, Giranda, V. 登録日 2012-06-28 公開日 2012-08-22 最終更新日 2017-11-15 実験手法 X-RAY DIFFRACTION (1.6 Å) 主引用文献 Crystal Structure of the Urokinase To be Published
4FUF	Crystal Structure of the Urokinase 分子名称: 8-(3-bromopropoxy)-7-methoxynaphthalene-2-carboximidamide, ACETATE ION, GLYCEROL, ... 著者 Kang, Y.N, Stuckey, J.A, Nienaber, V, Giranda, V. 登録日 2012-06-28 公開日 2012-08-22 最終更新日 2017-11-15 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Crystal Structure of the Urokinase to be published
4GAW	Crystal structure of active human granzyme H 分子名称: CHLORIDE ION, Granzyme H, SULFATE ION 著者 Wang, L, Li, Q, Wu, L, Zhang, K, Tong, L, Sun, F, Fan, Z. 登録日 2012-07-25 公開日 2013-01-16 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (3 Å) 主引用文献 Identification of SERPINB1 as a physiological inhibitor of human granzyme H J.Immunol., 190, 2013
4FUC	Crystal Structure of the Urokinase 分子名称: 6-[(Z)-AMINO(IMINO)METHYL]-N-[4-(AMINOMETHYL)PHENYL]-2-NAPHTHAMIDE, ACETATE ION, GLYCEROL, ... 著者 Kang, Y.N, Stuckey, J.A, Nienaber, V, Giranda, V. 登録日 2012-06-28 公開日 2012-08-22 最終更新日 2017-11-15 実験手法 X-RAY DIFFRACTION (1.72 Å) 主引用文献 Crystal Structure of the Urokinase to be published
4FU8	Crystal Structure of the Urokinase 分子名称: ACETATE ION, SUCCINIC ACID, SULFATE ION, ... 著者 Kang, Y.N, Stuckey, J.A, Nienaber, V, Giranda, V. 登録日 2012-06-28 公開日 2012-08-22 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Crystal Structure of the Urokinase to be published
4FUI	Crystal Structure of the Urokinase 分子名称: 7-METHOXY-8-[1-(METHYLSULFONYL)-1H-PYRAZOL-4-YL]NAPHTHALENE-2-CARBOXIMIDAMIDE, GLYCEROL, SODIUM ION, ... 著者 Kang, Y.N, Stuckey, J.A, Nienaber, V, Giranda, V. 登録日 2012-06-28 公開日 2012-08-22 最終更新日 2017-11-15 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Crystal Structure of the Urokinase to be published
4E05	Anophelin from the malaria vector inhibits thrombin through a novel reverse-binding mechanism 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, SODIUM ION, Salivary anti-thrombin peptide anophelin, ... 著者 Figueiredo, A.C, de Sanctis, D, Gutierrez-Gallego, R, Cereija, T.B, Macedo-Ribeiro, S, Fuentes-Prior, P, Pereira, P.J.B. 登録日 2012-03-02 公開日 2012-12-05 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (2.304 Å) 主引用文献 Unique thrombin inhibition mechanism by anophelin, an anticoagulant from the malaria vector. Proc.Natl.Acad.Sci.USA, 109, 2012
4DW2	The crystal structure of uPA in complex with the Fab fragment of mAb-112 分子名称: Fab fragment of pro-uPA antibody mAb-112, SULFATE ION, Urokinase-type plasminogen activator 著者 Jiang, L, Botkjaer, K.A, Andersen, L.M, Yuan, C, Andreasen, P.A, Huang, M. 登録日 2012-02-24 公開日 2013-01-16 実験手法 X-RAY DIFFRACTION (2.97 Å) 主引用文献 Rezymogenation of active urokinase induced by an inhibitory antibody. Biochem.J., 449, 2013
5NB7	Complement factor D 分子名称: 1-[2-[(1~{R},3~{S},5~{R})-3-[(6-bromanylpyridin-2-yl)carbamoyl]-2-azabicyclo[3.1.0]hexan-2-yl]-2-oxidanylidene-ethyl]indazole-3-carboxamide, Complement factor D, DIMETHYL SULFOXIDE 著者 Mac Sweeney, A, Ostermann, N. 登録日 2017-03-01 公開日 2017-06-28 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (1.33 Å) 主引用文献 Discovery of Highly Potent and Selective Small-Molecule Reversible Factor D Inhibitors Demonstrating Alternative Complement Pathway Inhibition in Vivo. J. Med. Chem., 60, 2017
4FUG	Crystal Structure of the Urokinase 分子名称: ACETATE ION, GLYCEROL, SULFATE ION, ... 著者 Kang, Y.N, Stuckey, J.A, Nienaber, V, Giranda, V. 登録日 2012-06-28 公開日 2012-08-22 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Crystal Structure of the Urokinase to be published
4FUH	Crystal Structure of the Urokinase 分子名称: 6-[(phenylcarbamoyl)amino]naphthalene-2-carboximidamide, ACETATE ION, GLYCEROL, ... 著者 Kang, Y.N, Stuckey, J.A, Nienaber, V, Giranda, V. 登録日 2012-06-28 公開日 2012-08-22 最終更新日 2017-11-15 実験手法 X-RAY DIFFRACTION (1.6 Å) 主引用文献 Crystal Structure of the Urokinase to be published
5NAR	Complement factor D in complex with the inhibitor (S)-pyrrolidine-1,2-dicarboxylic acid 1-[(1-carbamoyl-1H-indol-3-yl)-amide] 2-[(3-trifluoromethoxy-phenyl)-amide] 分子名称: (2~{S})-~{N}1-(1-aminocarbonylindol-3-yl)-~{N}2-[3-(trifluoromethyloxy)phenyl]pyrrolidine-1,2-dicarboxamide, Complement factor D, SULFATE ION 著者 Mac Sweeney, A, Ostermann, N. 登録日 2017-02-28 公開日 2017-06-28 最終更新日 2017-07-26 実験手法 X-RAY DIFFRACTION (1.55 Å) 主引用文献 Discovery of Highly Potent and Selective Small-Molecule Reversible Factor D Inhibitors Demonstrating Alternative Complement Pathway Inhibition in Vivo. J. Med. Chem., 60, 2017
5NAW	Complement factor D in complex with the inhibitor (1R,3S,5R)-2-Aza-bicyclo[3.1.0]hexane-2,3-dicarboxylic acid 2-[(1-carbamoyl-1H-indol-3-yl)-amide] 3-[(3-trifluoromethoxy-phenyl)-amide] 分子名称: (1~{R},3~{S},5~{R})-~{N}2-(1-aminocarbonylindol-3-yl)-~{N}3-[3-(trifluoromethyloxy)phenyl]-2-azabicyclo[3.1.0]hexane-2,3-dicarboxamide, Complement factor D 著者 Mac Sweeney, A, Ostermann, N. 登録日 2017-02-28 公開日 2017-06-28 最終更新日 2024-05-01 実験手法 X-RAY DIFFRACTION (1.25 Å) 主引用文献 Discovery of Highly Potent and Selective Small-Molecule Reversible Factor D Inhibitors Demonstrating Alternative Complement Pathway Inhibition in Vivo. J. Med. Chem., 60, 2017
5NHU	HUMAN ALPHA THROMBIN COMPLEXED WITH ANOPHELES GAMBIAE cE5 ANTICOAGULANT 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, AGAP008004-PA, Prothrombin, ... 著者 Ripoll-Rozada, J, Pereira, P.J.B. 登録日 2017-03-22 公開日 2017-06-14 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (1.45 Å) 主引用文献 Functional analyses yield detailed insight into the mechanism of thrombin inhibition by the antihemostatic salivary protein cE5 from Anopheles gambiae. J. Biol. Chem., 292, 2017
4DIH	X-ray structure of the complex between human alpha thrombin and thrombin binding aptamer in the presence of sodium ions 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, CHLORIDE ION, D-phenylalanyl-N-[(2S,3S)-6-{[amino(iminio)methyl]amino}-1-chloro-2-hydroxyhexan-3-yl]-L-prolinamide, ... 著者 Russo Krauss, I, Merlino, A, Mazzarella, L, Sica, F. 登録日 2012-01-31 公開日 2012-07-18 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 High-resolution structures of two complexes between thrombin and thrombin-binding aptamer shed light on the role of cations in the aptamer inhibitory activity. Nucleic Acids Res., 40, 2012
5NBA	Complement factor D in complex with the inhibitor (2S,4R)-4-Fluoro-pyrrolidine-1,2-dicarboxylic acid 1-[(1-carbamoyl-1H-indol-3-yl)-amide] 2-[(3-trifluoromethoxy-phenyl)-amide] 分子名称: (2~{S},4~{R})-~{N}1-(1-aminocarbonylindol-3-yl)-4-fluoranyl-~{N}2-[3-(trifluoromethyloxy)phenyl]pyrrolidine-1,2-dicarboxamide, Complement factor D 著者 Mac Sweeney, A, Ostermann, N. 登録日 2017-03-01 公開日 2017-06-28 最終更新日 2017-07-26 実験手法 X-RAY DIFFRACTION (1.87 Å) 主引用文献 Discovery of Highly Potent and Selective Small-Molecule Reversible Factor D Inhibitors Demonstrating Alternative Complement Pathway Inhibition in Vivo. J. Med. Chem., 60, 2017
4DVA	The crystal structure of human urokinase-type plasminogen activator catalytic domain 分子名称: HEXAETHYLENE GLYCOL, SULFATE ION, Urokinase-type plasminogen activator 著者 Jiang, L, Botkjaer, K.A, Andersen, L.M, Yuan, C, Andreasen, P.A, Huang, M. 登録日 2012-02-23 公開日 2013-01-16 実験手法 X-RAY DIFFRACTION (1.94 Å) 主引用文献 Rezymogenation of active urokinase induced by an inhibitory antibody Biochem.J., 449, 2013
5NB6	Complement factor D in complex with the inhibitor (2S,4S)-4-Amino-pyrrolidine-1,2-dicarboxylic acid 1-[(1-carbamoyl-1H-indol-3-yl)-amide] 2-[(3-trifluoromethoxy-phenyl)-amide] 分子名称: (2~{S},4~{S})-~{N}1-(1-aminocarbonylindol-3-yl)-4-azanyl-~{N}2-[3-(trifluoromethyloxy)phenyl]pyrrolidine-1,2-dicarboxamide, Complement factor D 著者 Mac Sweeney, A, Ostermann, N. 登録日 2017-03-01 公開日 2017-06-28 最終更新日 2017-07-26 実験手法 X-RAY DIFFRACTION (1.75 Å) 主引用文献 Discovery of Highly Potent and Selective Small-Molecule Reversible Factor D Inhibitors Demonstrating Alternative Complement Pathway Inhibition in Vivo. J. Med. Chem., 60, 2017
5NAT	Complement factor D in complex with the inhibitor (S)-Pyrrolidine-1,2-dicarboxylic acid 1-[(1-methyl-1H-indol-3-yl)-amide] 2-[(3-trifluoromethoxy-phenyl)-amide] 分子名称: (2~{S})-~{N}1-(1-methylindol-3-yl)-~{N}2-[3-(trifluoromethyloxy)phenyl]pyrrolidine-1,2-dicarboxamide, Complement factor D, GLYCEROL 著者 Mac Sweeney, A, Ostermann, N. 登録日 2017-02-28 公開日 2018-03-21 最終更新日 2019-10-02 実験手法 X-RAY DIFFRACTION (1.17 Å) 主引用文献 Discovery of Highly Potent and Selective Small-Molecule Reversible Factor D Inhibitors Demonstrating Alternative Complement Pathway Inhibition in Vivo. J.Med.Chem., 60, 2017
2FWW	human beta-tryptase II complexed with 4-piperidinebutyrate to make acylenzyme 分子名称: 4-PIPERIDINEBUTYRATE, Tryptase beta-2 著者 Katz, B.A. 登録日 2006-02-03 公開日 2006-02-14 最終更新日 2017-10-18 実験手法 X-RAY DIFFRACTION (2.25 Å) 主引用文献 Structure-guided design of Peptide-based tryptase inhibitors. Biochemistry, 45, 2006
4GSO	structure of Jararacussin-I 分子名称: Thrombin-like enzyme BjussuSP-1 著者 Ullah, A, Souza, T.C.A.B, Zanphorlin, L.M, Mariutti, R, Sanata, S.V, Murakami, M.T, Arni, R.K. 登録日 2012-08-28 公開日 2012-12-12 最終更新日 2013-01-02 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 Crystal structure of Jararacussin-I: The highly negatively charged catalytic interface contributes to macromolecular selectivity in snake venom thrombin-like enzymes. Protein Sci., 22, 2013
5MM6	Thrombin Mutant A190S in complex with (S)-1-(D-phenylalanyl)-N-(4-carbamimidoylbenzyl)pyrrolidine-2-carboxamide 分子名称: D-phenylalanyl-N-{4-[amino(iminio)methyl]benzyl}-L-prolinamide, DIMETHYL SULFOXIDE, GLYCEROL, ... 著者 Marca, A, Sandner, A, Heine, A, Klebe, G. 登録日 2016-12-08 公開日 2017-12-20 最終更新日 2018-06-27 実験手法 X-RAY DIFFRACTION (1.29 Å) 主引用文献 Thrombin Mutant A190S in complex with (S)-1-(D-phenylalanyl)-N-(4-carbamimidoylbenzyl)pyrrolidine-2-carboxamide to be published

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