8V0C

Structure of TDP1 catalytic domain complexed with compound IB06

Summary for 8V0C

• Entry DOI: 10.2210/pdb8v0c/pdb
• Descriptor: Tyrosyl-DNA phosphodiesterase 1, 1,2-ETHANEDIOL, (8M)-8-(2-{[2-(fluorosulfonyl)ethyl]amino}phenyl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid, ... (6 entities in total)
• Functional Keywords: phosphodiesterase, drug target, cancer, dna binding protein, hydrolase-inhibitor complex, hydrolase/inhibitor
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 2
• Total formula weight: 105820.36

Authors

Lountos, G.T.,Zhao, X.Z.,Barakat, I.,Wang, W.,Agama, K.,Al Mahmud, M.R.,Pommier, Y.,Burke Jr., T.R. (deposition date: 2023-11-17, release date: 2024-09-25)

• Primary citation: Lountos, G.T.,Zhao, X.Z.,Barakat, I.,Wang, W.,Agama, K.,Al Mahmud, M.R.,Pommier, Y.,Burke Jr., T.R.; Structures of TDP1 complexed with inhibitors; To Be Published,

Experimental method

X-RAY DIFFRACTION (1.62 Å)