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8UZZ

Structure of TDP1 catalytic domain complexed with compound IB03

Summary for 8UZZ
Entry DOI10.2210/pdb8uzz/pdb
DescriptorTyrosyl-DNA phosphodiesterase 1, 1,2-ETHANEDIOL, (8M)-8-{2-[(fluorosulfonyl)oxy]phenyl}-4-oxo-1,4-dihydroquinoline-3-carboxylic acid, ... (6 entities in total)
Functional Keywordsphosphodiesterase, drug target, cancer, dna binding protein, hydrolase-inhibitor complex, hydrolase/inhibitor
Biological sourceHomo sapiens (human)
Total number of polymer chains2
Total formula weight105844.36
Authors
Lountos, G.T.,Zhao, X.Z.,Barakat, I.,Wang, W.,Agama, K.,Al Mahmud, M.R.,Pommier, Y.,Burke Jr., T.R. (deposition date: 2023-11-16, release date: 2024-09-25, Last modification date: 2024-11-13)
Primary citationLountos, G.T.,Zhao, X.Z.,Barakat, I.,Wang, W.,Agama, K.,Al Mahmud, M.R.,Pommier, Y.,Burke Jr., T.R.
Structureal analysis of TDP1 in complex with inhbitors
To Be Published,
Experimental method
X-RAY DIFFRACTION (1.93 Å)
Structure validation

227561

PDB entries from 2024-11-20

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