1M4B
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![BU of 1m4b by Molmil](/molmil-images/mine/1m4b) | Crystal Structure of Human Interleukin-2 K43C Covalently Modified at C43 with 2-[2-(2-Cyclohexyl-2-guanidino-acetylamino)-acetylamino]-N-(3-mercapto-propyl)-propionamide | 分子名称: | 2-[2-(2-CYCLOHEXYL-2-GUANIDINO-ACETYLAMINO)-ACETYLAMINO]-N-(3-MERCAPTO-PROPYL)-PROPIONAMIDE, interleukin-2 | 著者 | Arkin, M.A, Randal, M, DeLano, W.L, Hyde, J, Luong, T.N, Oslob, J.D, Raphael, D.R, Taylor, L, Wang, J, McDowell, R.S, Wells, J.A, Braisted, A.C. | 登録日 | 2002-07-02 | 公開日 | 2002-07-31 | 最終更新日 | 2021-10-27 | 実験手法 | X-RAY DIFFRACTION (2.15 Å) | 主引用文献 | Binding of small molecules to an adaptive
protein-protein interface Proc.Natl.Acad.Sci.USA, 100, 2003
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2VFD
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![BU of 2vfd by Molmil](/molmil-images/mine/2vfd) | Crystal structure of the F96S mutant of Plasmodium falciparum triosephosphate isomerase | 分子名称: | SULFATE ION, TRIOSEPHOSPHATE ISOMERASE | 著者 | Gayathri, P, Banerjee, M, Vijayalakshmi, A, Balaram, H, Balaram, P, Murthy, M.R.N. | 登録日 | 2007-11-03 | 公開日 | 2008-12-09 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (1.4 Å) | 主引用文献 | Biochemical and Structural Characterization of Residue 96 Mutants of Plasmodium Falciparum Triosephosphate Isomerase: Active-Site Loop Conformation, Hydration and Identification of a Dimer-Interface Ligand-Binding Site. Acta Crystallogr.,Sect.D, 65, 2009
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8E10
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![BU of 8e10 by Molmil](/molmil-images/mine/8e10) | Structure of mouse polymerase beta | 分子名称: | DNA polymerase beta, MALONIC ACID | 著者 | Thompson, M.K, Sharma, N, Prakash, A. | 登録日 | 2022-08-09 | 公開日 | 2023-02-01 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (1.65 Å) | 主引用文献 | Pol beta /XRCC1 heterodimerization dictates DNA damage recognition and basal Pol beta protein levels without interfering with mouse viability or fertility. DNA Repair (Amst), 123, 2023
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8E11
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![BU of 8e11 by Molmil](/molmil-images/mine/8e11) | |
2BJG
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![BU of 2bjg by Molmil](/molmil-images/mine/2bjg) | Crystal Structure of Conjugated Bile Acid Hydrolase from Clostridium perfringens in Complex with Reaction Products Taurine and Deoxycholate | 分子名称: | 1,2-ETHANEDIOL, CHOLOYLGLYCINE HYDROLASE | 著者 | Rossocha, M, Schultz-Heienbrok, R, Von Moeller, H, Coleman, J.P, Saenger, W. | 登録日 | 2005-02-02 | 公開日 | 2005-05-03 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Conjugated Bile Acid Hydrolase is a Tetrameric N-Terminal Thiol Hydrolase with Specific Recognition of its Cholyl But not of its Tauryl Product Biochemistry, 44, 2005
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2HXU
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![BU of 2hxu by Molmil](/molmil-images/mine/2hxu) | Crystal structure of K220A mutant of L-Fuconate Dehydratase from Xanthomonas campestris liganded with Mg++ and L-fuconate | 分子名称: | 6-deoxy-L-galactonic acid, L-fuconate dehydratase, MAGNESIUM ION, ... | 著者 | Fedorov, A.A, Fedorov, E.V, Yew, W.S, Rakus, J.F, Gerlt, J.A, Almo, S.C. | 登録日 | 2006-08-03 | 公開日 | 2006-12-19 | 最終更新日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Evolution of Enzymatic Activities in the Enolase Superfamily: l-Fuconate Dehydratase from Xanthomonas campestris. Biochemistry, 45, 2006
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6EDB
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![BU of 6edb by Molmil](/molmil-images/mine/6edb) | Crystal structure of SRY.hcGAS-21bp dsDNA complex | 分子名称: | DNA (5'-D(*CP*GP*AP*TP*CP*CP*GP*GP*GP*AP*TP*CP*TP*AP*AP*AP*CP*AP*AP*TP*G)-3'), DNA (5'-D(*GP*CP*AP*TP*TP*GP*TP*TP*TP*AP*GP*AP*TP*CP*CP*CP*GP*GP*AP*TP*C)-3'), Sex-determining region Y protein,Cyclic GMP-AMP synthase, ... | 著者 | Xie, W, Lama, L, Adura, C, Glickman, J.F, Tuschl, T, Patel, D.J. | 登録日 | 2018-08-09 | 公開日 | 2019-05-29 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (3.209 Å) | 主引用文献 | Human cGAS catalytic domain has an additional DNA-binding interface that enhances enzymatic activity and liquid-phase condensation. Proc.Natl.Acad.Sci.USA, 116, 2019
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1M48
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![BU of 1m48 by Molmil](/molmil-images/mine/1m48) | Crystal Structure of Human IL-2 Complexed with (R)-N-[2-[1-(Aminoiminomethyl)-3-piperidinyl]-1-oxoethyl]-4-(phenylethynyl)-L-phenylalanine methyl ester | 分子名称: | 2-[3-METHYL-4-(N-METHYL-GUANIDINO)-BUTYRYLAMINO]-3-(4-PHENYLETHYNYL-PHENYL)-PROPIONIC ACID METHYL ESTER, interleukin-2 | 著者 | Arkin, M.A, Randal, M, DeLano, W.L, Hyde, J, Luong, T.N, Oslob, J.D, Raphael, D.R, Taylor, L, Wang, J, McDowell, R.S, Wells, J.A, Braisted, A.C. | 登録日 | 2002-07-02 | 公開日 | 2002-07-31 | 最終更新日 | 2017-10-11 | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | 主引用文献 | Binding of small molecules to an adaptive
protein-protein interface Proc.Natl.Acad.Sci.USA, 100, 2003
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1M4A
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![BU of 1m4a by Molmil](/molmil-images/mine/1m4a) | Crystal Structure of Human Interleukin-2 Y31C Covalently Modified at C31 with (1H-Indol-3-yl)-(2-mercapto-ethoxyimino)-acetic acid | 分子名称: | (1H-INDOL-3-YL)-(2-MERCAPTO-ETHOXYIMINO)-ACETIC ACID, GLYCEROL, interleukin-2 | 著者 | Arkin, M.A, Randal, M, DeLano, W.L, Hyde, J, Luong, T.N, Oslob, J.D, Raphael, D.R, Taylor, L, Wang, J, McDowell, R.S, Wells, J.A, Braisted, A.C. | 登録日 | 2002-07-02 | 公開日 | 2002-07-31 | 最終更新日 | 2021-10-27 | 実験手法 | X-RAY DIFFRACTION (2.18 Å) | 主引用文献 | Binding of small molecules to an adaptive
protein-protein interface Proc.Natl.Acad.Sci.USA, 100, 2003
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6EDC
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![BU of 6edc by Molmil](/molmil-images/mine/6edc) | hcGAS-16bp dsDNA complex | 分子名称: | Cyclic GMP-AMP synthase, DNA (5'-D(*AP*AP*AP*TP*TP*GP*CP*CP*GP*AP*AP*GP*AP*CP*GP*AP*A)-3'), DNA (5'-D(*TP*TP*CP*GP*TP*CP*TP*TP*CP*GP*GP*CP*AP*AP*T)-3'), ... | 著者 | Xie, W, Lama, L, Adura, C, Glickman, J.F, Tuschl, T, Patel, D.J. | 登録日 | 2018-08-09 | 公開日 | 2019-05-29 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (2.712 Å) | 主引用文献 | Human cGAS catalytic domain has an additional DNA-binding interface that enhances enzymatic activity and liquid-phase condensation. Proc.Natl.Acad.Sci.USA, 116, 2019
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2QBW
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![BU of 2qbw by Molmil](/molmil-images/mine/2qbw) | The crystal structure of PDZ-Fibronectin fusion protein | 分子名称: | PDZ-Fibronectin fusion protein, Polypeptide | 著者 | Huang, J, Makabe, K, Koide, A, Koide, S. | 登録日 | 2007-06-18 | 公開日 | 2008-04-22 | 最終更新日 | 2024-02-21 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Design of protein function leaps by directed domain interface evolution. Proc.Natl.Acad.Sci.Usa, 105, 2008
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5SZ8
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![BU of 5sz8 by Molmil](/molmil-images/mine/5sz8) | |
3L0H
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![BU of 3l0h by Molmil](/molmil-images/mine/3l0h) | Crystal Structure Analysis of W21A mutant of human GSTA1-1 in complex with S-hexylglutathione | 分子名称: | Glutathione S-transferase A1, S-HEXYLGLUTATHIONE | 著者 | Fanucchi, S, Achilonu, I.A, Adamson, R.J, Fernandes, M.A, Burke, J.P, Dirr, H.W. | 登録日 | 2009-12-10 | 公開日 | 2010-01-12 | 最終更新日 | 2024-02-21 | 実験手法 | X-RAY DIFFRACTION (2.13 Å) | 主引用文献 | Stability of the domain interface contributes towards the catalytic function at the H-site of class alpha glutathione transferase A1-1. Biochim.Biophys.Acta, 1804, 2010
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3S48
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![BU of 3s48 by Molmil](/molmil-images/mine/3s48) | Human Alpha-Haemoglobin Complexed with the First NEAT Domain of IsdH from Staphylococcus aureus | 分子名称: | Hemoglobin subunit alpha, Iron-regulated surface determinant protein H, PROTOPORPHYRIN IX CONTAINING FE | 著者 | Kumar, K.K, Jacques, D.A, Caradoc-Davies, T.T, Guss, J.M, Gell, D.A. | 登録日 | 2011-05-19 | 公開日 | 2012-05-23 | 最終更新日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (3.05 Å) | 主引用文献 | The structure of alpha-haemoglobin in complex with a haemoglobin-binding domain from Staphylococcus aureus reveals the elusive alpha-haemoglobin dimerization interface ACTA CRYSTALLOGR.,SECT.F, 70, 2014
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3HNI
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![BU of 3hni by Molmil](/molmil-images/mine/3hni) | Crystal structure of the Zn-induced tetramer of the engineered cyt cb562 variant RIDC-1 | 分子名称: | PROTOPORPHYRIN IX CONTAINING FE, Soluble cytochrome b562, ZINC ION | 著者 | Salgado, E.N, Lewis, R.A, Brodin, J, Tezcan, F.A. | 登録日 | 2009-05-31 | 公開日 | 2010-02-09 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (2.35 Å) | 主引用文献 | Metal templated design of protein interfaces. Proc.Natl.Acad.Sci.USA, 107, 2010
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5VR9
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![BU of 5vr9 by Molmil](/molmil-images/mine/5vr9) | CH1/Ckappa Fab based on Matuzumab | 分子名称: | CH1/Ckappa Fab heavy chain, CH1/Ckappa Fab light chain | 著者 | Hendle, J. | 登録日 | 2017-05-10 | 公開日 | 2017-08-02 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (2.15 Å) | 主引用文献 | Computational design of a specific heavy chain/ kappa light chain interface for expressing fully IgG bispecific antibodies. Protein Sci., 26, 2017
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5VSH
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![BU of 5vsh by Molmil](/molmil-images/mine/5vsh) | CH1/Clambda Fab based on Pertuzumab | 分子名称: | CH1/Clambda Fab heavy chain, CH1/Clambda Fab light chain, SULFATE ION | 著者 | Hendle, J. | 登録日 | 2017-05-11 | 公開日 | 2017-08-02 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (2.55 Å) | 主引用文献 | Computational design of a specific heavy chain/ kappa light chain interface for expressing fully IgG bispecific antibodies. Protein Sci., 26, 2017
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4DYX
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![BU of 4dyx by Molmil](/molmil-images/mine/4dyx) | |
3HNJ
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![BU of 3hnj by Molmil](/molmil-images/mine/3hnj) | Crystal structure of the Zn-induced tetramer of the engineered cyt cb562 variant RIDC-2 | 分子名称: | PROTOPORPHYRIN IX CONTAINING FE, Soluble cytochrome b562, ZINC ION | 著者 | Salgado, E.N, Lewis, R.A, Brodin, J, Tezcan, F.A. | 登録日 | 2009-05-31 | 公開日 | 2010-02-09 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Metal templated design of protein interfaces. Proc.Natl.Acad.Sci.USA, 107, 2010
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2OEL
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![BU of 2oel by Molmil](/molmil-images/mine/2oel) | Crystal structure of a rubisco-like protein from Geobacillus kaustophilus liganded with Mg2+ and HCO3- ions | 分子名称: | 2,3-diketo-5-methylthiopentyl-1-phosphate enolase, CARBONATE ION, MAGNESIUM ION | 著者 | Fedorov, A.A, Imker, H.J, Fedorov, E.V, Almo, S.C, Gerlt, J.A. | 登録日 | 2006-12-30 | 公開日 | 2007-03-20 | 最終更新日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Mechanistic Diversity in the RuBisCO Superfamily: The "Enolase" in the Methionine Salvage Pathway in Geobacillus kaustophilus. Biochemistry, 46, 2007
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3HNL
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![BU of 3hnl by Molmil](/molmil-images/mine/3hnl) | Crystal structure of the Cu-induced dimer of the engineered cyt cb562 variant RIDC-1 | 分子名称: | CHLORIDE ION, COPPER (II) ION, PROTOPORPHYRIN IX CONTAINING FE, ... | 著者 | Salgado, E.N, Lewis, R.A, Brodin, J, Tezcan, F.A. | 登録日 | 2009-05-31 | 公開日 | 2010-02-09 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Metal templated design of protein interfaces. Proc.Natl.Acad.Sci.USA, 107, 2010
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3HNK
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![BU of 3hnk by Molmil](/molmil-images/mine/3hnk) | Crystal structure of the dimeric assembly of the cyt cb562 variant RIDC-1 | 分子名称: | PROTOPORPHYRIN IX CONTAINING FE, Soluble cytochrome b562 | 著者 | Salgado, E.N, Lewis, R.A, Brodin, J, Tezcan, F.A. | 登録日 | 2009-05-31 | 公開日 | 2010-02-09 | 最終更新日 | 2024-02-21 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Metal templated design of protein interfaces. Proc.Natl.Acad.Sci.USA, 107, 2010
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2OEK
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![BU of 2oek by Molmil](/molmil-images/mine/2oek) | Crystal structure of a rubisco-like protein from Geobacillus kaustophilus liganded with Mg2+ ions | 分子名称: | 2,3-diketo-5-methylthiopentyl-1-phosphate enolase, MAGNESIUM ION | 著者 | Fedorov, A.A, Imker, H.J, Fedorov, E.V, Almo, S.C, Gerlt, J.A. | 登録日 | 2006-12-30 | 公開日 | 2007-03-20 | 最終更新日 | 2024-04-03 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Mechanistic Diversity in the RuBisCO Superfamily: The "Enolase" in the Methionine Salvage Pathway in Geobacillus kaustophilus. Biochemistry, 46, 2007
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5VSI
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![BU of 5vsi by Molmil](/molmil-images/mine/5vsi) | CH1/Ckappa Fab mutant 15.1 | 分子名称: | 1,2-ETHANEDIOL, CH1/Ckappa Fab heavy chain, CH1/Ckappa Fab light chain, ... | 著者 | Hendle, J. | 登録日 | 2017-05-11 | 公開日 | 2017-08-02 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (1.51 Å) | 主引用文献 | Computational design of a specific heavy chain/ kappa light chain interface for expressing fully IgG bispecific antibodies. Protein Sci., 26, 2017
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6BNO
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![BU of 6bno by Molmil](/molmil-images/mine/6bno) | Structure of bare actin filament | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, Actin, alpha skeletal muscle, ... | 著者 | Gurel, P.S, Alushin, G.A. | 登録日 | 2017-11-17 | 公開日 | 2018-01-10 | 最終更新日 | 2024-03-13 | 実験手法 | ELECTRON MICROSCOPY (5.5 Å) | 主引用文献 | Cryo-EM structures reveal specialization at the myosin VI-actin interface and a mechanism of force sensitivity. Elife, 6, 2017
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