8A1G
Structure of the SNX1-SNX5 complex
Summary for 8A1G
| Entry DOI | 10.2210/pdb8a1g/pdb |
| Descriptor | Sorting nexin-1, Sorting nexin-5, N-PROPANOL, ... (4 entities in total) |
| Functional Keywords | snx, membrane trafficking., transport protein, protein transport |
| Biological source | Homo sapiens (human) More |
| Total number of polymer chains | 4 |
| Total formula weight | 102505.41 |
| Authors | Lopez-Robles, C.,Scaramuzza, S.,Astorga-Simon, E.N.,Banos-Mateos, S.,Vidaurrazaga, A.,Rojas, A.L.,Castano, D.,Hierro, A. (deposition date: 2022-06-01, release date: 2023-06-14, Last modification date: 2024-06-19) |
| Primary citation | Lopez-Robles, C.,Scaramuzza, S.,Astorga-Simon, E.N.,Ishida, M.,Williamson, C.D.,Banos-Mateos, S.,Gil-Carton, D.,Romero-Durana, M.,Vidaurrazaga, A.,Fernandez-Recio, J.,Rojas, A.L.,Bonifacino, J.S.,Castano-Diez, D.,Hierro, A. Architecture of the ESCPE-1 membrane coat. Nat.Struct.Mol.Biol., 30:958-969, 2023 Cited by PubMed Abstract: Recycling of membrane proteins enables the reuse of receptors, ion channels and transporters. A key component of the recycling machinery is the endosomal sorting complex for promoting exit 1 (ESCPE-1), which rescues transmembrane proteins from the endolysosomal pathway for transport to the trans-Golgi network and the plasma membrane. This rescue entails the formation of recycling tubules through ESCPE-1 recruitment, cargo capture, coat assembly and membrane sculpting by mechanisms that remain largely unknown. Herein, we show that ESCPE-1 has a single-layer coat organization and suggest how synergistic interactions between ESCPE-1 protomers, phosphoinositides and cargo molecules result in a global arrangement of amphipathic helices to drive tubule formation. Our results thus define a key process of tubule-based endosomal sorting. PubMed: 37322239DOI: 10.1038/s41594-023-01014-7 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.5 Å) |
Structure validation
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