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4XU2
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BU of 4xu2 by Molmil
Mycobacterium tuberculosis biotin ligase complexed with bisubstrate inhibitor 87 with a 3'deoxy ribose
分子名称: 3',5'-dideoxy-5'-[({5-[(3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl]pentanoyl}sulfamoyl)amino]adenosine, Bifunctional ligase/repressor BirA
著者De la Mora-Rey, T, Finzel, B.C.
登録日2015-01-24
公開日2015-09-02
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (1.8500284 Å)
主引用文献Targeting Mycobacterium tuberculosis Biotin Protein Ligase (MtBPL) with Nucleoside-Based Bisubstrate Adenylation Inhibitors.
J.Med.Chem., 58, 2015
4XTW
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BU of 4xtw by Molmil
Mycobacterium tuberculosis biotin ligase complexed with bisubstrate inhibitor 46 with azide in place of 2'OH
分子名称: 1,2-ETHANEDIOL, 2'-azido-2',5'-dideoxy-5'-[({5-[(3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl]pentanoyl}sulfamoyl)amino]adenosine, Bifunctional ligase/repressor BirA
著者De la Mora-Rey, T, Finzel, B.C.
登録日2015-01-24
公開日2015-09-02
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (2.30014467 Å)
主引用文献Targeting Mycobacterium tuberculosis Biotin Protein Ligase (MtBPL) with Nucleoside-Based Bisubstrate Adenylation Inhibitors.
J.Med.Chem., 58, 2015
4XTZ
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BU of 4xtz by Molmil
Mycobacterium tuberculosis biotin ligase complexed with bisubstrate inhibitor 69 that has a fluorine in place of the ribose 2'OH
分子名称: 9-[2-deoxy-2-fluoro-5-O-({5-[(3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl]pentanoyl}sulfamoyl)-beta-D-arabinofuranosyl]-9H-purin-6-amine, Bifunctional ligase/repressor BirA
著者De la Mora-Rey, T, Finzel, B.C.
登録日2015-01-24
公開日2015-09-02
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (1.90000677 Å)
主引用文献Targeting Mycobacterium tuberculosis Biotin Protein Ligase (MtBPL) with Nucleoside-Based Bisubstrate Adenylation Inhibitors.
J.Med.Chem., 58, 2015
4XU0
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BU of 4xu0 by Molmil
Mycobacterium tuberculosis biotin ligase complexed with bisubstrate inhibitor 73 that has a 2'-methyl on the ribose
分子名称: 2'-C-methyl-5'-O-({5-[(3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl]pentanoyl}sulfamoyl)adenosine, Bifunctional ligase/repressor BirA
著者De la Mora-Rey, T, Finzel, B.C.
登録日2015-01-24
公開日2015-09-02
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (1.60000169 Å)
主引用文献Targeting Mycobacterium tuberculosis Biotin Protein Ligase (MtBPL) with Nucleoside-Based Bisubstrate Adenylation Inhibitors.
J.Med.Chem., 58, 2015
4XU3
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BU of 4xu3 by Molmil
Mycobacterium tuberculosis biotin ligase complexed with bisubstrate inhibitor 90 that has an acyclic ether in place of the ribose
分子名称: Bifunctional ligase/repressor BirA, CHLORIDE ION, N-({2-[(6-amino-9H-purin-9-yl)methoxy]ethyl}sulfamoyl)-5-[(3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl]pentanamide
著者De la Mora-Rey, T, Finzel, B.C.
登録日2015-01-24
公開日2015-09-02
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (2.242677 Å)
主引用文献Targeting Mycobacterium tuberculosis Biotin Protein Ligase (MtBPL) with Nucleoside-Based Bisubstrate Adenylation Inhibitors.
J.Med.Chem., 58, 2015
4XTV
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BU of 4xtv by Molmil
Mycobacterium tuberculosis biotin ligase complexed with bisubstrate inhibitor 36 (N-({[(1R,3S)-3-(6-amino-9H-purin-9-yl)cyclopentyl]methyl}sulfamoyl)-5-[(3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl]pentanamide)
分子名称: Bifunctional ligase/repressor BirA, N-({[(1R,3S)-3-(6-amino-9H-purin-9-yl)cyclopentyl]methyl}sulfamoyl)-5-[(3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl]pentanamide
著者De la Mora-Rey, T, Finzel, B.C.
登録日2015-01-24
公開日2015-09-02
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (1.45000839 Å)
主引用文献Targeting Mycobacterium tuberculosis Biotin Protein Ligase (MtBPL) with Nucleoside-Based Bisubstrate Adenylation Inhibitors.
J.Med.Chem., 58, 2015
4XU1
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BU of 4xu1 by Molmil
Mycobacterium tuberculosis biotin ligase complexed with bisubstrate inhibitor 82 that incorporates a morpholine in place of the ribose
分子名称: 1,2-ETHANEDIOL, Bifunctional ligase/repressor BirA, DIMETHYL SULFOXIDE, ...
著者De la Mora-Rey, T, Finzel, B.C.
登録日2015-01-24
公開日2015-09-02
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (1.70001328 Å)
主引用文献Targeting Mycobacterium tuberculosis Biotin Protein Ligase (MtBPL) with Nucleoside-Based Bisubstrate Adenylation Inhibitors.
J.Med.Chem., 58, 2015
3QEJ
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BU of 3qej by Molmil
S74E-dCK mutant in complex with UDP
分子名称: Deoxycytidine kinase, URIDINE-5'-DIPHOSPHATE
著者Hazra, S, Lavie, A.
登録日2011-01-20
公開日2011-03-16
最終更新日2024-02-21
実験手法X-RAY DIFFRACTION (2.49 Å)
主引用文献Post-translational phosphorylation of serine 74 of human deoxycytidine kinase favors the enzyme adopting the open conformation making it competent for nucleoside binding and release.
Biochemistry, 50, 2011
4WU9
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BU of 4wu9 by Molmil
Structure of cisPtNAP-NCP145
分子名称: DNA (145-MER), Histone H2A type 1, Histone H2B 1.1, ...
著者Chua, E.Y.D, Davey, G.E, Chin, C.F, Droge, P, Ang, W.H, Davey, C.A.
登録日2014-10-31
公開日2015-09-02
最終更新日2024-03-20
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献Stereochemical control of nucleosome targeting by platinum-intercalator antitumor agents.
Nucleic Acids Res., 43, 2015
8VX4
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BU of 8vx4 by Molmil
Human OGG1 bound to a 35-bp DNA with an 8-oxoG in the middle
分子名称: DNA (35-MER), N-glycosylase/DNA lyase
著者You, Q, Li, H.
登録日2024-02-03
公開日2024-10-09
最終更新日2025-05-21
実験手法ELECTRON MICROSCOPY (3.7 Å)
主引用文献Human 8-oxoguanine glycosylase OGG1 binds nucleosome at the dsDNA ends and the super-helical locations.
Commun Biol, 7, 2024
6E33
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BU of 6e33 by Molmil
Crystal Structure of Pho7-DNA complex
分子名称: DNA (5'-D(*GP*AP*TP*TP*TP*GP*AP*AP*TP*GP*TP*CP*CP*GP*AP*AP*GP*GP*AP*T)-3'), DNA (5'-D(*TP*CP*CP*TP*TP*CP*GP*GP*AP*CP*AP*TP*TP*CP*AP*AP*AP*TP*CP*A)-3'), Uncharacterized transcriptional regulatory protein C27B12.11c, ...
著者Garg, A, Goldgur, Y, Shuman, S.
登録日2018-07-13
公開日2018-10-24
最終更新日2024-03-13
実験手法X-RAY DIFFRACTION (1.705 Å)
主引用文献Distinctive structural basis for DNA recognition by the fission yeast Zn2Cys6 transcription factor Pho7 and its role in phosphate homeostasis.
Nucleic Acids Res., 46, 2018
3QEN
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BU of 3qen by Molmil
S74E dCK in complex with 5-bromodeoxycytidine and UDP
分子名称: 5-bromo-2'-deoxycytidine, Deoxycytidine kinase, URIDINE-5'-DIPHOSPHATE
著者Lavie, A, Hazra, S.
登録日2011-01-20
公開日2011-03-16
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (1.997 Å)
主引用文献Post-translational phosphorylation of serine 74 of human deoxycytidine kinase favors the enzyme adopting the open conformation making it competent for nucleoside binding and release.
Biochemistry, 50, 2011
3QEO
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BU of 3qeo by Molmil
S74E-R104M-D133A dCK variant in complex with L-deoxythymidine and UDP
分子名称: Deoxycytidine kinase, L-deoxythymidine, URIDINE-5'-DIPHOSPHATE
著者Lavie, A, Hazra, S.
登録日2011-01-20
公開日2011-03-16
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (1.897 Å)
主引用文献Post-translational phosphorylation of serine 74 of human deoxycytidine kinase favors the enzyme adopting the open conformation making it competent for nucleoside binding and release.
Biochemistry, 50, 2011
5GAO
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BU of 5gao by Molmil
Head region of the yeast spliceosomal U4/U6.U5 tri-snRNP
分子名称: Pre-mRNA-splicing factor 8, Pre-mRNA-splicing helicase BRR2, Saccharomyces cerevisiae strain UOA_M2 chromosome 5 sequence, ...
著者Nguyen, T.H.D, Galej, W.P, Bai, X.C, Oubridge, C, Scheres, S.H.W, Newman, A.J, Nagai, K.
登録日2015-12-15
公開日2016-01-27
最終更新日2024-05-15
実験手法ELECTRON MICROSCOPY (4.2 Å)
主引用文献Cryo-EM structure of the yeast U4/U6.U5 tri-snRNP at 3.7 angstrom resolution.
Nature, 530, 2016
5GAM
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BU of 5gam by Molmil
Foot region of the yeast spliceosomal U4/U6.U5 tri-snRNP
分子名称: GUANOSINE-5'-TRIPHOSPHATE, Pre-mRNA-splicing factor 8, Pre-mRNA-splicing factor SNU114, ...
著者Nguyen, T.H.D, Galej, W.P, Bai, X.C, Oubridge, C, Scheres, S.H.W, Newman, A.J, Nagai, K.
登録日2015-12-15
公開日2016-02-03
最終更新日2024-05-15
実験手法ELECTRON MICROSCOPY (3.7 Å)
主引用文献Cryo-EM structure of the yeast U4/U6.U5 tri-snRNP at 3.7 Angstrom resolution
Nature, 530, 2016
8A1G
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BU of 8a1g by Molmil
Structure of the SNX1-SNX5 complex
分子名称: N-PROPANOL, Sorting nexin-1, Sorting nexin-5
著者Lopez-Robles, C, Scaramuzza, S, Astorga-Simon, E.N, Banos-Mateos, S, Vidaurrazaga, A, Rojas, A.L, Castano, D, Hierro, A.
登録日2022-06-01
公開日2023-06-14
最終更新日2024-06-19
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Architecture of the ESCPE-1 membrane coat.
Nat.Struct.Mol.Biol., 30, 2023
8ABQ
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BU of 8abq by Molmil
Structure of the SNX1-SNX5 complex, Pt derivative
分子名称: PLATINUM (II) ION, Sorting nexin-1, Sorting nexin-5
著者Lopez-Robles, C, Scaramuzza, S, Astorga-Simon, E.N, Banos-Mateos, S, Vidaurrazaga, A, Rojas, A.L, Castano, D, Hierro, A.
登録日2022-07-04
公開日2023-06-21
最終更新日2024-06-19
実験手法X-RAY DIFFRACTION (2.81 Å)
主引用文献Architecture of the ESCPE-1 membrane coat.
Nat.Struct.Mol.Biol., 30, 2023
8AFZ
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BU of 8afz by Molmil
Architecture of the ESCPE-1 membrane coat
分子名称: Cation-independent mannose-6-phosphate receptor, Sorting nexin-1, Sorting nexin-5
著者Lopez-Robles, C, Scaramuzza, S, Astorga-Simon, E, Ishida, M, Williamsom, C.D, Banos-Mateos, S, Gil-Carton, D, Romero, M, Vidaurrazaga, A, Fernandez-Recio, J, Rojas, A.L, Bonifacino, J.S, Castano-Diez, D, Hierro, A.
登録日2022-07-18
公開日2023-06-21
最終更新日2024-07-24
実験手法ELECTRON MICROSCOPY (10 Å)
主引用文献Architecture of the ESCPE-1 membrane coat.
Nat.Struct.Mol.Biol., 30, 2023
6L69
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BU of 6l69 by Molmil
Crystal structure of CYP154C2 from Streptomyces avermitilis
分子名称: Cytochrome P450 hydroxylase, PROTOPORPHYRIN IX CONTAINING FE
著者Xu, L.H, Fushinobu, S.
登録日2019-10-28
公開日2020-09-23
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (1.5 Å)
主引用文献Regio- and stereoselective hydroxylation of testosterone by a novel cytochrome P450 154C2 from Streptomyces avermitilis.
Biochem.Biophys.Res.Commun., 522, 2020
7YI0
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BU of 7yi0 by Molmil
Cryo-EM structure of Rpd3S complex
分子名称: Chromatin modification-related protein EAF3, Histone deacetylase RPD3, Transcriptional regulatory protein RCO1, ...
著者Li, H.T, Yan, C.Y, Guan, H.P, Wang, P.
登録日2022-07-14
公開日2023-06-14
最終更新日2025-07-02
実験手法ELECTRON MICROSCOPY (3.2 Å)
主引用文献Diverse modes of H3K36me3-guided nucleosomal deacetylation by Rpd3S.
Nature, 620, 2023
6U9I
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BU of 6u9i by Molmil
Crystal structure of BvnE pinacolase from Penicillium brevicompactum
分子名称: BvnE, DI(HYDROXYETHYL)ETHER, GLYCEROL
著者Ye, Y, Du, L, Zhang, X, Newmister, S.A, McCauley, M, Alegre-Requena, J.V, Zhang, W, Mu, S, Minami, A, Fraley, A.E, Adrover-Castellano, M.L, Carney, N, Shende, V.V, Oikawa, H, Kato, H, Tsukamoto, S, Paton, R.S, Williams, R.M, Sherman, D.H, Li, S.
登録日2019-09-09
公開日2020-09-09
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (1.777 Å)
主引用文献Fungal-derived brevianamide assembly by a stereoselective semipinacolase.
Nat Catal, 3, 2020
8ZB0
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BU of 8zb0 by Molmil
Cryo-EM structure of human ZnT1
分子名称: Proton-coupled zinc antiporter SLC30A1, ZINC ION
著者Sun, S, Xie, E, Xu, S, Ji, S.
登録日2024-04-25
公開日2025-03-12
実験手法ELECTRON MICROSCOPY (3.7 Å)
主引用文献The Intestinal Transporter SLC30A1 Plays a Critical Role in Regulating Systemic Zinc Homeostasis.
Adv Sci, 11, 2024
5OVN
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BU of 5ovn by Molmil
Crystal Structure of FIV Reverse Transcriptase
分子名称: POL protein
著者Galilee, M, Alian, A.
登録日2017-08-29
公開日2018-01-17
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (2.942 Å)
主引用文献The structure of FIV reverse transcriptase and its implications for non-nucleoside inhibitor resistance.
PLoS Pathog., 14, 2018
4WU8
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BU of 4wu8 by Molmil
Structure of trPtNAP-NCP145
分子名称: DNA (145-MER), Histone H2A type 1, Histone H2B 1.1, ...
著者Chua, E.Y.D, Davey, C.A.
登録日2014-10-31
公開日2015-09-02
最終更新日2024-03-20
実験手法X-RAY DIFFRACTION (2.45 Å)
主引用文献Stereochemical control of nucleosome targeting by platinum-intercalator antitumor agents.
Nucleic Acids Res., 43, 2015
7VZ4
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BU of 7vz4 by Molmil
Cryo-EM structure of human nucleosome core particle composed of the Widom 601L DNA sequence
分子名称: DNA (145-MER), Histone H2A type 1-B/E, Histone H2B type 1-J, ...
著者Takizawa, Y, Ho, C.-H, Sato, S, Danev, R, Kurumizaka, H.
登録日2021-11-15
公開日2023-05-17
最終更新日2024-06-26
実験手法ELECTRON MICROSCOPY (1.89 Å)
主引用文献Methods for High Resolution Cryo-EM Analyses of Nucleosomes
To Be Published

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件を2025-07-09に公開中

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