4RHX
Structures of Mycobacterium tuberculosis 6-oxopurine phosphoribosyltransferase which is a potential target for drug development against this disease
Summary for 4RHX
Entry DOI | 10.2210/pdb4rhx/pdb |
Descriptor | Hypoxanthine-guanine phosphoribosyltransferase, [2-([2-(2-amino-6-oxo-1,6-dihydro-9H-purin-9-yl)ethyl]{2-[(2-oxoethyl)(2-phosphonoethyl)amino]ethyl}amino)ethyl]phosphonic acid, MAGNESIUM ION, ... (4 entities in total) |
Functional Keywords | 6-oxopurine phosphoribosyltransferase, cytoplasmic, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Mycobacterium tuberculosis |
Total number of polymer chains | 4 |
Total formula weight | 90739.57 |
Authors | Eng, W.S.,Hockova, D.,Spacek, P.,West, N.P.,Woods, K.,Naesens, L.M.J.,Keough, D.T.,Guddat, L.W. (deposition date: 2014-10-03, release date: 2015-05-20, Last modification date: 2024-02-28) |
Primary citation | Eng, W.S.,Hockova, D.,Spacek, P.,Janeba, Z.,West, N.P.,Woods, K.,Naesens, L.M.,Keough, D.T.,Guddat, L.W. First Crystal Structures of Mycobacterium tuberculosis 6-Oxopurine Phosphoribosyltransferase: Complexes with GMP and Pyrophosphate and with Acyclic Nucleoside Phosphonates Whose Prodrugs Have Antituberculosis Activity. J.Med.Chem., 58:4822-4838, 2015 Cited by PubMed: 25915781DOI: 10.1021/acs.jmedchem.5b00611 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.0322 Å) |
Structure validation
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