PDB: 98041 件ウェブページステータス検索Chemie searchBIRD

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7BJF	14-3-3 sigma with RelA/p65 binding site pS45 and covalently bound TCF521-069 分子名称: (5-methyl-2-nitro-phenyl) cyclobutanecarboxylate, 14-3-3 protein sigma, CHLORIDE ION, ... 著者 Wolter, M, Ottmann, C. 登録日 2021-01-14 公開日 2021-06-09 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (1.4 Å) 主引用文献 An Exploration of Chemical Properties Required for Cooperative Stabilization of the 14-3-3 Interaction with NF-kappa B-Utilizing a Reversible Covalent Tethering Approach. J.Med.Chem., 64, 2021
7BGR	14-3-3 sigma with Pin1 binding site pS72 and covalently bound LvD1016 分子名称: 14-3-3 protein sigma, 2-methyl-4-(2-phenylimidazol-1-yl)benzaldehyde, CALCIUM ION, ... 著者 Wolter, M, Dijck, L.v, Cossar, P.J, Ottmann, C. 登録日 2021-01-08 公開日 2021-06-16 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Reversible Covalent Imine-Tethering for Selective Stabilization of 14-3-3 Hub Protein Interactions. J.Am.Chem.Soc., 143, 2021
8WU7	Structure of a cis-Geranylfarnesyl Diphosphate Synthase from Streptomyces clavuligerus 分子名称: Isoprenyl transferase 著者 Li, F.R, Wang, Q.L, Pan, X.M, Dong, L.B. 登録日 2023-10-20 公開日 2024-05-08 最終更新日 2024-07-10 実験手法 X-RAY DIFFRACTION (2.09 Å) 主引用文献 Discovery, Structure, and Engineering of a cis-Geranylfarnesyl Diphosphate Synthase. Angew.Chem.Int.Ed.Engl., 63, 2024
7BKH	14-3-3 sigma with RelA/p65 binding site pS45 and covalently bound TCF521-153 分子名称: 14-3-3 protein sigma, 4-nitro-3-[(3S)-3-oxidanylpiperidin-1-yl]benzaldehyde, Transcription factor p65 著者 Wolter, M, Ottmann, C. 登録日 2021-01-16 公開日 2021-06-09 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (1.4 Å) 主引用文献 An Exploration of Chemical Properties Required for Cooperative Stabilization of the 14-3-3 Interaction with NF-kappa B-Utilizing a Reversible Covalent Tethering Approach. J.Med.Chem., 64, 2021
7BDP	14-3-3 sigma with Pin1 binding site pS72 and covalently bound LvD1017 分子名称: 14-3-3 protein sigma, 2-chloranyl-4-(2-phenylimidazol-1-yl)benzaldehyde, MAGNESIUM ION, ... 著者 Wolter, M, Dijck, L.v, Cossar, P.J, Ottmann, C. 登録日 2020-12-22 公開日 2021-06-16 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (1.75 Å) 主引用文献 Reversible Covalent Imine-Tethering for Selective Stabilization of 14-3-3 Hub Protein Interactions. J.Am.Chem.Soc., 143, 2021
7BGV	14-3-3 sigma with Pin1 binding site pS72 and covalently bound LvD1012 分子名称: 14-3-3 protein sigma, 3-methoxy-4-(2-phenylimidazol-1-yl)benzaldehyde, CALCIUM ION, ... 著者 Wolter, M, Dijck, L.v, Cossar, P.J, Ottmann, C. 登録日 2021-01-08 公開日 2021-06-16 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (1.683 Å) 主引用文献 Reversible Covalent Imine-Tethering for Selective Stabilization of 14-3-3 Hub Protein Interactions. J.Am.Chem.Soc., 143, 2021
7BDT	14-3-3 sigma with Pin1 binding site pS72 and covalently bound LvD1009 分子名称: 14-3-3 protein sigma, 2-bromanyl-4-(2-phenylimidazol-1-yl)benzaldehyde, MAGNESIUM ION, ... 著者 Wolter, M, Dijck, L.v, Cossar, P.J, Ottmann, C. 登録日 2020-12-22 公開日 2021-06-16 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (1.75 Å) 主引用文献 Reversible Covalent Imine-Tethering for Selective Stabilization of 14-3-3 Hub Protein Interactions. J.Am.Chem.Soc., 143, 2021
8X52	Cryo-EM structure of human gamma-secretase in complex with Abeta49 分子名称: 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... 著者 Guo, X, Yan, C, Lei, J, Zhou, R, Shi, Y. 登録日 2023-11-16 公開日 2024-05-29 最終更新日 2024-06-19 実験手法 ELECTRON MICROSCOPY (2.9 Å) 主引用文献 Molecular mechanism of substrate recognition and cleavage by human gamma-secretase. Science, 384, 2024
7BDY	14-3-3 sigma with Pin1 binding site pS72 and covalently bound PC2068B 分子名称: 14-3-3 protein sigma, 2-bromanyl-4-[2-(5-bromanyl-2-fluoranyl-phenyl)imidazol-1-yl]benzaldehyde, CALCIUM ION, ... 著者 Wolter, M, Dijck, L.v, Cossar, P.J, Ottmann, C. 登録日 2020-12-22 公開日 2021-06-16 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (1.801 Å) 主引用文献 Reversible Covalent Imine-Tethering for Selective Stabilization of 14-3-3 Hub Protein Interactions. J.Am.Chem.Soc., 143, 2021
8X53	Cryo-EM structure of human gamma-secretase in complex with Abeta46 分子名称: 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... 著者 Guo, X, Yan, C, Lei, J, Zhou, R, Shi, Y. 登録日 2023-11-16 公開日 2024-05-29 最終更新日 2024-06-19 実験手法 ELECTRON MICROSCOPY (3 Å) 主引用文献 Molecular mechanism of substrate recognition and cleavage by human gamma-secretase. Science, 384, 2024
8X54	Cryo-EM structure of human gamma-secretase in complex with APP-C99 分子名称: 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... 著者 Guo, X, Yan, C, Lei, J, Zhou, R, Shi, Y. 登録日 2023-11-16 公開日 2024-05-29 最終更新日 2024-06-19 実験手法 ELECTRON MICROSCOPY (2.9 Å) 主引用文献 Molecular mechanism of substrate recognition and cleavage by human gamma-secretase. Science, 384, 2024
7BFW	14-3-3 sigma with Pin1 binding site pS72 and covalently bound PC2068A 分子名称: 14-3-3 protein sigma, CALCIUM ION, CHLORIDE ION, ... 著者 Wolter, M, Dijck, L.v, Cossar, P.J, Ottmann, C. 登録日 2021-01-05 公開日 2021-06-16 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Reversible Covalent Imine-Tethering for Selective Stabilization of 14-3-3 Hub Protein Interactions. J.Am.Chem.Soc., 143, 2021
7JPR	ORC-OPEN: Human Origin Recognition Complex (ORC) in an open conformation 分子名称: ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, Origin recognition complex subunit 1, ... 著者 Jaremko, M.J, Joshua-Tor, L. 登録日 2020-08-09 公開日 2020-09-09 最終更新日 2024-03-06 実験手法 ELECTRON MICROSCOPY (4 Å) 主引用文献 The dynamic nature of the human Origin Recognition Complex revealed through five cryoEM structures. Elife, 9, 2020
7BI3	14-3-3 sigma with RelA/p65 binding site pS45 and covalently bound TCF521-179 分子名称: 14-3-3 protein sigma, 4-[(6-methoxy-3,4-dihydro-2~{H}-quinolin-1-yl)sulfonyl]benzaldehyde, CALCIUM ION, ... 著者 Wolter, M, Ottmann, C. 登録日 2021-01-12 公開日 2021-06-16 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (1.2 Å) 主引用文献 An Exploration of Chemical Properties Required for Cooperative Stabilization of the 14-3-3 Interaction with NF-kappa B-Utilizing a Reversible Covalent Tethering Approach. J.Med.Chem., 64, 2021
7BG3	14-3-3 sigma with Pin1 binding site pS72 and covalently bound PC2046 分子名称: 1-(3-bromanyl-4-methyl-phenyl)-2-(2-bromophenyl)imidazole, 14-3-3 protein sigma, CALCIUM ION, ... 著者 Wolter, M, Dijck, L.v, Cossar, P.J, Ottmann, C. 登録日 2021-01-05 公開日 2021-06-16 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (1.4 Å) 主引用文献 Reversible Covalent Imine-Tethering for Selective Stabilization of 14-3-3 Hub Protein Interactions. J.Am.Chem.Soc., 143, 2021
7BGW	14-3-3 sigma with Pin1 binding site pS72 and covalently bound LvD1011 分子名称: 14-3-3 protein sigma, 4-(2-phenylimidazol-1-yl)naphthalene-1-carbaldehyde, CALCIUM ION, ... 著者 Wolter, M, Dijck, L.v, Cossar, P.J, Ottmann, C. 登録日 2021-01-08 公開日 2021-06-16 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Reversible Covalent Imine-Tethering for Selective Stabilization of 14-3-3 Hub Protein Interactions. J.Am.Chem.Soc., 143, 2021
7BIY	14-3-3 sigma with RelA/p65 binding site pS45 and covalently bound TCF521-175 分子名称: 1-(4-methanoylphenyl)carbonylpiperidine-4-carbonitrile, 14-3-3 protein sigma, CHLORIDE ION, ... 著者 Wolter, M, Ottmann, C. 登録日 2021-01-13 公開日 2021-06-16 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 An Exploration of Chemical Properties Required for Cooperative Stabilization of the 14-3-3 Interaction with NF-kappa B-Utilizing a Reversible Covalent Tethering Approach. J.Med.Chem., 64, 2021
7U0M	Crystal structure of a enoyl-[acyl-carrier-protein] reductase (InhA) from Mycobacterium abscessus bound to NAD and NITD-916 分子名称: 6-[(4,4-dimethylcyclohexyl)methyl]-4-hydroxy-3-phenylpyridin-2(1H)-one, Enoyl-[acyl-carrier-protein] reductase [NADH], NICOTINAMIDE-ADENINE-DINUCLEOTIDE, ... 著者 Seattle Structural Genomics Center for Infectious Disease, Seattle Structural Genomics Center for Infectious Disease (SSGCID) 登録日 2022-02-18 公開日 2022-10-05 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (1.45 Å) 主引用文献 Efficacy and Mode of Action of a Direct Inhibitor of Mycobacterium abscessus InhA. Acs Infect Dis., 8, 2022
7JU7	The crystal structure of SARS-CoV-2 Main Protease in complex with masitinib 分子名称: 3C-like proteinase, DIMETHYL SULFOXIDE, GLYCEROL, ... 著者 Tan, K, Maltseva, N.I, Welk, L.F, Jedrzejczak, R.P, Joachimiak, A, Center for Structural Genomics of Infectious Diseases (CSGID) 登録日 2020-08-19 公開日 2020-09-09 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (1.6 Å) 主引用文献 Masitinib is a broad coronavirus 3CL inhibitor that blocks replication of SARS-CoV-2. Science, 373, 2021
6YAS	HYDROXYNITRILE LYASE FROM HEVEA BRASILIENSIS, ROOM TEMPERATURE STRUCTURE 分子名称: PROTEIN (HYDROXYNITRILE LYASE), SULFATE ION 著者 Zuegg, J, Wagner, U.G, Gugganig, M, Kratky, C. 登録日 1999-03-15 公開日 1999-10-13 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Three-dimensional structures of enzyme-substrate complexes of the hydroxynitrile lyase from Hevea brasiliensis. Protein Sci., 8, 1999
8UI0	Structure of poised transcription complex Pol II-DSIF-NELF - pre-translocated 分子名称: DNA, DNA (38-MER), DNA-directed RNA polymerase II subunit E, ... 著者 Vos, S.M, Su, B.G. 登録日 2023-10-09 公開日 2024-03-20 最終更新日 2024-09-11 実験手法 ELECTRON MICROSCOPY (2.7 Å) 主引用文献 Distinct negative elongation factor conformations regulate RNA polymerase II promoter-proximal pausing. Mol.Cell, 84, 2024
8UHD	Structure of paused transcription complex Pol II-DSIF-NELF - post-translocated 分子名称: DNA-directed RNA polymerase II subunit E, DNA-directed RNA polymerase II subunit RPB3, DNA-directed RNA polymerase II subunit RPB7, ... 著者 Su, B.G, Vos, S.M. 登録日 2023-10-08 公開日 2024-03-20 最終更新日 2024-09-11 実験手法 ELECTRON MICROSCOPY (2.8 Å) 主引用文献 Distinct negative elongation factor conformations regulate RNA polymerase II promoter-proximal pausing. Mol.Cell, 84, 2024
8UHG	Structure of paused transcription complex Pol II-DSIF-NELF - poised post-translocated 分子名称: DNA-directed RNA polymerase II subunit E, DNA-directed RNA polymerase II subunit RPB11-a, DNA-directed RNA polymerase II subunit RPB3, ... 著者 Vos, S.M, Su, B.G. 登録日 2023-10-09 公開日 2024-03-20 最終更新日 2024-04-17 実験手法 ELECTRON MICROSCOPY (2.7 Å) 主引用文献 Distinct negative elongation factor conformations regulate RNA polymerase II promoter-proximal pausing. Mol.Cell, 84, 2024
8UHA	Structure of paused transcription complex Pol II-DSIF-NELF - tilted 分子名称: DNA (28-MER), DNA (38-MER), DNA-directed RNA polymerase II subunit E, ... 著者 Vos, S.M, Su, B.G. 登録日 2023-10-08 公開日 2024-03-20 最終更新日 2024-09-11 実験手法 ELECTRON MICROSCOPY (3.5 Å) 主引用文献 Distinct negative elongation factor conformations regulate RNA polymerase II promoter-proximal pausing. Mol.Cell, 84, 2024
7VTN	Cryo-EM structure of the Cas13bt3-crRNA-target RNA ternary complex 分子名称: Cas13bt3, crRNA, target RNA 著者 Nakagawa, R, Soumya, K, Han, A, Takeda, N.S, Tomita, A, Hirano, H, Kusakizako, T, Tomohiro, N, Yamashita, K, Feng, Z, Nishimasu, H, Nureki, O. 登録日 2021-10-30 公開日 2022-09-07 最終更新日 2024-06-26 実験手法 ELECTRON MICROSCOPY (3.38 Å) 主引用文献 Structure and engineering of the minimal type VI CRISPR-Cas13bt3. Mol.Cell, 82, 2022

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