6EVN

Crystal structure of peptide-substrate-binding domain of human type II collagen prolyl 4-hydroxylase complex with Pro-Pro-Gly-Pro-Ala-Gly-Pro-Pro-Gly.

Summary for 6EVN

• Entry DOI: 10.2210/pdb6evn/pdb
• Related: 6EVL 6EVM
• Descriptor: Prolyl 4-hydroxylase subunit alpha-2, PRO-PRO-GLY-PRO-ALA-GLY-PRO-PRO-GLY, SULFATE ION, ... (5 entities in total)
• Functional Keywords: tetratricopeptide repeat, collagen synthesis, prolyl 4-hydroxylase, hydrolase
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 2
• Total formula weight: 13170.75

Authors

Murthy, A.V.,Sulu, R.,Koski, M.K.,Wierenga, R.K. (deposition date: 2017-11-02, release date: 2018-09-12, Last modification date: 2018-10-31)

• Primary citation: Murthy, A.V.,Sulu, R.,Koski, M.K.,Tu, H.,Anantharajan, J.,Sah-Teli, S.K.,Myllyharju, J.,Wierenga, R.K.; Structural enzymology binding studies of the peptide-substrate-binding domain of human collagen prolyl 4-hydroxylase (type-II): High affinity peptides have a PxGP sequence motif.; Protein Sci., 27:1692-1703, 2018; PubMed: 30168208; DOI: 10.1002/pro.3450

Experimental method

X-RAY DIFFRACTION (1.48 Å)