1M49
Crystal Structure of Human Interleukin-2 Complexed with SP-1985
Summary for 1M49
Entry DOI | 10.2210/pdb1m49/pdb |
Related | 1M47 1M48 1M4A 1M4B 1M4C |
Descriptor | interleukin-2, 2-[2-(1-CARBAMIMIDOYL-PIPERIDIN-3-YL)-ACETYLAMINO]-3-{4-[2-(3-OXALYL-1H-INDOL-7-YL)ETHYL]-PHENYL}-PROPIONIC ACID METHYL ESTER (3 entities in total) |
Functional Keywords | cytokine, four-helix bundle, small molecule complex |
Biological source | Homo sapiens (human) |
Cellular location | Secreted: P60568 |
Total number of polymer chains | 2 |
Total formula weight | 31995.22 |
Authors | Arkin, M.A.,Randal, M.,DeLano, W.L.,Hyde, J.,Luong, T.N.,Oslob, J.D.,Raphael, D.R.,Taylor, L.,Wang, J.,McDowell, R.S.,Wells, J.A.,Braisted, A.C. (deposition date: 2002-07-02, release date: 2002-07-31, Last modification date: 2017-10-11) |
Primary citation | Arkin, M.A.,Randal, M.,DeLano, W.L.,Hyde, J.,Luong, T.N.,Oslob, J.D.,Raphael, D.R.,Taylor, L.,Wang, J.,McDowell, R.S.,Wells, J.A.,Braisted, A.C. Binding of small molecules to an adaptive protein-protein interface Proc.Natl.Acad.Sci.USA, 100:1603-1608, 2003 Cited by PubMed: 12582206DOI: 10.1073/pnas.252756299 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2 Å) |
Structure validation
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