8W07
Crystal Structure of the ER-alpha Ligand-binding Domain (L372S, L536S) in complex with k-402
This is a non-PDB format compatible entry.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, B, C, D) | Estrogen receptor | polymer | 242 | 27561.4 | 4 | UniProt (P03372) Pfam (PF00104) | Homo sapiens (human) | ER,ER-alpha,Estradiol receptor,Nuclear receptor subfamily 3 group A member 1 |
| 2 | E (A) | (1R,2S,4R)-N-cyclohexyl-5,6-bis(4-hydroxyphenyl)-N-(4-methoxyphenyl)-7-oxabicyclo[2.2.1]hept-5-ene-2-sulfonamide | non-polymer | 547.7 | 1 | Chemie (A1AHY) | |||
| 3 | F, G, H (B, C, D) | (1S,2R,4S)-N-cyclohexyl-5,6-bis(4-hydroxyphenyl)-N-(4-methoxyphenyl)-7-oxabicyclo[2.2.1]hept-5-ene-2-sulfonamide | non-polymer | 547.7 | 3 | Chemie (A1AHZ) | |||
| 4 | I, J, K, L (A, B, C, D) | water | water | 18.0 | 330 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 305 - 546 (UniProt: P03372)
| PDB | External Database | Details |
|---|---|---|
| Ser 372 | Leu 372 | engineered mutation |
| Ser 536 | Leu 536 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 110245.5 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 2190.6 | |
| All* | Total formula weight | 112436.2 |
