1M4B

Crystal Structure of Human Interleukin-2 K43C Covalently Modified at C43 with 2-[2-(2-Cyclohexyl-2-guanidino-acetylamino)-acetylamino]-N-(3-mercapto-propyl)-propionamide

Summary for 1M4B

Entry DOI	10.2210/pdb1m4b/pdb
Related	1M47 1M48 1M49 1M4A 1M4C
Descriptor	interleukin-2, 2-[2-(2-CYCLOHEXYL-2-GUANIDINO-ACETYLAMINO)-ACETYLAMINO]-N-(3-MERCAPTO-PROPYL)-PROPIONAMIDE (3 entities in total)
Functional Keywords	cytokine, four-helix bundle, small molecule complex
Biological source	Homo sapiens (human)
Cellular location	Secreted: P60568
Total number of polymer chains	1
Total formula weight	15810.48
Authors	Arkin, M.A.,Randal, M.,DeLano, W.L.,Hyde, J.,Luong, T.N.,Oslob, J.D.,Raphael, D.R.,Taylor, L.,Wang, J.,McDowell, R.S.,Wells, J.A.,Braisted, A.C. (deposition date: 2002-07-02, release date: 2002-07-31, Last modification date: 2021-10-27)
Primary citation	Arkin, M.A.,Randal, M.,DeLano, W.L.,Hyde, J.,Luong, T.N.,Oslob, J.D.,Raphael, D.R.,Taylor, L.,Wang, J.,McDowell, R.S.,Wells, J.A.,Braisted, A.C. Binding of small molecules to an adaptive protein-protein interface Proc.Natl.Acad.Sci.USA, 100:1603-1608, 2003 Cited by PubMed: 12582206 DOI: 10.1073/pnas.252756299 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.15 Å)

Structure validation