6OHK
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6OKK
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3HZR
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5KQX
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![BU of 5kqx by Molmil](/molmil-images/mine/5kqx) | Protease E35D-SQV | 分子名称: | (2S)-N-[(2S,3R)-4-[(2S,3S,4aS,8aS)-3-(tert-butylcarbamoyl)-3,4,4a,5,6,7,8,8a-octahydro-1H-isoquinolin-2-yl]-3-hydroxy-1 -phenyl-butan-2-yl]-2-(quinolin-2-ylcarbonylamino)butanediamide, Protease E35D-SQV | 著者 | Liu, Z, Poole, K.M, Mahon, B.P, McKenna, R, Fanucci, G.E. | 登録日 | 2016-07-06 | 公開日 | 2016-09-21 | 最終更新日 | 2024-03-06 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Effects of Hinge-region Natural Polymorphisms on Human Immunodeficiency Virus-Type 1 Protease Structure, Dynamics, and Drug Pressure Evolution. J.Biol.Chem., 291, 2016
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5KR0
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![BU of 5kr0 by Molmil](/molmil-images/mine/5kr0) | Protease E35D-APV | 分子名称: | GLYCEROL, Protease E35D-APV, {3-[(4-AMINO-BENZENESULFONYL)-ISOBUTYL-AMINO]-1-BENZYL-2-HYDROXY-PROPYL}-CARBAMIC ACID TETRAHYDRO-FURAN-3-YL ESTER | 著者 | Liu, Z, Poole, K.M, Mahon, B.P, McKenna, R, Fanucci, G.E. | 登録日 | 2016-07-06 | 公開日 | 2016-09-21 | 最終更新日 | 2024-03-06 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Effects of Hinge-region Natural Polymorphisms on Human Immunodeficiency Virus-Type 1 Protease Structure, Dynamics, and Drug Pressure Evolution. J.Biol.Chem., 291, 2016
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6QXB
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![BU of 6qxb by Molmil](/molmil-images/mine/6qxb) | NMR structure of peptide 7, characterized by a cis-4-amino-Pro residue, with a significant lower MIC on E. coli | 分子名称: | PHE-VAL-CAP-TRP-PHE-SER-LYS-PHE-LEU-GLY-ARG-ILE-LEU-NH2 | 著者 | Brancaccio, D, Carotenuto, A, Merlino, F, Grieco, P, Novellino, E. | 登録日 | 2019-03-07 | 公開日 | 2019-05-29 | 最終更新日 | 2023-06-14 | 実験手法 | SOLUTION NMR | 主引用文献 | The Outcomes of Decorated Prolines in the Discovery of Antimicrobial Peptides from Temporin-L. Chemmedchem, 14, 2019
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6QXC
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![BU of 6qxc by Molmil](/molmil-images/mine/6qxc) | NMR structure of peptide 8, characterized by a trans-4-cyclohexyl-Pro, with a dramatic reduction in activity on E. coli ATCC and lost effect on P. aeruginosa. | 分子名称: | PHE-VAL-TCP-TRP-PHE-SER-LYS-PHE-LEU-GLY-ARG-ILE-LEU-NH2 | 著者 | Brancaccio, D, Carotenuto, A, Merlino, F, Grieco, P, Novellino, E. | 登録日 | 2019-03-07 | 公開日 | 2019-05-29 | 最終更新日 | 2023-06-14 | 実験手法 | SOLUTION NMR | 主引用文献 | The Outcomes of Decorated Prolines in the Discovery of Antimicrobial Peptides from Temporin-L. Chemmedchem, 14, 2019
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6ZO5
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![BU of 6zo5 by Molmil](/molmil-images/mine/6zo5) | Fusidic acid binding to the TM1/TM2 groove of AcrB-G619P_G621P | 分子名称: | (2S)-3-hydroxypropane-1,2-diyl didecanoate, (2S)-3-{[(R)-(2-aminoethoxy)(hydroxy)phosphoryl]oxy}-2-hydroxypropyl hexadecanoate, 1,2-ETHANEDIOL, ... | 著者 | Tam, H.K, Foong, W.E, Pos, K.M. | 登録日 | 2020-07-07 | 公開日 | 2021-05-19 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Allosteric drug transport mechanism of multidrug transporter AcrB. Nat Commun, 12, 2021
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6ZO9
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![BU of 6zo9 by Molmil](/molmil-images/mine/6zo9) | Binding of two rifabutins to the access pocket of AcrB-G621P T protomer | 分子名称: | (2S)-3-hydroxypropane-1,2-diyl didecanoate, 1,2-ETHANEDIOL, CHLORIDE ION, ... | 著者 | Tam, H.K, Foong, W.E, Pos, K.M. | 登録日 | 2020-07-07 | 公開日 | 2021-05-19 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | 主引用文献 | Allosteric drug transport mechanism of multidrug transporter AcrB. Nat Commun, 12, 2021
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6ZOB
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![BU of 6zob by Molmil](/molmil-images/mine/6zob) | 3-Formylrifamycin SV binding to the access pocket of AcrB L protomer | 分子名称: | (2S)-3-hydroxypropane-1,2-diyl didecanoate, (2S,12Z,14E,16S,17S,18R,19R,20R,21S,22R,23S,24E)-8-formyl-5,6,9,17,19-pentahydroxy-23-methoxy-2,4,12,16,18,20,22-heptam ethyl-1,11-dioxo-1,2-dihydro-2,7-(epoxypentadeca[1,11,13]trienoimino)naphtho[2,1-b]furan-21-yl acetate, 1,2-ETHANEDIOL, ... | 著者 | Tam, H.K, Foong, W.E, Pos, K.M. | 登録日 | 2020-07-07 | 公開日 | 2021-05-19 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | Allosteric drug transport mechanism of multidrug transporter AcrB. Nat Commun, 12, 2021
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6ZOH
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![BU of 6zoh by Molmil](/molmil-images/mine/6zoh) | 3-Formylrifamycin SV binding to the access pocket of AcrB-G619P_G621P L and T protomers | 分子名称: | (2S)-3-hydroxypropane-1,2-diyl didecanoate, (2S)-3-{[(R)-(2-aminoethoxy)(hydroxy)phosphoryl]oxy}-2-hydroxypropyl hexadecanoate, (2S,12Z,14E,16S,17S,18R,19R,20R,21S,22R,23S,24E)-8-formyl-5,6,9,17,19-pentahydroxy-23-methoxy-2,4,12,16,18,20,22-heptam ethyl-1,11-dioxo-1,2-dihydro-2,7-(epoxypentadeca[1,11,13]trienoimino)naphtho[2,1-b]furan-21-yl acetate, ... | 著者 | Tam, H.K, Foong, W.E, Pos, K.M. | 登録日 | 2020-07-07 | 公開日 | 2021-05-19 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | Allosteric drug transport mechanism of multidrug transporter AcrB. Nat Commun, 12, 2021
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6ZOF
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![BU of 6zof by Molmil](/molmil-images/mine/6zof) | Fusidic acid binding to the TM7/TM8 groove of AcrB-F380A T protomer | 分子名称: | DARPIN, DECANE, DECYLAMINE-N,N-DIMETHYL-N-OXIDE, ... | 著者 | Tam, H.K, Foong, W.E, Pos, K.M. | 登録日 | 2020-07-07 | 公開日 | 2021-05-19 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (3.3 Å) | 主引用文献 | Allosteric drug transport mechanism of multidrug transporter AcrB. Nat Commun, 12, 2021
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6ZOA
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![BU of 6zoa by Molmil](/molmil-images/mine/6zoa) | Partially induced AcrB T protomer and DDM binding to the TM8/PC2 pathway of AcrB L2 protomer | 分子名称: | 1,2-ETHANEDIOL, CHLORIDE ION, DARPIN, ... | 著者 | Tam, H.K, Foong, W.E, Pos, K.M. | 登録日 | 2020-07-07 | 公開日 | 2021-05-19 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (3.05 Å) | 主引用文献 | Allosteric drug transport mechanism of multidrug transporter AcrB. Nat Commun, 12, 2021
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6ZUF
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![BU of 6zuf by Molmil](/molmil-images/mine/6zuf) | Urea-based Foldamer Inhibitor chimera C2 in complex with ASF1 Histone chaperone | 分子名称: | C2 foldamer/peptide hybrid inhibitor of histone chaperone ASF1, GLYCEROL, Histone chaperone ASF1A, ... | 著者 | Bakail, M, Mbianda, J, Perrin, E.M, Guerois, R, Legrand, P, Traore, S, Douat, C, Guichard, G, Ochsenbein, F. | 登録日 | 2020-07-22 | 公開日 | 2021-06-09 | 最終更新日 | 2024-07-10 | 実験手法 | X-RAY DIFFRACTION (1.798 Å) | 主引用文献 | Optimal anchoring of a foldamer inhibitor of ASF1 histone chaperone through backbone plasticity. Sci Adv, 7, 2021
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7Z14
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![BU of 7z14 by Molmil](/molmil-images/mine/7z14) | Cryo-EM structure of Torpedo nicotinic acetylcholine receptor in complex with a short-chain neurotoxin. | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Acetylcholine receptor subunit alpha, ... | 著者 | Nys, M.A.E.M, Zarkadas, E, Ulens, C, Nury, H. | 登録日 | 2022-02-24 | 公開日 | 2022-08-17 | 最終更新日 | 2022-08-24 | 実験手法 | ELECTRON MICROSCOPY (3.15 Å) | 主引用文献 | The molecular mechanism of snake short-chain alpha-neurotoxin binding to muscle-type nicotinic acetylcholine receptors. Nat Commun, 13, 2022
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7ACR
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![BU of 7acr by Molmil](/molmil-images/mine/7acr) | Structure of post-translocated trans-translation complex on E. coli stalled ribosome. | 分子名称: | 16S ribosomal RNA, 23S ribosomal RNA, 30S ribosomal protein S10, ... | 著者 | Guyomar, C, D'Urso, G, Chat, S, Giudice, E, Gillet, R. | 登録日 | 2020-09-11 | 公開日 | 2021-08-18 | 最終更新日 | 2024-04-24 | 実験手法 | ELECTRON MICROSCOPY (3.44 Å) | 主引用文献 | Structures of tmRNA and SmpB as they transit through the ribosome. Nat Commun, 12, 2021
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7AC7
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![BU of 7ac7 by Molmil](/molmil-images/mine/7ac7) | Structure of accomodated trans-translation complex on E. Coli stalled ribosome. | 分子名称: | 16S ribosomal RNA, 23S ribosomal RNA, 30S ribosomal protein S10, ... | 著者 | Guyomar, C, D'Urso, G, Chat, S, Giudice, E, Gillet, R. | 登録日 | 2020-09-10 | 公開日 | 2021-08-18 | 最終更新日 | 2024-04-24 | 実験手法 | ELECTRON MICROSCOPY (3.08 Å) | 主引用文献 | Structures of tmRNA and SmpB as they transit through the ribosome. Nat Commun, 12, 2021
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7ACJ
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![BU of 7acj by Molmil](/molmil-images/mine/7acj) | Structure of translocated trans-translation complex on E. coli stalled ribosome. | 分子名称: | 16S ribosomal RNA, 23S ribosomal RNA, 30S ribosomal protein S10, ... | 著者 | Guyomar, C, D'Urso, G, Chat, S, Giudice, E, Gillet, R. | 登録日 | 2020-09-11 | 公開日 | 2021-08-18 | 最終更新日 | 2024-04-24 | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | 主引用文献 | Structures of tmRNA and SmpB as they transit through the ribosome. Nat Commun, 12, 2021
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7ABZ
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![BU of 7abz by Molmil](/molmil-images/mine/7abz) | Structure of pre-accomodated trans-translation complex on E. coli stalled ribosome. | 分子名称: | 16S ribosomal RNA, 23S ribosomal RNA, 30S ribosomal protein S10, ... | 著者 | Guyomar, C, D'Urso, G, Chat, S, Giudice, E, Gillet, R. | 登録日 | 2020-09-09 | 公開日 | 2021-08-18 | 最終更新日 | 2024-04-24 | 実験手法 | ELECTRON MICROSCOPY (3.21 Å) | 主引用文献 | Structures of tmRNA and SmpB as they transit through the ribosome. Nat Commun, 12, 2021
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5Y0A
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6OM6
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![BU of 6om6 by Molmil](/molmil-images/mine/6om6) | Structure of trans-translation inhibitor bound to E. coli 70S ribosome with P site tRNA | 分子名称: | 16S ribosomal RNA, 23S ribosomal RNA, 30S ribosomal protein S10, ... | 著者 | Hoffer, E.D, Mehrani, A, Keiler, K.C, Stagg, S.M, Dunham, C.M. | 登録日 | 2019-04-18 | 公開日 | 2021-02-10 | 最終更新日 | 2021-09-22 | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | 主引用文献 | trans-Translation inhibitors bind to a novel site on the ribosome and clear Neisseria gonorrhoeae in vivo. Nat Commun, 12, 2021
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4XB6
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![BU of 4xb6 by Molmil](/molmil-images/mine/4xb6) | Structure of the E. coli C-P lyase core complex | 分子名称: | Alpha-D-ribose 1-methylphosphonate 5-phosphate C-P lyase, Alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase subunit PhnG, Alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase subunit PhnH, ... | 著者 | Brodersen, D.E. | 登録日 | 2014-12-16 | 公開日 | 2015-08-19 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | Structural insights into the bacterial carbon-phosphorus lyase machinery. Nature, 525, 2015
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5FPV
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![BU of 5fpv by Molmil](/molmil-images/mine/5fpv) | Crystal structure of human JMJD2A in complex with compound KDOAM20A | 分子名称: | 2-{[(2-{[(E)-2-(dimethylamino)ethenyl](ethyl)amino}-2-oxoethyl)amino]methyl}pyridine-4-carboxylic acid, LYSINE-SPECIFIC DEMETHYLASE 4A, MANGANESE (II) ION, ... | 著者 | Srikannathasan, V, Gileadi, C, von Delft, F, Arrowsmith, C.H, Bountra, C, Edwards, A, Oppermann, U. | 登録日 | 2015-12-03 | 公開日 | 2016-01-13 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (2.44 Å) | 主引用文献 | Structural Analysis of Human Kdm5B Guides Histone Demethylase Inhibitor Development. Nat.Chem.Biol., 12, 2016
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6UWT
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4XAX
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![BU of 4xax by Molmil](/molmil-images/mine/4xax) | Crystal structure of Thermus thermophilus CarD in complex with the Thermus aquaticus RNA polymerase beta1 domain | 分子名称: | 1,2-ETHANEDIOL, CarD, DNA-directed RNA polymerase subunit beta domain 1 | 著者 | Chen, J, Bae, B, Campbell, E.A, Darst, S.A. | 登録日 | 2014-12-15 | 公開日 | 2015-09-16 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (2.404 Å) | 主引用文献 | CarD uses a minor groove wedge mechanism to stabilize the RNA polymerase open promoter complex. Elife, 4, 2015
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