8X7X
 
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9BRT
 | | Intact V-ATPase State 1 and synaptophysin complex in mouse brain isolated synaptic vesicles | | 分子名称: | Renin receptor cytoplasmic fragment, Ribonuclease kappa, Synaptophysin, ... | | 著者 | Wang, C, Jiang, W, Yang, K, Wang, X, Guo, Q, Brunger, A.T. | | 登録日 | 2024-05-11 | | 公開日 | 2024-06-19 | | 最終更新日 | 2024-08-07 | | 実験手法 | ELECTRON MICROSCOPY (4.3 Å) | | 主引用文献 | Structure and topography of the synaptic V-ATPase-synaptophysin complex.
Nature, 631, 2024
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8XSX
 | | Cryo-EM structure of the human 80S ribosome with Tigecycline, E-tRNA, SERBP1 and eEF2 | | 分子名称: | 18S rRNA, 28S rRNA, 40S ribosomal protein S10, ... | | 著者 | Li, X, Wang, M, Cheng, J. | | 登録日 | 2024-01-10 | | 公開日 | 2024-07-10 | | 実験手法 | ELECTRON MICROSCOPY (2.4 Å) | | 主引用文献 | Structural basis for differential inhibition of eukaryotic ribosomes by tigecycline.
Nat Commun, 15, 2024
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9AVW
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9EOU
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8WX7
 | | Crystal structure of SHP2 in complex with JAB-3186 | | 分子名称: | (5~{S})-1'-[6-azanyl-5-(2-azanyl-3-chloranyl-pyridin-4-yl)sulfanyl-pyrazin-2-yl]spiro[5,7-dihydrocyclopenta[b]pyridine-6,4'-piperidine]-5-amine, 1,2-ETHANEDIOL, CHLORIDE ION, ... | | 著者 | Ma, C, Gao, P, Kang, D, Han, H, Sun, X, Zhang, W, Qian, D, Wang, Y, Long, W. | | 登録日 | 2023-10-27 | | 公開日 | 2024-08-14 | | 実験手法 | X-RAY DIFFRACTION (2.02 Å) | | 主引用文献 | Discovery of JAB-3312, a Potent SHP2 Allosteric Inhibitor for Cancer Treatment.
J.Med.Chem., 2024
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8WY4
 | | GajA tetramer with ATP | | 分子名称: | ADENOSINE-5'-TRIPHOSPHATE, Endonuclease GajA | | 著者 | Li, J, Wang, Z, Wang, L. | | 登録日 | 2023-10-30 | | 公開日 | 2024-02-28 | | 最終更新日 | 2024-05-22 | | 実験手法 | ELECTRON MICROSCOPY (2.81 Å) | | 主引用文献 | Structures and activation mechanism of the Gabija anti-phage system.
Nature, 629, 2024
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9BOK
 | | Crystal structure of reduced bovine trypsin, 50mM DTT-treated | | 分子名称: | BENZAMIDINE, Cationic trypsin | | 著者 | Zhou, D, Chen, L, Rose, J.P, Wang, B.C. | | 登録日 | 2024-05-03 | | 公開日 | 2024-08-07 | | 実験手法 | X-RAY DIFFRACTION (1.35 Å) | | 主引用文献 | Crystal structure of reduced bovine trypsin, 50mM DTT-treated
To Be Published
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8Y38
 | | Cryo-EM structure of Staphylococcus aureus 70S ribosome (strain 15B196) in complex with MCX-190. | | 分子名称: | 16S ribosomal RNA, 23S ribosomal RNA, 5S ribosomal RNA, ... | | 著者 | Li, Y, Lu, G, Li, J, Pei, X, Lin, J. | | 登録日 | 2024-01-28 | | 公開日 | 2024-07-24 | | 実験手法 | ELECTRON MICROSCOPY (2.58 Å) | | 主引用文献 | Synthetic macrolides overcoming MLS B K-resistant pathogens.
Cell Discov, 10, 2024
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8X2T
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9BCB
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8WBQ
 | | Crystal structure of cis-Epoxysuccinate Hydrolases RhCESH[L] mutant E212Q complexed with L-TA. | | 分子名称: | Epoxide hydrolase, L(+)-TARTARIC ACID | | 著者 | Dong, S, Xuan, J.S, Feng, Y.G, Cui, Q. | | 登録日 | 2023-09-10 | | 公開日 | 2024-01-31 | | 最終更新日 | 2024-02-21 | | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | | 主引用文献 | Deciphering the stereo-specific catalytic mechanisms of cis-epoxysuccinate hydrolases producing L(+)-tartaric acid.
J.Biol.Chem., 300, 2024
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9CIJ
 | | Crystal structure of Staphylococcal nuclease variant Delta+PHS V23E/L36R at cryogenic temperature | | 分子名称: | CALCIUM ION, THYMIDINE-3',5'-DIPHOSPHATE, Thermonuclease | | 著者 | Zhang, Y, Schlessman, L.J, Siegler, M.A, Garcia-Moreno E, B. | | 登録日 | 2024-07-03 | | 公開日 | 2024-08-07 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | Crystal structure of Staphylococcal nuclease variant Delta+PHS V23E/L36R at cryogenic temperature
To Be Published
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8VL9
 | | Crystal structure of EloBC-VHL-CDO1 complex bound to compound 8 molecular glue | | 分子名称: | CITRIC ACID, Cysteine dioxygenase type 1, Elongin-B, ... | | 著者 | Shu, W, Ma, X, Tutter, A, Buckley, D, Golosov, A, Michaud, G. | | 登録日 | 2024-01-11 | | 公開日 | 2024-03-13 | | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | | 主引用文献 | A small molecule VHL molecular glue degrader for cysteine dioxygenase 1
To Be Published
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8XB9
 | | The Crystal Structure of polo-box domain of PLK1 from Biortus. | | 分子名称: | 1,2-ETHANEDIOL, Serine/threonine-protein kinase PLK1 | | 著者 | Wang, F, Cheng, W, Yuan, Z, Meng, Q, Zhang, B. | | 登録日 | 2023-12-06 | | 公開日 | 2023-12-27 | | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | | 主引用文献 | The Crystal Structure of polo-box domain of PLK1 from Biortus
To Be Published
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9BRB
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8WZX
 | | Cryo-EM structure of the hamster prion 23-144 fibril at pH 3.7 | | 分子名称: | Major prion protein | | 著者 | Lee, C.-H, Saw, J.-E, Chen, E, Wang, C.-H, Chen, R. | | 登録日 | 2023-11-02 | | 公開日 | 2024-05-01 | | 最終更新日 | 2024-05-08 | | 実験手法 | ELECTRON MICROSCOPY (2.88 Å) | | 主引用文献 | The Positively Charged Cluster in the N-terminal Disordered Region may Affect Prion Protein Misfolding: Cryo-EM Structure of Hamster PrP(23-144) Fibrils.
J.Mol.Biol., 436, 2024
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9B12
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8VTZ
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8VEW
 | | Crystal structure of PRMT5:MEP50 in complex with MTA and oxamide compound 24 | | 分子名称: | 5'-DEOXY-5'-METHYLTHIOADENOSINE, 5-{2-[(2R,5S)-5-methyl-2-phenylpiperidin-1-yl](oxo)acetamido}pyridine-3-carboxamide, CHLORIDE ION, ... | | 著者 | Whittington, D.A. | | 登録日 | 2023-12-20 | | 公開日 | 2024-04-24 | | 最終更新日 | 2024-05-08 | | 実験手法 | X-RAY DIFFRACTION (2.69 Å) | | 主引用文献 | Discovery of TNG908: A Selective, Brain Penetrant, MTA-Cooperative PRMT5 Inhibitor That Is Synthetically Lethal with MTAP -Deleted Cancers.
J.Med.Chem., 67, 2024
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9F42
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8VW1
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9CIK
 | | Crystal structure of Staphylococcal nuclease variant Delta+PHS V23R/L36D at cryogenic temperature | | 分子名称: | CALCIUM ION, THYMIDINE-3',5'-DIPHOSPHATE, Thermonuclease | | 著者 | Zhang, Y, Schlessman, J.L, SIegler, M.A, Garcia-Moreno E, B. | | 登録日 | 2024-07-03 | | 公開日 | 2024-08-07 | | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | | 主引用文献 | Crystal structure of Staphylococcal nuclease variant Delta+PHS V23R/L36D at cryogenic temperature
To Be Published
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8WBB
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8Y2D
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