4RHY

Crystal structures of Mycobacterium tuberculosis 6-oxopurine phosphoribosyltransferase which is a potential target for drug development against this disease

Summary for 4RHY

Entry DOI	10.2210/pdb4rhy/pdb
Descriptor	Hypoxanthine-guanine phosphoribosyltransferase, MAGNESIUM ION, [2-({2-[bis(2-phosphonoethyl)amino]ethyl}[2-(6-oxo-3,6-dihydro-9H-purin-9-yl)ethyl]amino)ethyl]phosphonic acid, ... (4 entities in total)
Functional Keywords	6-oxopurine phosphoribosyltransferase, cytoplasmic, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological source	Mycobacterium tuberculosis
Total number of polymer chains	4
Total formula weight	90943.50
Authors	Eng, W.S.,Hockova, D.,Spacek, P.,West, N.P.,Woods, K.,Naesens, L.M.J.,Keough, D.T.,Guddat, L.W. (deposition date: 2014-10-03, release date: 2015-05-20, Last modification date: 2024-02-28)
Primary citation	Eng, W.S.,Hockova, D.,Spacek, P.,Janeba, Z.,West, N.P.,Woods, K.,Naesens, L.M.,Keough, D.T.,Guddat, L.W. First Crystal Structures of Mycobacterium tuberculosis 6-Oxopurine Phosphoribosyltransferase: Complexes with GMP and Pyrophosphate and with Acyclic Nucleoside Phosphonates Whose Prodrugs Have Antituberculosis Activity. J.Med.Chem., 58:4822-4838, 2015 Cited by PubMed: 25915781 DOI: 10.1021/acs.jmedchem.5b00611 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.3196 Å)

Structure validation