5EYM
MEK1 IN COMPLEX WITH BI 847325
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Dual specificity mitogen-activated protein kinase kinase 1 | polymer | 359 | 40056.2 | 2 | UniProt (Q02750) Pfam (PF00069) | Homo sapiens (Human) | MKK1,ERK activator kinase 1,MAPK/ERK kinase 1,MEK 1 |
| 2 | C, G (A, B) | 3-[(3~{Z})-3-[[[4-[(dimethylamino)methyl]phenyl]amino]-phenyl-methylidene]-2-oxidanylidene-1~{H}-indol-6-yl]-~{N}-ethyl-prop-2-ynamide | non-polymer | 464.6 | 2 | Chemie (5U5) | |||
| 3 | D, E, F (A) | CALCIUM ION | non-polymer | 40.1 | 3 | Chemie (CA) | |||
| 4 | H, I (A, B) | water | water | 18.0 | 17 | Chemie (HOH) |
Sequence modifications
A, B: 35 - 393 (UniProt: Q02750)
| PDB | External Database | Details |
|---|---|---|
| Asn 298 | Ser 298 | engineered mutation |
| Lys 299 | Ser 299 | engineered mutation |
| Phe 300 | Tyr 300 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 80112.3 | |
| Non-Polymers* | Number of molecules | 5 |
| Total formula weight | 1049.3 | |
| All* | Total formula weight | 81161.7 |
