3IX9
 
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6BBA
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6SP1
 | | KEAP1 IN COMPLEX WITH COMPOUND 6 | | 分子名称: | (1~{S},2~{R})-2-[[(1~{S})-1-[[1,3-bis(oxidanylidene)isoindol-2-yl]methyl]-5-(2-hydroxyethyloxy)-3,4-dihydro-1~{H}-isoquinolin-2-yl]carbonyl]cyclohexane-1-carboxylic acid, ACETATE ION, Kelch-like ECH-associated protein 1 | | 著者 | Ontoria, J.M, Biancofiore, I, Fezzardi, P, Torrente de Haro, E, Colarusso, S, Bianchi, E, Andreini, M, Patsilinakos, A, Summa, V, Pacifici, R, Munoz-Sanjuan, I, Park, L, Bresciani, A, Dominguez, C, Toledo-Sherman, L, Harper, S. | | 登録日 | 2019-08-30 | | 公開日 | 2020-06-03 | | 実験手法 | X-RAY DIFFRACTION (2.57 Å) | | 主引用文献 | Combined Peptide and Small-Molecule Approach toward Nonacidic THIQ Inhibitors of the KEAP1/NRF2 Interaction.
Acs Med.Chem.Lett., 11, 2020
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2V7G
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1C35
 | | SOLUTION STRUCTURE OF A QUADRUPLEX FORMING DNA AND ITS INTERMIDIATE | | 分子名称: | DNA (5'-D(*GP*GP*TP*TP*GP*GP*TP*GP*TP*GP*GP*TP*TP*GP*G)-3'), POTASSIUM ION | | 著者 | Bolton, P.H, Marathias, V.M, Wang, K. | | 登録日 | 1999-07-25 | | 公開日 | 1999-08-18 | | 最終更新日 | 2024-05-22 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Structures of the potassium-saturated, 2:1, and intermediate, 1:1, forms of a quadruplex DNA.
Nucleic Acids Res., 28, 2000
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6EVO
 | | Crystal structure the peptide-substrate-binding domain of human type II collagen prolyl 4-hydroxylase complexed with Pro-Pro-Gly-Pro-Arg-Gly-Pro-Pro-Gly. | | 分子名称: | DIMETHYL SULFOXIDE, PRO-PRO-GLY-PRO-ARG-GLY-PRO-PRO-GLY, Prolyl 4-hydroxylase subunit alpha-2, ... | | 著者 | Murthy, A.V, Sulu, R, Koski, M.K, Wierenga, R.K. | | 登録日 | 2017-11-02 | | 公開日 | 2018-09-12 | | 最終更新日 | 2024-05-08 | | 実験手法 | X-RAY DIFFRACTION (1.55 Å) | | 主引用文献 | Structural enzymology binding studies of the peptide-substrate-binding domain of human collagen prolyl 4-hydroxylase (type-II): High affinity peptides have a PxGP sequence motif.
Protein Sci., 27, 2018
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5C2X
 | | Crystal structure of deoxyribose-phosphate aldolase from Colwellia psychrerythraea (tetragonal form) | | 分子名称: | CARBONATE ION, Deoxyribose-phosphate aldolase, SULFATE ION, ... | | 著者 | Dick, M, Weiergraeber, O.H, Pietruszka, J. | | 登録日 | 2015-06-16 | | 公開日 | 2016-02-03 | | 最終更新日 | 2024-01-10 | | 実験手法 | X-RAY DIFFRACTION (2.11 Å) | | 主引用文献 | Trading off stability against activity in extremophilic aldolases.
Sci Rep, 6, 2016
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6EYX
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5FZR
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5FZS
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1RC1
 | | Human GAR Tfase complex structure with polyglutamated 10-(trifluoroacetyl)-5,10-dideazaacyclic-5,6,7,8-tetrahydrofolic acid | | 分子名称: | N-{4-4-(2,4-DIAMINO-6-OXO-1,6-DIHYDRO-PYRIMIDIN-5-YL)-1-(2,2,2-TRIFLUORO-1,1-DIHYDROXY-ETHYL)-BUT-2-YL-BENZOYL}-GAMMA-GLUTAMYL-GAMMA-GLUTAMYL-GLUTAMIC ACID, PHOSPHATE ION, PHOSPHORIBOSYLGLYCINAMIDE FORMYLTRANSFERASE | | 著者 | Zhang, Y, Desharnais, J, Boger, D.L, Wilson, I.A. | | 登録日 | 2003-11-03 | | 公開日 | 2005-06-14 | | 最終更新日 | 2023-08-23 | | 実験手法 | X-RAY DIFFRACTION (2.25 Å) | | 主引用文献 | Human GAR Tfase complex structure
To be Published
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6EVM
 | | Crystal structure of a Pro-9 complexed peptide-substrate-binding domain of human type II collagen prolyl 4-hydroxylase | | 分子名称: | DIMETHYL SULFOXIDE, Pro-9, Prolyl 4-hydroxylase subunit alpha-2, ... | | 著者 | Murthy, A.V, Sulu, R, Koski, M.K, Wierenga, R.K. | | 登録日 | 2017-11-02 | | 公開日 | 2018-09-12 | | 最終更新日 | 2024-01-17 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Structural enzymology binding studies of the peptide-substrate-binding domain of human collagen prolyl 4-hydroxylase (type-II): High affinity peptides have a PxGP sequence motif.
Protein Sci., 27, 2018
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1RFR
 | | NMR structure of the 30mer stemloop-D of coxsackieviral RNA | | 分子名称: | stemloop-D RNA of the 5'-cloverleaf of coxsackievirus B3 | | 著者 | Ohlenschlager, O, Wohnert, J, Bucci, E, Seitz, S, Hafner, S, Ramachandran, R, Zell, R, Gorlach, M. | | 登録日 | 2003-11-10 | | 公開日 | 2004-03-23 | | 最終更新日 | 2024-05-22 | | 実験手法 | SOLUTION NMR | | 主引用文献 | The structure of the stemloop D subdomain of coxsackievirus B3 cloverleaf
RNA and its interaction with the proteinase 3C.
STRUCTURE, 12, 2004
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2WBB
 | | FRUCTOSE-1,6-BISPHOSPHATASE(D-FRUCTOSE-1,6-BISPHOSPHATE-1- PHOSPHOHYDROLASE) (E.C.3.1.3.11) COMPLEXED WITH AN AMP SITE INHIBITOR | | 分子名称: | FRUCTOSE-1,6-BISPHOSPHATASE 1, N-{[(2Z)-5-BROMO-1,3-THIAZOL-2(3H)-YLIDENE]CARBAMOYL}-4-METHYLBENZENESULFONAMIDE | | 著者 | Ruf, A, Joseph, C, Benz, J, Fol, B, Tetaz, T, Kitas, E, Mohr, P, Kuhn, B, Wessel, H.P, Hebeisen, P, Haap, W, Huber, W, Alvarez Sanchez, R, Paehler, A, Bernadeau, A, Gubler, M, Schott, B, Tozzo, E. | | 登録日 | 2009-02-26 | | 公開日 | 2009-12-22 | | 最終更新日 | 2023-12-13 | | 実験手法 | X-RAY DIFFRACTION (2.22 Å) | | 主引用文献 | Sulfonylureido Thiazoles as Fructose-1,6-Bisphosphatase Inhibitors for the Treatment of Type-2 Diabetes.
Bioorg.Med.Chem.Lett., 20, 2010
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6EVN
 | | Crystal structure of peptide-substrate-binding domain of human type II collagen prolyl 4-hydroxylase complex with Pro-Pro-Gly-Pro-Ala-Gly-Pro-Pro-Gly. | | 分子名称: | DIMETHYL SULFOXIDE, PRO-PRO-GLY-PRO-ALA-GLY-PRO-PRO-GLY, Prolyl 4-hydroxylase subunit alpha-2, ... | | 著者 | Murthy, A.V, Sulu, R, Koski, M.K, Wierenga, R.K. | | 登録日 | 2017-11-02 | | 公開日 | 2018-09-12 | | 最終更新日 | 2024-05-08 | | 実験手法 | X-RAY DIFFRACTION (1.48 Å) | | 主引用文献 | Structural enzymology binding studies of the peptide-substrate-binding domain of human collagen prolyl 4-hydroxylase (type-II): High affinity peptides have a PxGP sequence motif.
Protein Sci., 27, 2018
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6EW2
 | | Human myelin protein P2 F57A mutant, tetragonal crystal form | | 分子名称: | CHLORIDE ION, Myelin P2 protein, PALMITIC ACID | | 著者 | Laulumaa, S, Lehtimaki, M, Kursula, P. | | 登録日 | 2017-11-03 | | 公開日 | 2018-07-11 | | 最終更新日 | 2024-01-17 | | 実験手法 | X-RAY DIFFRACTION (1.588 Å) | | 主引用文献 | Structure and dynamics of a human myelin protein P2 portal region mutant indicate opening of the beta barrel in fatty acid binding proteins.
BMC Struct. Biol., 18, 2018
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1RXT
 | | Crystal structure of human myristoyl-CoA:protein N-myristoyltransferase. | | 分子名称: | COBALT (II) ION, Glycylpeptide N-tetradecanoyltransferase 1, SULFATE ION | | 著者 | Yang, J, Wang, Y, Frey, G, Abeles, R.H, Petsko, G.A, Ringe, D. | | 登録日 | 2003-12-18 | | 公開日 | 2005-04-12 | | 最終更新日 | 2024-02-14 | | 実験手法 | X-RAY DIFFRACTION (3 Å) | | 主引用文献 | Crystal structure of human myristoyl-CoA:protein N-myristoyltransferase
To be Published
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5G1S
 | | Open conformation of Francisella tularensis ClpP at 1.7 A | | 分子名称: | (4R)-2-METHYLPENTANE-2,4-DIOL, (4S)-2-METHYL-2,4-PENTANEDIOL, ACETATE ION, ... | | 著者 | Diaz-Saez, L, Pankov, G, Hunter, W.N. | | 登録日 | 2016-03-30 | | 公開日 | 2016-10-19 | | 最終更新日 | 2024-05-01 | | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | | 主引用文献 | Open and compressed conformations of Francisella tularensis ClpP.
Proteins, 85, 2017
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4IZN
 | | Structure of pcDronpa-A69T mutant | | 分子名称: | Fluorescent protein Dronpa, POTASSIUM ION | | 著者 | De Zitter, E, Nguyen Bich, N, Van Meervelt, L, Moeyaert, B. | | 登録日 | 2013-01-30 | | 公開日 | 2014-02-05 | | 最終更新日 | 2023-11-15 | | 実験手法 | X-RAY DIFFRACTION (2.15 Å) | | 主引用文献 | Green-to-red photoconvertible Dronpa mutant for multimodal super-resolution fluorescence microscopy
ACS Nano, 8, 2014
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6EVL
 | | Crystal structure of an unlignaded peptide-substrate-binding domain of human type II collagen prolyl 4-hydroxylase | | 分子名称: | DIMETHYL SULFOXIDE, GLYCINE, Prolyl 4-hydroxylase subunit alpha-2, ... | | 著者 | Murthy, A.V, Sulu, R, Koski, M.K, Wierenga, R.K. | | 登録日 | 2017-11-02 | | 公開日 | 2018-09-12 | | 最終更新日 | 2024-01-17 | | 実験手法 | X-RAY DIFFRACTION (1.87 Å) | | 主引用文献 | Structural enzymology binding studies of the peptide-substrate-binding domain of human collagen prolyl 4-hydroxylase (type-II): High affinity peptides have a PxGP sequence motif.
Protein Sci., 27, 2018
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6EVP
 | | Crystal structure the peptide-substrate-binding domain of human type II collagen prolyl 4-hydroxylase complexed with Pro-Pro-Gly-Pro-Glu-Gly-Pro-Pro-Gly. | | 分子名称: | DIMETHYL SULFOXIDE, PRO-PRO-GLY-PRO-GLU-GLY-PRO-PRO-GLY, Prolyl 4-hydroxylase subunit alpha-2, ... | | 著者 | Murthy, A.V, Sulu, R, Koski, M.K, Wierenga, R.K. | | 登録日 | 2017-11-02 | | 公開日 | 2018-09-12 | | 最終更新日 | 2024-05-08 | | 実験手法 | X-RAY DIFFRACTION (1.68 Å) | | 主引用文献 | Structural enzymology binding studies of the peptide-substrate-binding domain of human collagen prolyl 4-hydroxylase (type-II): High affinity peptides have a PxGP sequence motif.
Protein Sci., 27, 2018
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6CD8
 | | Complex of GID4 fragment with short peptide | | 分子名称: | Glucose-induced degradation protein 4 homolog, Tetrapeptide PSRV, UNKNOWN ATOM OR ION | | 著者 | Dong, C, Tempel, W, Bountra, C, Arrowsmith, C.H, Edwards, A.M, Min, J, Structural Genomics Consortium (SGC) | | 登録日 | 2018-02-08 | | 公開日 | 2018-03-07 | | 最終更新日 | 2023-10-04 | | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | | 主引用文献 | Molecular basis of GID4-mediated recognition of degrons for the Pro/N-end rule pathway.
Nat. Chem. Biol., 14, 2018
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6CDJ
 | | HIV-1 wild type protease with GRL-03314A, 6-5-5-ring fused umbrella-like tetrahydropyranofuran as the P2-ligand, a cyclopropylaminobenzothiazole as the P2'-ligand and 3,5-difluorophenylmethyl as the P1-ligand | | 分子名称: | (2aS,4R,4aS,7aS,7bS)-octahydro-2H-1,7-dioxacyclopenta[cd]inden-4-yl [(2S,3R)-4-[{[2-(cyclopropylamino)-1,3-benzothiazol-6-yl]sulfonyl}(2-methylpropyl)amino]-1-(3,5-difluorophenyl)-3-hydroxybutan-2-yl]carbamate, ACETATE ION, CHLORIDE ION, ... | | 著者 | Wang, Y.-F, Agniswamy, J, Weber, I.T. | | 登録日 | 2018-02-08 | | 公開日 | 2018-05-30 | | 最終更新日 | 2023-10-04 | | 実験手法 | X-RAY DIFFRACTION (1.13 Å) | | 主引用文献 | Design and Synthesis of Highly Potent HIV-1 Protease Inhibitors Containing Tricyclic Fused Ring Systems as Novel P2 Ligands: Structure-Activity Studies, Biological and X-ray Structural Analysis.
J. Med. Chem., 61, 2018
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5GL0
 | | Structure of RyR1 in a closed state (C4 conformer) | | 分子名称: | Peptidyl-prolyl cis-trans isomerase FKBP1A, Ryanodine receptor 1, ZINC ION | | 著者 | Bai, X.C, Yan, Z, Wu, J.P, Yan, N. | | 登録日 | 2016-07-07 | | 公開日 | 2016-08-24 | | 最終更新日 | 2024-03-27 | | 実験手法 | ELECTRON MICROSCOPY (4.2 Å) | | 主引用文献 | The Central domain of RyR1 is the transducer for long-range allosteric gating of channel opening
Cell Res., 26, 2016
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6JN2
 | | Crystal structure of the coiled-coil domains of human DOT1L in complex with AF10 | | 分子名称: | Histone-lysine N-methyltransferase, H3 lysine-79 specific, Protein AF-10 | | 著者 | Song, X, Wang, M, Yang, N, Xu, R.M. | | 登録日 | 2019-03-13 | | 公開日 | 2019-09-18 | | 最終更新日 | 2024-03-27 | | 実験手法 | X-RAY DIFFRACTION (3.6 Å) | | 主引用文献 | A higher-order configuration of the heterodimeric DOT1L-AF10 coiled-coil domains potentiates their leukemogenenic activity.
Proc.Natl.Acad.Sci.USA, 116, 2019
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