4RHY
Crystal structures of Mycobacterium tuberculosis 6-oxopurine phosphoribosyltransferase which is a potential target for drug development against this disease
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000166 | molecular_function | nucleotide binding |
| A | 0000287 | molecular_function | magnesium ion binding |
| A | 0004422 | molecular_function | hypoxanthine phosphoribosyltransferase activity |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005829 | cellular_component | cytosol |
| A | 0006166 | biological_process | purine ribonucleoside salvage |
| A | 0006177 | biological_process | GMP biosynthetic process |
| A | 0006178 | biological_process | guanine salvage |
| A | 0006188 | biological_process | IMP biosynthetic process |
| A | 0016757 | molecular_function | glycosyltransferase activity |
| A | 0032263 | biological_process | GMP salvage |
| A | 0032264 | biological_process | IMP salvage |
| A | 0043101 | biological_process | purine-containing compound salvage |
| A | 0046100 | biological_process | hypoxanthine metabolic process |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0052657 | molecular_function | guanine phosphoribosyltransferase activity |
| B | 0000166 | molecular_function | nucleotide binding |
| B | 0000287 | molecular_function | magnesium ion binding |
| B | 0004422 | molecular_function | hypoxanthine phosphoribosyltransferase activity |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005829 | cellular_component | cytosol |
| B | 0006166 | biological_process | purine ribonucleoside salvage |
| B | 0006177 | biological_process | GMP biosynthetic process |
| B | 0006178 | biological_process | guanine salvage |
| B | 0006188 | biological_process | IMP biosynthetic process |
| B | 0016757 | molecular_function | glycosyltransferase activity |
| B | 0032263 | biological_process | GMP salvage |
| B | 0032264 | biological_process | IMP salvage |
| B | 0043101 | biological_process | purine-containing compound salvage |
| B | 0046100 | biological_process | hypoxanthine metabolic process |
| B | 0046872 | molecular_function | metal ion binding |
| B | 0052657 | molecular_function | guanine phosphoribosyltransferase activity |
| C | 0000166 | molecular_function | nucleotide binding |
| C | 0000287 | molecular_function | magnesium ion binding |
| C | 0004422 | molecular_function | hypoxanthine phosphoribosyltransferase activity |
| C | 0005737 | cellular_component | cytoplasm |
| C | 0005829 | cellular_component | cytosol |
| C | 0006166 | biological_process | purine ribonucleoside salvage |
| C | 0006177 | biological_process | GMP biosynthetic process |
| C | 0006178 | biological_process | guanine salvage |
| C | 0006188 | biological_process | IMP biosynthetic process |
| C | 0016757 | molecular_function | glycosyltransferase activity |
| C | 0032263 | biological_process | GMP salvage |
| C | 0032264 | biological_process | IMP salvage |
| C | 0043101 | biological_process | purine-containing compound salvage |
| C | 0046100 | biological_process | hypoxanthine metabolic process |
| C | 0046872 | molecular_function | metal ion binding |
| C | 0052657 | molecular_function | guanine phosphoribosyltransferase activity |
| D | 0000166 | molecular_function | nucleotide binding |
| D | 0000287 | molecular_function | magnesium ion binding |
| D | 0004422 | molecular_function | hypoxanthine phosphoribosyltransferase activity |
| D | 0005737 | cellular_component | cytoplasm |
| D | 0005829 | cellular_component | cytosol |
| D | 0006166 | biological_process | purine ribonucleoside salvage |
| D | 0006177 | biological_process | GMP biosynthetic process |
| D | 0006178 | biological_process | guanine salvage |
| D | 0006188 | biological_process | IMP biosynthetic process |
| D | 0016757 | molecular_function | glycosyltransferase activity |
| D | 0032263 | biological_process | GMP salvage |
| D | 0032264 | biological_process | IMP salvage |
| D | 0043101 | biological_process | purine-containing compound salvage |
| D | 0046100 | biological_process | hypoxanthine metabolic process |
| D | 0046872 | molecular_function | metal ion binding |
| D | 0052657 | molecular_function | guanine phosphoribosyltransferase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE MG A 301 |
| Chain | Residue |
| A | GLU122 |
| A | ASP123 |
| A | HOH403 |
| A | HOH404 |
| A | HOH448 |
| A | HOH455 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE MG A 302 |
| Chain | Residue |
| A | HOH402 |
| A | HOH405 |
| A | HOH447 |
| A | ASP182 |
| A | 3QG303 |
| A | HOH401 |
| site_id | AC3 |
| Number of Residues | 25 |
| Details | BINDING SITE FOR RESIDUE 3QG A 303 |
| Chain | Residue |
| A | LEU65 |
| A | LYS66 |
| A | GLY67 |
| A | SER92 |
| A | VAL125 |
| A | ASP126 |
| A | SER127 |
| A | GLY128 |
| A | LEU129 |
| A | THR130 |
| A | LYS154 |
| A | PHE175 |
| A | VAL176 |
| A | LEU181 |
| A | ASP182 |
| A | ARG188 |
| A | MG302 |
| A | HOH402 |
| A | HOH403 |
| A | HOH404 |
| A | HOH406 |
| A | HOH408 |
| A | HOH449 |
| A | HOH450 |
| A | HOH451 |
| site_id | AC4 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE MG B 301 |
| Chain | Residue |
| B | GLU122 |
| B | ASP123 |
| B | HOH402 |
| B | HOH403 |
| B | HOH450 |
| B | HOH455 |
| site_id | AC5 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE MG B 302 |
| Chain | Residue |
| B | ASP182 |
| B | 3QG303 |
| B | HOH401 |
| B | HOH404 |
| B | HOH405 |
| site_id | AC6 |
| Number of Residues | 20 |
| Details | BINDING SITE FOR RESIDUE 3QG B 303 |
| Chain | Residue |
| B | LEU65 |
| B | LYS66 |
| B | GLY67 |
| B | VAL125 |
| B | ASP126 |
| B | SER127 |
| B | GLY128 |
| B | LEU129 |
| B | THR130 |
| B | LYS154 |
| B | PHE175 |
| B | VAL176 |
| B | ASP182 |
| B | ARG188 |
| B | MG302 |
| B | HOH401 |
| B | HOH404 |
| B | HOH431 |
| B | HOH446 |
| B | HOH455 |
| site_id | AC7 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE MG C 301 |
| Chain | Residue |
| C | GLU122 |
| C | ASP123 |
| C | HOH401 |
| C | HOH402 |
| C | HOH403 |
| C | HOH446 |
| site_id | AC8 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE MG C 302 |
| Chain | Residue |
| C | ASP182 |
| C | 3QG303 |
| C | HOH404 |
| C | HOH405 |
| C | HOH408 |
| C | HOH445 |
| site_id | AC9 |
| Number of Residues | 20 |
| Details | BINDING SITE FOR RESIDUE 3QG C 303 |
| Chain | Residue |
| C | HOH409 |
| C | LEU65 |
| C | LYS66 |
| C | GLY67 |
| C | SER92 |
| C | VAL125 |
| C | ASP126 |
| C | SER127 |
| C | GLY128 |
| C | LEU129 |
| C | THR130 |
| C | LYS154 |
| C | PHE175 |
| C | VAL176 |
| C | ASP182 |
| C | ARG188 |
| C | MG302 |
| C | HOH403 |
| C | HOH406 |
| C | HOH408 |
| site_id | BC1 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE MG D 301 |
| Chain | Residue |
| D | GLU122 |
| D | ASP123 |
| D | HOH401 |
| D | HOH402 |
| D | HOH403 |
| D | HOH407 |
| site_id | BC2 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE MG D 302 |
| Chain | Residue |
| D | ASP182 |
| D | 3QG303 |
| D | HOH406 |
| D | HOH413 |
| D | HOH453 |
| D | HOH460 |
| site_id | BC3 |
| Number of Residues | 22 |
| Details | BINDING SITE FOR RESIDUE 3QG D 303 |
| Chain | Residue |
| D | LYS66 |
| D | GLY67 |
| D | SER92 |
| D | VAL124 |
| D | ASP126 |
| D | SER127 |
| D | GLY128 |
| D | LEU129 |
| D | THR130 |
| D | LYS154 |
| D | ASP174 |
| D | PHE175 |
| D | VAL176 |
| D | ASP182 |
| D | ARG188 |
| D | MG302 |
| D | HOH404 |
| D | HOH405 |
| D | HOH406 |
| D | HOH412 |
| D | HOH435 |
| D | HOH455 |
Functional Information from PROSITE/UniProt
| site_id | PS00103 |
| Number of Residues | 13 |
| Details | PUR_PYR_PR_TRANSFER Purine/pyrimidine phosphoribosyl transferases signature. VLIVEDVVDSGlT |
| Chain | Residue | Details |
| A | VAL118-THR130 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 4 |
| Details | ACT_SITE: Proton acceptor => ECO:0000250|UniProtKB:P0A9M2 |
| Chain | Residue | Details |
| A | ASP126 | |
| B | ASP126 | |
| C | ASP126 | |
| D | ASP126 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 12 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:25915781, ECO:0007744|PDB:4RHT, ECO:0007744|PDB:5KNP |
| Chain | Residue | Details |
| A | LYS66 | |
| D | LYS66 | |
| D | GLY67 | |
| D | ARG188 | |
| A | GLY67 | |
| A | ARG188 | |
| B | LYS66 | |
| B | GLY67 | |
| B | ARG188 | |
| C | LYS66 | |
| C | GLY67 | |
| C | ARG188 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 20 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:25915781, ECO:0007744|PDB:4RHT |
| Chain | Residue | Details |
| A | GLU122 | |
| B | ASP182 | |
| C | GLU122 | |
| C | ASP123 | |
| C | LYS154 | |
| C | PHE175 | |
| C | ASP182 | |
| D | GLU122 | |
| D | ASP123 | |
| D | LYS154 | |
| D | PHE175 | |
| A | ASP123 | |
| D | ASP182 | |
| A | LYS154 | |
| A | PHE175 | |
| A | ASP182 | |
| B | GLU122 | |
| B | ASP123 | |
| B | LYS154 | |
| B | PHE175 |
