8UZZ
Structure of TDP1 catalytic domain complexed with compound IB03
Summary for 8UZZ
Entry DOI | 10.2210/pdb8uzz/pdb |
Descriptor | Tyrosyl-DNA phosphodiesterase 1, 1,2-ETHANEDIOL, (8M)-8-{2-[(fluorosulfonyl)oxy]phenyl}-4-oxo-1,4-dihydroquinoline-3-carboxylic acid, ... (6 entities in total) |
Functional Keywords | phosphodiesterase, drug target, cancer, dna binding protein, hydrolase-inhibitor complex, hydrolase/inhibitor |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 2 |
Total formula weight | 105844.36 |
Authors | Lountos, G.T.,Zhao, X.Z.,Barakat, I.,Wang, W.,Agama, K.,Al Mahmud, M.R.,Pommier, Y.,Burke Jr., T.R. (deposition date: 2023-11-16, release date: 2024-09-25, Last modification date: 2024-11-13) |
Primary citation | Lountos, G.T.,Zhao, X.Z.,Barakat, I.,Wang, W.,Agama, K.,Al Mahmud, M.R.,Pommier, Y.,Burke Jr., T.R. Structureal analysis of TDP1 in complex with inhbitors To Be Published, |
Experimental method | X-RAY DIFFRACTION (1.93 Å) |
Structure validation
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