8W07
Crystal Structure of the ER-alpha Ligand-binding Domain (L372S, L536S) in complex with k-402
This is a non-PDB format compatible entry.
Summary for 8W07
Entry DOI | 10.2210/pdb8w07/pdb |
Descriptor | Estrogen receptor, (1R,2S,4R)-N-cyclohexyl-5,6-bis(4-hydroxyphenyl)-N-(4-methoxyphenyl)-7-oxabicyclo[2.2.1]hept-5-ene-2-sulfonamide, (1S,2R,4S)-N-cyclohexyl-5,6-bis(4-hydroxyphenyl)-N-(4-methoxyphenyl)-7-oxabicyclo[2.2.1]hept-5-ene-2-sulfonamide, ... (4 entities in total) |
Functional Keywords | estrogen receptor alpha, nuclear protein |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 4 |
Total formula weight | 112436.16 |
Authors | Min, C.K.,Nwachukwu, J.C.,Hou, Y.,Russo, R.J.,Papa, A.,Min, J.,Peng, R.,Kim, S.H.,Ziegler, Y.,Rangarajan, E.S.,Izard, T.,Katzenellenbogen, B.S.,Katzenellenbogen, J.K.,Nettles, K.W. (deposition date: 2024-02-13, release date: 2024-06-12) |
Primary citation | Min, C.K.,Nwachukwu, J.C.,Hou, Y.,Russo, R.J.,Papa, A.,Min, J.,Peng, R.,Kim, S.H.,Ziegler, Y.,Rangarajan, E.S.,Izard, T.,Katzenellenbogen, B.S.,Katzenellenbogen, J.A.,Nettles, K.W. Asymmetric allostery in estrogen receptor-alpha homodimers drives responses to the ensemble of estrogens in the hormonal milieu. Proc.Natl.Acad.Sci.USA, 121:e2321344121-e2321344121, 2024 Cited by PubMed: 38830107DOI: 10.1073/pnas.2321344121 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.83 Å) |
Structure validation
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