5EYM

MEK1 IN COMPLEX WITH BI 847325

Summary for 5EYM

• Entry DOI: 10.2210/pdb5eym/pdb
• Descriptor: Dual specificity mitogen-activated protein kinase kinase 1, 3-[(3~{Z})-3-[[[4-[(dimethylamino)methyl]phenyl]amino]-phenyl-methylidene]-2-oxidanylidene-1~{H}-indol-6-yl]-~{N}-ethyl-prop-2-ynamide, CALCIUM ION, ... (4 entities in total)
• Functional Keywords: kinase, inhibitor, transferase
• Biological source: Homo sapiens (Human)
• Cellular location: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome : Q02750
• Total number of polymer chains: 2
• Total formula weight: 81161.69

Authors

Bader, G.,Reiser, U.,Zahn, S.K.,Treu, M. (deposition date: 2015-11-25, release date: 2016-08-17, Last modification date: 2024-01-10)

• Primary citation: Sini, P.,Gurtler, U.,Zahn, S.K.,Baumann, C.,Rudolph, D.,Baumgartinger, R.,Strauss, E.,Haslinger, C.,Tontsch-Grunt, U.,Waizenegger, I.C.,Solca, F.,Bader, G.,Zoephel, A.,Treu, M.,Reiser, U.,Garin-Chesa, P.,Boehmelt, G.,Kraut, N.,Quant, J.,Adolf, G.R.; Pharmacological Profile of BI 847325, an Orally Bioavailable, ATP-Competitive Inhibitor of MEK and Aurora Kinases.; Mol.Cancer Ther., 15:2388-2398, 2016; PubMed: 27496137; DOI: 10.1158/1535-7163.MCT-16-0066

Experimental method

X-RAY DIFFRACTION (2.7 Å)