PDB: 46200 件ウェブページステータス検索Chemie searchBIRD

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7KIB	PRMT5:MEP50 Complexed with 5,5-Bicyclic Inhibitor Compound 4 分子名称: (2R,3R,3aS,6S,6aR)-6-[(2-amino-3-bromoquinolin-7-yl)oxy]-2-(4-amino-7H-pyrrolo[2,3-d]pyrimidin-7-yl)hexahydro-3aH-cyclopenta[b]furan-3,3a-diol, 1,2-ETHANEDIOL, CHLORIDE ION, ... 著者 Palte, R.L, Hayes, R.P. 登録日 2020-10-23 公開日 2021-04-21 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (2.52 Å) 主引用文献 The Discovery of Two Novel Classes of 5,5-Bicyclic Nucleoside-Derived PRMT5 Inhibitors for the Treatment of Cancer. J.Med.Chem., 64, 2021
7BV7	INTS3 complexed with INTS6 分子名称: Integrator complex subunit 3, Integrator complex subunit 6 著者 Jia, Y, Bharath, S.R, Song, H. 登録日 2020-04-09 公開日 2021-07-14 最終更新日 2024-05-29 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Crystal structure of the INTS3/INTS6 complex reveals the functional importance of INTS3 dimerization in DSB repair. Cell Discov, 7, 2021
6Y6X	Tetracenomycin X bound to the human ribosome 分子名称: 28S ribosomal RNA, 5.8S ribosomal RNA, 5S ribosomal RNA, ... 著者 Buschauer, R, Cheng, J, Berninghausen, O, Beckmann, R, Wilson, D.N. 登録日 2020-02-27 公開日 2020-07-08 最終更新日 2023-11-08 実験手法 ELECTRON MICROSCOPY (2.8 Å) 主引用文献 Tetracenomycin X inhibits translation by binding within the ribosomal exit tunnel. Nat.Chem.Biol., 16, 2020
6NT5	Cryo-EM structure of full-length human STING in the apo state 分子名称: Stimulator of interferon protein 著者 Shang, G, Zhang, C, Chen, Z.J, Bai, X, Zhang, X. 登録日 2019-01-28 公開日 2019-03-06 最終更新日 2024-03-20 実験手法 ELECTRON MICROSCOPY (4.1 Å) 主引用文献 Cryo-EM structures of STING reveal its mechanism of activation by cyclic GMP-AMP. Nature, 567, 2019
6YVV	Condensin complex from S.cerevisiae ATP-free apo bridged state 分子名称: Condensin complex subunit 1,Ycs4, Condensin complex subunit 2,Brn1, Structural maintenance of chromosomes protein 2,Structural maintenance of chromosomes protein 2, ... 著者 Lee, B.-G, Cawood, C, Gutierrez-Escribano, P, Nakane, T, Merkel, F, Hassler, M, Haering, C.H, Aragon, L, Lowe, J. 登録日 2020-04-28 公開日 2020-07-15 最終更新日 2024-05-22 実験手法 ELECTRON MICROSCOPY (7.5 Å) 主引用文献 Cryo-EM structures of holo condensin reveal a subunit flip-flop mechanism. Nat.Struct.Mol.Biol., 27, 2020
8QH5	CryoEM structure of UVSSA(VHS)-CSA-DDB1-DDA1 分子名称: DET1- and DDB1-associated protein 1, DNA damage-binding protein 1, DNA excision repair protein ERCC-8, ... 著者 Lee, S.-H, Sixma, T.K. 登録日 2023-09-06 公開日 2024-08-14 実験手法 ELECTRON MICROSCOPY (3.4 Å) 主引用文献 CryoEM structure of UVSSA(VHS)-CSA-DDB1-DDA1 To Be Published
6N2G	Crystal structure of Caenorhabditis elegans NAP1 分子名称: Nucleosome Assembly Protein 著者 Bhattacharyya, S, DArcy, S. 登録日 2018-11-13 公開日 2019-01-30 最終更新日 2024-03-13 実験手法 X-RAY DIFFRACTION (3.003 Å) 主引用文献 Characterization of Caenorhabditis elegans Nucleosome Assembly Protein 1 Uncovers the Role of Acidic Tails in Histone Binding. Biochemistry, 58, 2019
2E1N	Crystal structure of the Cyanobacterium circadian clock modifier Pex 分子名称: Pex, SULFATE ION 著者 Arita, K, Shimizu, T. 登録日 2006-10-26 公開日 2006-11-28 最終更新日 2024-03-13 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Structural and Biochemical Characterization of a Cyanobacterium Circadian Clock-modifier Protein J.Biol.Chem., 282, 2007
1H56	Structural and biochemical characterization of a new magnesium ion binding site near Tyr94 in the restriction endonuclease PvuII 分子名称: MAGNESIUM ION, TYPE II RESTRICTION ENZYME PVUII 著者 Spyrida, A, Matzen, C, Lanio, T, Jeltsch, A, Simoncsits, A, Athanasiadis, A, Scheuring-Vanamee, E, Kokkinidis, M, Pingoud, A. 登録日 2001-05-20 公開日 2003-08-07 最終更新日 2023-12-13 実験手法 X-RAY DIFFRACTION (3 Å) 主引用文献 Structural and Biochemical Characterization of a New Mg(2+) Binding Site Near Tyr94 in the Restriction Endonuclease PvuII. J.Mol.Biol., 331, 2003
2GKD	Structural insight into self-sacrifice mechanism of enediyne resistance 分子名称: 5'-D(*CP*TP*AP*TP*CP*AP*TP*AP*TP*GP*C)-3', 5'-D(*GP*CP*AP*TP*AP*TP*GP*AP*TP*AP*G)-3', CalC 著者 Singh, S, Thorson, J.S. 登録日 2006-04-01 公開日 2006-08-22 最終更新日 2024-05-29 実験手法 SOLUTION NMR 主引用文献 Structural insight into the self-sacrifice mechanism of enediyne resistance. Acs Chem.Biol., 1, 2006
1GRJ	GREA TRANSCRIPT CLEAVAGE FACTOR FROM ESCHERICHIA COLI 分子名称: GREA PROTEIN 著者 Darst, S.A, Stebbins, C.E. 登録日 1995-05-02 公開日 1995-07-10 最終更新日 2024-02-07 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Crystal structure of the GreA transcript cleavage factor from Escherichia coli. Nature, 373, 1995
2F3X	Crystal structure of FapR (in complex with effector)- a global regulator of fatty acid biosynthesis in B. subtilis 分子名称: MALONYL-COENZYME A, Transcription factor fapR 著者 Buschiazzo, A, Guerin, M.E, Alzari, P.M. 登録日 2005-11-22 公開日 2006-10-31 最終更新日 2024-02-14 実験手法 X-RAY DIFFRACTION (3.1 Å) 主引用文献 Structural basis of lipid biosynthesis regulation in Gram-positive bacteria. Embo J., 25, 2006
4X23	CRYSTAL STRUCTURE OF CENP-C IN COMPLEX WITH THE NUCLEOSOME CORE PARTICLE 分子名称: CENP-C, DNA (147-MER), Histone H2A, ... 著者 Jiang, J.S. 登録日 2014-11-25 公開日 2014-12-10 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (3.5 Å) 主引用文献 A conserved mechanism for centromeric nucleosome recognition by centromere protein CENP-C. Science, 340, 2013
9J1S	Human replication protein A: RPA70 subunit N-terminal domain 分子名称: Replication protein A 70 kDa DNA-binding subunit 著者 Chakraborty, M, Ganguly, S.S, Das, A.K, Ganguly, A. 登録日 2024-08-05 公開日 2024-10-09 実験手法 X-RAY DIFFRACTION (1.55 Å) 主引用文献 Human replication protein A: RPA70 subunit N-terminal domain To Be Published
4XLG	C. glabrata Slx1 in complex with Slx4CCD. 分子名称: CHLORIDE ION, Structure-specific endonuclease subunit SLX1, Structure-specific endonuclease subunit SLX4, ... 著者 Gaur, V, Wyatt, H.D.M, Komorowska, W, Szczepanowski, R.H, de Sanctis, D, Gorecka, K.M, West, S.C, Nowotny, M. 登録日 2015-01-13 公開日 2015-03-25 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (1.78 Å) 主引用文献 Structural and Mechanistic Analysis of the Slx1-Slx4 Endonuclease. Cell Rep, 10, 2015
8UN9	Crystal structure of the MrfB exonuclease catalytic core 分子名称: Exonuclease MrfB, MAGNESIUM ION 著者 Manthei, K.A, Nandakumar, J, Simmons, L.A. 登録日 2023-10-18 公開日 2024-05-01 最終更新日 2024-07-03 実験手法 X-RAY DIFFRACTION (2.103 Å) 主引用文献 Structural and biochemical characterization of the mitomycin C repair exonuclease MrfB. Nucleic Acids Res., 52, 2024
2HTJ	NMR structure of E.coli PapI 分子名称: P fimbrial regulatory protein KS71A 著者 Kawamura, T, Zhou, H, Le, L.U.K, Dahlquist, F.W. 登録日 2006-07-25 公開日 2007-01-30 最終更新日 2024-05-29 実験手法 SOLUTION NMR 主引用文献 Solution Structure of Escherichia coli PapI, a Key Regulator of the Pap Pili Phase Variation. J.Mol.Biol., 365, 2007
8TK0	Structure of Gabija AB complex 分子名称: Endonuclease GajA 著者 Shen, Z.F, Yang, X.Y, Fu, T.M. 登録日 2023-07-24 公開日 2024-04-24 最終更新日 2024-09-04 実験手法 ELECTRON MICROSCOPY (3.23 Å) 主引用文献 Molecular basis of Gabija anti-phage supramolecular assemblies. Nat.Struct.Mol.Biol., 31, 2024
4O5V	Crystal structure of T. acidophilum IdeR 分子名称: FE (II) ION, Iron-dependent transcription repressor related protein 著者 Lee, J.Y, Yeo, H.K. 登録日 2013-12-20 公開日 2014-11-05 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Structural analysis and insight into metal-ion activation of the iron-dependent regulator from Thermoplasma acidophilum. Acta Crystallogr.,Sect.D, 70, 2014
8UV1	Structure of TDP1 complexed with compound IB01 分子名称: 1,2-ETHANEDIOL, 8-(fluorosulfonyl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid, Tyrosyl-DNA phosphodiesterase 1 著者 Lountos, G.T, Zhao, X.Z, Barakat, I, Wang, W, Agama, K, Al Mahmud, M.R, Pommier, Y, Burke, T.R. 登録日 2023-11-02 公開日 2024-09-25 実験手法 X-RAY DIFFRACTION (1.83 Å) 主引用文献 Structure of TDP1 complexed with compound IB01 To Be Published
8UZV	Structure of TDP1 catalytic domain complexed with compound IB02 分子名称: 1,2-ETHANEDIOL, 8-{[2-(fluorosulfonyl)ethyl]amino}-4-oxo-1,4-dihydroquinoline-3-carboxylic acid, DI(HYDROXYETHYL)ETHER, ... 著者 Lountos, G.T, Zhao, X.Z, Barakat, I, Wang, W, Agama, K, Al Mahmud, M.R, Pommier, Y, Burke Jr, T.R. 登録日 2023-11-16 公開日 2024-09-25 実験手法 X-RAY DIFFRACTION (1.846 Å) 主引用文献 Structure of TDP1 catalytic domain complexed with compound IB02 To Be Published
8UZZ	Structure of TDP1 catalytic domain complexed with compound IB03 分子名称: (8M)-8-{2-[(fluorosulfonyl)oxy]phenyl}-4-oxo-1,4-dihydroquinoline-3-carboxylic acid, 1,2-ETHANEDIOL, DI(HYDROXYETHYL)ETHER, ... 著者 Lountos, G.T, Zhao, X.Z, Barakat, I, Wang, W, Agama, K, Al Mahmud, M.R, Pommier, Y, Burke Jr, T.R. 登録日 2023-11-16 公開日 2024-09-25 実験手法 X-RAY DIFFRACTION (1.93 Å) 主引用文献 Structureal analysis of TDP1 in complex with inhbitors To Be Published
8V0C	Structure of TDP1 catalytic domain complexed with compound IB06 分子名称: (8M)-8-(2-{[2-(fluorosulfonyl)ethyl]amino}phenyl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid, 1,2-ETHANEDIOL, DI(HYDROXYETHYL)ETHER, ... 著者 Lountos, G.T, Zhao, X.Z, Barakat, I, Wang, W, Agama, K, Al Mahmud, M.R, Pommier, Y, Burke Jr, T.R. 登録日 2023-11-17 公開日 2024-09-25 実験手法 X-RAY DIFFRACTION (1.62 Å) 主引用文献 Structures of TDP1 complexed with inhibitors To Be Published
8V0B	Structure of TDP1 catalytic domain complexed with compound IB05 分子名称: 1,2-ETHANEDIOL, 8-{4-[(fluorosulfonyl)oxy]phenyl}-4-oxo-1,4-dihydroquinoline-3-carboxylic acid, DI(HYDROXYETHYL)ETHER, ... 著者 Lountos, G.T, Zhao, X.Z, Barakat, I, Wang, W, Agama, K, Al Mahmud, M.R, Pommier, Y, Burke Jr, T.R. 登録日 2023-11-17 公開日 2024-09-25 実験手法 X-RAY DIFFRACTION (1.65 Å) 主引用文献 Structures of TDP1 complexed with inhibitors To Be Published
8TWH	Crystal structure of (GGGTT)3GGG G-quadruplex in complex with small molecule ligand RHPS4 分子名称: (GGGTT)3GGG DNA, 3,11-DIFLUORO-6,8,13-TRIMETHYL-8H-QUINO[4,3,2-KL]ACRIDIN-13-IUM, POTASSIUM ION 著者 Yatsunyk, L.A, Martin, K.N, Lam, G. 登録日 2023-08-21 公開日 2024-09-04 実験手法 X-RAY DIFFRACTION (2.47 Å) 主引用文献 Crystal structure of (GGGTT)3GGG G-quadruplex in complex with small molecule ligand RHPS4 To be published

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