6KU3
 
 | Crystal structure of gibberellin 2-oxidase3 (GA2ox3)in rice | 分子名称: | 2-OXOGLUTARIC ACID, GIBBERELLIN A4, GLYCEROL, ... | 著者 | Takehara, S, Mikami, B, Sakuraba, S, Matsuoka, M, Ueguchi-Tanaka, M. | 登録日 | 2019-08-30 | 公開日 | 2020-05-13 | 最終更新日 | 2024-10-23 | 実験手法 | X-RAY DIFFRACTION (2.15 Å) | 主引用文献 | A common allosteric mechanism regulates homeostatic inactivation of auxin and gibberellin. Nat Commun, 11, 2020
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6KUN
 
 | Crystal structure of dioxygenase for auxin oxidation (DAO) in rice | 分子名称: | 1H-INDOL-3-YLACETIC ACID, 2-OXOGLUTARIC ACID, 2-oxoglutarate-dependent dioxygenase DAO, ... | 著者 | Takehara, S, Mikami, B, Sakuraba, S, Matsuoka, M, Ueguchi-Tanaka, M. | 登録日 | 2019-09-02 | 公開日 | 2020-05-13 | 最終更新日 | 2024-10-23 | 実験手法 | X-RAY DIFFRACTION (2.002 Å) | 主引用文献 | A common allosteric mechanism regulates homeostatic inactivation of auxin and gibberellin. Nat Commun, 11, 2020
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4RHT
 
 | Crystal structures of Mycobacterium tuberculosis 6-oxopurine phosphoribosyltransferase which is a potential target for drug development against this disease | 分子名称: | GUANOSINE-5'-MONOPHOSPHATE, Hypoxanthine-guanine phosphoribosyltransferase Hpt, MAGNESIUM ION, ... | 著者 | Eng, W.S, Hockova, D, Spacek, P, West, N.P, Woods, K, Naesens, L.M.J, Keough, D.T, Guddat, L.W. | 登録日 | 2014-10-03 | 公開日 | 2015-05-20 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (2.7633 Å) | 主引用文献 | First Crystal Structures of Mycobacterium tuberculosis 6-Oxopurine Phosphoribosyltransferase: Complexes with GMP and Pyrophosphate and with Acyclic Nucleoside Phosphonates Whose Prodrugs Have Antituberculosis Activity. J.Med.Chem., 58, 2015
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4RHY
 
 | Crystal structures of Mycobacterium tuberculosis 6-oxopurine phosphoribosyltransferase which is a potential target for drug development against this disease | 分子名称: | Hypoxanthine-guanine phosphoribosyltransferase, MAGNESIUM ION, [2-({2-[bis(2-phosphonoethyl)amino]ethyl}[2-(6-oxo-3,6-dihydro-9H-purin-9-yl)ethyl]amino)ethyl]phosphonic acid | 著者 | Eng, W.S, Hockova, D, Spacek, P, West, N.P, Woods, K, Naesens, L.M.J, Keough, D.T, Guddat, L.W. | 登録日 | 2014-10-03 | 公開日 | 2015-05-20 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (2.3196 Å) | 主引用文献 | First Crystal Structures of Mycobacterium tuberculosis 6-Oxopurine Phosphoribosyltransferase: Complexes with GMP and Pyrophosphate and with Acyclic Nucleoside Phosphonates Whose Prodrugs Have Antituberculosis Activity. J.Med.Chem., 58, 2015
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4RHX
 
 | Structures of Mycobacterium tuberculosis 6-oxopurine phosphoribosyltransferase which is a potential target for drug development against this disease | 分子名称: | Hypoxanthine-guanine phosphoribosyltransferase, MAGNESIUM ION, [2-([2-(2-amino-6-oxo-1,6-dihydro-9H-purin-9-yl)ethyl]{2-[(2-oxoethyl)(2-phosphonoethyl)amino]ethyl}amino)ethyl]phosphonic acid | 著者 | Eng, W.S, Hockova, D, Spacek, P, West, N.P, Woods, K, Naesens, L.M.J, Keough, D.T, Guddat, L.W. | 登録日 | 2014-10-03 | 公開日 | 2015-05-20 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (2.0322 Å) | 主引用文献 | First Crystal Structures of Mycobacterium tuberculosis 6-Oxopurine Phosphoribosyltransferase: Complexes with GMP and Pyrophosphate and with Acyclic Nucleoside Phosphonates Whose Prodrugs Have Antituberculosis Activity. J.Med.Chem., 58, 2015
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5EKX
 
 | DENGUE 3 NS5 METHYLTRANSFERASE BOUND TO S-ADENOSYLMETHIONINE AND FRAGMENT NB2E11 | 分子名称: | 4-chloro-5-methylbenzene-1,2-diamine, NS5 METHYLTRANSFERASE, S-ADENOSYLMETHIONINE | 著者 | Barral, K, Bricogne, G, Sharff, A. | 登録日 | 2015-11-04 | 公開日 | 2016-10-26 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (1.76 Å) | 主引用文献 | Discovery of novel dengue virus NS5 methyltransferase non-nucleoside inhibitors by fragment-based drug design. Eur.J.Med.Chem., 125, 2016
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6Z6P
 
 | HDAC-PC-Nuc | 分子名称: | DNA (145-MER), HDA1 complex subunit 2, HDA1 complex subunit 3,HDA1 complex subunit 3, ... | 著者 | Lee, J.-H, Bollschweiler, D, Schaefer, T, Huber, R. | 登録日 | 2020-05-28 | 公開日 | 2021-02-17 | 最終更新日 | 2024-11-20 | 実験手法 | ELECTRON MICROSCOPY (4.43 Å) | 主引用文献 | Structural basis for the regulation of nucleosome recognition and HDAC activity by histone deacetylase assemblies. Sci Adv, 7, 2021
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5EHI
 
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5E9Q
 
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5EHG
 
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5EIF
 
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5ERC
 
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8X7I
 
 | Cryo-EM structures of RNF168/UbcH5c-Ub in complex with H2AK13Ub nucleosomes determined by intein-based E2-Ub-NCP conjugation strategy | 分子名称: | DNA (147-MER), E3 ubiquitin-protein ligase RNF168, Histone H2A type 1-B/E, ... | 著者 | Ai, H.S, Tong, Z.B, Deng, Z.H, Pan, M, Liu, L. | 登録日 | 2023-11-24 | 公開日 | 2024-08-07 | 最終更新日 | 2025-06-18 | 実験手法 | ELECTRON MICROSCOPY (3.27 Å) | 主引用文献 | Capturing Snapshots of Nucleosomal H2A K13/K15 Ubiquitination Mediated by the Monomeric E3 Ligase RNF168 Biorxiv, 2024
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8X7J
 
 | Cryo-EM structures of RNF168/UbcH5c-Ub/nucleosomes complex determined by activity-based chemical trapping strategy | 分子名称: | DNA (144-MER), E3 ubiquitin-protein ligase RNF168, Histone H2A type 1-B/E, ... | 著者 | Ai, H.S, Tong, Z.B, Deng, Z.H, Pan, M, Liu, L. | 登録日 | 2023-11-24 | 公開日 | 2024-08-07 | 最終更新日 | 2025-07-02 | 実験手法 | ELECTRON MICROSCOPY (3.39 Å) | 主引用文献 | Capturing Snapshots of Nucleosomal H2A K13/K15 Ubiquitination Mediated by the Monomeric E3 Ligase RNF168 Biorxiv, 2024
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1SD1
 
 | STRUCTURE OF HUMAN 5'-DEOXY-5'-METHYLTHIOADENOSINE PHOSPHORYLASE COMPLEXED WITH FORMYCIN A | 分子名称: | (1S)-1-(7-amino-1H-pyrazolo[4,3-d]pyrimidin-3-yl)-1,4-anhydro-D-ribitol, 5'-methylthioadenosine phosphorylase | 著者 | Lee, J.E, Settembre, E.C, Cornell, K.A, Riscoe, M.K, Sufrin, J.R, Ealick, S.E, Howell, P.L. | 登録日 | 2004-02-12 | 公開日 | 2004-05-18 | 最終更新日 | 2024-02-14 | 実験手法 | X-RAY DIFFRACTION (2.03 Å) | 主引用文献 | Structural Comparison of MTA Phosphorylase and MTA/AdoHcy Nucleosidase Explains Substrate Preferences and Identifies Regions Exploitable for Inhibitor Design. Biochemistry, 43, 2004
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1SD2
 
 | STRUCTURE OF HUMAN 5'-DEOXY-5'-METHYLTHIOADENOSINE PHOSPHORYLASE COMPLEXED WITH 5'-METHYLTHIOTUBERCIDIN | 分子名称: | 2-(4-AMINO-PYRROLO[2,3-D]PYRIMIDIN-7-YL)-5-METHYLSULFANYLMETHYL-TETRAHYDRO-FURAN-3,4-DIOL, 5'-methylthioadenosine phosphorylase, SULFATE ION | 著者 | Lee, J.E, Settembre, E.C, Cornell, K.A, Riscoe, M.K, Sufrin, J.R, Ealick, S.E, Howell, P.L. | 登録日 | 2004-02-12 | 公開日 | 2004-05-18 | 最終更新日 | 2024-02-14 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Structural Comparison of MTA Phosphorylase and MTA/AdoHcy Nucleosidase Explains Substrate Preferences and Identifies Regions Exploitable for Inhibitor Design. Biochemistry, 43, 2004
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5FDL
 
 | Crystal Structure of K103N/Y181C Mutant HIV-1 Reverse Transcriptase (RT) in Complex with IDX899 | 分子名称: | P51 Reverse transcriptase, P66 Reverse transcriptase, methyl (R)-(2-carbamoyl-5-chloro-1H-indol-3-yl)[3-(2-cyanoethyl)-5-methylphenyl]phosphinate | 著者 | Dousson, C.B, Alexandre, F.-R, Convard, T, Fisher, M, Lamers, M.B.A.C, Leonard, P.M. | 登録日 | 2015-12-16 | 公開日 | 2016-02-17 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (3.1 Å) | 主引用文献 | Discovery of the Aryl-phospho-indole IDX899, a Highly Potent Anti-HIV Non-nucleoside Reverse Transcriptase Inhibitor. J.Med.Chem., 59, 2016
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5F0W
 
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5F5U
 
 | Crystal structure of the Snu23-Prp38-MFAP1(217-258) complex of Chaetomium thermophilum | 分子名称: | Prp38, Putative uncharacterized protein, Zinc finger domain-containing protein | 著者 | Ulrich, A.K.C, Seeger, M, Bartlick, N, Wahl, M.C. | 登録日 | 2015-12-04 | 公開日 | 2016-10-19 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (2.748 Å) | 主引用文献 | Scaffolding in the Spliceosome via Single alpha Helices. Structure, 24, 2016
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2ZI9
 
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5F5V
 
 | Crystal structure of the Snu23-Prp38-MFAP1(217-296) complex of Chaetomium thermophilum | 分子名称: | Prp38, Putative uncharacterized protein, Zinc finger domain-containing protein | 著者 | Ulrich, A.K.C, Seeger, M, Bartlick, N, Wahl, M.C. | 登録日 | 2015-12-04 | 公開日 | 2016-10-12 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (3.1 Å) | 主引用文献 | Scaffolding in the Spliceosome via Single alpha Helices. Structure, 24, 2016
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6DZ3
 
 | Crystal structure of human 5'-deoxy-5'-methylthioadenosine phosphorylase in complex with (3R,4S)-1-((4-amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl)methyl)-4-(((3-(1-butyl-1H-1,2,3-triazol-4-yl)propyl)thio)methyl)pyrrolidin-3-ol | 分子名称: | (3R,4S)-1-[(4-amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl)methyl]-4-({[3-(1-butyl-1H-1,2,3-triazol-4-yl)propyl]sulfanyl}methyl)pyrrolidin-3-ol, 1,2-ETHANEDIOL, ACETIC ACID, ... | 著者 | Harijan, R.K, Ducati, R.G, Bonanno, J.B, Almo, S.C, Schramm, V.L. | 登録日 | 2018-07-02 | 公開日 | 2019-03-20 | 最終更新日 | 2024-10-23 | 実験手法 | X-RAY DIFFRACTION (1.91 Å) | 主引用文献 | Selective Inhibitors of Helicobacter pylori Methylthioadenosine Nucleosidase and Human Methylthioadenosine Phosphorylase. J. Med. Chem., 62, 2019
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6DZ0
 
 | Crystal structure of human 5'-deoxy-5'-methylthioadenosine phosphorylase in complex with (3R,4S)-1-((4-amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl)methyl)-4-((pent-4-yn-1-ylthio)methyl)pyrrolidin-3-ol | 分子名称: | (3R,4S)-1-[(4-amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl)methyl]-4-{[(pent-4-yn-1-yl)sulfanyl]methyl}pyrrolidin-3-ol, 1,2-ETHANEDIOL, CHLORIDE ION, ... | 著者 | Harijan, R.K, Ducati, R.G, Bonanno, J.B, Almo, S.C, Schramm, V.L. | 登録日 | 2018-07-02 | 公開日 | 2019-03-20 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (1.62 Å) | 主引用文献 | Selective Inhibitors of Helicobacter pylori Methylthioadenosine Nucleosidase and Human Methylthioadenosine Phosphorylase. J. Med. Chem., 62, 2019
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5F5S
 
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4IJQ
 
 | Human hypoxanthine-guanine phosphoribosyltransferase in complex with [(2-((Guanine-9H-yl)methyl)propane-1,3-diyl)bis(oxy)]bis(methylene))diphosphonic acid | 分子名称: | Hypoxanthine-guanine phosphoribosyltransferase, MAGNESIUM ION, SULFATE ION, ... | 著者 | Guddat, L.W, Keough, D.T, Hockova, D. | 登録日 | 2012-12-22 | 公開日 | 2013-03-27 | 最終更新日 | 2024-03-20 | 実験手法 | X-RAY DIFFRACTION (2.004 Å) | 主引用文献 | Acyclic nucleoside phosphonates containing a second phosphonate group are potent inhibitors of 6-oxopurine phosphoribosyltransferases and have antimalarial activity J.Med.Chem., 56, 2013
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