PDB: 456 件ウェブページステータス検索Chemie searchBIRD

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4X6H	Development of N-(Functionalized benzoyl)-homocycloleucyl-glycinonitriles as Potent Cathepsin K Inhibitors. 分子名称: 4-amino-3-fluoro-N-(1-{[(2Z)-2-iminoethyl]carbamoyl}cyclohexyl)benzamide, 4-amino-N-{1-[(cyanomethyl)carbamoyl]cyclohexyl}-3-fluorobenzamide, Cathepsin K, ... 著者 Borisek, J, Mohar, B, Vizovisek, M, Sosnowski, P, Turk, D, Turk, B, Novic, M. 登録日 2014-12-08 公開日 2015-09-23 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (1 Å) 主引用文献 Development of N-(Functionalized benzoyl)-homocycloleucyl-glycinonitriles as Potent Cathepsin K Inhibitors. J.Med.Chem., 58, 2015
4X6I	Development of N-(Functionalized benzoyl)-homocycloleucyl-glycinonitriles as Potent Cathepsin K Inhibitors. 分子名称: 2-amino-4-bromo-N-{1-[(cyanomethyl)carbamoyl]cyclohexyl}benzamide, Cathepsin K, SULFATE ION 著者 Borisek, J, Mohar, B, Vizovisek, M, Sosnowski, P, Turk, D, Turk, B, Novic, M. 登録日 2014-12-08 公開日 2015-09-30 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (1.87 Å) 主引用文献 Development of N-(Functionalized benzoyl)-homocycloleucyl-glycinonitriles as Potent Cathepsin K Inhibitors. J.Med.Chem., 58, 2015
4YYS	Ficin B crystal form II 分子名称: Ficin isoform B, PHOSPHATE ION 著者 Azarkan, M, Baeyens-Volant, D, Loris, R. 登録日 2015-03-24 公開日 2016-04-13 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (1.35 Å) 主引用文献 Crystal structure of four variants of the protease Ficin from the common fig To Be Published
4YYQ	Ficin A 分子名称: Ficin isoform A 著者 Azarkan, M, Baeyens-Volant, D, Loris, R. 登録日 2015-03-24 公開日 2016-04-13 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (1.594 Å) 主引用文献 Crystal structure of four variants of the protease Ficin from the common fig To Be Published
4YYV	Ficin isoform C crystal form II 分子名称: 3,6,9,12,15,18-HEXAOXAICOSANE, Ficin isoform C, SULFATE ION 著者 Azarkan, M, Baeyens-Volant, D, Loris, R. 登録日 2015-03-24 公開日 2016-04-13 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (1.902 Å) 主引用文献 Crystal structure of four variants of the protease Ficin from the common fig To Be Published
1YT7	Cathepsin K complexed with a constrained ketoamide inhibitor 分子名称: (1R)-2,2-DIMETHYL-1-({5-[4-(TRIFLUOROMETHYL)PHENYL]-1,3,4-OXADIAZOL-2-YL}METHYL)PROPYL (1S)-1-{OXO[(2-OXO-1,3-OXAZOLIDIN-3-YL)AMINO]ACETYL}PENTYLCARBAMATE, Cathepsin K, SULFATE ION 著者 Barrett, D.G, Boncek, V.M, Catalano, J.G, Deaton, D.N, Hassell, A.M, Jurgensen, C.H, Long, S.T, McFadyen, R.B, Miller, A.B, Miller, L.R, Payne, J.A, Ray, J.A, Samano, V, Shewchuk, L.M, Tavares, F.X, Wells-Knecht, K.J, Willard, D.H, Wright, L.L, Zhou, H.Q. 登録日 2005-02-10 公開日 2005-07-19 最終更新日 2023-08-23 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 P(2)-P(3) conformationally constrained ketoamide-based inhibitors of cathepsin K. Bioorg.Med.Chem.Lett., 15, 2005
4YYU	Ficin C crystal form I 分子名称: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, Ficin isoform C, SULFATE ION 著者 Azarkan, M, Baeyens-Volant, D, Loris, R. 登録日 2015-03-24 公開日 2016-04-13 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (1.177 Å) 主引用文献 Crystal structure of four variants of the protease Ficin from the common fig To Be Published
2ACT	CRYSTALLOGRAPHIC REFINEMENT OF THE STRUCTURE OF ACTINIDIN AT 1.7 ANGSTROMS RESOLUTION BY FAST FOURIER LEAST-SQUARES METHODS 分子名称: ACTINIDIN PRECURSOR, AMMONIUM ION 著者 Baker, E.N. 登録日 1979-11-27 公開日 1980-03-07 最終更新日 2017-11-29 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 Crystallographic Refinement of the Structure of Actinidin at 1.7 Angstroms Resolution by Fast Fourier Least-Squares Methods Acta Crystallogr.,Sect.A, 36, 1980
1YAL	CARICA PAPAYA CHYMOPAPAIN AT 1.7 ANGSTROMS RESOLUTION 分子名称: CHYMOPAPAIN 著者 Maes, D, Bouckaert, J, Poortmans, F, Wyns, L, Looze, Y. 登録日 1996-06-20 公開日 1996-12-23 最終更新日 2023-08-09 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 Structure of chymopapain at 1.7 A resolution. Biochemistry, 35, 1996
2ATO	Crystal structure of Human Cathepsin K in complex with myocrisin 分子名称: (S)-(1,2-DICARBOXYETHYLTHIO)GOLD, Cathepsin K, SULFATE ION 著者 Weidauer, E, Yasuda, Y, Biswal, B.K, Kerr, L.D, Cherney, M.M, Gordon, R.E, James, M.N.G, Bromme, D. 登録日 2005-08-25 公開日 2006-08-29 最終更新日 2023-08-23 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Effects of disease-modifying anti-rheumatic drugs (DMARDs) on the activities of rheumatoid arthritis-associated cathepsins K and S. Biol.Chem., 388, 2007
2B1N	Crystal structure of a papain-fold protein without the catalytic cysteine from seeds of Pachyrhizus erosus 分子名称: SPE31, alpha-L-fucopyranose-(1-3)-[2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)]2-acetamido-2-deoxy-beta-D-glucopyranose, peptide (LYS)(ALA)(SER)(VAL)(GLY) 著者 Zhang, M, Wei, Z, Chang, S. 登録日 2005-09-16 公開日 2006-10-03 最終更新日 2020-07-29 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Crystal structure of a papain-fold protein without the catalytic residue: a novel member in the cysteine proteinase family J.Mol.Biol., 358, 2006
2AS8	Crystal structure of mature and fully active Der p 1 allergen 分子名称: MAGNESIUM ION, Major mite fecal allergen Der p 1 著者 de Halleux, S, Stura, E, VanderElst, L, Carlier, V, Jacquemin, M, Saint-Remy, J.-M. 登録日 2005-08-23 公開日 2005-12-06 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (1.95 Å) 主引用文献 Three-dimensional structure and IgE-binding properties of mature fully active Der p 1, a clinically relevant major allergen J.Allergy Clin.Immunol., 117, 2006
2AUX	Cathepsin K complexed with a semicarbazone inhibitor 分子名称: (1R)-2-METHYL-1-(PHENYLMETHYL)PROPYL[(1S)-1-FORMYLPENTYL]CARBAMATE, Cathepsin K 著者 Adkison, K.K, Barrett, D.G, Deaton, D.N, Gampe, R.T, Hassell, A.M, Long, S.T, McFadyen, R.B, Miller, A.B, Miller, L.R, Shewchuk, L.M. 登録日 2005-08-29 公開日 2006-08-08 最終更新日 2023-08-23 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Semicarbazone-based inhibitors of cathepsin K, are they prodrugs for aldehyde inhibitors? Bioorg.Med.Chem.Lett., 16, 2006
2AUZ	Cathepsin K complexed with a semicarbazone inhibitor 分子名称: 1-(PHENYLMETHYL)CYCLOPENTYL[(1S)-1-FORMYLPENTYL]CARBAMATE, Cathepsin K, SULFATE ION 著者 Adkison, K.K, Barrett, D.G, Deaton, D.N, Gampe, R.T, Hassell, A.M, Long, S.T, McFadyen, R.B, Miller, A.B, Miller, L.R, Shewchuk, L.M. 登録日 2005-08-29 公開日 2006-08-08 最終更新日 2023-08-23 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Semicarbazone-based inhibitors of cathepsin K, are they prodrugs for aldehyde inhibitors? Bioorg.Med.Chem.Lett., 16, 2006
1KHQ	ORTHORHOMBIC FORM OF PAPAIN/ZLFG-DAM COVALENT COMPLEX 分子名称: Papain, peptidic inhibitor 著者 Janowski, R, Kozak, M, Jankowska, E, Grzonka, Z, Jaskolski, M. 登録日 2001-11-30 公開日 2003-09-09 最終更新日 2023-08-16 実験手法 X-RAY DIFFRACTION (1.6 Å) 主引用文献 Two polymorphs of a covalent complex between papain and a diazomethylketone inhibitor J.Pept.Res., 64, 2004
1KHP	Monoclinic form of papain/ZLFG-DAM covalent complex 分子名称: Papain, peptidic inhibitor 著者 Janowski, R, Kozak, M, Jankowska, E, Grzonka, Z, Jaskolski, M. 登録日 2001-11-30 公開日 2003-09-09 最終更新日 2023-08-16 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Two polymorphs of a covalent complex between papain and a diazomethylketone inhibitor J.Pept.Res., 64, 2004
1IWD	Proposed Amino Acid Sequence and the 1.63 Angstrom X-ray Crystal Structure of a Plant Cysteine Protease Ervatamin B: Insight into the Structural Basis of its Stability and Substrate Specificity. 分子名称: ERVATAMIN B, THIOSULFATE 著者 Chakrabarti, C, Biswas, S, Dattagupta, J.K. 登録日 2002-05-02 公開日 2003-05-06 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (1.63 Å) 主引用文献 Proposed amino acid sequence and the 1.63 A X-ray crystal structure of a plant cysteine protease, ervatamin B: Some insights into the structural basis of its stability and substrate specificity Proteins, 51, 2003
1ITO	Crystal Structure Analysis of Bovine Spleen Cathepsin B-E64c complex 分子名称: Cathepsin B, N-[1-HYDROXYCARBOXYETHYL-CARBONYL]LEUCYLAMINO-2-METHYL-BUTANE 著者 Yamamoto, A, Tomoo, T, Matsugi, K, Hara, T, In, Y, Murata, M, Kitamura, K, Ishida, T. 登録日 2002-01-19 公開日 2003-01-19 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (2.286 Å) 主引用文献 Structural basis for development of cathepsin B-specific noncovalent-type inhibitor: crystal structure of cathepsin B-E64c complex BIOCHIM.BIOPHYS.ACTA, 1597, 2002
1ME3	High Resolution Crystal Structure Analysis Of Cruzain non-covalently Bound To A Hydroxymethyl Ketone Inhibitor (II) 分子名称: Cruzipain, [1-(3-HYDROXY-2-OXO-1-PHENETHYL-PROPYLCARBAMOYL)2-PHENYL-ETHYL]-CARBAMIC ACID PYRIDIN-4-YLMETHYL ESTER 著者 Brinen, L.S, Huang, L, Ellman, J.A. 登録日 2002-08-07 公開日 2002-12-18 最終更新日 2017-10-11 実験手法 X-RAY DIFFRACTION (1.2 Å) 主引用文献 Crystal Structures of Reversible Ketone-based Inhibitors of the Cysteine Protease Cruzain Bioorg.Med.Chem., 11, 2003
1HUC	THE REFINED 2.15 ANGSTROMS X-RAY CRYSTAL STRUCTURE OF HUMAN LIVER CATHEPSIN B: THE STRUCTURAL BASIS FOR ITS SPECIFICITY 分子名称: CATHEPSIN B 著者 Musil, D, Bode, W. 登録日 1993-04-21 公開日 1995-01-26 最終更新日 2024-06-05 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 The refined 2.15 A X-ray crystal structure of human liver cathepsin B: the structural basis for its specificity. EMBO J., 10, 1991
1ME4	High Resolution Crystal Structure Analysis Of Cruzain non-covalently Bound To A Hydroxymethyl Ketone Inhibitor (I) 分子名称: CRUZIPAIN, [1-(1-BENZYL-3-HYDROXY-2-OXO-PROPYLCARBAMOYL)-2-PHENYL-ETHYL]-CARBAMIC ACID BENZYL ESTER 著者 Brinen, L.S, Huang, L, Ellman, J.A. 登録日 2002-08-07 公開日 2002-12-18 最終更新日 2017-10-11 実験手法 X-RAY DIFFRACTION (1.2 Å) 主引用文献 Crystal Structures of Reversible Ketone-based Inhibitors of the Cysteine Protease Cruzain Bioorg.Med.Chem., 11, 2003
1MHW	Design of non-covalent inhibitors of human cathepsin L. From the 96-residue proregion to optimized tripeptides 分子名称: 4-biphenylacetyl-Cys-(D)Arg-Tyr-N-(2-phenylethyl) amide, Cathepsin L 著者 Chowdhury, S, Sivaraman, J, Wang, J, Devanathan, G, Lachance, P, Qi, H, Menard, R, Lefebvre, J, Konishi, Y, Cygler, M, Sulea, T, Purisima, E.O. 登録日 2002-08-21 公開日 2002-12-11 最終更新日 2017-10-11 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Design of non-covalent inhibitors of human cathepsin L. From the 96-residue proregion to optimized tripeptides J.Med.Chem., 45, 2002
1M6D	Crystal structure of human cathepsin F 分子名称: 4-MORPHOLIN-4-YL-PIPERIDINE-1-CARBOXYLIC ACID [1-(3-BENZENESULFONYL-1-PROPYL-ALLYLCARBAMOYL)-2-PHENYLETHYL]-AMIDE, Cathepsin F 著者 Somoza, J.R, Palmer, J.T, Ho, J.D. 登録日 2002-07-15 公開日 2003-07-15 最終更新日 2021-10-27 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 The crystal structure of human cathepsin F and its implications for the development of novel immunomodulators J.Mol.Biol., 322, 2002
2YJC	CATHEPSIN L WITH A NITRILE INHIBITOR 分子名称: (2S,4R)-1-[1-(4-chlorophenyl)cyclopropyl]carbonyl-4-(2-chlorophenyl)sulfonyl-N-[1-(iminomethyl)cyclopropyl]pyrrolidine-2-carboxamide, CATHEPSIN L1 著者 Banner, D.W, Benz, J.M, Haap, W. 登録日 2011-05-19 公開日 2011-11-23 最終更新日 2011-11-30 実験手法 X-RAY DIFFRACTION (1.14 Å) 主引用文献 Halogen Bonding at the Active Sites of Human Cathepsin L and Mek1 Kinase: Efficient Interactions in Different Environments. Chemmedchem, 6, 2011
2YJ9	CATHEPSIN L WITH A NITRILE INHIBITOR 分子名称: (2S,4R)-4-(2-chlorophenyl)sulfonyl-N-[1-(iminomethyl)cyclopropyl]-1-[1-[4-(trifluoromethyl)phenyl]cyclopropyl]carbonyl-pyrrolidine-2-carboxamide, CATHEPSIN L1, GLYCEROL 著者 Banner, D.W, Benz, J.M, Haap, W. 登録日 2011-05-19 公開日 2011-11-23 実験手法 X-RAY DIFFRACTION (1.35 Å) 主引用文献 Halogen Bonding at the Active Sites of Human Cathepsin L and Mek1 Kinase: Efficient Interactions in Different Environments. Chemmedchem, 6, 2011

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