8W03
Crystal Structure of the ER-alpha Ligand-binding Domain (L372S, L536S) in complex with k-1154
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, B, C, D) | Estrogen receptor | polymer | 242 | 27618.4 | 4 | UniProt (P03372) Pfam (PF00104) | Homo sapiens (human) | ER,ER-alpha,Estradiol receptor,Nuclear receptor subfamily 3 group A member 1 |
| 2 | E, F, G, H (A, B, C, D) | (1S,2R,4S)-N-(4-chlorophenyl)-5,6-bis(4-hydroxyphenyl)-N-(2,2,2-trifluoroethyl)-7-oxabicyclo[2.2.1]hept-5-ene-2-sulfonamide | non-polymer | 552.0 | 4 | Chemie (OBT) | |||
| 3 | I, J, K, L (A, B, C, D) | water | water | 18.0 | 412 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 305 - 546 (UniProt: P03372)
| PDB | External Database | Details |
|---|---|---|
| Ser 372 | Leu 372 | engineered mutation |
| Ser 536 | Leu 536 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 110473.7 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 2207.8 | |
| All* | Total formula weight | 112681.6 |
