PDB: 222624 件ウェブページステータス検索Chemie searchBIRD

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8W15	HTT in complex with HAP40 in the apo state. 分子名称: 40-kDa huntingtin-associated protein, Huntingtin 著者 Poweleit, N, Boudet, J, Doherty, E. 登録日 2024-02-15 公開日 2024-03-13 実験手法 ELECTRON MICROSCOPY (2.72 Å) 主引用文献 Discovery of a Small Molecule Ligand to the Huntingtin/HAP40 complex To Be Published
8W12	Cryo-EM structure of VP3-VP6 heterohexamer 分子名称: Core protein VP3, VP6 著者 Xia, X, Sung, P.Y, Martynowycz, M.W, Gonen, T, Roy, P, Zhou, Z.H. 登録日 2024-02-14 公開日 2024-04-24 最終更新日 2024-05-08 実験手法 ELECTRON MICROSCOPY (3.5 Å) 主引用文献 RNA genome packaging and capsid assembly of bluetongue virus visualized in host cells. Cell, 187, 2024
8W0Z	Human LCAD complexed with Lauric Acid 分子名称: FLAVIN-ADENINE DINUCLEOTIDE, LAURIC ACID, Long-chain specific acyl-CoA dehydrogenase, ... 著者 Xia, C, Kim, J.J.P. 登録日 2024-02-14 公開日 2024-06-19 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Structural basis for expanded substrate specificities of human long chain acyl-CoA dehydrogenase and related acyl-CoA dehydrogenases. Sci Rep, 14, 2024
8W0Y	Crystal structure of broadly neutralizing antibody hcab17 in complex with Hepatitis C virus envelope glycoprotein E2 ectodomain 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Envelope glycoprotein E2, ... 著者 Flyak, A.I, Wilcox, X.E. 登録日 2024-02-14 公開日 2024-03-27 最終更新日 2024-04-17 実験手法 X-RAY DIFFRACTION (3.31 Å) 主引用文献 Convergent evolution and targeting of diverse E2 epitopes by human broadly neutralizing antibodies are associated with HCV clearance. Immunity, 57, 2024
8W0X	Crystal structure of broadly neutralizing antibody hcab40 in complex with Hepatitis C virus envelope glycoprotein E2 ectodomain 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Envelope glycoprotein E2, ... 著者 Flyak, A.I, Wilcox, X.E. 登録日 2024-02-14 公開日 2024-03-27 最終更新日 2024-04-17 実験手法 X-RAY DIFFRACTION (3.12 Å) 主引用文献 Convergent evolution and targeting of diverse E2 epitopes by human broadly neutralizing antibodies are associated with HCV clearance. Immunity, 57, 2024
8W0W	Crystal structure of broadly neutralizing antibody hcab64 in complex with Hepatitis C virus envelope glycoprotein E2 ectodomain 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Envelope glycoprotein E2, ... 著者 Flyak, A.I, Wilcox, X.E. 登録日 2024-02-14 公開日 2024-03-27 最終更新日 2024-04-17 実験手法 X-RAY DIFFRACTION (2.13 Å) 主引用文献 Convergent evolution and targeting of diverse E2 epitopes by human broadly neutralizing antibodies are associated with HCV clearance. Immunity, 57, 2024
8W0V	Crystal structure of broadly neutralizing antibody hcab55 in complex with Hepatitis C virus envelope glycoprotein E2 ectodomain 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Envelope glycoprotein E2, ... 著者 Flyak, A.I, Wilcox, X.E. 登録日 2024-02-14 公開日 2024-03-27 最終更新日 2024-04-17 実験手法 X-RAY DIFFRACTION (2.59 Å) 主引用文献 Convergent evolution and targeting of diverse E2 epitopes by human broadly neutralizing antibodies are associated with HCV clearance. Immunity, 57, 2024
8W0U	Human LCAD complexed with Acetoacetyl Coenzyme A 分子名称: ACETOACETYL-COENZYME A, FLAVIN-ADENINE DINUCLEOTIDE, Long-chain specific acyl-CoA dehydrogenase, ... 著者 Xia, C, Kim, J.J.P. 登録日 2024-02-14 公開日 2024-06-19 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 Structural basis for expanded substrate specificities of human long chain acyl-CoA dehydrogenase and related acyl-CoA dehydrogenases. Sci Rep, 14, 2024
8W0T	Human LCAD 分子名称: FLAVIN-ADENINE DINUCLEOTIDE, Long-chain specific acyl-CoA dehydrogenase, mitochondrial 著者 Xia, C, Kim, J.J.P. 登録日 2024-02-14 公開日 2024-06-19 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Structural basis for expanded substrate specificities of human long chain acyl-CoA dehydrogenase and related acyl-CoA dehydrogenases. Sci Rep, 14, 2024
8W0S	Human EBP complexed with compound 3a 分子名称: 1-methyl-8-[(oxan-4-yl)methyl]-3-[4-(trifluoromethyl)phenyl]-1,3,8-triazaspiro[4.5]decane-2,4-dione, 3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase 著者 Sun, D, Masureel, M. 登録日 2024-02-14 公開日 2024-06-19 実験手法 ELECTRON MICROSCOPY (2.8 Å) 主引用文献 Discovery and Optimization of Selective Brain-Penetrant EBP Inhibitors that Enhance Oligodendrocyte Formation. J.Med.Chem., 67, 2024
8W0R	Human EBP complexed with compound 1 分子名称: 1-methyl-1'-[(oxan-4-yl)methyl]-5-(trifluoromethyl)spiro[indole-2,4'-piperidin]-3(1H)-one, 3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase 著者 Sun, D, Masureel, M. 登録日 2024-02-14 公開日 2024-06-19 実験手法 ELECTRON MICROSCOPY (2.8 Å) 主引用文献 Discovery and Optimization of Selective Brain-Penetrant EBP Inhibitors that Enhance Oligodendrocyte Formation. J.Med.Chem., 67, 2024
8W0Q	Pembrolizumab CDR-H3 Loop Mimic 分子名称: Pembrolizumab CDR-H3 Loop Mimic 著者 Feig, M, Roche, S.P. 登録日 2024-02-14 公開日 2024-07-03 最終更新日 2024-07-10 実験手法 SOLUTION NMR 主引用文献 De Novo Synthesis and Structural Elucidation of CDR-H3 Loop Mimics. Acs Chem.Biol., 2024
8W0M	Crystal structure of Acetyl-CoA synthetase 2 from Candida albicans in complex with a Acetyl Sulfamate AMP ester inhibitor 分子名称: 5'-O-(acetylsulfamoyl)adenosine, Acetyl-coenzyme A synthetase 2 著者 Seattle Structural Genomics Center for Infectious Disease, Seattle Structural Genomics Center for Infectious Disease (SSGCID) 登録日 2024-02-13 公開日 2024-02-21 実験手法 X-RAY DIFFRACTION (3.1 Å) 主引用文献 Crystal structure of Acetyl-CoA synthetase 2 from Candida albicans in complex with a Acetyl Sulfamate AMP ester inhibitor To be published
8W0L	Crystal structure of Acetyl-CoA synthetase 2 from Candida albicans in complex with a propyne AMP ester inhibitor and CoA 分子名称: 5'-O-{(S)-hydroxy[(prop-2-yn-1-yl)oxy]phosphoryl}adenosine, Acetyl-coenzyme A synthetase 2, CHLORIDE ION, ... 著者 Seattle Structural Genomics Center for Infectious Disease, Seattle Structural Genomics Center for Infectious Disease (SSGCID) 登録日 2024-02-13 公開日 2024-02-21 実験手法 X-RAY DIFFRACTION (2.75 Å) 主引用文献 Crystal structure of Acetyl-CoA synthetase 2 from Candida albicans in complex with a propyne AMP ester inhibitor and CoA To be published
8W0K	Minimal PutA proline dehydrogenase domain (design #2) complexed with 1-hydroxyethane-1-sulfonate 分子名称: (1R)-1-hydroxyethane-1-sulfonic acid, Bifunctional protein PutA fusion protein, FLAVIN-ADENINE DINUCLEOTIDE 著者 Tanner, J.J, Meeks, K.R. 登録日 2024-02-13 公開日 2024-07-03 実験手法 X-RAY DIFFRACTION (1.42 Å) 主引用文献 Screening a knowledge-based library of low molecular weight compounds against the proline biosynthetic enzyme 1-pyrroline-5-carboxylate 1 (PYCR1) Protein Sci., 33, 2024
8W0J	Crystal structure of Acetyl-CoA synthetase 2 from Candida albicans in complex with a propyne AMP ester inhibitor 分子名称: 5'-O-{(S)-hydroxy[(prop-2-yn-1-yl)oxy]phosphoryl}adenosine, Acetyl-coenzyme A synthetase 2, CHLORIDE ION, ... 著者 Seattle Structural Genomics Center for Infectious Disease, Seattle Structural Genomics Center for Infectious Disease (SSGCID) 登録日 2024-02-13 公開日 2024-02-21 実験手法 X-RAY DIFFRACTION (2.85 Å) 主引用文献 Crystal structure of Acetyl-CoA synthetase 2 from Candida albicans in complex with a propyne AMP ester inhibitor To be published
8W0H	Crystal structure of Acetyl-CoA synthetase 2 from Candida albicans in complex with an isopropyl AMP ester inhibitor (trigonal form) 分子名称: 5'-O-{(R)-hydroxy[(propan-2-yl)oxy]phosphoryl}adenosine, Acetyl-coenzyme A synthetase 2, CHLORIDE ION, ... 著者 Seattle Structural Genomics Center for Infectious Disease, Seattle Structural Genomics Center for Infectious Disease (SSGCID) 登録日 2024-02-13 公開日 2024-02-21 実験手法 X-RAY DIFFRACTION (2.95 Å) 主引用文献 Crystal structure of Acetyl-CoA synthetase 2 from Candida albicans in complex with an isopropyl AMP ester inhibitor (trigonal form) To be published
8W0D	Crystal structure of Acetyl-CoA synthetase 2 from Candida albicans in complex with an isopropyl AMP ester inhibitor 分子名称: 5'-O-{(R)-hydroxy[(propan-2-yl)oxy]phosphoryl}adenosine, Acetyl-coenzyme A synthetase 2, CHLORIDE ION, ... 著者 Seattle Structural Genomics Center for Infectious Disease, Seattle Structural Genomics Center for Infectious Disease (SSGCID) 登録日 2024-02-13 公開日 2024-02-21 実験手法 X-RAY DIFFRACTION (2.7 Å) 主引用文献 Crystal structure of Acetyl-CoA synthetase 2 from Candida albicans in complex with an isopropyl AMP ester inhibitor To be published
8W0C	Crystal structure of Acetyl-CoA synthetase 2 from Candida albicans in complex with a cyclopentyl ester AMP inhibitor 分子名称: 5'-O-[(S)-(cyclopentyloxy)(hydroxy)phosphoryl]adenosine, Acetyl-coenzyme A synthetase 2, CHLORIDE ION, ... 著者 Seattle Structural Genomics Center for Infectious Disease, Seattle Structural Genomics Center for Infectious Disease (SSGCID) 登録日 2024-02-13 公開日 2024-02-21 実験手法 X-RAY DIFFRACTION (2.35 Å) 主引用文献 Crystal structure of Acetyl-CoA synthetase 2 from Candida albicans in complex with a cyclopentyl ester AMP inhibitor To be published
8W0B	Crystal structure of Acetyl-CoA synthetase 2 from Candida albicans in complex with a cyclopropyl AMP ester inhibitor 分子名称: 5'-O-[(R)-(cyclopropyloxy)(hydroxy)phosphoryl]adenosine, Acetyl-coenzyme A synthetase 2, GLYCEROL, ... 著者 Seattle Structural Genomics Center for Infectious Disease, Seattle Structural Genomics Center for Infectious Disease (SSGCID) 登録日 2024-02-13 公開日 2024-02-21 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Crystal structure of Acetyl-CoA synthetase 2 from Candida albicans in complex with a cyclopropyl AMP ester inhibitor To be published
8W0A	Human DNA polymerase theta helicase domain in complex with ssDNA, dimer form 分子名称: DNA (5'-D(P*TP*TP*TP*TP*TP*TP*T)-3'), DNA polymerase theta 著者 Ito, F, Li, Z, Chen, X.S. 登録日 2024-02-13 公開日 2024-06-26 実験手法 ELECTRON MICROSCOPY (3.2 Å) 主引用文献 Structural Basis for Pol theta-Helicase DNA Binding and Microhomology-Mediated End-Joining. Biorxiv, 2024
8W09	HIV-1 wild-type intasome core 分子名称: (4R,12aS)-N-(2,4-difluorobenzyl)-7-hydroxy-4-methyl-6,8-dioxo-3,4,6,8,12,12a-hexahydro-2H-pyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazine-9-carboxamide, Integrase, MAGNESIUM ION, ... 著者 Li, M, Craigie, R. 登録日 2024-02-13 公開日 2024-04-17 最終更新日 2024-04-24 実験手法 ELECTRON MICROSCOPY (3.2 Å) 主引用文献 HIV-1 Integrase Assembles Multiple Species of Stable Synaptic Complex Intasomes That Are Active for Concerted DNA Integration In vitro. J.Mol.Biol., 436, 2024
8W07	Crystal Structure of the ER-alpha Ligand-binding Domain (L372S, L536S) in complex with k-402 分子名称: (1R,2S,4R)-N-cyclohexyl-5,6-bis(4-hydroxyphenyl)-N-(4-methoxyphenyl)-7-oxabicyclo[2.2.1]hept-5-ene-2-sulfonamide, (1S,2R,4S)-N-cyclohexyl-5,6-bis(4-hydroxyphenyl)-N-(4-methoxyphenyl)-7-oxabicyclo[2.2.1]hept-5-ene-2-sulfonamide, Estrogen receptor 著者 Min, C.K, Nwachukwu, J.C, Hou, Y, Russo, R.J, Papa, A, Min, J, Peng, R, Kim, S.H, Ziegler, Y, Rangarajan, E.S, Izard, T, Katzenellenbogen, B.S, Katzenellenbogen, J.K, Nettles, K.W. 登録日 2024-02-13 公開日 2024-06-12 実験手法 X-RAY DIFFRACTION (1.83 Å) 主引用文献 Asymmetric allostery in estrogen receptor-alpha homodimers drives responses to the ensemble of estrogens in the hormonal milieu. Proc.Natl.Acad.Sci.USA, 121, 2024
8W04	Crystal structure of DUF1735-domain containing protein (GH18-like) from Bacteroides faecium at 2.9 A resolution (Space group P21) 分子名称: DUF1735 domain-containing protein 著者 Sastre, D.E, Navarro, M.V.A.S, Sultana, N, Sundberg, E.J. 登録日 2024-02-13 公開日 2024-05-29 最終更新日 2024-06-26 実験手法 X-RAY DIFFRACTION (2.91 Å) 主引用文献 Human gut microbes express functionally distinct endoglycosidases to metabolize the same N-glycan substrate. Nat Commun, 15, 2024
8W03	Crystal Structure of the ER-alpha Ligand-binding Domain (L372S, L536S) in complex with k-1154 分子名称: (1S,2R,4S)-N-(4-chlorophenyl)-5,6-bis(4-hydroxyphenyl)-N-(2,2,2-trifluoroethyl)-7-oxabicyclo[2.2.1]hept-5-ene-2-sulfonamide, Estrogen receptor 著者 Min, C.K, Nwachukwu, J.C, Hou, Y, Russo, R.J, Papa, A, Min, J, Peng, R, Kim, S.H, Ziegler, Y, Rangarajan, E.S, Izard, T, Katzenellenbogen, B.S, Katzenellenbogen, J.A, Nettles, K.W. 登録日 2024-02-13 公開日 2024-06-12 実験手法 X-RAY DIFFRACTION (1.68 Å) 主引用文献 Asymmetric allostery in estrogen receptor-alpha homodimers drives responses to the ensemble of estrogens in the hormonal milieu. Proc.Natl.Acad.Sci.USA, 121, 2024

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