8W03

Crystal Structure of the ER-alpha Ligand-binding Domain (L372S, L536S) in complex with k-1154

Summary for 8W03

Entry DOI	10.2210/pdb8w03/pdb
Descriptor	Estrogen receptor, (1S,2R,4S)-N-(4-chlorophenyl)-5,6-bis(4-hydroxyphenyl)-N-(2,2,2-trifluoroethyl)-7-oxabicyclo[2.2.1]hept-5-ene-2-sulfonamide (3 entities in total)
Functional Keywords	estrogen receptor, nuclear protein
Biological source	Homo sapiens (human)
Total number of polymer chains	4
Total formula weight	112681.56
Authors	Min, C.K.,Nwachukwu, J.C.,Hou, Y.,Russo, R.J.,Papa, A.,Min, J.,Peng, R.,Kim, S.H.,Ziegler, Y.,Rangarajan, E.S.,Izard, T.,Katzenellenbogen, B.S.,Katzenellenbogen, J.A.,Nettles, K.W. (deposition date: 2024-02-13, release date: 2024-06-12)
Primary citation	Min, C.K.,Nwachukwu, J.C.,Hou, Y.,Russo, R.J.,Papa, A.,Min, J.,Peng, R.,Kim, S.H.,Ziegler, Y.,Rangarajan, E.S.,Izard, T.,Katzenellenbogen, B.S.,Katzenellenbogen, J.A.,Nettles, K.W. Asymmetric allostery in estrogen receptor-alpha homodimers drives responses to the ensemble of estrogens in the hormonal milieu. Proc.Natl.Acad.Sci.USA, 121:e2321344121-e2321344121, 2024 Cited by PubMed: 38830107 DOI: 10.1073/pnas.2321344121 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.68 Å)

Structure validation