6Y6X

Tetracenomycin X bound to the human ribosome

This is a non-PDB format compatible entry.

Summary for 6Y6X

• Entry DOI: 10.2210/pdb6y6x/pdb
• EMDB information: 10709
• Descriptor: 28S ribosomal RNA, 60S ribosomal protein L7a, 60S ribosomal protein L9, ... (49 entities in total)
• Functional Keywords: translation inhibitor, antibiotic
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 46
• Total formula weight: 2522979.29

Authors

Buschauer, R.,Cheng, J.,Berninghausen, O.,Beckmann, R.,Wilson, D.N. (deposition date: 2020-02-27, release date: 2020-07-08, Last modification date: 2023-11-08)

• Primary citation: Osterman, I.A.,Wieland, M.,Maviza, T.P.,Lashkevich, K.A.,Lukianov, D.A.,Komarova, E.S.,Zakalyukina, Y.V.,Buschauer, R.,Shiriaev, D.I.,Leyn, S.A.,Zlamal, J.E.,Biryukov, M.V.,Skvortsov, D.A.,Tashlitsky, V.N.,Polshakov, V.I.,Cheng, J.,Polikanov, Y.S.,Bogdanov, A.A.,Osterman, A.L.,Dmitriev, S.E.,Beckmann, R.,Dontsova, O.A.,Wilson, D.N.,Sergiev, P.V.; Tetracenomycin X inhibits translation by binding within the ribosomal exit tunnel.; Nat.Chem.Biol., 16:1071-1077, 2020; PubMed: 32601485; DOI: 10.1038/s41589-020-0578-x

Experimental method

ELECTRON MICROSCOPY (2.8 Å)