6CA8
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465D
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![BU of 465d by Molmil](/molmil-images/mine/465d) | STRUCTURE OF THE TOPOISOMERASE II POISON BOUND TO DNA | 分子名称: | 9-AMINO-(N-(2-DIMETHYLAMINO)ETHYL)ACRIDINE-4-CARBOXAMIDE, DNA (5'-D(*CP*GP*TP*AP*CP*G)-3') | 著者 | Adams, A, Guss, J.M, Collyer, C.A, Denny, W.A, Wakelin, L.P. | 登録日 | 1999-04-14 | 公開日 | 1999-08-25 | 最終更新日 | 2024-04-03 | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | 主引用文献 | Crystal structure of the topoisomerase II poison 9-amino-[N-(2-dimethylamino)ethyl]acridine-4-carboxamide bound to the DNA hexanucleotide d(CGTACG)2. Biochemistry, 38, 1999
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4R1F
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![BU of 4r1f by Molmil](/molmil-images/mine/4r1f) | |
3PWT
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![BU of 3pwt by Molmil](/molmil-images/mine/3pwt) | |
1ZXM
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![BU of 1zxm by Molmil](/molmil-images/mine/1zxm) | Human Topo IIa ATPase/AMP-PNP | 分子名称: | DNA topoisomerase II, alpha isozyme, MAGNESIUM ION, ... | 著者 | Wei, H, Ruthenburg, A.J, Bechis, S.K, Verdine, G.L. | 登録日 | 2005-06-08 | 公開日 | 2005-08-23 | 最終更新日 | 2024-02-14 | 実験手法 | X-RAY DIFFRACTION (1.87 Å) | 主引用文献 | Nucleotide-dependent Domain Movement in the ATPase Domain of a Human Type IIA DNA Topoisomerase. J.Biol.Chem., 280, 2005
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4BUL
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![BU of 4bul by Molmil](/molmil-images/mine/4bul) | Novel hydroxyl tricyclics (e.g. GSK966587) as potent inhibitors of bacterial type IIA topoisomerases | 分子名称: | (S)-4-((4-(((2,3-dihydro-[1,4]dioxino[2,3-c]pyridin-7-yl)methyl)amino)piperidin-1-yl)methyl)-3-fluoro-4-hydroxy-4H-pyrrolo[3,2,1-de][1,5]naphthyridin-7(5H)-one, 5'-D(*AP*GP*CP*CP*GP*TP*AP*GP*GP*TP*AP*CP*AP*CP *CP*GP*CP*AP*C)-3', 5'-D(*TP*GP*TP*GP*CP*GP*GP*TP*GP*TP*AP*CP*CP*TP *AP*CP*GP*GP*CP*T)-3', ... | 著者 | Miles, T.J, Hennessy, A.J, Bax, B, Brooks, G, Brown, B.S, Brown, P, Cailleau, N, Chen, D, Dabbs, S, Davies, D.T, Esken, J.M, Giordano, I, Hoover, J.L, Huang, J, Jones, G.E, Sukmar, S.K.K, Spitzfaden, C, Markwell, R.E, Minthorn, E.A, Rittenhouse, S, Gwynn, M.N, Pearson, N.D. | 登録日 | 2013-06-20 | 公開日 | 2013-08-07 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | Novel Hydroxyl Tricyclics (E.G., Gsk966587) as Potent Inhibitors of Bacterial Type Iia Topoisomerases. Bioorg.Med.Chem.Lett., 23, 2013
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2XKK
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![BU of 2xkk by Molmil](/molmil-images/mine/2xkk) | CRYSTAL STRUCTURE OF MOXIFLOXACIN, DNA, and A. BAUMANNII TOPO IV (PARE-PARC FUSION TRUNCATE) | 分子名称: | 1-cyclopropyl-6-fluoro-8-methoxy-7-[(4aS,7aS)-octahydro-6H-pyrrolo[3,4-b]pyridin-6-yl]-4-oxo-1,4-dihydroquinoline-3-carboxylic acid, DNA, MAGNESIUM ION, ... | 著者 | Wohlkonig, A, Chan, P.F, Fosberry, A.P, Homes, P, Huang, J, Kranz, M, Leydon, V.R, Miles, T.J, Pearson, N.D, Perera, R.L, Shillings, A.J, Gwynn, M.N, Bax, B.D. | 登録日 | 2010-07-08 | 公開日 | 2010-09-01 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (3.25 Å) | 主引用文献 | Structural Basis of Quinolone Inhibition of Type Iia Topoisomerases and Target-Mediated Resistance Nat.Struct.Mol.Biol., 17, 2010
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2XKJ
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![BU of 2xkj by Molmil](/molmil-images/mine/2xkj) | CRYSTAL STRUCTURE OF CATALYTIC CORE OF A. BAUMANNII TOPO IV (PARE- PARC FUSION TRUNCATE) | 分子名称: | GLYCEROL, SULFATE ION, TOPOISOMERASE IV | 著者 | Wohlkonig, A, Chan, P.F, Fosberry, A.P, Homes, P, Huang, J, Kranz, M, Leydon, V.R, Miles, T.J, Pearson, N.D, Perera, R.L, Shillings, A.J, Gwynn, M.N, Bax, B.D. | 登録日 | 2010-07-08 | 公開日 | 2010-09-01 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Structural Basis of Quinolone Inhibition of Type Iia Topoisomerases and Target-Mediated Resistance Nat.Struct.Mol.Biol., 17, 2010
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3NO0
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![BU of 3no0 by Molmil](/molmil-images/mine/3no0) | |
8KGL
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![BU of 8kgl by Molmil](/molmil-images/mine/8kgl) | |
4GFN
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![BU of 4gfn by Molmil](/molmil-images/mine/4gfn) | Pyrrolopyrimidine inhibitors of dna gyrase b and topoisomerase iv, part i: structure guided discovery and optimization of dual targeting agents with potent, broad-spectrum enzymatic | 分子名称: | (1R,5S,6s)-3-[5-chloro-6-ethyl-2-(pyrimidin-5-ylsulfanyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]-3-azabicyclo[3.1.0]hexan-6-amine, DNA gyrase subunit B, GLYCEROL | 著者 | Bensen, D.C, Trzoss, M, Tari, L.W. | 登録日 | 2012-08-03 | 公開日 | 2013-02-13 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Pyrrolopyrimidine inhibitors of DNA gyrase B (GyrB) and topoisomerase IV (ParE). Part I: Structure guided discovery and optimization of dual targeting agents with potent, broad-spectrum enzymatic activity. Bioorg.Med.Chem.Lett., 23, 2013
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4GEE
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![BU of 4gee by Molmil](/molmil-images/mine/4gee) | Pyrrolopyrimidine inhibitors of DNA gyrase B and topoisomerase IV, part I: structure guided discovery and optimization of dual targeting agents with potent, broad-spectrum enzymatic activity. | 分子名称: | (1R,5S,6s)-3-[5-chloro-6-ethyl-2-(pyrimidin-5-yloxy)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]-3-azabicyclo[3.1.0]hexan-6-amine, DNA gyrase subunit B, GLYCEROL | 著者 | Bensen, D.C, Chen, Z, Tari, L.W. | 登録日 | 2012-08-01 | 公開日 | 2013-02-13 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | Pyrrolopyrimidine inhibitors of DNA gyrase B (GyrB) and topoisomerase IV (ParE). Part I: Structure guided discovery and optimization of dual targeting agents with potent, broad-spectrum enzymatic activity. Bioorg.Med.Chem.Lett., 23, 2013
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4GGL
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![BU of 4ggl by Molmil](/molmil-images/mine/4ggl) | Pyrrolopyrimidine inhibitors of dna gyrase b and topoisomerase iv, part i: structure guided discovery and optimization of dual targeting agents with potent, broad-spectrum enzymatic activity | 分子名称: | 7-({4-[(3R)-3-aminopyrrolidin-1-yl]-5-chloro-6-ethyl-7H-pyrrolo[2,3-d]pyrimidin-2-yl}sulfanyl)pyrido[2,3-b]pyrazin-2(1H)-one, DNA gyrase subunit B, GLYCEROL | 著者 | Bensen, D.C, Creighton, C.J, Tari, L.W. | 登録日 | 2012-08-06 | 公開日 | 2013-02-13 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (1.69 Å) | 主引用文献 | Pyrrolopyrimidine inhibitors of DNA gyrase B (GyrB) and topoisomerase IV (ParE). Part I: Structure guided discovery and optimization of dual targeting agents with potent, broad-spectrum enzymatic activity. Bioorg.Med.Chem.Lett., 23, 2013
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8KGQ
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![BU of 8kgq by Molmil](/molmil-images/mine/8kgq) | |
8KGO
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![BU of 8kgo by Molmil](/molmil-images/mine/8kgo) | |
8KGR
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![BU of 8kgr by Molmil](/molmil-images/mine/8kgr) | Structure of African swine fever virus topoisomerase II in complex with dsDNA | 分子名称: | DNA (32-MER), DNA (33-MER), DNA topoisomerase 2, ... | 著者 | Cong, J, Xin, U, Li, X, Chen, Y. | 登録日 | 2023-08-19 | 公開日 | 2024-04-03 | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | 主引用文献 | Structure of African swine fever virus topoisomerase II in complex with dsDNA To Be Published
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8KGP
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![BU of 8kgp by Molmil](/molmil-images/mine/8kgp) | |
8KGN
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![BU of 8kgn by Molmil](/molmil-images/mine/8kgn) | |
8KGM
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![BU of 8kgm by Molmil](/molmil-images/mine/8kgm) | |
4HYP
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![BU of 4hyp by Molmil](/molmil-images/mine/4hyp) | Pyrrolopyrimidine inhibitors of dna gyrase b and topoisomerase iv, part i: structure guided discovery and optimization of dual targeting agents with potent, broad-spectrum enzymatic activity. | 分子名称: | DNA gyrase subunit B, MAGNESIUM ION, N-[7-(1H-imidazol-1-yl)-2-(pyridin-3-yl)[1,3]thiazolo[5,4-d]pyrimidin-5-yl]cyclopropanecarboxamide | 著者 | Bensen, D.C, Creighton, C.J, Tari, L.W. | 登録日 | 2012-11-13 | 公開日 | 2013-02-13 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | Pyrrolopyrimidine inhibitors of DNA gyrase B (GyrB) and topoisomerase IV (ParE). Part I: Structure guided discovery and optimization of dual targeting agents with potent, broad-spectrum enzymatic activity. Bioorg.Med.Chem.Lett., 23, 2013
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4HXW
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![BU of 4hxw by Molmil](/molmil-images/mine/4hxw) | Pyrrolopyrimidine inhibitors of dna gyrase b and topoisomerase iv, part i: structure guided discovery and optimization of dual targeting agents with potent, broad-spectrum enzymatic activity. | 分子名称: | (3R)-1-[5-chloro-6-ethyl-2-(pyrido[2,3-b]pyrazin-7-ylsulfanyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]pyrrolidin-3-amine, DNA gyrase subunit B, TERTIARY-BUTYL ALCOHOL | 著者 | Bensen, D.C, Trzoss, M, Tari, L.W. | 登録日 | 2012-11-12 | 公開日 | 2013-02-13 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (1.69 Å) | 主引用文献 | Pyrrolopyrimidine inhibitors of DNA gyrase B (GyrB) and topoisomerase IV (ParE). Part I: Structure guided discovery and optimization of dual targeting agents with potent, broad-spectrum enzymatic activity. Bioorg.Med.Chem.Lett., 23, 2013
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3OLC
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![BU of 3olc by Molmil](/molmil-images/mine/3olc) | |
2XT2
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![BU of 2xt2 by Molmil](/molmil-images/mine/2xt2) | Structure of the pentapeptide repeat protein AlbG, a resistance factor for the topoisomerase poison albicidin. | 分子名称: | MCBG-LIKE PROTEIN, SULFATE ION | 著者 | Vetting, M.W, Hegde, S.S, Blanchard, J.S. | 登録日 | 2010-10-05 | 公開日 | 2010-10-13 | 最終更新日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (1.999 Å) | 主引用文献 | Pentapeptide-Repeat Proteins that Act as Topoisomerase Poison Resistance Factors Have a Common Dimer Interface. Acta Crystallogr.,Sect.F, 67, 2011
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2XT4
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![BU of 2xt4 by Molmil](/molmil-images/mine/2xt4) | |
8KGS
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![BU of 8kgs by Molmil](/molmil-images/mine/8kgs) | |