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3NLB

Novel kinase profile highlights the temporal basis of context dependent checkpoint pathways to cell death

Summary for 3NLB
Entry DOI10.2210/pdb3nlb/pdb
Related2C3J 2C3K 2CGU 2CGV 2CGW 2CGX
DescriptorSerine/threonine-protein kinase Chk1, 3-methyl-5-[5-(1-methylethyl)-1H-benzimidazol-2-yl]-N-(1-methylpiperidin-4-yl)-1H-pyrazole-4-carboxamide (3 entities in total)
Functional Keywordskinase domain, checkpoint kinase, atp binding, transferase, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological sourceHomo sapiens (human)
Cellular locationNucleus: O14757
Total number of polymer chains1
Total formula weight34528.64
Authors
Massey, A.J.,Borgognoni, J.,Bentley, C.,Foloppe, N.,Fiumana, A.,Walmsley, L. (deposition date: 2010-06-21, release date: 2011-05-18, Last modification date: 2024-03-20)
Primary citationMassey, A.J.,Borgognoni, J.,Bentley, C.,Foloppe, N.,Fiumana, A.,Walmsley, L.
Context-dependent cell cycle checkpoint abrogation by a novel kinase inhibitor
Plos One, 5:e13123-e13123, 2010
Cited by
PubMed: 20976184
DOI: 10.1371/journal.pone.0013123
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.9 Å)
Structure validation

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