3NLB

Novel kinase profile highlights the temporal basis of context dependent checkpoint pathways to cell death

Summary for 3NLB

Entry DOI	10.2210/pdb3nlb/pdb
Related	2C3J 2C3K 2CGU 2CGV 2CGW 2CGX
Descriptor	Serine/threonine-protein kinase Chk1, 3-methyl-5-[5-(1-methylethyl)-1H-benzimidazol-2-yl]-N-(1-methylpiperidin-4-yl)-1H-pyrazole-4-carboxamide (3 entities in total)
Functional Keywords	kinase domain, checkpoint kinase, atp binding, transferase, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological source	Homo sapiens (human)
Cellular location	Nucleus: O14757
Total number of polymer chains	1
Total formula weight	34528.64
Authors	Massey, A.J.,Borgognoni, J.,Bentley, C.,Foloppe, N.,Fiumana, A.,Walmsley, L. (deposition date: 2010-06-21, release date: 2011-05-18, Last modification date: 2024-03-20)
Primary citation	Massey, A.J.,Borgognoni, J.,Bentley, C.,Foloppe, N.,Fiumana, A.,Walmsley, L. Context-dependent cell cycle checkpoint abrogation by a novel kinase inhibitor Plos One, 5:e13123-e13123, 2010 Cited by PubMed Abstract: Checkpoint kinase 1 and 2 (Chk1/Chk2), and the Aurora kinases play a critical role in the activation of the DNA damage response and mitotic spindle checkpoints. We have identified a novel inhibitor of these kinases and utilized this molecule to probe the functional interplay between these two checkpoints. PubMed: 20976184 DOI: 10.1371/journal.pone.0013123 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.9 Å)

Structure validation