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1M49

Crystal Structure of Human Interleukin-2 Complexed with SP-1985

Functional Information from GO Data
ChainGOidnamespacecontents
A0002250biological_processadaptive immune response
A0002366biological_processleukocyte activation involved in immune response
A0002376biological_processimmune system process
A0002639biological_processpositive regulation of immunoglobulin production
A0002903biological_processnegative regulation of B cell apoptotic process
A0005125molecular_functioncytokine activity
A0005134molecular_functioninterleukin-2 receptor binding
A0005515molecular_functionprotein binding
A0005576cellular_componentextracellular region
A0005615cellular_componentextracellular space
A0006955biological_processimmune response
A0007155biological_processcell adhesion
A0007186biological_processG protein-coupled receptor signaling pathway
A0007200biological_processphospholipase C-activating G protein-coupled receptor signaling pathway
A0007204biological_processpositive regulation of cytosolic calcium ion concentration
A0007259biological_processcell surface receptor signaling pathway via JAK-STAT
A0007267biological_processcell-cell signaling
A0008083molecular_functiongrowth factor activity
A0008284biological_processpositive regulation of cell population proliferation
A0019209molecular_functionkinase activator activity
A0030101biological_processnatural killer cell activation
A0030217biological_processT cell differentiation
A0030246molecular_functioncarbohydrate binding
A0030307biological_processpositive regulation of cell growth
A0030890biological_processpositive regulation of B cell proliferation
A0031851molecular_functionkappa-type opioid receptor binding
A0032740biological_processpositive regulation of interleukin-17 production
A0034105biological_processpositive regulation of tissue remodeling
A0038110biological_processinterleukin-2-mediated signaling pathway
A0042102biological_processpositive regulation of T cell proliferation
A0042104biological_processpositive regulation of activated T cell proliferation
A0043066biological_processnegative regulation of apoptotic process
A0043208molecular_functionglycosphingolipid binding
A0045471biological_processresponse to ethanol
A0045582biological_processpositive regulation of T cell differentiation
A0045591biological_processpositive regulation of regulatory T cell differentiation
A0045621biological_processpositive regulation of lymphocyte differentiation
A0050729biological_processpositive regulation of inflammatory response
A0060999biological_processpositive regulation of dendritic spine development
A0070665biological_processpositive regulation of leukocyte proliferation
A0097696biological_processcell surface receptor signaling pathway via STAT
A1900100biological_processpositive regulation of plasma cell differentiation
A1901327biological_processresponse to tacrolimus
A1902107biological_processpositive regulation of leukocyte differentiation
A2000320biological_processnegative regulation of T-helper 17 cell differentiation
B0002250biological_processadaptive immune response
B0002366biological_processleukocyte activation involved in immune response
B0002376biological_processimmune system process
B0002639biological_processpositive regulation of immunoglobulin production
B0002903biological_processnegative regulation of B cell apoptotic process
B0005125molecular_functioncytokine activity
B0005134molecular_functioninterleukin-2 receptor binding
B0005515molecular_functionprotein binding
B0005576cellular_componentextracellular region
B0005615cellular_componentextracellular space
B0006955biological_processimmune response
B0007155biological_processcell adhesion
B0007186biological_processG protein-coupled receptor signaling pathway
B0007200biological_processphospholipase C-activating G protein-coupled receptor signaling pathway
B0007204biological_processpositive regulation of cytosolic calcium ion concentration
B0007259biological_processcell surface receptor signaling pathway via JAK-STAT
B0007267biological_processcell-cell signaling
B0008083molecular_functiongrowth factor activity
B0008284biological_processpositive regulation of cell population proliferation
B0019209molecular_functionkinase activator activity
B0030101biological_processnatural killer cell activation
B0030217biological_processT cell differentiation
B0030246molecular_functioncarbohydrate binding
B0030307biological_processpositive regulation of cell growth
B0030890biological_processpositive regulation of B cell proliferation
B0031851molecular_functionkappa-type opioid receptor binding
B0032740biological_processpositive regulation of interleukin-17 production
B0034105biological_processpositive regulation of tissue remodeling
B0038110biological_processinterleukin-2-mediated signaling pathway
B0042102biological_processpositive regulation of T cell proliferation
B0042104biological_processpositive regulation of activated T cell proliferation
B0043066biological_processnegative regulation of apoptotic process
B0043208molecular_functionglycosphingolipid binding
B0045471biological_processresponse to ethanol
B0045582biological_processpositive regulation of T cell differentiation
B0045591biological_processpositive regulation of regulatory T cell differentiation
B0045621biological_processpositive regulation of lymphocyte differentiation
B0050729biological_processpositive regulation of inflammatory response
B0060999biological_processpositive regulation of dendritic spine development
B0070665biological_processpositive regulation of leukocyte proliferation
B0097696biological_processcell surface receptor signaling pathway via STAT
B1900100biological_processpositive regulation of plasma cell differentiation
B1901327biological_processresponse to tacrolimus
B1902107biological_processpositive regulation of leukocyte differentiation
B2000320biological_processnegative regulation of T-helper 17 cell differentiation
Functional Information from PDB Data
site_idAC1
Number of Residues17
DetailsBINDING SITE FOR RESIDUE CMM A 201
ChainResidue
ALYS35
APRO65
AALA73
AGLN126
ASER127
ASER130
AHOH208
AHOH240
AHOH248
AARG38
AMET39
ATHR41
APHE42
ALYS43
ATYR45
ATHR51
AGLU62

site_idAC2
Number of Residues18
DetailsBINDING SITE FOR RESIDUE CMM B 202
ChainResidue
AGLU60
ALYS64
AGLU67
AARG83
AILE86
ASER87
AASN90
AVAL91
BARG38
BTHR41
BPHE42
BLYS43
BTYR45
BGLU62
BPRO65
BLEU72
BHOH228
BHOH229

Functional Information from PROSITE/UniProt
site_idPS00424
Number of Residues13
DetailsINTERLEUKIN_2 Interleukin-2 signature. TELkhLqCLeeEL
ChainResidueDetails
ATHR51-LEU63

246704

PDB entries from 2025-12-24

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