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5EYM

MEK1 IN COMPLEX WITH BI 847325

Functional Information from GO Data
ChainGOidnamespacecontents
A0000165biological_processMAPK cascade
A0000166molecular_functionnucleotide binding
A0000187biological_processobsolete activation of MAPK activity
A0003056biological_processregulation of vascular associated smooth muscle contraction
A0004672molecular_functionprotein kinase activity
A0004674molecular_functionprotein serine/threonine kinase activity
A0004708molecular_functionMAP kinase kinase activity
A0004712molecular_functionprotein serine/threonine/tyrosine kinase activity
A0004713molecular_functionprotein tyrosine kinase activity
A0005078molecular_functionMAP-kinase scaffold activity
A0005515molecular_functionprotein binding
A0005524molecular_functionATP binding
A0005634cellular_componentnucleus
A0005737cellular_componentcytoplasm
A0005739cellular_componentmitochondrion
A0005769cellular_componentearly endosome
A0005770cellular_componentlate endosome
A0005783cellular_componentendoplasmic reticulum
A0005794cellular_componentGolgi apparatus
A0005813cellular_componentcentrosome
A0005829cellular_componentcytosol
A0005856cellular_componentcytoskeleton
A0005874cellular_componentmicrotubule
A0005886cellular_componentplasma membrane
A0005925cellular_componentfocal adhesion
A0005938cellular_componentcell cortex
A0006468biological_processprotein phosphorylation
A0006935biological_processchemotaxis
A0006979biological_processresponse to oxidative stress
A0007165biological_processsignal transduction
A0007507biological_processheart development
A0008285biological_processnegative regulation of cell population proliferation
A0010508biological_processpositive regulation of autophagy
A0010628biological_processpositive regulation of gene expression
A0010629biological_processnegative regulation of gene expression
A0014044biological_processSchwann cell development
A0014069cellular_componentpostsynaptic density
A0016020cellular_componentmembrane
A0016301molecular_functionkinase activity
A0016740molecular_functiontransferase activity
A0019901molecular_functionprotein kinase binding
A0021697biological_processcerebellar cortex formation
A0021953biological_processcentral nervous system neuron differentiation
A0030182biological_processneuron differentiation
A0030216biological_processkeratinocyte differentiation
A0030295molecular_functionprotein kinase activator activity
A0030335biological_processpositive regulation of cell migration
A0030424cellular_componentaxon
A0030425cellular_componentdendrite
A0030878biological_processthyroid gland development
A0031267molecular_functionsmall GTPase binding
A0031435molecular_functionmitogen-activated protein kinase kinase kinase binding
A0032402biological_processmelanosome transport
A0032839cellular_componentdendrite cytoplasm
A0032872biological_processregulation of stress-activated MAPK cascade
A0032968biological_processpositive regulation of transcription elongation by RNA polymerase II
A0034111biological_processnegative regulation of homotypic cell-cell adhesion
A0035987biological_processendodermal cell differentiation
A0036064cellular_componentciliary basal body
A0038133biological_processERBB2-ERBB3 signaling pathway
A0042552biological_processmyelination
A0043204cellular_componentperikaryon
A0043410biological_processpositive regulation of MAPK cascade
A0043539molecular_functionprotein serine/threonine kinase activator activity
A0044342biological_processtype B pancreatic cell proliferation
A0044877molecular_functionprotein-containing complex binding
A0045893biological_processpositive regulation of DNA-templated transcription
A0045933biological_processpositive regulation of muscle contraction
A0046579biological_processpositive regulation of Ras protein signal transduction
A0047496biological_processvesicle transport along microtubule
A0048009biological_processinsulin-like growth factor receptor signaling pathway
A0048313biological_processGolgi inheritance
A0048471cellular_componentperinuclear region of cytoplasm
A0048538biological_processthymus development
A0048678biological_processresponse to axon injury
A0048679biological_processregulation of axon regeneration
A0048812biological_processneuron projection morphogenesis
A0048870biological_processcell motility
A0050772biological_processpositive regulation of axonogenesis
A0051384biological_processresponse to glucocorticoid
A0060020biological_processBergmann glial cell differentiation
A0060324biological_processface development
A0060425biological_processlung morphogenesis
A0060440biological_processtrachea formation
A0060502biological_processepithelial cell proliferation involved in lung morphogenesis
A0060674biological_processplacenta blood vessel development
A0060711biological_processlabyrinthine layer development
A0070328biological_processtriglyceride homeostasis
A0070371biological_processERK1 and ERK2 cascade
A0070372biological_processregulation of ERK1 and ERK2 cascade
A0070374biological_processpositive regulation of ERK1 and ERK2 cascade
A0071902biological_processpositive regulation of protein serine/threonine kinase activity
A0090170biological_processregulation of Golgi inheritance
A0090398biological_processcellular senescence
A0097110molecular_functionscaffold protein binding
A0098696biological_processregulation of neurotransmitter receptor localization to postsynaptic specialization membrane
A0098978cellular_componentglutamatergic synapse
A0106310molecular_functionprotein serine kinase activity
A1903226biological_processpositive regulation of endodermal cell differentiation
A1903298biological_processnegative regulation of hypoxia-induced intrinsic apoptotic signaling pathway
A2000641biological_processregulation of early endosome to late endosome transport
A2001171biological_processpositive regulation of ATP biosynthetic process
B0000165biological_processMAPK cascade
B0000166molecular_functionnucleotide binding
B0000187biological_processobsolete activation of MAPK activity
B0003056biological_processregulation of vascular associated smooth muscle contraction
B0004672molecular_functionprotein kinase activity
B0004674molecular_functionprotein serine/threonine kinase activity
B0004708molecular_functionMAP kinase kinase activity
B0004712molecular_functionprotein serine/threonine/tyrosine kinase activity
B0004713molecular_functionprotein tyrosine kinase activity
B0005078molecular_functionMAP-kinase scaffold activity
B0005515molecular_functionprotein binding
B0005524molecular_functionATP binding
B0005634cellular_componentnucleus
B0005737cellular_componentcytoplasm
B0005739cellular_componentmitochondrion
B0005769cellular_componentearly endosome
B0005770cellular_componentlate endosome
B0005783cellular_componentendoplasmic reticulum
B0005794cellular_componentGolgi apparatus
B0005813cellular_componentcentrosome
B0005829cellular_componentcytosol
B0005856cellular_componentcytoskeleton
B0005874cellular_componentmicrotubule
B0005886cellular_componentplasma membrane
B0005925cellular_componentfocal adhesion
B0005938cellular_componentcell cortex
B0006468biological_processprotein phosphorylation
B0006935biological_processchemotaxis
B0006979biological_processresponse to oxidative stress
B0007165biological_processsignal transduction
B0007507biological_processheart development
B0008285biological_processnegative regulation of cell population proliferation
B0010508biological_processpositive regulation of autophagy
B0010628biological_processpositive regulation of gene expression
B0010629biological_processnegative regulation of gene expression
B0014044biological_processSchwann cell development
B0014069cellular_componentpostsynaptic density
B0016020cellular_componentmembrane
B0016301molecular_functionkinase activity
B0016740molecular_functiontransferase activity
B0019901molecular_functionprotein kinase binding
B0021697biological_processcerebellar cortex formation
B0021953biological_processcentral nervous system neuron differentiation
B0030182biological_processneuron differentiation
B0030216biological_processkeratinocyte differentiation
B0030295molecular_functionprotein kinase activator activity
B0030335biological_processpositive regulation of cell migration
B0030424cellular_componentaxon
B0030425cellular_componentdendrite
B0030878biological_processthyroid gland development
B0031267molecular_functionsmall GTPase binding
B0031435molecular_functionmitogen-activated protein kinase kinase kinase binding
B0032402biological_processmelanosome transport
B0032839cellular_componentdendrite cytoplasm
B0032872biological_processregulation of stress-activated MAPK cascade
B0032968biological_processpositive regulation of transcription elongation by RNA polymerase II
B0034111biological_processnegative regulation of homotypic cell-cell adhesion
B0035987biological_processendodermal cell differentiation
B0036064cellular_componentciliary basal body
B0038133biological_processERBB2-ERBB3 signaling pathway
B0042552biological_processmyelination
B0043204cellular_componentperikaryon
B0043410biological_processpositive regulation of MAPK cascade
B0043539molecular_functionprotein serine/threonine kinase activator activity
B0044342biological_processtype B pancreatic cell proliferation
B0044877molecular_functionprotein-containing complex binding
B0045893biological_processpositive regulation of DNA-templated transcription
B0045933biological_processpositive regulation of muscle contraction
B0046579biological_processpositive regulation of Ras protein signal transduction
B0047496biological_processvesicle transport along microtubule
B0048009biological_processinsulin-like growth factor receptor signaling pathway
B0048313biological_processGolgi inheritance
B0048471cellular_componentperinuclear region of cytoplasm
B0048538biological_processthymus development
B0048678biological_processresponse to axon injury
B0048679biological_processregulation of axon regeneration
B0048812biological_processneuron projection morphogenesis
B0048870biological_processcell motility
B0050772biological_processpositive regulation of axonogenesis
B0051384biological_processresponse to glucocorticoid
B0060020biological_processBergmann glial cell differentiation
B0060324biological_processface development
B0060425biological_processlung morphogenesis
B0060440biological_processtrachea formation
B0060502biological_processepithelial cell proliferation involved in lung morphogenesis
B0060674biological_processplacenta blood vessel development
B0060711biological_processlabyrinthine layer development
B0070328biological_processtriglyceride homeostasis
B0070371biological_processERK1 and ERK2 cascade
B0070372biological_processregulation of ERK1 and ERK2 cascade
B0070374biological_processpositive regulation of ERK1 and ERK2 cascade
B0071902biological_processpositive regulation of protein serine/threonine kinase activity
B0090170biological_processregulation of Golgi inheritance
B0090398biological_processcellular senescence
B0097110molecular_functionscaffold protein binding
B0098696biological_processregulation of neurotransmitter receptor localization to postsynaptic specialization membrane
B0098978cellular_componentglutamatergic synapse
B0106310molecular_functionprotein serine kinase activity
B1903226biological_processpositive regulation of endodermal cell differentiation
B1903298biological_processnegative regulation of hypoxia-induced intrinsic apoptotic signaling pathway
B2000641biological_processregulation of early endosome to late endosome transport
B2001171biological_processpositive regulation of ATP biosynthetic process
Functional Information from PDB Data
site_idAC1
Number of Residues11
Detailsbinding site for residue 5U5 A 401
ChainResidue
ALEU74
ALEU197
ACYS207
AALA95
ALYS97
AMET143
AGLU144
AHIS145
AMET146
AGLY149
AGLN153

site_idAC2
Number of Residues3
Detailsbinding site for residue CA A 402
ChainResidue
AASP65
AHOH501
BASP66

site_idAC3
Number of Residues6
Detailsbinding site for residue CA A 403
ChainResidue
AASP65
AASP66
AHOH507
BASP65
BASP66
BHOH503

site_idAC4
Number of Residues4
Detailsbinding site for residue CA A 404
ChainResidue
AASP66
BASP65
BHOH502
BHOH507

site_idAC5
Number of Residues12
Detailsbinding site for residue 5U5 B 401
ChainResidue
BLEU74
BGLY75
BVAL82
BALA95
BLYS97
BMET143
BGLU144
BHIS145
BMET146
BGLN153
BLEU197
BCYS207

Functional Information from PROSITE/UniProt
site_idPS00107
Number of Residues24
DetailsPROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. LGAGNGGVVFkVshkpsglv..........MARK
ChainResidueDetails
ALEU74-LYS97

site_idPS00108
Number of Residues13
DetailsPROTEIN_KINASE_ST Serine/Threonine protein kinases active-site signature. ImHrDVKpsNILV
ChainResidueDetails
AILE186-VAL198

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues2
DetailsActive site: {"description":"Proton acceptor","evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"},{"source":"PROSITE-ProRule","id":"PRU10027","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

site_idSWS_FT_FI2
Number of Residues8
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"19161339","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3EQH","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

site_idSWS_FT_FI3
Number of Residues20
DetailsBinding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"15543157","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17880056","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18951019","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19019675","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19706763","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"21310613","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

site_idSWS_FT_FI4
Number of Residues6
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"19161339","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3EQF","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

site_idSWS_FT_FI5
Number of Residues2
DetailsModified residue: {"description":"Phosphoserine; by BRAF and RAF1","evidences":[{"source":"PubMed","id":"10409742","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20956560","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"29433126","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"8131746","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

238895

PDB entries from 2025-07-16

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