6QXC

NMR structure of peptide 8, characterized by a trans-4-cyclohexyl-Pro, with a dramatic reduction in activity on E. coli ATCC and lost effect on P. aeruginosa.

Summary for 6QXC

• Entry DOI: 10.2210/pdb6qxc/pdb
• NMR Information: BMRB: 34367
• Descriptor: PHE-VAL-TCP-TRP-PHE-SER-LYS-PHE-LEU-GLY-ARG-ILE-LEU-NH2 (1 entity in total)
• Functional Keywords: temporins, antimicrobial, amps, proline derivatives, antibiotic
• Biological source: Pseudis bolbodactyla
• Total number of polymer chains: 1
• Total formula weight: 1692.12

Authors

Brancaccio, D.,Carotenuto, A.,Merlino, F.,Grieco, P.,Novellino, E. (deposition date: 2019-03-07, release date: 2019-05-29, Last modification date: 2023-06-14)

• Primary citation: Buommino, E.,Carotenuto, A.,Antignano, I.,Bellavita, R.,Casciaro, B.,Loffredo, M.R.,Merlino, F.,Novellino, E.,Mangoni, M.L.,Nocera, F.P.,Brancaccio, D.,Punzi, P.,Roversi, D.,Ingenito, R.,Bianchi, E.,Grieco, P.; The Outcomes of Decorated Prolines in the Discovery of Antimicrobial Peptides from Temporin-L.; Chemmedchem, 14:1283-1290, 2019; PubMed: 31087626; DOI: 10.1002/cmdc.201900221

Experimental method

SOLUTION NMR