PDB: 5515 件ウェブページステータス検索Chemie searchBIRD

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4LS1	Crystal structure of human dihydroorotate dehydrogenase (DHODH) with DH03A312 分子名称: 2-[(E)-{2-[4-(2-chlorophenyl)-1,3-thiazol-2-yl]hydrazinylidene}methyl]benzoic acid, ACETATE ION, Dihydroorotate dehydrogenase (quinone), ... 著者 Zhu, L, Li, H, Ren, X, Zhu, J. 登録日 2013-07-21 公開日 2014-07-23 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Crystal structure of human dihydroorotate dehydrogenase (DHODH) with DH03A312 To be Published
4LW7	Crystal structure of the mutant H128S of orotidine 5'-monophosphate decarboxylase from Methanobacterium thermoautotrophicum complexed with the inhibitor BMP 分子名称: 6-HYDROXYURIDINE-5'-PHOSPHATE, Orotidine 5'-phosphate decarboxylase 著者 Fedorov, A.A, Fedorov, E.V, Desai, B, Gerlt, J.A, Almo, S.C. 登録日 2013-07-26 公開日 2014-07-30 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (1.423 Å) 主引用文献 Crystal structure of the mutant H128S of orotidine 5'-monophosphate decarboxylase from Methanobacterium thermoautotrophicum complexed with the inhibitor BMP To be Published
4DF0	Crystal structure of orotidine 5'-monophosphate decarboxylase from Thermoproteus neutrophilus 分子名称: CHLORIDE ION, NICKEL (II) ION, Orotidine 5'-phosphate decarboxylase, ... 著者 Fedorov, A.A, Fedorov, E.V, Desai, B, Gerlt, J.A, Almo, S.C. 登録日 2012-01-22 公開日 2013-01-23 実験手法 X-RAY DIFFRACTION (1.5 Å) 主引用文献 Crystal structure of orotidine 5'-monophosphate decarboxylase from Thermoproteus neutrophilus To be Published
3E2P	Catalytic subunit of M. Jannaschii aspartate transcarbamoylase in an orthorhombic crystal form 分子名称: Aspartate carbamoyltransferase, SULFATE ION 著者 Vitali, J, Colaneri, M.J. 登録日 2008-08-06 公開日 2009-03-10 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (3 Å) 主引用文献 Structure of the catalytic trimer of Methanococcus jannaschii aspartate transcarbamoylase in an orthorhombic crystal form. Acta Crystallogr.,Sect.F, 64, 2008
2P1F	Human UMP Synthase (C-terminal Domain-Orotidine 5'-Monophosphate Decarboxylase) 分子名称: GLYCEROL, SODIUM ION, SULFATE ION, ... 著者 Liu, Y, Tang, H.L, Pai, E.F. 登録日 2007-03-05 公開日 2007-04-03 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (1.76 Å) 主引用文献 Human UMP Synthase (C-terminal Domain-Orotidine 5'-Monophosphate Decarboxylase) TO BE PUBLISHED
3EX6	D312N mutant of human orotidyl-5'-monophosphate decarboxylase in complex with 6-azido-UMP, covalent adduct 分子名称: CHLORIDE ION, GLYCEROL, Orotidine-5'-phosphate decarboxylase, ... 著者 Heinrich, D, Diederichsen, U, Rudolph, M. 登録日 2008-10-16 公開日 2009-04-07 最終更新日 2023-12-27 実験手法 X-RAY DIFFRACTION (1.3 Å) 主引用文献 Lys314 is a nucleophile in non-classical reactions of orotidine-5'-monophosphate decarboxylase Chemistry, 15, 2009
3EX4	human orotidyl-5'-monophosphate decarboxylase in complex with BMP 分子名称: 6-HYDROXYURIDINE-5'-PHOSPHATE, Orotidine-5'-phosphate decarboxylase 著者 Heinrich, D, Diederichsen, U, Rudolph, M. 登録日 2008-10-16 公開日 2009-04-07 最終更新日 2023-12-27 実験手法 X-RAY DIFFRACTION (1.24 Å) 主引用文献 Lys314 is a nucleophile in non-classical reactions of orotidine-5'-monophosphate decarboxylase Chemistry, 15, 2009
3FJ6	Human dihydroorotate dehydrogenase in complex with a leflunomide derivative inhibitor 2 分子名称: (2Z)-2-cyano-N-(2,2'-dichlorobiphenyl-4-yl)-3-hydroxybut-2-enamide, ACETATE ION, Dihydroorotate dehydrogenase, ... 著者 Heikkila, T. 登録日 2008-12-14 公開日 2009-06-09 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Structure-based design, synthesis, and characterization of inhibitors of human and Plasmodium falciparum dihydroorotate dehydrogenases J.Med.Chem., 52, 2009
3LHT	Crystal structure of the mutant V201F of orotidine 5'-monophosphate decarboxylase from Methanobacterium thermoautotrophicum complexed with inhibitor BMP 分子名称: 1-(5'-PHOSPHO-BETA-D-RIBOFURANOSYL)BARBITURIC ACID, Orotidine 5'-phosphate decarboxylase 著者 Fedorov, A.A, Fedorov, E.V, Wood, B.M, Gerlt, J.A, Almo, S.C. 登録日 2010-01-23 公開日 2010-06-16 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (1.35 Å) 主引用文献 Conformational changes in orotidine 5'-monophosphate decarboxylase: "remote" residues that stabilize the active conformation. Biochemistry, 49, 2010
3G1D	Crystal structure of orotidine 5'-monophosphate decarboxylase from Methanobacterium thermoautotrophicum complexed with uridine 5'-monophosphate 分子名称: Orotidine 5'-phosphate decarboxylase, URIDINE-5'-MONOPHOSPHATE 著者 Fedorov, A.A, Fedorov, E.V, Chan, K.K, Gerlt, J.A, Almo, S.C. 登録日 2009-01-29 公開日 2009-06-23 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (1.5 Å) 主引用文献 Mechanism of the orotidine 5'-monophosphate decarboxylase-catalyzed reaction: evidence for substrate destabilization. Biochemistry, 48, 2009
3LDV	1.77 Angstrom resolution crystal structure of orotidine 5'-phosphate decarboxylase from Vibrio cholerae O1 biovar eltor str. N16961 分子名称: CHLORIDE ION, MAGNESIUM ION, Orotidine 5'-phosphate decarboxylase 著者 Halavaty, A.S, Shuvalova, L, Minasov, G, Dubrovska, I, Winsor, J, Glass, E.M, Peterson, S.N, Anderson, W.F, Center for Structural Genomics of Infectious Diseases (CSGID) 登録日 2010-01-13 公開日 2010-01-26 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (1.77 Å) 主引用文献 1.77 Angstrom resolution crystal structure of orotidine 5'-phosphate decarboxylase from Vibrio cholerae O1 biovar eltor str. N16961 To be Published
3LTY	Crystal structure of the mutant V182A,I218A of orotidine 5'-monophosphate decarboxylase from Methanobacterium thermoautotrophicum complexed with inhibitor BMP 分子名称: 6-HYDROXYURIDINE-5'-PHOSPHATE, Orotidine 5'-phosphate decarboxylase 著者 Fedorov, A.A, Fedorov, E.V, Wood, B.M, Gerlt, J.A, Almo, S.C. 登録日 2010-02-16 公開日 2010-06-16 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (1.5 Å) 主引用文献 Conformational changes in orotidine 5'-monophosphate decarboxylase: "remote" residues that stabilize the active conformation. Biochemistry, 49, 2010
3G0X	Human dihydroorotate dehydrogenase in complex with a leflunomide derivative inhibitor 5 分子名称: (2Z)-N-biphenyl-4-yl-2-cyano-3-cyclopropyl-3-hydroxyprop-2-enamide, Dihydroorotate dehydrogenase, FLAVIN MONONUCLEOTIDE, ... 著者 Davies, M, Heikkila, T, McConkey, G.A, Fishwick, C.W.G, Parsons, M.R, Johnson, A.P. 登録日 2009-01-29 公開日 2009-06-09 最終更新日 2024-03-20 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Structure-based design, synthesis, and characterization of inhibitors of human and Plasmodium falciparum dihydroorotate dehydrogenases J.Med.Chem., 52, 2009
3G18	Crystal structure of orotidine 5'-monophosphate decarboxylase from Methanobacterium thermoautotrophicum 分子名称: Orotidine 5'-phosphate decarboxylase 著者 Fedorov, A.A, Fedorov, E.V, Chan, K.K, Gerlt, J.A, Almo, S.C. 登録日 2009-01-29 公開日 2009-06-23 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (1.6 Å) 主引用文献 Mechanism of the orotidine 5'-monophosphate decarboxylase-catalyzed reaction: evidence for substrate destabilization. Biochemistry, 48, 2009
3LV5	Crystal structure of the mutant I199E of orotidine 5'-monophosphate decarboxylase from Methanobacterium thermoautotrophicum complexed with inhibitor BMP 分子名称: 6-HYDROXYURIDINE-5'-PHOSPHATE, Orotidine 5'-phosphate decarboxylase 著者 Fedorov, A.A, Fedorov, E.V, Wood, B.M, Gerlt, J.A, Almo, S.C. 登録日 2010-02-19 公開日 2010-06-16 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (1.444 Å) 主引用文献 Conformational changes in orotidine 5'-monophosphate decarboxylase: "remote" residues that stabilize the active conformation. Biochemistry, 49, 2010
3LV6	Crystal structure of the mutant I218F of orotidine 5'-monophosphate decarboxylase from Methanobacterium thermoautotrophicum complexed with inhibitor BMP 分子名称: 6-HYDROXYURIDINE-5'-PHOSPHATE, Orotidine 5'-phosphate decarboxylase 著者 Fedorov, A.A, Fedorov, E.V, Wood, B.M, Gerlt, J.A, Almo, S.C. 登録日 2010-02-19 公開日 2010-06-16 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (1.451 Å) 主引用文献 Conformational changes in orotidine 5'-monophosphate decarboxylase: "remote" residues that stabilize the active conformation. Biochemistry, 49, 2010
3LXM	2.00 Angstrom resolution crystal structure of a catalytic subunit of an aspartate carbamoyltransferase (pyrB) from Yersinia pestis CO92 分子名称: Aspartate carbamoyltransferase, TETRAETHYLENE GLYCOL 著者 Halavaty, A.S, Minasov, G, Dubrovska, I, Winsor, J, Shuvalova, L, Peterson, S, Anderson, W.F, Center for Structural Genomics of Infectious Diseases (CSGID) 登録日 2010-02-25 公開日 2010-03-16 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 2.00 Angstrom resolution crystal structure of a catalytic subunit of an aspartate carbamoyltransferase (pyrB) from Yersinia pestis CO92 To be Published
3G3D	Crystal Structure of Human Orotidine 5'-monophosphate Decarboxylase Covalently Modified by 5-fluoro-6-azido-UMP 分子名称: 5-FLUORO-URIDINE-5'-MONOPHOSPHATE, GLYCEROL, SULFATE ION, ... 著者 Liu, Y, Tang, H.L, Bello, A, Poduch, E, Kotra, L, Pai, E. 登録日 2009-02-02 公開日 2009-03-03 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 Structure-activity relationships of orotidine-5'-monophosphate decarboxylase inhibitors as anticancer agents. J.Med.Chem., 52, 2009
3JZE	1.8 Angstrom resolution crystal structure of dihydroorotase (pyrC) from Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 分子名称: ACETIC ACID, BETA-MERCAPTOETHANOL, CHLORIDE ION, ... 著者 Minasov, G, Halavaty, A, Shuvalova, L, Dubrovska, I, Winsor, J, Papazisi, L, Anderson, W.F, Center for Structural Genomics of Infectious Diseases (CSGID) 登録日 2009-09-23 公開日 2009-09-29 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 1.8 Angstrom Resolution Crystal Structure of Dihydroorotase (pyrC) from Salmonella enterica subsp. enterica serovar Typhimurium str. LT2. TO BE PUBLISHED
3G3M	Crystal Structure of Human Orotidine 5'-monophosphate Decarboxylase Covalently Modified by 5-fluoro-6-iodo-UMP 分子名称: 5-FLUORO-URIDINE-5'-MONOPHOSPHATE, Uridine 5'-monophosphate synthase 著者 Liu, Y, Tang, H.L, Bello, A.M, Poduch, E, Kotra, L.P, Pai, E.F. 登録日 2009-02-02 公開日 2009-03-03 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (1.4 Å) 主引用文献 Structure-activity relationships of orotidine-5'-monophosphate decarboxylase inhibitors as anticancer agents. J.Med.Chem., 52, 2009
3MHU	Crystal structure of dihydroorotate dehydrogenase from Leishmania major in complex with 5-Nitroorotic acid 分子名称: 5-nitro-2,6-dioxo-1,2,3,6-tetrahydropyrimidine-4-carboxylic acid, Dihydroorotate dehydrogenase, FLAVIN MONONUCLEOTIDE, ... 著者 Pinheiro, M.P, Rocha, J.R, Cheleski, J, Montanari, C.A, Nonato, M.C. 登録日 2010-04-08 公開日 2011-02-23 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (1.85 Å) 主引用文献 Novel insights for dihydroorotate dehydrogenase class 1A inhibitors discovery. Eur.J.Med.Chem., 45, 2010
3MJY	Crystal structure of dihydroorotate dehydrogenase from Leishmania major in complex with 5-Aminoorotic acid 分子名称: 5-amino-2,6-dioxo-1,2,3,6-tetrahydropyrimidine-4-carboxylic acid, Dihydroorotate dehydrogenase, FLAVIN MONONUCLEOTIDE, ... 著者 Pinheiro, M.P, Rocha, J.R, Cheleski, J, Montanari, C.A, Nonato, M.C. 登録日 2010-04-13 公開日 2011-02-23 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (1.96 Å) 主引用文献 Novel insights for dihydroorotate dehydrogenase class 1A inhibitors discovery. Eur.J.Med.Chem., 45, 2010
3M47	Crystal structure of the mutant I218A of orotidine 5'-monophosphate decarboxylase from Methanobacterium thermoautotrophicum 分子名称: GLYCEROL, Orotidine 5'-phosphate decarboxylase 著者 Fedorov, A.A, Fedorov, E.V, Wood, B.M, Gerlt, J.A, Almo, S.C. 登録日 2010-03-10 公開日 2010-06-16 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (1.2 Å) 主引用文献 Conformational changes in orotidine 5'-monophosphate decarboxylase: "remote" residues that stabilize the active conformation. Biochemistry, 49, 2010
3FJL	Human dihydroorotate dehydrogenase in complex with a leflunomide derivative inhibitor 3 分子名称: (2Z)-2-cyano-N-(3'-ethoxybiphenyl-4-yl)-3-hydroxybut-2-enamide, ACETIC ACID, Dihydroorotate dehydrogenase, ... 著者 Heikkila, T. 登録日 2008-12-14 公開日 2009-06-09 最終更新日 2024-03-20 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Structure-based design, synthesis, and characterization of inhibitors of human and Plasmodium falciparum dihydroorotate dehydrogenases J.Med.Chem., 52, 2009
3G0U	Human dihydroorotate dehydrogenase in complex with a leflunomide derivative inhibitor 4 分子名称: (2Z)-N-(3-chloro-2'-methoxybiphenyl-4-yl)-2-cyano-3-hydroxybut-2-enamide, Dihydroorotate dehydrogenase, FLAVIN MONONUCLEOTIDE, ... 著者 Davis, M, Heikkila, T, McConkey, G.A, Fishwick, C.W.G, Parsons, M.R, Johnson, A.P. 登録日 2009-01-28 公開日 2009-06-09 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Structure-based design, synthesis, and characterization of inhibitors of human and Plasmodium falciparum dihydroorotate dehydrogenases J.Med.Chem., 52, 2009

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