PDB: 4955 件ウェブページステータス検索Chemie searchBIRD

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5E8S	TGF-BETA RECEPTOR TYPE 1 KINASE DOMAIN (WT) 分子名称: TGF-beta receptor type-1 著者 Sheriff, S. 登録日 2015-10-14 公開日 2016-05-11 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (1.45 Å) 主引用文献 Crystal structures of apo and inhibitor-bound TGF beta R2 kinase domain: insights into TGF beta R isoform selectivity. Acta Crystallogr D Struct Biol, 72, 2016
5E8Z	TGF-BETA RECEPTOR TYPE 1 KINASE DOMAIN (T204D) IN COMPLEX WITH 3-AMINO-6-[4-(2-HYDROXYETHYL)PHENYL]-N-[4-(MORPHOLIN-4-YL)PYRIDIN-3-YL]PYRAZINE-2-CARBOXAMIDE 分子名称: 3-amino-6-[4-(2-hydroxyethyl)phenyl]-N-[4-(morpholin-4-yl)pyridin-3-yl]pyrazine-2-carboxamide, TGF-beta receptor type-1 著者 Sheriff, S. 登録日 2015-10-14 公開日 2016-05-11 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (1.51 Å) 主引用文献 Crystal structures of apo and inhibitor-bound TGF beta R2 kinase domain: insights into TGF beta R isoform selectivity. Acta Crystallogr D Struct Biol, 72, 2016
3NDM	Crystal structure of Rho-Associated Protein Kinase (ROCK1) with a potent isoquinolone derivative 分子名称: (3S,4R)-N-(7-chloro-1-oxo-1,4-dihydroisoquinolin-6-yl)-4-(4-chlorophenyl)pyrrolidine-3-carboxamide, Rho-Associated Protein Kinase (ROCK1) 著者 Li, X. 登録日 2010-06-07 公開日 2010-12-08 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (3.3 Å) 主引用文献 Substituted 2H-isoquinolin-1-ones as potent Rho-kinase inhibitors: part 3, aryl substituted pyrrolidines. Bioorg.Med.Chem.Lett., 20, 2010
3MB7	Human CK2 catalytic domain in complex with a difurane derivative inhibitor (AMR) 分子名称: Casein kinase II subunit alpha, SULFATE ION, naphtho[2,1-b:7,8-b']difuran-2,9-dicarboxylic acid 著者 Reiser, J.-B, Prudent, R, Cochet, C. 登録日 2010-03-25 公開日 2010-05-05 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (1.65 Å) 主引用文献 New potent dual inhibitors of CK2 and Pim kinases: discovery and structural insights. Faseb J., 24, 2010
3MFS	CASK-4M CaM Kinase Domain, AMPPNP 分子名称: PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, Peripheral plasma membrane protein CASK 著者 Wahl, M.C, Mukherjee, K. 登録日 2010-04-03 公開日 2010-04-28 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Evolution of CASK into a Mg2+-sensitive kinase. Sci.Signal., 3, 2010
5EW9	Crystal Structure of Aurora A Kinase Domain Bound to MK-5108 分子名称: 4-(3-chloranyl-2-fluoranyl-phenoxy)-1-[[6-(1,3-thiazol-2-ylamino)pyridin-2-yl]methyl]cyclohexane-1-carboxylic acid, Aurora kinase A 著者 Shiau, A.K, Motamedi, A. 登録日 2015-11-20 公開日 2016-01-20 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (2.181 Å) 主引用文献 A Cell Biologist's Field Guide to Aurora Kinase Inhibitors. Front Oncol, 5, 2015
3MPA	Conformational plasticity of p38 MAP kinase DFG motif mutants in response to inhibitor binding 分子名称: 4-[5-(4-FLUORO-PHENYL)-2-(4-METHANESULFINYL-PHENYL)-3H-IMIDAZOL-4-YL]-PYRIDINE, Mitogen-activated protein kinase 14, octyl beta-D-glucopyranoside 著者 Namboodiri, H.V, Karpusas, M, Bukhtiyarova, M, Springman, E.B. 登録日 2010-04-26 公開日 2010-09-15 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Conformational plasticity of p38 MAP kinase DFG motif mutants in response to inhibitor binding TO BE PUBLISHED
3MTF	Crystal structure of the ACVR1 kinase in complex with a 2-aminopyridine inhibitor 分子名称: 1,2-ETHANEDIOL, 3-[6-amino-5-(3,4,5-trimethoxyphenyl)pyridin-3-yl]phenol, Activin receptor type-1, ... 著者 Chaikuad, A, Sanvitale, C, Cooper, C, Mahajan, P, Daga, N, Petrie, K, Alfano, I, Canning, P, Krojer, T, Vollmar, M, Knapp, S, von Delft, F, Weigelt, J, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Bullock, A, Structural Genomics Consortium (SGC) 登録日 2010-04-30 公開日 2010-06-23 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (2.15 Å) 主引用文献 A new class of small molecule inhibitor of BMP signaling. Plos One, 8, 2013
3MVJ	Human cyclic AMP-dependent protein kinase PKA inhibitor complex 分子名称: (3R)-1-(5-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)pyrrolidin-3-amine, cAMP-dependent protein kinase catalytic subunit alpha, cAMP-dependent protein kinase inhibitor alpha 著者 Pandit, J, Vajdos, F. 登録日 2010-05-04 公開日 2010-06-02 最終更新日 2017-11-08 実験手法 X-RAY DIFFRACTION (2.49 Å) 主引用文献 Design of selective, ATP-competitive inhibitors of Akt. J.Med.Chem., 53, 2010
5EYM	MEK1 IN COMPLEX WITH BI 847325 分子名称: 3-[(3~{Z})-3-[[[4-[(dimethylamino)methyl]phenyl]amino]-phenyl-methylidene]-2-oxidanylidene-1~{H}-indol-6-yl]-~{N}-ethyl-prop-2-ynamide, CALCIUM ION, Dual specificity mitogen-activated protein kinase kinase 1 著者 Bader, G, Reiser, U, Zahn, S.K, Treu, M. 登録日 2015-11-25 公開日 2016-08-17 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (2.7 Å) 主引用文献 Pharmacological Profile of BI 847325, an Orally Bioavailable, ATP-Competitive Inhibitor of MEK and Aurora Kinases. Mol.Cancer Ther., 15, 2016
5G15	Structure Aurora A (122-403) bound to activating monobody Mb1 and AMPPCP 分子名称: AURORA A KINASE, MAGNESIUM ION, MB1 MONOBODY, ... 著者 Zorba, A, Kutter, S, Kern, D, Koide, S, Koide, A. 登録日 2016-03-23 公開日 2018-03-14 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (2.06 Å) 主引用文献 Allosteric modulation of a human protein kinase with monobodies. Proc.Natl.Acad.Sci.USA, 116, 2019
5F95	Crystal structure of GSK3b in complex with Compound 18: 2-[(cyclopropylcarbonyl)amino]-N-(4-phenylpyridin-3-yl)pyridine-4-carboxamide 分子名称: 2-[(cyclopropylcarbonyl)amino]-N-(4-phenylpyridin-3-yl)pyridine-4-carboxamide, Glycogen synthase kinase-3 beta 著者 Lewis, H.A, Kish, K, Luo, G, Dubowchick, G.M. 登録日 2015-12-09 公開日 2016-02-03 最終更新日 2024-03-06 実験手法 X-RAY DIFFRACTION (2.525 Å) 主引用文献 Discovery of Isonicotinamides as Highly Selective, Brain Penetrable, and Orally Active Glycogen Synthase Kinase-3 Inhibitors. J.Med.Chem., 59, 2016
3NCZ	X-Ray Co-structure of Rho-Associated Protein Kinase (ROCK1) with a potent 2H-isoquinolin-1-one inhibitor 分子名称: Rho-associated protein kinase 1, cis-4-amino-N-(7-chloro-1-oxo-1,2-dihydroisoquinolin-6-yl)cyclohexanecarboxamide 著者 Li, X. 登録日 2010-06-06 公開日 2010-12-08 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (3 Å) 主引用文献 Substituted 2H-isoquinolin-1-ones as potent Rho-kinase inhibitors: Part 2, optimization for blood pressure reduction in spontaneously hypertensive rats. Bioorg.Med.Chem.Lett., 20, 2010
3NGA	Human CK2 catalytic domain in complex with CX-4945 分子名称: 5-[(3-chlorophenyl)amino]benzo[c][2,6]naphthyridine-8-carboxylic acid, Casein kinase II subunit alpha, SULFATE ION 著者 Ferguson, A.D. 登録日 2010-06-11 公開日 2010-12-15 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (2.71 Å) 主引用文献 Structural basis of CX-4945 binding to human protein kinase CK2. Febs Lett., 585, 2011
5FG8	Drosophila CaMKII-wt in complex with a fragment of the Eag potassium channel and Mg2+/ADP 分子名称: ADENOSINE-5'-DIPHOSPHATE, Calcium/calmodulin-dependent protein kinase type II alpha chain, GLYCEROL, ... 著者 Castro-Rodrigues, A.F, Morais-Cabral, J.H. 登録日 2015-12-20 公開日 2016-12-28 最終更新日 2024-05-08 実験手法 X-RAY DIFFRACTION (1.955 Å) 主引用文献 The Interaction between the Drosophila EAG Potassium Channel and the Protein Kinase CaMKII Involves an Extensive Interface at the Active Site of the Kinase. J.Mol.Biol., 430, 2018
3NLB	Novel kinase profile highlights the temporal basis of context dependent checkpoint pathways to cell death 分子名称: 3-methyl-5-[5-(1-methylethyl)-1H-benzimidazol-2-yl]-N-(1-methylpiperidin-4-yl)-1H-pyrazole-4-carboxamide, Serine/threonine-protein kinase Chk1 著者 Massey, A.J, Borgognoni, J, Bentley, C, Foloppe, N, Fiumana, A, Walmsley, L. 登録日 2010-06-21 公開日 2011-05-18 最終更新日 2024-03-20 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Context-dependent cell cycle checkpoint abrogation by a novel kinase inhibitor Plos One, 5, 2010
3KN6	Crystal structure of the C-terminal kinase domain of MSK1 分子名称: Ribosomal protein S6 kinase alpha-5 著者 D'Angelo, I, Malakhova, M, Dong, Z. 登録日 2009-11-12 公開日 2010-04-21 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 The crystal structure of the active form of the C-terminal kinase domain of mitogen- and stress-activated protein kinase 1. J.Mol.Biol., 399, 2010
3KVX	JNK3 bound to aminopyrimidine inhibitor, SR-3562 分子名称: Mitogen-activated protein kinase 10, N-[(2Z)-4-(3-fluoro-5-morpholin-4-ylphenyl)pyrimidin-2(1H)-ylidene]-4-(3-morpholin-4-yl-1H-1,2,4-triazol-1-yl)aniline 著者 Habel, J.E, Laughlin, J.D, LoGrasso, P. 登録日 2009-11-30 公開日 2009-12-22 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Synthesis, Biological Evaluation, X-ray Structure, and Pharmacokinetics of Aminopyrimidine c-jun-N-terminal Kinase (JNK) Inhibitors J.Med.Chem., 53, 2010
3KK8	CaMKII Substrate Complex A 分子名称: Calcium/calmodulin dependent protein kinase II, MAGNESIUM ION 著者 Kuriyan, J, Chao, L.H, Pellicena, P, Deindl, S, Barclay, L.A, Schulman, H. 登録日 2009-11-04 公開日 2010-02-09 最終更新日 2021-10-13 実験手法 X-RAY DIFFRACTION (1.72 Å) 主引用文献 Intersubunit capture of regulatory segments is a component of cooperative CaMKII activation. Nat.Struct.Mol.Biol., 17, 2010
3L1S	3-Aryl-4-(arylhydrazono)-1H-pyrazol-5-ones: Highly ligand efficient and potent inhibitors of GSK3 分子名称: (4E)-4-[(4-chlorophenyl)hydrazono]-5-(3,4-dimethoxyphenyl)-2,4-dihydro-3H-pyrazol-3-one, Glycogen synthase kinase-3 beta, PHOSPHATE ION 著者 Haar, T.E. 登録日 2009-12-14 公開日 2010-03-02 最終更新日 2024-04-03 実験手法 X-RAY DIFFRACTION (2.9 Å) 主引用文献 3-Aryl-4-(arylhydrazono)-1H-pyrazol-5-ones: Highly ligand efficient and potent inhibitors of GSK3beta. Bioorg.Med.Chem.Lett., 20, 2010
3NEW	p38-alpha complexed with Compound 10 分子名称: 4-(trifluoromethyl)-3-[3-(trifluoromethyl)phenyl]-1,7-dihydro-6H-pyrazolo[3,4-b]pyridin-6-one, Mitogen-activated protein kinase 14 著者 Goedken, E.R, Comess, K.M, Sun, C, Argiriadi, M, Jia, Y, Quinn, C.M, Banach, D.L, Marcotte, D, Borhani, D. 登録日 2010-06-09 公開日 2010-12-01 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (2.51 Å) 主引用文献 Discovery and Characterization of Non-ATP Site Inhibitors of the Mitogen Activated Protein (MAP) Kinases. Acs Chem.Biol., 6, 2011
3NAX	PDK1 in complex with inhibitor MP7 分子名称: 1-(3,4-difluorobenzyl)-2-oxo-N-{(1R)-2-[(2-oxo-2,3-dihydro-1H-benzimidazol-5-yl)oxy]-1-phenylethyl}-1,2-dihydropyridine-3-carboxamide, 3-phosphoinositide-dependent protein kinase 1 著者 Yan, Y, Munshi, S.K, Allison, T. 登録日 2010-06-02 公開日 2010-11-24 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (1.75 Å) 主引用文献 Genetic and pharmacological inhibition of PDK1 in cancer cells: characterization of a selective allosteric kinase inhibitor. J.Biol.Chem., 286, 2011
3NAY	PDK1 in complex with inhibitor MP6 分子名称: 3-phosphoinositide-dependent protein kinase 1, 4-(2-cyclopropylethylidene)-9-(1H-pyrazol-4-yl)-6-{[(1R)-1,2,2-trimethylpropyl]amino}benzo[c][1,6]naphthyridin-1(4H)-one 著者 Yan, Y, Munshi, S.K, Allison, T. 登録日 2010-06-02 公開日 2010-11-24 最終更新日 2018-01-24 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 Selective inhibition of PDK1 using an allosteric kinase inhibitor and RNAi impairs cancer cell migration and anchorage-independent growth of primary tumor lines J.Biol.Chem., 2010
3NIE	Crystal Structure of PF11_0147 分子名称: MAP2 kinase, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER 著者 Wernimont, A.K, Hutchinson, A, Sullivan, H, MacKenzie, F, Kozieradzki, I, Chau, I, Lew, J, Senisterra, G, Cossar, D, Amani, M, Artz, J.D, Bochkarev, A, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Weigelt, J, Hui, R, Hills, T, Structural Genomics Consortium (SGC) 登録日 2010-06-15 公開日 2010-08-11 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Crystal Structure of PF11_0147 To be Published
3NIZ	Cryptosporidium parvum cyclin-dependent kinase cgd5_2510 with ADP bound. 分子名称: ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, Rhodanese family protein 著者 Wernimont, A.K, Dong, A, Lew, J, Lin, Y.H, Hassanali, A, Arrowsmith, C.H, Edwards, A.M, Weigelt, J, Bountra, C, Bochkarev, A, Hui, R, Artz, J.D, Structural Genomics Consortium (SGC) 登録日 2010-06-16 公開日 2010-07-28 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Cryptosporidium parvum cyclin-dependent kinase cgd5_2510 with ADP bound. To be Published

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