1M49

Crystal Structure of Human Interleukin-2 Complexed with SP-1985

Summary for 1M49

• Entry DOI: 10.2210/pdb1m49/pdb
• Related: 1M47 1M48 1M4A 1M4B 1M4C
• Descriptor: interleukin-2, 2-[2-(1-CARBAMIMIDOYL-PIPERIDIN-3-YL)-ACETYLAMINO]-3-{4-[2-(3-OXALYL-1H-INDOL-7-YL)ETHYL]-PHENYL}-PROPIONIC ACID METHYL ESTER (3 entities in total)
• Functional Keywords: cytokine, four-helix bundle, small molecule complex
• Biological source: Homo sapiens (human)
• Cellular location: Secreted: P60568
• Total number of polymer chains: 2
• Total formula weight: 31995.22

Authors

Arkin, M.A.,Randal, M.,DeLano, W.L.,Hyde, J.,Luong, T.N.,Oslob, J.D.,Raphael, D.R.,Taylor, L.,Wang, J.,McDowell, R.S.,Wells, J.A.,Braisted, A.C. (deposition date: 2002-07-02, release date: 2002-07-31, Last modification date: 2017-10-11)

• Primary citation: Arkin, M.A.,Randal, M.,DeLano, W.L.,Hyde, J.,Luong, T.N.,Oslob, J.D.,Raphael, D.R.,Taylor, L.,Wang, J.,McDowell, R.S.,Wells, J.A.,Braisted, A.C.; Binding of small molecules to an adaptive protein-protein interface; Proc.Natl.Acad.Sci.USA, 100:1603-1608, 2003; PubMed: 12582206; DOI: 10.1073/pnas.252756299

Experimental method

X-RAY DIFFRACTION (2 Å)