8J6R
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![BU of 8j6r by Molmil](/molmil-images/mine/8j6r) | Cryo-EM structure of the MK-6892-bound human HCAR2-Gi1 complex | 分子名称: | 2-[[2,2-dimethyl-3-[3-(5-oxidanylpyridin-2-yl)-1,2,4-oxadiazol-5-yl]propanoyl]amino]cyclohexene-1-carboxylic acid, 2-acetamido-2-deoxy-beta-D-glucopyranose, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | 著者 | Mao, C, Gao, M, Zang, S, Zhu, Y, Ma, X, Zhang, Y. | 登録日 | 2023-04-26 | 公開日 | 2023-12-06 | 実験手法 | ELECTRON MICROSCOPY (2.76 Å) | 主引用文献 | Orthosteric and allosteric modulation of human HCAR2 signaling complex. Nat Commun, 14, 2023
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8J6Q
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![BU of 8j6q by Molmil](/molmil-images/mine/8j6q) | Cryo-EM structure of the 3-HB and compound 9n-bound human HCAR2-Gi1 complex | 分子名称: | (3R)-3-hydroxybutanoic acid, 2-acetamido-2-deoxy-beta-D-glucopyranose, 7-methyl-N-[(2R)-1-phenoxypropan-2-yl]-3-(4-propan-2-ylphenyl)pyrazolo[1,5-a]pyrimidine-6-carboxamide, ... | 著者 | Mao, C, Gao, M, Zang, S, Zhu, Y, Ma, X, Zhang, Y. | 登録日 | 2023-04-26 | 公開日 | 2023-12-06 | 実験手法 | ELECTRON MICROSCOPY (2.6 Å) | 主引用文献 | Orthosteric and allosteric modulation of human HCAR2 signaling complex. Nat Commun, 14, 2023
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8J6P
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![BU of 8j6p by Molmil](/molmil-images/mine/8j6p) | Cryo-EM structure of the MK-6892-bound human HCAR2-Gi1 complex | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 7-methyl-N-[(2R)-1-phenoxypropan-2-yl]-3-(4-propan-2-ylphenyl)pyrazolo[1,5-a]pyrimidine-6-carboxamide, CHOLESTEROL, ... | 著者 | Mao, C, Gao, M, Zang, S, Zhu, Y, Ma, X, Zhang, Y. | 登録日 | 2023-04-26 | 公開日 | 2023-12-06 | 実験手法 | ELECTRON MICROSCOPY (2.55 Å) | 主引用文献 | Orthosteric and allosteric modulation of human HCAR2 signaling complex. Nat Commun, 14, 2023
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8J6L
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![BU of 8j6l by Molmil](/molmil-images/mine/8j6l) | Cryo-EM structure of thehydroxycarboxylic acid receptor 2-Gi protein complex bound niacin | 分子名称: | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(i) subunit alpha-1, ... | 著者 | Yuan, Q, Zhu, S, Duan, J, Xu, H.E, Duan, X. | 登録日 | 2023-04-26 | 公開日 | 2024-04-03 | 実験手法 | ELECTRON MICROSCOPY (3.05 Å) | 主引用文献 | Molecular recognition of niacin and lipid-lowering drugs by the human hydroxycarboxylic acid receptor 2. Cell Rep, 42, 2023
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8J6J
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![BU of 8j6j by Molmil](/molmil-images/mine/8j6j) | Cryo-EM structure of thehydroxycarboxylic acid receptor 2-Gi protein complex bound with GSK256073 | 分子名称: | 8-chloranyl-3-pentyl-7H-purine-2,6-dione, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | 著者 | Yuan, Q, Zhu, S, Duan, J, Xu, H.E, Duan, X. | 登録日 | 2023-04-26 | 公開日 | 2024-01-10 | 実験手法 | ELECTRON MICROSCOPY (2.8 Å) | 主引用文献 | Molecular recognition of niacin and lipid-lowering drugs by the human hydroxycarboxylic acid receptor 2. Cell Rep, 42, 2023
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8J6I
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![BU of 8j6i by Molmil](/molmil-images/mine/8j6i) | Cryo-EM structure of thehydroxycarboxylic acid receptor 2-Gi protein complex bound MK-6892 | 分子名称: | 2-[[2,2-dimethyl-3-[3-(5-oxidanylpyridin-2-yl)-1,2,4-oxadiazol-5-yl]propanoyl]amino]cyclohexene-1-carboxylic acid, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | 著者 | Yuan, Q, Zhu, S, Duan, J, Xu, H.E, Duan, X. | 登録日 | 2023-04-26 | 公開日 | 2024-04-03 | 実験手法 | ELECTRON MICROSCOPY (2.92 Å) | 主引用文献 | Molecular recognition of niacin and lipid-lowering drugs by the human hydroxycarboxylic acid receptor 2. Cell Rep, 42, 2023
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8J6D
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![BU of 8j6d by Molmil](/molmil-images/mine/8j6d) | Structure of EP141-C3aR-Go complex | 分子名称: | Antibody fragment - ScFv16, C3a anaphylatoxin chemotactic receptor, EP141 peptide agonist, ... | 著者 | Yadav, M.K, Yadav, R, Maharana, J, Sarma, P, Banerjee, R, Shukla, A.K, Gati, C. | 登録日 | 2023-04-25 | 公開日 | 2023-10-18 | 最終更新日 | 2023-11-08 | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | 主引用文献 | Molecular basis of anaphylatoxin binding, activation, and signaling bias at complement receptors. Cell, 186, 2023
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8J24
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![BU of 8j24 by Molmil](/molmil-images/mine/8j24) | Cryo-EM structure of FFAR2 complex bound with acetic acid | 分子名称: | ACETATE ION, Free fatty acid receptor 2, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | 著者 | Tai, L, Li, F, Tang, W, Sun, X, Wang, J. | 登録日 | 2023-04-14 | 公開日 | 2024-01-24 | 最終更新日 | 2024-04-10 | 実験手法 | ELECTRON MICROSCOPY (2.6 Å) | 主引用文献 | Molecular recognition and activation mechanism of short-chain fatty acid receptors FFAR2/3. Cell Res., 34, 2024
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8J23
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![BU of 8j23 by Molmil](/molmil-images/mine/8j23) | Cryo-EM structure of FFAR2 complex in apo state | 分子名称: | Free fatty acid receptor 2, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | 著者 | Tai, L, Li, F, Sun, X, Tang, W, Wang, J. | 登録日 | 2023-04-14 | 公開日 | 2024-04-17 | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | 主引用文献 | Molecular recognition and activation mechanism of short chain fatty acid receptors FFAR2 and FFAR3 To Be Published
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8J22
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![BU of 8j22 by Molmil](/molmil-images/mine/8j22) | Cryo-EM structure of FFAR2 complex bound with TUG-1375 | 分子名称: | (2R,4R)-2-(2-chlorophenyl)-3-[4-(3,5-dimethyl-1,2-oxazol-4-yl)phenyl]carbonyl-1,3-thiazolidine-4-carboxylic acid, Free fatty acid receptor 2, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | 著者 | Tai, L, Li, F, Sun, X, Tang, W, Wang, J. | 登録日 | 2023-04-14 | 公開日 | 2024-01-24 | 最終更新日 | 2024-04-10 | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | 主引用文献 | Molecular recognition and activation mechanism of short-chain fatty acid receptors FFAR2/3. Cell Res., 34, 2024
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8J21
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![BU of 8j21 by Molmil](/molmil-images/mine/8j21) | Cryo-EM structure of FFAR3 complex bound with butyrate acid | 分子名称: | Free fatty acid receptor 3, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | 著者 | Tai, L, Li, F, Sun, X, Tang, W, Wang, J. | 登録日 | 2023-04-14 | 公開日 | 2024-01-24 | 最終更新日 | 2024-04-10 | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | 主引用文献 | Molecular recognition and activation mechanism of short-chain fatty acid receptors FFAR2/3. Cell Res., 34, 2024
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8J20
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![BU of 8j20 by Molmil](/molmil-images/mine/8j20) | Cryo-EM structure of FFAR3 bound with valeric acid and AR420626 | 分子名称: | (4R)-N-[2,5-bis(chloranyl)phenyl]-4-(furan-2-yl)-2-methyl-5-oxidanylidene-4,6,7,8-tetrahydro-1H-quinoline-3-carboxamide, Free fatty acid receptor 3, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | 著者 | Tai, L, Li, F, Sun, X, Tang, W, Wang, J. | 登録日 | 2023-04-14 | 公開日 | 2024-01-24 | 最終更新日 | 2024-04-10 | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | 主引用文献 | Molecular recognition and activation mechanism of short-chain fatty acid receptors FFAR2/3. Cell Res., 34, 2024
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8J1A
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![BU of 8j1a by Molmil](/molmil-images/mine/8j1a) | Cryo-EM structure of the GPR84 receptor-Gi complex with no ligand modeled | 分子名称: | Antibody fragment ScFv16, G-protein coupled receptor 84, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | 著者 | Liu, H, Yin, W, Xu, H.E. | 登録日 | 2023-04-12 | 公開日 | 2023-06-21 | 最終更新日 | 2024-05-08 | 実験手法 | ELECTRON MICROSCOPY (3.24 Å) | 主引用文献 | Structural insights into ligand recognition and activation of the medium-chain fatty acid-sensing receptor GPR84. Nat Commun, 14, 2023
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8J19
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![BU of 8j19 by Molmil](/molmil-images/mine/8j19) | Cryo-EM structure of the LY237-bound GPR84 receptor-Gi complex | 分子名称: | 6-nonylpyridine-2,4-diol, Antibody fragment ScFv16, G-protein coupled receptor 84, ... | 著者 | Liu, H, Yin, W, Xu, H.E. | 登録日 | 2023-04-12 | 公開日 | 2023-06-21 | 最終更新日 | 2024-05-08 | 実験手法 | ELECTRON MICROSCOPY (3.23 Å) | 主引用文献 | Structural insights into ligand recognition and activation of the medium-chain fatty acid-sensing receptor GPR84. Nat Commun, 14, 2023
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8J18
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![BU of 8j18 by Molmil](/molmil-images/mine/8j18) | Cryo-EM structure of the 3-OH-C12-bound GPR84 receptor-Gi complex | 分子名称: | (3R)-3-HYDROXYDODECANOIC ACID, Antibody fragment ScFv16, G-protein coupled receptor 84, ... | 著者 | Liu, H, Yin, W, Xu, H.E. | 登録日 | 2023-04-12 | 公開日 | 2023-06-21 | 最終更新日 | 2024-05-08 | 実験手法 | ELECTRON MICROSCOPY (2.89 Å) | 主引用文献 | Structural insights into ligand recognition and activation of the medium-chain fatty acid-sensing receptor GPR84. Nat Commun, 14, 2023
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8IZB
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![BU of 8izb by Molmil](/molmil-images/mine/8izb) | Lysophosphatidylserine receptor GPR174-Gs complex | 分子名称: | CHOLESTEROL, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | 著者 | Gong, W, Liu, G, Li, X, Zhang, X. | 登録日 | 2023-04-06 | 公開日 | 2023-11-01 | 最終更新日 | 2023-12-20 | 実験手法 | ELECTRON MICROSCOPY (3.06 Å) | 主引用文献 | Structural basis for ligand recognition and signaling of the lysophosphatidylserine receptors GPR34 and GPR174. Plos Biol., 21, 2023
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8IZ4
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![BU of 8iz4 by Molmil](/molmil-images/mine/8iz4) | Lysophosphatidylserine receptor GPR34-Gi complex | 分子名称: | Antibody fragment scFv16, CHOLESTEROL, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | 著者 | Gong, W, Liu, G, Li, X, Zhang, X. | 登録日 | 2023-04-06 | 公開日 | 2024-04-10 | 実験手法 | ELECTRON MICROSCOPY (2.93 Å) | 主引用文献 | Structural mechanisms of ligand binding and signaling in lysophosphatidylserine receptors To Be Published
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8IYW
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![BU of 8iyw by Molmil](/molmil-images/mine/8iyw) | Structure of GSK256073-GPR109A-G-protein complex | 分子名称: | 8-chloranyl-3-pentyl-7H-purine-2,6-dione, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | 著者 | Yadav, M.K, Sarma, P, Chami, M, Banerjee, R, Shukla, A.K. | 登録日 | 2023-04-06 | 公開日 | 2024-03-06 | 最終更新日 | 2024-03-20 | 実験手法 | ELECTRON MICROSCOPY (3.45 Å) | 主引用文献 | Structure-guided engineering of biased-agonism in the human niacin receptor via single amino acid substitution. Nat Commun, 15, 2024
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8IYS
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![BU of 8iys by Molmil](/molmil-images/mine/8iys) | TUG891-bound FFAR4 in complex with Gq | 分子名称: | 3-{4-[(4-fluoro-4'-methyl[1,1'-biphenyl]-2-yl)methoxy]phenyl}propanoic acid, Free fatty acid receptor 4, GUANOSINE-5'-DIPHOSPHATE, ... | 著者 | He, Y, Yin, H. | 登録日 | 2023-04-06 | 公開日 | 2023-06-21 | 最終更新日 | 2023-08-16 | 実験手法 | ELECTRON MICROSCOPY (2.95 Å) | 主引用文献 | Structural basis of omega-3 fatty acid receptor FFAR4 activation and G protein coupling selectivity. Cell Res., 33, 2023
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8IYH
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![BU of 8iyh by Molmil](/molmil-images/mine/8iyh) | Structure of MK6892-GPR109A-G-protein complex | 分子名称: | 2-[[2,2-dimethyl-3-[3-(5-oxidanylpyridin-2-yl)-1,2,4-oxadiazol-5-yl]propanoyl]amino]cyclohexene-1-carboxylic acid, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | 著者 | Yadav, M.K, Sarma, P, Chami, M, Banerjee, R, Shukla, A.K. | 登録日 | 2023-04-04 | 公開日 | 2024-03-06 | 最終更新日 | 2024-03-20 | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | 主引用文献 | Structure-guided engineering of biased-agonism in the human niacin receptor via single amino acid substitution. Nat Commun, 15, 2024
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8IY9
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![BU of 8iy9 by Molmil](/molmil-images/mine/8iy9) | Structure of Niacin-GPR109A-G protein complex | 分子名称: | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(o) subunit alpha, ... | 著者 | Yadav, M.K, Sarma, P, Chami, M, Banerjee, R, Shukla, A.K. | 登録日 | 2023-04-04 | 公開日 | 2024-03-06 | 最終更新日 | 2024-03-20 | 実験手法 | ELECTRON MICROSCOPY (3.37 Å) | 主引用文献 | Structure-guided engineering of biased-agonism in the human niacin receptor via single amino acid substitution. Nat Commun, 15, 2024
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8IY5
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![BU of 8iy5 by Molmil](/molmil-images/mine/8iy5) | ETB-Gi complex bound to endothelin-1 | 分子名称: | Endothelin type B receptor, Endothelin-1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | 著者 | Sano, F.K, Akasaka, H, Shihoya, W, Nureki, O. | 登録日 | 2023-04-04 | 公開日 | 2023-08-16 | 最終更新日 | 2023-12-06 | 実験手法 | ELECTRON MICROSCOPY (2.8 Å) | 主引用文献 | Cryo-EM structure of the endothelin-1-ET B -G i complex. Elife, 12, 2023
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8IW9
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![BU of 8iw9 by Molmil](/molmil-images/mine/8iw9) | Cryo-EM structure of the CAD-bound mTAAR9-Gs complex | 分子名称: | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(s) subunit alpha isoforms short, ... | 著者 | Sun, J.P, Li, Q, Yang, F, Xu, Y.F, Guo, L.L, Lian, S, Zhang, M.H, Rong, N.K. | 登録日 | 2023-03-29 | 公開日 | 2023-05-31 | 最終更新日 | 2023-06-14 | 実験手法 | ELECTRON MICROSCOPY (3.08 Å) | 主引用文献 | Structural basis of amine odorant perception by a mammal olfactory receptor. Nature, 618, 2023
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8IW7
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![BU of 8iw7 by Molmil](/molmil-images/mine/8iw7) | Cryo-EM structure of the PEA-bound mTAAR9-Gs complex | 分子名称: | 2-PHENYLETHYLAMINE, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | 著者 | Sun, J.P, Li, Q, Yang, F, Xu, Y.F, Guo, L.L, Lian, S, Zhang, M.H, Rong, N.K. | 登録日 | 2023-03-29 | 公開日 | 2023-05-31 | 最終更新日 | 2023-06-14 | 実験手法 | ELECTRON MICROSCOPY (2.97 Å) | 主引用文献 | Structural basis of amine odorant perception by a mammal olfactory receptor. Nature, 618, 2023
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8IW4
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![BU of 8iw4 by Molmil](/molmil-images/mine/8iw4) | Cryo-EM structure of the SPE-bound mTAAR9-Gs complex | 分子名称: | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(s) subunit alpha isoforms short, ... | 著者 | Sun, J.P, Li, Q, Yang, F, Xu, Y.F, Guo, L.L, Lian, S, Zhang, M.H, Rong, N.K. | 登録日 | 2023-03-29 | 公開日 | 2023-05-31 | 最終更新日 | 2023-06-14 | 実験手法 | ELECTRON MICROSCOPY (3.49 Å) | 主引用文献 | Structural basis of amine odorant perception by a mammal olfactory receptor. Nature, 618, 2023
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