8W0X

Crystal structure of broadly neutralizing antibody hcab40 in complex with Hepatitis C virus envelope glycoprotein E2 ectodomain

Summary for 8W0X

Entry DOI	10.2210/pdb8w0x/pdb
Descriptor	Envelope glycoprotein E2, hcab40 Fab Heavy Chain, hcab40 Fab Light Chain, ... (9 entities in total)
Functional Keywords	hcv glycoprotein, broadly neutralizing antibodies, immune system, immune system-viral protein complex, immune system/viral protein
Biological source	Hepacivirus hominis More
Total number of polymer chains	3
Total formula weight	83721.46
Authors	Flyak, A.I.,Wilcox, X.E. (deposition date: 2024-02-14, release date: 2024-03-27, Last modification date: 2024-04-17)
Primary citation	Ogega, C.O.,Skinner, N.E.,Schoenle, M.V.,Wilcox, X.E.,Frumento, N.,Wright, D.A.,Paul, H.T.,Sinnis-Bourozikas, A.,Clark, K.E.,Figueroa, A.,Bjorkman, P.J.,Ray, S.C.,Flyak, A.I.,Bailey, J.R. Convergent evolution and targeting of diverse E2 epitopes by human broadly neutralizing antibodies are associated with HCV clearance. Immunity, 57:890-903.e6, 2024 Cited by PubMed: 38518779 DOI: 10.1016/j.immuni.2024.03.001 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3.12 Å)

Structure validation